Concurrent imaging of large-scale vasculature, myelin content and cell density of post-mortem human brain with serial sectioning PSOCT-2PM

Shuaibin Chang; Hui Wang; Jiarui Yang; Bruce Fischl; Shih-Chi Chen; David A. Boas; David A. Boas; Ichun Anderson Chen

doi:10.1364/OCT.2022.CS4E.4

Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN)
Technical Digest Series (Optica Publishing Group, 2022),
paper CS4E.4
•https://doi.org/10.1364/OCT.2022.CS4E.4

Concurrent imaging of large-scale vasculature, myelin content and cell density of post-mortem human brain with serial sectioning PSOCT-2PM

Shuaibin Chang, Hui Wang, Jiarui Yang, Bruce Fischl, Shih-Chi Chen, David A. Boas, and Ichun Anderson Chen

Optical Coherence Tomography 2022

Fort Lauderdale, Florida United States
24–27 April 2022
ISBN: 978-1-957171-03-6

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Polarization Sensitive Optical Coherence Tomography (CS4E)

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S. Chang, H. Wang, J. Yang, B. Fischl, S. Chen, D. A. Boas, and I. A. Chen, "Concurrent imaging of large-scale vasculature, myelin content and cell density of post-mortem human brain with serial sectioning PSOCT-2PM," in Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN), Technical Digest Series (Optica Publishing Group, 2022), paper CS4E.4.

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Abstract

A dual-modality microscope combining polarization sensitive optical coherence tomography (PSOCT) and two photon microscopy (2PM) is built for block-face imaging of large human brain blocks, which enriches the biological features that can be obtained simultaneously.

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