Abstract

Laser speckle contrast imaging (LSCI) methods are extensively used in assessment of blood flow to detect various pathological conditions in different parts of human body. In contrast to LSCI being deployed for larger region of interest (few centimeters), we present a laser speckle imaging at microscopic level. Rather than utilizing the conventional speckle contrast, we adopt intensity auto-correlation using recently developed Multi-step Volterra Integral method(MVIM) to quantify the micro-perfusion. The proposed laser speckle correlation microscopy (LSCM) system is validated using microfluidic flow phantom experiments.

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