Abstract

Laser speckle contrast imaging maps the changes in blood flow by estimating the decorrelation time of a scattered light field. However, speckle contrast is a biased statistics estimator that results in a theoretic bias between its expected value and the true value. Moreover, the average of speckle contrast depends on the statistical sampling size, which further hinders the estimation of decorrelation time from speckle contrast. Here, we present a new, to the best of our knowledge, unbiased statistics analysis based on auto-inverse covariance to improve the estimation of decorrelation time using laser speckle. Theoretical and experimental results demonstrate that the speckle auto-inverse covariance analysis is mean-invariant, so that the average of the estimation is not dependent on the sampling size. Furthermore, it can produce less statistical fluctuation, especially for slow flow, and consume less computation time than that of speckle contrast analysis.

© 2019 Optical Society of America

Full Article  |  PDF Article
More Like This
Fluctuations of temporal contrast in laser speckle imaging of blood flow

Jiachi Hong, Yang Wang, Xiao Chen, Jingling Lu, and Pengcheng Li
Opt. Lett. 43(21) 5214-5217 (2018)

Improving the estimation of flow speed for laser speckle imaging with single exposure time

Yang Wang, Dong Wen, Xiao Chen, Qin Huang, Ming Chen, Jinling Lu, and Pengcheng Li
Opt. Lett. 42(1) 57-60 (2017)

Laser speckle contrast imaging of blood flow in the deep brain using microendoscopy

Ming Chen, Dong Wen, Songlin Huang, Shen Gui, Zhihong Zhang, Jinling Lu, and Pengcheng Li
Opt. Lett. 43(22) 5627-5630 (2018)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (5)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (14)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription