Abstract

In this abstract, we introduce a swpet-source optical coherence tomography (OCT) and OCT angiography (OCTA) system with a 112 field of view (FOV) to enable high-resolution peripheral retinal imaging in rat eyes. To achieve this unprecedented FOV, a contact imaging probe for rat eye was developed. This system was demonstrated on healthy adult rats, as well as oxygen induced retinopathy (OIR) rats and healthy controls with the same age. The ultrawide-field (UWF) OCT and OCTA system could allow earlier recognition of peripheral retinal disease, such as OIR, and prevent permanent vision loss. Additionally, adequate visualization of the peripheral retina has a great potential for better understanding disease mechanisms regarding the periphery. This UWF-OCT/OCTA offers significant values in clinical retinal studies and basic vision science.

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