Abstract

Reaction mechanisms in chemistry and biochemistry involve structural change, not merely static structure (1). These structural changes can be very rapid, spanning the time range from femtoseconds to seconds and above. We have developed and applied timeresolved X-ray crystallography(2,3) to monitor directly the changes in electron density and hence in atomic location, as biological macromolecules respond to light.

© 2000 Optical Society of America

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