Abstract

Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive optical technique for imaging the skin in vivo in depth and at high resolution. Confocal Raman microspectroscopy (CRM) is a label-free technique that provides point-wise information on the molecular content of the analyzed sample. We present the development of a prototype platform allowing the co-localized acquisition of LC-OCT images and Raman spectra on ex vivo skin samples with an accuracy of ± 20 μm. We present results obtained on healthy skin as well as preliminary results obtained on a basal cell carcinoma surgery, aiming at identifying molecular tumor markers.

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