NIRS-Based Quantitative Measurement of Autoregulatory Effects on Microvascular Hemoglobin Oxygenation: Assessment of Differences between Non-Diabetic and Type II Diabetic Subjects

Onyeoziri R. Nwanguma; Harry L. Graber; Harry L. Graber; Rahul Valluru; Randall L. Barbour; Randall L. Barbour

doi:10.1364/BIOMED.2008.BSuE57

Biomedical Optics
OSA Technical Digest (CD) (Optica Publishing Group, 2008),
paper BSuE57
•https://doi.org/10.1364/BIOMED.2008.BSuE57

NIRS-Based Quantitative Measurement of Autoregulatory Effects on Microvascular Hemoglobin Oxygenation: Assessment of Differences between Non-Diabetic and Type II Diabetic Subjects

Onyeoziri R. Nwanguma, Harry L. Graber, Rahul Valluru, and Randall L. Barbour

Biomedical Optics 2008

St. Petersburg, Florida United States
16–19 March 2008
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BIOMED Poster Session I (BSuE)

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O. R. Nwanguma, H. L. Graber, R. Valluru, and R. L. Barbour, "NIRS-Based Quantitative Measurement of Autoregulatory Effects on Microvascular Hemoglobin Oxygenation: Assessment of Differences between Non-Diabetic and Type II Diabetic Subjects," in Biomedical Optics, OSA Technical Digest (CD) (Optica Publishing Group, 2008), paper BSuE57.

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Abstract

By examining the simultaneous evolution of oxyhemoglobin and deoxyhemoglobin in NIRS image time series, we have derived indices of the competency of autoregulation. Applying these measures to data collected from the forearms of type II diabetics and normal subjects reveals statistically significant differences between the two patient populations. While some of the analyses involve application of a transient ischemia protocol, others consider only resting baseline data.

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