PARP-1 expression in melanocytic lesions: towards PARPi-FL based molecular diagnosis of melanoma

Aditi Sahu; Aundree Hermawan; Aundree Hermawan; Melissa Gill; Melissa Gill; Ucalene Harris; Thomas Reiner; Thomas Reiner; Thomas Reiner; Ashfaq Marghoob; M. Cecelia Lezcano; Anthony Rossi; Allan Halpern; Klaus Busam; Chih-Shan Jason Chen; Manu Jain; Milind Rajadhyaksha

doi:10.1364/TRANSLATIONAL.2022.TW3B.4

Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN)
Technical Digest Series (Optica Publishing Group, 2022),
paper TW3B.4
•https://doi.org/10.1364/TRANSLATIONAL.2022.TW3B.4

PARP-1 expression in melanocytic lesions: towards PARPi-FL based molecular diagnosis of melanoma

Aditi Sahu, Aundree Hermawan, Melissa Gill, Ucalene Harris, Thomas Reiner, Ashfaq Marghoob, M. Cecelia Lezcano, Anthony Rossi, Allan Halpern, Klaus Busam, Chih-Shan Jason Chen, Manu Jain, and Milind Rajadhyaksha

Clinical and Translational Biophotonics 2022

Fort Lauderdale, Florida United States
24–27 April 2022
ISBN: 978-1-957171-03-6

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A. Sahu, A. Hermawan, M. Gill, U. Harris, T. Reiner, A. Marghoob, M. C. Lezcano, A. Rossi, A. Halpern, K. Busam, C. J. Chen, M. Jain, and M. Rajadhyaksha, "PARP-1 expression in melanocytic lesions: towards PARPi-FL based molecular diagnosis of melanoma," in Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN), Technical Digest Series (Optica Publishing Group, 2022), paper TW3B.4.

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Abstract

Towards early melanoma diagnosis using a poly-ADP-ribose polymerase1 (PARP1)-targeted fluorophore, we evaluated PARP1 expression in benign and malignant lesions. Higher PARP1 expression in malignant lesions confirms clinical utility of the approach.

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