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Conferences > BRAIN > 2023 > BTu2B > BTu2B.3

5-HT2A Receptor Agonism Changes Neuronal Network Activity and Disrupts Neurovascular Coupling in Mice

Jonah Padawer-Curry, Joshua S. Siegel, Jordan G. McCall, Ginger E. Nicol, and Adam Q. Bauer

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Abstract

Thy1-jRGECO1a mice were imaged under awake, resting-state conditions using wide-field optical imaging. Non-hallucinogenic 5-HT2a receptor agonism significantly reduced neuronal and hemodynamic bilateral functional connectivity, activity, and neurovascular coupling in a region- and frequency-band-specific manner.

© 2023 The Author(s)

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