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Swept-wavelength null polarimetry for highly sensitive birefringence laser scanning microscopy

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Abstract

We have recently demonstrated a high-speed null polarimeter [Opt. Express 30, 18889 (2022) [CrossRef]  ] based on passive polarization optics and using a fast swept-wavelength laser source. We report here its implementation in a laser-scanning microscope setup, enabling highly sensitive linear retardance imaging with a pixel dwell time of 10 μs. The instrument is also able to measure light depolarization induced by the sample. Images of biological samples, including cancerous tissue and cells, illustrate its performances.

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Supplementary Material (1)

NameDescription
Visualization 1       Evolution of optical retardation over time during the apoptosis of a cancerous HGT-1 cell.

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Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

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