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Optica Publishing Group Optics Letters Early Posting access

You have attempted to access the full-text of an Early Posting article. Access is available via an institutional subscription.

See the Early Posting FAQ page for additional information.

Simultaneous deep ultraviolet transmission and scattering microscopy for virtual histology

Optics Letters

Brendyn Cikaluk, Mohammad Masoumi, Brendon Restall, Matthew Martell, Nathaniel Haven, and Roger Zemp
received 11/23/2023; accepted 04/16/2024; posted 04/17/2024; Doc. ID 514077
Abstract: In recent years, the emergence of a variety of novel opticalmicroscopy techniques has enabled the generationof virtual optical stains of unlabelled tissue specimens,which have the potential to transform existing clinicalhistopathology workflows. In this work, we present a simultaneousdeep ultraviolet transmission and scatteringmicroscopy system that can produce virtual histologyimages that show good concordance to conventionalgold-standard histological processing techniques. Theresults of this work demonstrate the system’s diagnosticpotential for characterizing unlabelled thin tissuesections and streamlining histological workflows.

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