Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Three-dimensional Fourier-domain optical coherence tomography of alveolar mechanics in stepwise inflated and deflated isolated and perfused rabbit lungs

Not Accessible

Your library or personal account may give you access

Abstract

Fourier domain optical coherence tomography (FD-OCT) was used to acquire three-dimensional image stacks of isolated and perfused rabbit lungs (n = 4) at different constant pulmonary airway pressures (CPAP) and during vascular fixation. After despeckling and applying a threshold, the images were segmented into air and tissue, and registered to each other to compensate for movement between CPAP steps. The air-filled cross-sectional areas were quantified using a semiautomatic algorithm. The cross-sectional area of alveolar structures taken at all three perpendicular planes increased with increasing CPAP. Between the minimal CPAP of 3 mbar and the maximum of 25 mbar the areas increased to about 140% of their initial value. There was no systematic dependency of inflation rate on initial size of the alveolar structure. During the perfusion fixation of the lungs with glutaraldehyde morphometric changes of the alveolar geometry measured with FD-OCT were negligible.

© 2007 SPIE

PDF Article
More Like This
3D Fourier Domain Optical Coherence Tomography of post perfusion fixated ethanol-filled isolated rabbit lungs

Sven Meissner, Lilla Knels, and Edmund Koch
7372_17 European Conference on Biomedical Optics (ECBO) 2009

Common-Path Fourier Domain Optical Coherence Tomography of Irradiated Human Skin and Ventilated Isolated Rabbit Lungs

A. Popp, M. Wendel, L. Knels, P. Knuschke, M. Mehner, T. Koch, E. Koch, D. Boller, and P. Koch
TuB2 European Conference on Biomedical Optics (ECBO) 2005

4D in vivo imaging of subpleural lung parenchyma by Swept Source Optical Coherence Tomography

S. Meissner, A. Tabuchi, M. Mertens, H. Homann, J. Walther, W. M. Kuebler, and E. Koch
7372_0K European Conference on Biomedical Optics (ECBO) 2009

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved