The purpose of this study was to show the effectiveness of therapeutic drug level testing by Paper-based Surfaced Enhanced Raman Spectroscopy (PSERS) for artificial lacrimal fluid. We have been used substrates which consist of a common filter paper and gold nano-rods. The targets were Phenobarbital (PB) which dissolved in artificial lacrimal fluid. We measured them using PSERS which the wavelength was 785nm, the power was 30mW. It was found that there were the strong peaks of PB at 997cm-1 and 1026cm-1 which corresponded with solid PB spectral peak for 1mM artificial lacrimal fluid. The results demonstrated the usefulness of this method. It is concluded that our method for therapeutic drug level testing is very efficient.
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