Would you like to have a surface-enhanced Raman scattering (SERS) sensor that is easy to make but provides the opportunity to detect analytes at the nanomolar level? Indeed, creation of such a device could help to discover the full potential of the SERS effect for the extensive use in biodiagnostics. In their article, Jung-Sub Wi and co-authors demonstrate an elegant approach killing two birds with one stone: simple and large-scale fabrication of the sensor on a flexible substrate as well as elimination of the adjustment steps for the plasmonic nanosystems to maximize the Raman scattering signal. The oblique-angle deposition of gold on the polymer nanogratings made by the UV-nanoimprint lithography makes it possible to obtain plasmonic nanotrenches without additional chemical processing. Such periodic arrays show the distinctive dependence of the Raman signal enhancement on the incident light polarization, which provides an easy opportunity to maximize the Raman response. The achieved nanomolar-level sensitivity of the sensor is demonstrated by the example of miRNA-125b detection. The demonstrated results lead to the reasonable expectation that such SERS sensors have great potential for the future developments and wide applications in biomedicine.

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