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Conferences > ECBO > 2023 > CTI > 126321C
  • Optical Coherence Imaging Techniques and Imaging in Scattering Media V
  • Technical Digest Series (Optica Publishing Group, 2023),
  • paper 126321C
  • •https://doi.org/10.1117/12.2670861

Label-free intra-tissue activity imaging of alveolar organoid with three-dimensional dynamic optical coherence tomography

Rion Morishita, Pradipta Mukherjee, Ibrahim Abd El-Sadek, Toshio Suzuki, Antonia Lichtenegger, YiHeng Lim, Zhu Yiqiang, Shuichi Makita, Yuki Yamamoto, Tetsuharu Nagamoto, and Yoshiaki Yasuno

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Abstract

Organoid is three-dimensional (3D) in vitro cell culture which closely mimics the structure and function of human organs, and hence generally used in the medical and pharmaceutical research [1]. Recently, a human induced pluripotent stem cell (hiPSC)-derived alveolar organoid and its fibrosis model have been demonstrated [2,3]. These alveolar organoids have structures of alveoli and fibroblasts, where they are known to conduct the material metabolism or undergo fibrosis changes [2,3].

© 2023 SPIE

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