Abstract

To correct eye motion artifacts in en face optical coherence tomography angiography (OCT-A) images, a Lissajous scanning method with subsequent software-based motion correction is proposed. The standard Lissajous scanning pattern is modified to be compatible with OCT-A and a corresponding motion correction algorithm is designed. The effectiveness of our method was demonstrated by comparing en face OCT-A images with and without motion correction. The method was further validated by comparing motion-corrected images with scanning laser ophthalmoscopy images, and the repeatability of the method was evaluated using a checkerboard image. A motion-corrected en face OCT-A image from a blinking case is presented to demonstrate the ability of the method to deal with eye blinking. Results show that the method can produce accurate motion-free en face OCT-A images of the posterior segment of the eye in vivo.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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2017 (1)

2016 (3)

2015 (1)

2014 (2)

2013 (3)

2012 (5)

2011 (3)

2009 (1)

M. K. Garvin, M. D. Abramoff, X. Wu, S. R. Russell, T. L. Burns, and M. Sonka, “Automated 3-D Intraretinal Layer Segmentation of Macular Spectral-Domain Optical Coherence Tomography Images,” IEEE Trans. Med. Imaging 28(9), 1436–1447 (2009).
[Crossref] [PubMed]

2007 (2)

M. Pircher, B. Baumann, E. Götzinger, H. Sattmann, and C. K. Hitzenberger, “Simultaneous SLO/OCT imaging of the human retina with axial eye motion correction,” Opt. Express 15(25), 16922–16932 (2007).
[Crossref] [PubMed]

R. P. C. Lira, C. L. d. A. Oliveira, M. V. R. B. Marques, A. R. Silva, and C. d. C. Pessoa, “Adverse reactions of fluorescein angiography: a prospective study,” Arq. Bras. Oftalmol. 70(4), 615–618 (2007).
[Crossref] [PubMed]

2006 (2)

S. Makita, Y. Hong, M. Yamanari, T. Yatagai, and Y. Yasuno, “Optical coherence angiography,” Opt. Express 14(17), 7821–7840 (2006).
[Crossref] [PubMed]

K. Li, X. Wu, D. Z. Chen, and M. Sonka, “Optimal Surface Segmentation in Volumetric Images-A Graph-Theoretic Approach,” IEEE Trans. Pattern Anal. Mach. Intell. 28(1), 119–134 (2006).
[Crossref] [PubMed]

2005 (1)

2004 (1)

1996 (1)

S. L. Owens, “Indocyanine green angiography,” Br. J. Ophthalmol. 80(3), 263–266 (1996).
[Crossref] [PubMed]

1994 (1)

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse Reactions due to Indocyanine Green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and A. Et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

1989 (1)

R. Benya, J. Quintana, and B. Brundage, “Adverse reactions to indocyanine green: A case report and a review of the literature,” Cathet. Cardiovasc. Diagn. 17(4), 231–233 (1989).
[Crossref] [PubMed]

1986 (1)

U. Karhunen, C. Raitta, and R. Kala, “Adverse reactions to fluorescein angiography,” Acta Ophthalmol. (Copenh.) 64(3), 282–286 (1986).
[Crossref]

1983 (1)

S. R. Sternberg, “Biomedical Image Processing,” Computer 16(1), 22–34 (1983).
[Crossref]

1961 (1)

H. R. Novotny and D. L. Alvis, “A Method of Photographing Fluorescence in Circulating Blood in the Human Retina,” Circulation 24(1), 82–86 (1961).
[Crossref] [PubMed]

Abramoff, M. D.

X. Chen, M. Niemeijer, L. Zhang, K. Lee, M. D. Abramoff, and M. Sonka, “Segmentation Three-Dimensional of Abnormalities Fluid-Associated in OCT RetinalThree-Dimensional Segmentation of Fluid-Associated Abnormalities in Retinal OCT: Probability Constrained Graph-Search-Graph-Cut,” IEEE Trans. Med. Imaging 31(8), 1521–1531 (2012).
[Crossref] [PubMed]

M. K. Garvin, M. D. Abramoff, X. Wu, S. R. Russell, T. L. Burns, and M. Sonka, “Automated 3-D Intraretinal Layer Segmentation of Macular Spectral-Domain Optical Coherence Tomography Images,” IEEE Trans. Med. Imaging 28(9), 1436–1447 (2009).
[Crossref] [PubMed]

Alvis, D. L.

H. R. Novotny and D. L. Alvis, “A Method of Photographing Fluorescence in Circulating Blood in the Human Retina,” Circulation 24(1), 82–86 (1961).
[Crossref] [PubMed]

Arathorn, D. W.

Baumann, B.

Bazaei, A.

A. Bazaei, Y. K. Yong, and S. O. R. Moheimani, “High-speed Lissajous-scan atomic force microscopy: Scan pattern planning and control design issues,” Rev. Sci. Instrum. 83(6), 063701 (2012).
[Crossref] [PubMed]

Beaton, S.

Benya, R.

R. Benya, J. Quintana, and B. Brundage, “Adverse reactions to indocyanine green: A case report and a review of the literature,” Cathet. Cardiovasc. Diagn. 17(4), 231–233 (1989).
[Crossref] [PubMed]

Blatter, C.

L. Ginner, C. Blatter, D. Fechtig, T. Schmoll, M. Gröschl, and R. A. Leitgeb, “Wide-Field OCT Angiography at 400 KHz Utilizing Spectral Splitting,” Photonics 1(4), 369–379 (2014).
[Crossref]

Bock, R.

Boer, J. F. d.

Braaf, B.

Branchini, L.

Brundage, B.

R. Benya, J. Quintana, and B. Brundage, “Adverse reactions to indocyanine green: A case report and a review of the literature,” Cathet. Cardiovasc. Diagn. 17(4), 231–233 (1989).
[Crossref] [PubMed]

Budai, A.

Burns, T. L.

M. K. Garvin, M. D. Abramoff, X. Wu, S. R. Russell, T. L. Burns, and M. Sonka, “Automated 3-D Intraretinal Layer Segmentation of Macular Spectral-Domain Optical Coherence Tomography Images,” IEEE Trans. Med. Imaging 28(9), 1436–1447 (2009).
[Crossref] [PubMed]

Cabrera, M. T.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and A. Et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Chen, C.-L.

Chen, D. Z.

K. Li, X. Wu, D. Z. Chen, and M. Sonka, “Optimal Surface Segmentation in Volumetric Images-A Graph-Theoretic Approach,” IEEE Trans. Pattern Anal. Mach. Intell. 28(1), 119–134 (2006).
[Crossref] [PubMed]

Chen, X.

X. Chen, M. Niemeijer, L. Zhang, K. Lee, M. D. Abramoff, and M. Sonka, “Segmentation Three-Dimensional of Abnormalities Fluid-Associated in OCT RetinalThree-Dimensional Segmentation of Fluid-Associated Abnormalities in Retinal OCT: Probability Constrained Graph-Search-Graph-Cut,” IEEE Trans. Med. Imaging 31(8), 1521–1531 (2012).
[Crossref] [PubMed]

Chen, Y.

Y. Chen, Y.-J. Hong, S. Makita, and Y. Yasuno, “Three-dimensional eye motion correction by Lissajous scan optical coherence tomography,” Biomed. Opt. Express 8(3), 1783–1802 (2017).
[Crossref] [PubMed]

Y.-J. Hong, Y. Chen, E. Li, M. Miura, S. Makita, and Y. Yasuno, “Eye motion corrected OCT imaging with Lissajous scan pattern,” Proceedings of SPIE 9693, 96930 (2016).
[Crossref]

Chen, Z.

Chiu, S. J.

Choi, B.

Chou, L.

Dilworth, W. D.

Dongye, C.

Drexler, W.

W. Drexler and J. G. Fujimoto, Optical Coherence Tomography: Technology and Applications (Springer Science & Business Media, 2008).
[Crossref]

Duan, L.

Duker, J. S.

Durbin, M. K.

P. J. Rosenfeld, M. K. Durbin, L. Roisman, F. Zheng, A. Miller, G. Robbins, K. B. Schaal, and G. Gregori, “ZEISS Angioplex™Spectral Domain Optical Coherence Tomography Angiography: Technical Aspects,” in “OCT angiography in retinal and macular diseases,”, vol. 56 of Developments in OphthalmologyF. Bandello, E. Souied, and G. Querques, eds. (S. Karger AG, 2016), pp. 18–29. .
[Crossref]

Estrada, R.

Et, A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and A. Et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Farsiu, S.

Fechtig, D.

L. Ginner, C. Blatter, D. Fechtig, T. Schmoll, M. Gröschl, and R. A. Leitgeb, “Wide-Field OCT Angiography at 400 KHz Utilizing Spectral Splitting,” Photonics 1(4), 369–379 (2014).
[Crossref]

Ferguson, R. D.

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and A. Et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Freedman, S. F.

Fujimoto, J. G.

Gabriele, M. L.

Garvin, M. K.

M. K. Garvin, M. D. Abramoff, X. Wu, S. R. Russell, T. L. Burns, and M. Sonka, “Automated 3-D Intraretinal Layer Segmentation of Macular Spectral-Domain Optical Coherence Tomography Images,” IEEE Trans. Med. Imaging 28(9), 1436–1447 (2009).
[Crossref] [PubMed]

Ginner, L.

L. Ginner, C. Blatter, D. Fechtig, T. Schmoll, M. Gröschl, and R. A. Leitgeb, “Wide-Field OCT Angiography at 400 KHz Utilizing Spectral Splitting,” Photonics 1(4), 369–379 (2014).
[Crossref]

Götzinger, E.

Gragoudas, E. S.

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse Reactions due to Indocyanine Green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref] [PubMed]

Gregori, G.

P. J. Rosenfeld, M. K. Durbin, L. Roisman, F. Zheng, A. Miller, G. Robbins, K. B. Schaal, and G. Gregori, “ZEISS Angioplex™Spectral Domain Optical Coherence Tomography Angiography: Technical Aspects,” in “OCT angiography in retinal and macular diseases,”, vol. 56 of Developments in OphthalmologyF. Bandello, E. Souied, and G. Querques, eds. (S. Karger AG, 2016), pp. 18–29. .
[Crossref]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and A. Et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Gröschl, M.

L. Ginner, C. Blatter, D. Fechtig, T. Schmoll, M. Gröschl, and R. A. Leitgeb, “Wide-Field OCT Angiography at 400 KHz Utilizing Spectral Splitting,” Photonics 1(4), 369–379 (2014).
[Crossref]

Guyer, D. R.

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse Reactions due to Indocyanine Green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref] [PubMed]

Hammer, D. X.

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and A. Et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Hendargo, H. C.

Hitzenberger, C. K.

Hong, Y.

Hong, Y.-J.

Hope-Ross, M.

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse Reactions due to Indocyanine Green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref] [PubMed]

Hornegger, J.

Huang, D.

Huber, R.

Hwang, T. S.

Iftimia, N. V.

Ikuno, Y.

Ishikawa, H.

Izatt, J. A.

Jia, W.

Jia, Y.

Ju, M. J.

Kagemann, L.

Kala, R.

U. Karhunen, C. Raitta, and R. Kala, “Adverse reactions to fluorescein angiography,” Acta Ophthalmol. (Copenh.) 64(3), 282–286 (1986).
[Crossref]

Kampik, A.

Karhunen, U.

U. Karhunen, C. Raitta, and R. Kala, “Adverse reactions to fluorescein angiography,” Acta Ophthalmol. (Copenh.) 64(3), 282–286 (1986).
[Crossref]

Kasaragod, D.

Klein, T.

Ko, T.

Kraus, M. F.

Krupsky, S.

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse Reactions due to Indocyanine Green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref] [PubMed]

Kurokawa, K.

Lee, K.

X. Chen, M. Niemeijer, L. Zhang, K. Lee, M. D. Abramoff, and M. Sonka, “Segmentation Three-Dimensional of Abnormalities Fluid-Associated in OCT RetinalThree-Dimensional Segmentation of Fluid-Associated Abnormalities in Retinal OCT: Probability Constrained Graph-Search-Graph-Cut,” IEEE Trans. Med. Imaging 31(8), 1521–1531 (2012).
[Crossref] [PubMed]

Leitgeb, R. A.

L. Ginner, C. Blatter, D. Fechtig, T. Schmoll, M. Gröschl, and R. A. Leitgeb, “Wide-Field OCT Angiography at 400 KHz Utilizing Spectral Splitting,” Photonics 1(4), 369–379 (2014).
[Crossref]

Li, D.

Li, E.

Y.-J. Hong, Y. Chen, E. Li, M. Miura, S. Makita, and Y. Yasuno, “Eye motion corrected OCT imaging with Lissajous scan pattern,” Proceedings of SPIE 9693, 96930 (2016).
[Crossref]

Li, K.

K. Li, X. Wu, D. Z. Chen, and M. Sonka, “Optimal Surface Segmentation in Volumetric Images-A Graph-Theoretic Approach,” IEEE Trans. Pattern Anal. Mach. Intell. 28(1), 119–134 (2006).
[Crossref] [PubMed]

Lim, Y.

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and A. Et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Lira, R. P. C.

R. P. C. Lira, C. L. d. A. Oliveira, M. V. R. B. Marques, A. R. Silva, and C. d. C. Pessoa, “Adverse reactions of fluorescein angiography: a prospective study,” Arq. Bras. Oftalmol. 70(4), 615–618 (2007).
[Crossref] [PubMed]

Liu, G.

Liu, J. J.

Makita, S.

Marques, M. V. R. B.

R. P. C. Lira, C. L. d. A. Oliveira, M. V. R. B. Marques, A. R. Silva, and C. d. C. Pessoa, “Adverse reactions of fluorescein angiography: a prospective study,” Arq. Bras. Oftalmol. 70(4), 615–618 (2007).
[Crossref] [PubMed]

Mayer, M. A.

Miller, A.

P. J. Rosenfeld, M. K. Durbin, L. Roisman, F. Zheng, A. Miller, G. Robbins, K. B. Schaal, and G. Gregori, “ZEISS Angioplex™Spectral Domain Optical Coherence Tomography Angiography: Technical Aspects,” in “OCT angiography in retinal and macular diseases,”, vol. 56 of Developments in OphthalmologyF. Bandello, E. Souied, and G. Querques, eds. (S. Karger AG, 2016), pp. 18–29. .
[Crossref]

Miura, M.

Moheimani, S. O. R.

A. Bazaei, Y. K. Yong, and S. O. R. Moheimani, “High-speed Lissajous-scan atomic force microscopy: Scan pattern planning and control design issues,” Rev. Sci. Instrum. 83(6), 063701 (2012).
[Crossref] [PubMed]

Neubauer, A.

Niemeijer, M.

X. Chen, M. Niemeijer, L. Zhang, K. Lee, M. D. Abramoff, and M. Sonka, “Segmentation Three-Dimensional of Abnormalities Fluid-Associated in OCT RetinalThree-Dimensional Segmentation of Fluid-Associated Abnormalities in Retinal OCT: Probability Constrained Graph-Search-Graph-Cut,” IEEE Trans. Med. Imaging 31(8), 1521–1531 (2012).
[Crossref] [PubMed]

Novotny, H. R.

H. R. Novotny and D. L. Alvis, “A Method of Photographing Fluorescence in Circulating Blood in the Human Retina,” Circulation 24(1), 82–86 (1961).
[Crossref] [PubMed]

Oliveira, C. L. d. A.

R. P. C. Lira, C. L. d. A. Oliveira, M. V. R. B. Marques, A. R. Silva, and C. d. C. Pessoa, “Adverse reactions of fluorescein angiography: a prospective study,” Arq. Bras. Oftalmol. 70(4), 615–618 (2007).
[Crossref] [PubMed]

Orlock, D. A.

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse Reactions due to Indocyanine Green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref] [PubMed]

Owens, S. L.

S. L. Owens, “Indocyanine green angiography,” Br. J. Ophthalmol. 80(3), 263–266 (1996).
[Crossref] [PubMed]

Paunescu, L. A.

Pechauer, A. D.

Pessoa, C. d. C.

R. P. C. Lira, C. L. d. A. Oliveira, M. V. R. B. Marques, A. R. Silva, and C. d. C. Pessoa, “Adverse reactions of fluorescein angiography: a prospective study,” Arq. Bras. Oftalmol. 70(4), 615–618 (2007).
[Crossref] [PubMed]

Pircher, M.

Potsaid, B.

Puliafito, C. A.

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse Reactions due to Indocyanine Green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and A. Et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Qi, W.

Quintana, J.

R. Benya, J. Quintana, and B. Brundage, “Adverse reactions to indocyanine green: A case report and a review of the literature,” Cathet. Cardiovasc. Diagn. 17(4), 231–233 (1989).
[Crossref] [PubMed]

Raitta, C.

U. Karhunen, C. Raitta, and R. Kala, “Adverse reactions to fluorescein angiography,” Acta Ophthalmol. (Copenh.) 64(3), 282–286 (1986).
[Crossref]

Reznicek, L.

Robbins, G.

P. J. Rosenfeld, M. K. Durbin, L. Roisman, F. Zheng, A. Miller, G. Robbins, K. B. Schaal, and G. Gregori, “ZEISS Angioplex™Spectral Domain Optical Coherence Tomography Angiography: Technical Aspects,” in “OCT angiography in retinal and macular diseases,”, vol. 56 of Developments in OphthalmologyF. Bandello, E. Souied, and G. Querques, eds. (S. Karger AG, 2016), pp. 18–29. .
[Crossref]

Roisman, L.

P. J. Rosenfeld, M. K. Durbin, L. Roisman, F. Zheng, A. Miller, G. Robbins, K. B. Schaal, and G. Gregori, “ZEISS Angioplex™Spectral Domain Optical Coherence Tomography Angiography: Technical Aspects,” in “OCT angiography in retinal and macular diseases,”, vol. 56 of Developments in OphthalmologyF. Bandello, E. Souied, and G. Querques, eds. (S. Karger AG, 2016), pp. 18–29. .
[Crossref]

Roorda, A.

Rosenfeld, P. J.

P. J. Rosenfeld, M. K. Durbin, L. Roisman, F. Zheng, A. Miller, G. Robbins, K. B. Schaal, and G. Gregori, “ZEISS Angioplex™Spectral Domain Optical Coherence Tomography Angiography: Technical Aspects,” in “OCT angiography in retinal and macular diseases,”, vol. 56 of Developments in OphthalmologyF. Bandello, E. Souied, and G. Querques, eds. (S. Karger AG, 2016), pp. 18–29. .
[Crossref]

Russell, S. R.

M. K. Garvin, M. D. Abramoff, X. Wu, S. R. Russell, T. L. Burns, and M. Sonka, “Automated 3-D Intraretinal Layer Segmentation of Macular Spectral-Domain Optical Coherence Tomography Images,” IEEE Trans. Med. Imaging 28(9), 1436–1447 (2009).
[Crossref] [PubMed]

Sattmann, H.

Schaal, K. B.

P. J. Rosenfeld, M. K. Durbin, L. Roisman, F. Zheng, A. Miller, G. Robbins, K. B. Schaal, and G. Gregori, “ZEISS Angioplex™Spectral Domain Optical Coherence Tomography Angiography: Technical Aspects,” in “OCT angiography in retinal and macular diseases,”, vol. 56 of Developments in OphthalmologyF. Bandello, E. Souied, and G. Querques, eds. (S. Karger AG, 2016), pp. 18–29. .
[Crossref]

Schmoll, T.

L. Ginner, C. Blatter, D. Fechtig, T. Schmoll, M. Gröschl, and R. A. Leitgeb, “Wide-Field OCT Angiography at 400 KHz Utilizing Spectral Splitting,” Photonics 1(4), 369–379 (2014).
[Crossref]

Schottenhamml, J.

Schuman, J.

Schuman, J. S.

Sheehy, C. K.

Silva, A. R.

R. P. C. Lira, C. L. d. A. Oliveira, M. V. R. B. Marques, A. R. Silva, and C. d. C. Pessoa, “Adverse reactions of fluorescein angiography: a prospective study,” Arq. Bras. Oftalmol. 70(4), 615–618 (2007).
[Crossref] [PubMed]

Slakter, J. S.

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse Reactions due to Indocyanine Green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref] [PubMed]

Sonka, M.

X. Chen, M. Niemeijer, L. Zhang, K. Lee, M. D. Abramoff, and M. Sonka, “Segmentation Three-Dimensional of Abnormalities Fluid-Associated in OCT RetinalThree-Dimensional Segmentation of Fluid-Associated Abnormalities in Retinal OCT: Probability Constrained Graph-Search-Graph-Cut,” IEEE Trans. Med. Imaging 31(8), 1521–1531 (2012).
[Crossref] [PubMed]

M. K. Garvin, M. D. Abramoff, X. Wu, S. R. Russell, T. L. Burns, and M. Sonka, “Automated 3-D Intraretinal Layer Segmentation of Macular Spectral-Domain Optical Coherence Tomography Images,” IEEE Trans. Med. Imaging 28(9), 1436–1447 (2009).
[Crossref] [PubMed]

K. Li, X. Wu, D. Z. Chen, and M. Sonka, “Optimal Surface Segmentation in Volumetric Images-A Graph-Theoretic Approach,” IEEE Trans. Pattern Anal. Mach. Intell. 28(1), 119–134 (2006).
[Crossref] [PubMed]

Sorenson, J. A.

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse Reactions due to Indocyanine Green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref] [PubMed]

Sternberg, S. R.

S. R. Sternberg, “Biomedical Image Processing,” Computer 16(1), 22–34 (1983).
[Crossref]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and A. Et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Subhash, H.

Sugiyama, S.

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and A. Et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Tan, O.

Tang, S.

Tiruveedhula, P.

Tokayer, J.

Tomasi, C.

Uematsu, S.

Ustun, T.

Vienola, K. V.

Wallace, D. K.

Wang, J.

Wang, Y.

Wieser, W.

Wilson, D. J.

Wollstein, G.

Wu, X.

M. K. Garvin, M. D. Abramoff, X. Wu, S. R. Russell, T. L. Burns, and M. Sonka, “Automated 3-D Intraretinal Layer Segmentation of Macular Spectral-Domain Optical Coherence Tomography Images,” IEEE Trans. Med. Imaging 28(9), 1436–1447 (2009).
[Crossref] [PubMed]

K. Li, X. Wu, D. Z. Chen, and M. Sonka, “Optimal Surface Segmentation in Volumetric Images-A Graph-Theoretic Approach,” IEEE Trans. Pattern Anal. Mach. Intell. 28(1), 119–134 (2006).
[Crossref] [PubMed]

Yamanari, M.

Yang, Q.

Yannuzzi, L. A.

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse Reactions due to Indocyanine Green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref] [PubMed]

Yasuno, Y.

Yatagai, T.

Yong, Y. K.

A. Bazaei, Y. K. Yong, and S. O. R. Moheimani, “High-speed Lissajous-scan atomic force microscopy: Scan pattern planning and control design issues,” Rev. Sci. Instrum. 83(6), 063701 (2012).
[Crossref] [PubMed]

Yu, L.

Zang, P.

Zhang, L.

X. Chen, M. Niemeijer, L. Zhang, K. Lee, M. D. Abramoff, and M. Sonka, “Segmentation Three-Dimensional of Abnormalities Fluid-Associated in OCT RetinalThree-Dimensional Segmentation of Fluid-Associated Abnormalities in Retinal OCT: Probability Constrained Graph-Search-Graph-Cut,” IEEE Trans. Med. Imaging 31(8), 1521–1531 (2012).
[Crossref] [PubMed]

Zhang, M.

Zheng, F.

P. J. Rosenfeld, M. K. Durbin, L. Roisman, F. Zheng, A. Miller, G. Robbins, K. B. Schaal, and G. Gregori, “ZEISS Angioplex™Spectral Domain Optical Coherence Tomography Angiography: Technical Aspects,” in “OCT angiography in retinal and macular diseases,”, vol. 56 of Developments in OphthalmologyF. Bandello, E. Souied, and G. Querques, eds. (S. Karger AG, 2016), pp. 18–29. .
[Crossref]

Acta Ophthalmol. (Copenh.) (1)

U. Karhunen, C. Raitta, and R. Kala, “Adverse reactions to fluorescein angiography,” Acta Ophthalmol. (Copenh.) 64(3), 282–286 (1986).
[Crossref]

Arq. Bras. Oftalmol. (1)

R. P. C. Lira, C. L. d. A. Oliveira, M. V. R. B. Marques, A. R. Silva, and C. d. C. Pessoa, “Adverse reactions of fluorescein angiography: a prospective study,” Arq. Bras. Oftalmol. 70(4), 615–618 (2007).
[Crossref] [PubMed]

Biomed. Opt. Express (10)

R. Estrada, C. Tomasi, M. T. Cabrera, D. K. Wallace, S. F. Freedman, and S. Farsiu, “Enhanced video indirect ophthalmoscopy (VIO) via robust mosaicing,” Biomed. Opt. Express 2(10), 2871–2887 (2011).
[Crossref] [PubMed]

M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express 3(6), 1182–1199 (2012).
[Crossref] [PubMed]

K. V. Vienola, B. Braaf, C. K. Sheehy, Q. Yang, P. Tiruveedhula, D. W. Arathorn, J. F. d. Boer, and A. Roorda, “Real-time eye motion compensation for OCT imaging with tracking SLO,” Biomed. Opt. Express 3(11), 2950–2963 (2012).
[Crossref] [PubMed]

H. C. Hendargo, R. Estrada, S. J. Chiu, C. Tomasi, S. Farsiu, and J. A. Izatt, “Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary beds using speckle variance optical coherence tomography,” Biomed. Opt. Express 4(6), 803–821 (2013).
[Crossref] [PubMed]

T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, “Multi-MHz retinal OCT,” Biomed. Opt. Express 4(10), 1890–1908 (2013).
[Crossref] [PubMed]

M. F. Kraus, J. J. Liu, J. Schottenhamml, C.-L. Chen, A. Budai, L. Branchini, T. Ko, H. Ishikawa, G. Wollstein, J. Schuman, J. S. Duker, J. G. Fujimoto, and J. Hornegger, “Quantitative 3d-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization,” Biomed. Opt. Express 5(8), 2591–2613 (2014).
[Crossref] [PubMed]

S. Sugiyama, Y.-J. Hong, D. Kasaragod, S. Makita, S. Uematsu, Y. Ikuno, M. Miura, and Y. Yasuno, “Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography,” Biomed. Opt. Express 6(12), 4951–4974 (2015).
[Crossref] [PubMed]

S. Makita, K. Kurokawa, Y.-J. Hong, M. Miura, and Y. Yasuno, “Noise-immune complex correlation for optical coherence angiography based on standard and Jones matrix optical coherence tomography,” Biomed. Opt. Express 7(4), 1525–1548 (2016).
[Crossref] [PubMed]

P. Zang, G. Liu, M. Zhang, C. Dongye, J. Wang, A. D. Pechauer, T. S. Hwang, D. J. Wilson, D. Huang, D. Li, and Y. Jia, “Automated motion correction using parallel-strip registration for wide-field en face OCT angiogram,” Biomed. Opt. Express 7(7), 2823–2836 (2016).
[Crossref] [PubMed]

Y. Chen, Y.-J. Hong, S. Makita, and Y. Yasuno, “Three-dimensional eye motion correction by Lissajous scan optical coherence tomography,” Biomed. Opt. Express 8(3), 1783–1802 (2017).
[Crossref] [PubMed]

Br. J. Ophthalmol. (1)

S. L. Owens, “Indocyanine green angiography,” Br. J. Ophthalmol. 80(3), 263–266 (1996).
[Crossref] [PubMed]

Cathet. Cardiovasc. Diagn. (1)

R. Benya, J. Quintana, and B. Brundage, “Adverse reactions to indocyanine green: A case report and a review of the literature,” Cathet. Cardiovasc. Diagn. 17(4), 231–233 (1989).
[Crossref] [PubMed]

Circulation (1)

H. R. Novotny and D. L. Alvis, “A Method of Photographing Fluorescence in Circulating Blood in the Human Retina,” Circulation 24(1), 82–86 (1961).
[Crossref] [PubMed]

Computer (1)

S. R. Sternberg, “Biomedical Image Processing,” Computer 16(1), 22–34 (1983).
[Crossref]

IEEE Trans. Med. Imaging (2)

M. K. Garvin, M. D. Abramoff, X. Wu, S. R. Russell, T. L. Burns, and M. Sonka, “Automated 3-D Intraretinal Layer Segmentation of Macular Spectral-Domain Optical Coherence Tomography Images,” IEEE Trans. Med. Imaging 28(9), 1436–1447 (2009).
[Crossref] [PubMed]

X. Chen, M. Niemeijer, L. Zhang, K. Lee, M. D. Abramoff, and M. Sonka, “Segmentation Three-Dimensional of Abnormalities Fluid-Associated in OCT RetinalThree-Dimensional Segmentation of Fluid-Associated Abnormalities in Retinal OCT: Probability Constrained Graph-Search-Graph-Cut,” IEEE Trans. Med. Imaging 31(8), 1521–1531 (2012).
[Crossref] [PubMed]

IEEE Trans. Pattern Anal. Mach. Intell. (1)

K. Li, X. Wu, D. Z. Chen, and M. Sonka, “Optimal Surface Segmentation in Volumetric Images-A Graph-Theoretic Approach,” IEEE Trans. Pattern Anal. Mach. Intell. 28(1), 119–134 (2006).
[Crossref] [PubMed]

Ophthalmology (1)

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse Reactions due to Indocyanine Green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref] [PubMed]

Opt. Express (7)

D. X. Hammer, R. D. Ferguson, N. V. Iftimia, T. Ustun, G. Wollstein, H. Ishikawa, M. L. Gabriele, W. D. Dilworth, L. Kagemann, and J. S. Schuman, “Advanced scanning methods with tracking optical coherence tomography,” Opt. Express 13(20), 7937–7947 (2005).
[Crossref] [PubMed]

S. Makita, Y. Hong, M. Yamanari, T. Yatagai, and Y. Yasuno, “Optical coherence angiography,” Opt. Express 14(17), 7821–7840 (2006).
[Crossref] [PubMed]

M. Pircher, B. Baumann, E. Götzinger, H. Sattmann, and C. K. Hitzenberger, “Simultaneous SLO/OCT imaging of the human retina with axial eye motion correction,” Opt. Express 15(25), 16922–16932 (2007).
[Crossref] [PubMed]

G. Liu, W. Qi, L. Yu, and Z. Chen, “Real-time bulk-motion-correction free Doppler variance optical coherence tomography for choroidal capillary vasculature imaging,” Opt. Express 19(4), 3657–3666 (2011).
[Crossref] [PubMed]

G. Liu, L. Chou, W. Jia, W. Qi, B. Choi, and Z. Chen, “Intensity-based modified Doppler variance algorithm: application to phase instable and phase stable optical coherence tomography systems,” Opt. Express 19(12), 11429–11440 (2011).
[Crossref] [PubMed]

Y. Jia, O. Tan, J. Tokayer, B. Potsaid, Y. Wang, J. J. Liu, M. F. Kraus, H. Subhash, J. G. Fujimoto, J. Hornegger, and D. Huang, “Split-spectrum amplitude-decorrelation angiography with optical coherence tomography,” Opt. Express 20(4), 4710–4725 (2012).
[Crossref] [PubMed]

M. J. Ju, Y.-J. Hong, S. Makita, Y. Lim, K. Kurokawa, L. Duan, M. Miura, S. Tang, and Y. Yasuno, “Advanced multi-contrast Jones matrix optical coherence tomography for Doppler and polarization sensitive imaging,” Opt. Express 21(16), 19412–19436 (2013).
[Crossref] [PubMed]

Opt. Lett. (1)

Photonics (1)

L. Ginner, C. Blatter, D. Fechtig, T. Schmoll, M. Gröschl, and R. A. Leitgeb, “Wide-Field OCT Angiography at 400 KHz Utilizing Spectral Splitting,” Photonics 1(4), 369–379 (2014).
[Crossref]

Proceedings of SPIE (1)

Y.-J. Hong, Y. Chen, E. Li, M. Miura, S. Makita, and Y. Yasuno, “Eye motion corrected OCT imaging with Lissajous scan pattern,” Proceedings of SPIE 9693, 96930 (2016).
[Crossref]

Rev. Sci. Instrum. (1)

A. Bazaei, Y. K. Yong, and S. O. R. Moheimani, “High-speed Lissajous-scan atomic force microscopy: Scan pattern planning and control design issues,” Rev. Sci. Instrum. 83(6), 063701 (2012).
[Crossref] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and A. Et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Other (2)

W. Drexler and J. G. Fujimoto, Optical Coherence Tomography: Technology and Applications (Springer Science & Business Media, 2008).
[Crossref]

P. J. Rosenfeld, M. K. Durbin, L. Roisman, F. Zheng, A. Miller, G. Robbins, K. B. Schaal, and G. Gregori, “ZEISS Angioplex™Spectral Domain Optical Coherence Tomography Angiography: Technical Aspects,” in “OCT angiography in retinal and macular diseases,”, vol. 56 of Developments in OphthalmologyF. Bandello, E. Souied, and G. Querques, eds. (S. Karger AG, 2016), pp. 18–29. .
[Crossref]

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Figures (13)

Fig. 1
Fig. 1 Process diagram of OCT-A image reconstruction from Lissajous-scanned OCT signal. The boxes and circular nodes represent the processes and the data, respectively. In the red region, the OCT and OCT-A data are represented by the acquisition time sequence, i.e., the data along the original Lissajous scan trajectory. In contrast, in the blue region, these data are presented as remapped data on a Cartesian grid. The notations used in the following sections are listed in Appendix A.
Fig. 2
Fig. 2 Example set of repeating scans in the modified Lissajous scanning pattern. The probe beam scans the green trajectory multiple times and the scan set is called the “repeat-cycle-set.” The red line indicates the trajectory that connects the repeating cycles, and is called the “margin.”
Fig. 3
Fig. 3 Temporal profiles of the phase of the modified Lissajous scanning pattern, where the number of repeats (M) is 4. Red regions indicate the scan margin.
Fig. 4
Fig. 4 Example of OCT-A map (a) before and (b) after rapid eye motion artifact removal. The vertical and horizontal directions in the images represent the indexes of the repeat-cycle-set and the A-line in the repeat-cycle-set, respectively.
Fig. 5
Fig. 5 Whole depth en face OCT-A images of (a), (b) the optic nerve head and (c), (d) the macula. (a) and (c) show images without motion correction, while (b) and (d) show the images with motion correction.
Fig. 6
Fig. 6 Estimated lateral shifts with First motion estimation step. (a) Estimated motion in ONH imaging [Figs. 5(a) and 5(b)]. (b) Estimated motion in macular imaging [Figs. 5(c) and 5(d)].
Fig. 7
Fig. 7 En face OCT-A image (yellow) overlaid on a scanning laser ophthalmoscope (SLO) image (cyan). Because the SLO image is regarded as a motion-free reference standard, this image demonstrates that our method provides a sufficient motion correction capability.
Fig. 8
Fig. 8 (c) Checkerboard image created from the two motion-corrected en face images that were shown in (a) and (b), where the brighter squares are from (a) and the darker squares are from (b). (d) shows a set of magnified images of (c), in which the colored boxes indicate the magnified region.
Fig. 9
Fig. 9 En face OCT-A images of three retinal vascular plexuses. (a) Superficial plexus; from the ILM to 24.8 µm above the IPL-INL boundary. (b) Intermediate plexus; ±24.8 µm around the IPL-INL boundary. (c) Deep plexus; from 24.8 µm below the IPL-INL boundary to the OPL-HFL boundary.
Fig. 10
Fig. 10 (a)–(c) show slab OCT-A images at different depths and correspond to Figs. 9(a)–(c), respectively. These images are color-coded and are then combined as shown in (d).
Fig. 11
Fig. 11 Examples of non-Cartesian remapped OCT (a) and OCT-A (b). The blink appears as the dark horizontal line in the OCT image and as the white (highly decorrelated) line in the OCT-A image. The blink region is removed from the OCT-A image at the same time as the rapid motion artifacts (c).
Fig. 12
Fig. 12 (a) Motion-corrected en face OCT-A image in blinking case. (b) Comparison with corresponding SLO image.
Fig. 13
Fig. 13 Color-coded slab en face OCT-A images with (a) raster scan and (b) modified Lissajous scan with motion correction. In both cases, the macular region scanned over an area of 3 × 3 mm2. The same location was scanned by Cirrus HD-OCT Model 5000 (Carl Zeiss). The color-coded AngioPlex image is shown in (c).

Tables (1)

Tables Icon

Table 1 Table 1. Descriptions of symbols.

Equations (28)

Equations on this page are rendered with MathJax. Learn more.

x ( t ) = A x cos ( 2 π t / T x )
y ( t ) = A y cos ( 2 π t / T y ) ,
x ( t ) = A x cos [ 2 π χ x ( t ) / T x ]
y ( t ) = A y cos [ 2 π χ y ( t ) / T y ]
χ x ( t ) = { t ( k n ) Δ T , for k T c n Δ T t k T c n Δ T + T x   for k T c n Δ T + T x < t < ( k + 1 ) T c n Δ T ( k + 1 ) T x     and m < M 1
χ y ( t ) = t ( k n ) ( T c T y )
n = t M T c Δ T .
k = t + n Δ T T c .
Δ T δ T A ,
x i   = A x cos [ 2 π χ x , i / T x ]
y i   = A y cos [ 2 π χ y , i / T y ]
χ x , i = i T A
χ y , i = i T A + ( k n ) ( T y T x )
x i   = A x cos [ 2 π ( l / L x + m + M n ) ] ,
y i   = A y cos [ 2 π { ( l + L x n ) T A / T y + m + ( M 1 ) n } ] .
g n ( T c ; l , z , m , p ) = [ g ( l , n , z , m , p ) g ( l , n , z , m + 1 , p ) ] ,
E l , n = z { 1 M [ r n ( T c ; l , z ) ] } ,
M [ a ] = { 1 , if a 1 < 1 , a , otherwise . .
h ( x , y ; θ , f , σ x , σ y ) = 1 2 π σ x σ y e 1 2 ( ξ 2 / σ x 2 + υ 2 / σ y 2 ) cos ( 2 π f ξ ) ,
ξ = x cos θ + y sin θ ,
υ = x sin θ + y cos θ .
f = 1 / s .
h ( x , y ; θ , s ) = 18 π s 2 e 18 ( ξ 2 + υ 2 ) / s 2 cos ( 2 π s ξ ) .
E ( x , y ) = max θ , s [ E ( x , y ) h ( x , y ; θ , s ) ] ,
α = 1 r .
R j = r j b = 1 j 1 α b
r j ( x , y ) [ E j   ( x , y ) B j ( x , y ) ] max x , y , j [ E j   ( x , y ) B j ( x , y ) ] ,
E ( x , y ) = max j [ R j ( x , y ) C j ] .

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