Estimation of relative elasticity in tissue samples has emerged as a new functional imaging extension to photoacoustic remote sensing microscopy, thanks to the recent work published by Yanchi Yuan et al. Photoacoustic remote sensing microscopy utilizes a pulsed excitation laser to induce reflectivity modulations in a co-focused interrogation beam, where the magnitude of these reflectivity modulations corresponds to absorption contrast. In this work, the authors derive an inverse square relationship between elasticity and the temporal characteristics of these reflectivity modulations. By imaging a variety of tissue types, they validate the ability to measure relative differences in tissue elasticity. This has the potential to add rich complementary information to conventional photoacoustic remote sensing microscopy, allowing simultaneous non-contact imaging of molecular and functional contrasts combined with co-registered mapping of biomechanical properties in tissue samples, broadening the scope of potential applications in which photoacoustic remote sensing microscopy may be successfully utilized.

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