We compared in vivo hypoxia targeting of 4-nitroimidazole-piperazine-indocyanine derivative (6) with imidazole- (5) and 2-nitroimidazole-indocyanine dye-conjugate (4). Results showed 1.5-fold and 2.5-fold intensity ratio between each pair. This is also supported by cell and immunohistochemistry results.

© 2016 Optical Society of America

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