Abstract
An accurate tumor delineation in neurosurgery is still a very challenging problem which we are addressing with optical coherence elastography (OCE). Because of the highly viscoelastic properties of brain tissue, we developed a new Air-Jet based tissue excitation source and evaluated the tissue stiffness with a 3.2 MHz swept-source Optical Coherence Tomography (OCT) system with a line scan rate of 2.45 kHz. The phase based displacement per pixel is measured and stiffness maps are calculated for brain tumor samples. However, certain features in the stiffness maps are seemingly not correlatable to the tissue features in the histological sections. Therefore, the structural properties of the histological sections e.g. fiber orientation, cell nuclei concentration and the “onion structure” with their rotational direction for meningioma were given greater consideration. The structural information are extracted from the histological sections via color deconvolution and structural tensor analysis. First results show that the stiffness transitions correlate with some structures of the histological sections. In summary, the Air-Jet OCE seems to be capable of measuring the stiffness as well as the structural composition of the sample. The long-term aim of this project is to establish OCE to support tumor delineation in the field of neurosurgery.
© 2023 SPIE
PDF ArticleMore Like This
Nicolas Detrez, Katharina Rewerts, Moritz Matthiae, Steffen Buschschlüter, Matteo Mario Bonsanto, Dirk Theisen-Kunde, and Ralf Brinkmann
EW4A.10 European Conference on Biomedical Optics (ECBO) 2021
Sazgar Burhan, Nicolas Detrez, Madita Göb, Matteo Mario Bonsanto, Ralf Brinkmann, and Robert Huber
1263215 European Conference on Biomedical Optics (ECBO) 2023
Wes M. Allen, Philip Wijesinghe, Kelsey M. Kennedy, Lixin Chin, David D. Sampson, and Brendan F. Kennedy
FW4E.7 Frontiers in Optics (FiO) 2015