Abstract
A number of recent studies have focused on the possibility of using the NIR techniques to monitor a change of glucose concentration in tissue [1,2]. The basis of the method rests on the fact that a change of refractive index in the extracellular fluid due to the presence of additional glucose causes a small change in the overall scattering property of the tissue that could be detected by the NIR techniques. Chance et al [ 3] show that in lipid and yeast cell suspensions, an increase in concentration of a general solute, such as sugars and electrolytes, gives rise to a decrease in scattering factor of the suspension. These results are in good agreement with those given in Refs. 1 and 2. However, in the tissue measurement performed on a perfused rat liver, the results obtained by adding mannitol (or glucose) to the perfusate of the perfused liver displayed a behavior in contrast to those in the lipid suspensions [3] and can not be well explained by the change of only refractive index. In order to employ the NIR techniques for a broad use in noninvasive physiological monitoring, we wish to show in this paper the solute-induced correlation between optical properties in tissue and its refractive index as well as its osmolarity.
© 1996 Optical Society of America
PDF ArticleMore Like This
Steven L. Jacques
OPC364 Advances in Optical Imaging and Photon Migration (BIOMED) 1996
Tamara L. Troy, David L. Page, and Eva M. Sevick-Muraca
AP4 Biomedical Optical Spectroscopy and Diagnostics (BIOMED) 1996
J. T. Bruulsema, M. Essenpreis, L. Heinemann, J. E. Hayward, M. Berger, F. A. Gries, T. Koschinsky, J. Sandahl-Christiansen, H. Orskov, T. J. Farrell, M. S. Patterson, and D. Böcker
CM1 Biomedical Optical Spectroscopy and Diagnostics (BIOMED) 1996