Abstract

Angle-resolved low-coherence interferometry (a/LCI) detects precancer by enabling depth-resolved measurements of nuclear morphology in vivo. A significant limitation of a/LCI is the point-probe nature of the method, sampling <0.5  mm2 before probe relocation is necessary. In this work, we demonstrate a scanning method capable of assessing an area >100  mm2 without repositioning. By utilizing a reflection-only three-optic rotator prism and a two-axis scanning mirror, we demonstrate radial scans of a sample with a linear range of 12 mm and a full rotational range of 180°. Use of this design will improve the diagnostic utility of a/LCI for wide-area screening of tissue health.

© 2017 Optical Society of America

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Supplementary Material (1)

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» Visualization 1       This animation showcases the scanning motion of our system for wide-area angle-resolved low-coherence interferometry.

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