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Smart Microlasers for Self-detecting Exosomes from Cancer Spheroids

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Abstract

By employing cavity energy transfer and coupling strong light-matter interactions on the interfaces, we have developed an approach of producing self-propelled whispering-gallery-mode (WGM) microlasers to enhance subtle biological signals. An intelligent microlaser is achieved to reflect the abundance of extracellular biomarkers derived from 3D multicellular cancer spheroids in circulating biological fluids. This high-throughput method exhibited a great potential in biological detection, drug screening, and organ-on-chip applications.

© 2023 The Author(s)

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