Abstract
In diabetes, changes in the function of the short-wavelength sensitive system (S-pathway) precede changes in more standard measures of visual function and may be observed prior to, or in the absence of, diabetic retinopathy (e.g. Adams, 1982; Zisman and Adams, 1982). Diabetes is fundamentally a metabolic disorder, characterized by elevated blood glucose. It is reasonable then, to consider the altered metabolic state of the diabetic as the underlying cause of the early loss of S-cone sensitivity. It has, however, proven difficult to separate metabolic from structural bases for the early vision loss, because l)the development of retinopathy is itself affected by metabolic control, and 2) vascular changes may be present though undetected in people with 'no retinopathy'.
© 1996 Optical Society of America
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