Abstract

Imaging of neuronal activity with fluorescent indicators is an important technique in neuroscience. However, it remains challenging to record volumetric image data at fast frame rates and good resolution. One promising technique to achieve this goal is light sheet microscopy (LSM), but the right angle configuration of the excitation and imaging system limits its application. Oblique plane microscopy (OPM), a variant of LSM, circumvents this limitation by exciting oblique planes and detecting the image through the same microscope objective lens. So far, these techniques have relied on the use of high numerical aperture (NA) detection objective lenses, which limits their field of view. Here we present an OPM technique that allows for the use of low NA objective lenses by redirecting the light with the help of a diffraction grating. The microscope maintains a micrometer-scale lateral resolution over a large addressable imaging volume of 3.3×3.0×1.0mm3. We demonstrate its practicality by imaging the whole brain of larval and juvenile zebrafish.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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    [Crossref]
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    [Crossref]
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2019 (2)

M. Kumar and Y. Kozorovitskiy, “Tilt-invariant scanned oblique plane illumination microscopy for large-scale volumetric imaging,” Opt. Lett. 44, 1706–1709 (2019).
[Crossref]

R. D. Vaadia, W. Li, V. Voleti, A. Singhania, E. M. C. Hillman, and W. B. Grueber, “Characterization of proprioceptive system dynamics in behaving Drosophila larvae using high-speed volumetric microscopy,” Curr. Biol. 29, 935–944 (2019).
[Crossref]

2018 (2)

Y. Shin, D. Kim, and H.-S. Kwon, “Oblique scanning 2-photon light-sheet fluorescence microscopy for rapid volumetric imaging,” J. Biophoton. 11, e201700270 (2018).
[Crossref]

M. Kumar, S. Kishore, J. Nasenbeny, D. L. McLean, and Y. Kozorovitskiy, “Integrated one-and two-photon scanned oblique plane illumination (sopi) microscopy for rapid volumetric imaging,” Opt. Express 26, 13027–13041 (2018).
[Crossref]

2017 (5)

B. Huang, D. Xie, and R. Mcgorty, “High-NA open-top selective-plane illumination microscopy for biological imaging,” Opt. Express 25, 17798–17810 (2017).
[Crossref]

R. Lu, W. Sun, Y. Liang, A. Kerlin, J. Bierfeld, J. D. Seelig, D. E. Wilson, B. Scholl, B. Mohar, M. Tanimoto, M. Koyama, D. Fitzpatrick, M. B. Orger, and N. Ji, “Video-rate volumetric functional imaging of the brain at synaptic resolution,” Nat. Neurosci. 20, 620–628 (2017).
[Crossref]

T. Nöbauer, O. Skocek, A. J. Pernía-Andrade, L. Weilguny, F. M. Traub, M. I. Molodtsov, and A. Vaziri, “Video rate volumetric Ca2+ imaging across cortex using seeded iterative demixing (SID) microscopy,” Nat. Methods 14, 811–818 (2017).
[Crossref]

L. Cong, Z. Wang, Y. Chai, W. Hang, C. Shang, W. Yang, L. Bai, J. Du, K. Wang, and Q. Wen, “Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio),” eLife 6, e28158 (2017).
[Crossref]

A. Agostinho, A. Jost, D. C. Jans, H. Blom, H. Brismar, K. Bernhem, L. Nilsson, M. Müller, R. Heintzmann, S. Abrahamsson, and T. J. Lambert, “Multifocus structured illumination microscopy for fast volumetric super-resolution imaging,” Biomed. Opt. Express 8, 4135–4140(2017).
[Crossref]

2016 (5)

B. Hajj, B. Mehl, C. Wu, C. Cho, C. I. Bargmann, J. A. Liddle, J. Wisniewski, J.-B. Fiche, J. Pulupa, L. Oudjedi, L. Chen, L. Yu, M. Davanco, M. Nollmann, M. Dahan, M. El Beheiry, M. Mir, R. Ilic, S. Abrahamsson, T. Lionnet, X. Darzacq, and X. Jin, “Multifocus microscopy with precise color multi-phase diffractive optics applied in functional neuronal imaging,” Biomed. Opt. Express 7, 855–869 (2016).
[Crossref]

J. N. Stirman, I. T. Smith, M. W. Kudenov, and S. L. Smith, “Wide field-of-view, multi-region, two-photon imaging of neuronal activity in the mammalian brain,” Nat. Biotechnol. 34, 857–862 (2016).
[Crossref]

N. J. Sofroniew, D. Flickinger, J. King, and K. Svoboda, “A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging,” eLife 5, 413 (2016).
[Crossref]

R. Prevedel, A. J. Verhoef, A. J. Pernía-Andrade, S. Weisenburger, B. S. Huang, T. Nöbauer, A. Fernández, J. E. Delcour, P. Golshani, A. Baltuska, and A. Vaziri, “Fast volumetric calcium imaging across multiple cortical layers using sculpted light,” Nat. Methods 13, 1021–1028 (2016).
[Crossref]

M. B. Sikkel, S. Kumar, V. Maioli, C. Rowlands, F. Gordon, S. E. Harding, A. R. Lyon, K. T. MacLeod, and C. Dunsby, “High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes,” J. Biophoton. 9, 311–323 (2016).
[Crossref]

2015 (1)

M. B. Bouchard, V. Voleti, C. S. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high-speed volumetric imaging of behaving organisms,” Nat. Photonics 9, 113–119 (2015).
[Crossref]

2014 (1)

R. Prevedel, Y.-G. Yoon, M. Hoffmann, N. Pak, G. Wetzstein, S. Kato, T. Schrödel, R. Raskar, M. Zimmer, E. S. Boyden, and A. Vaziri, “Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy,” Nat. Methods 11, 727–730 (2014).
[Crossref]

2013 (3)

M. B. Ahrens, M. B. Orger, D. N. Robson, J. M. Li, and P. J. Keller, “Whole-brain functional imaging at cellular resolution using light-sheet microscopy,” Nat. Methods 10, 413–420 (2013).
[Crossref]

S. Abrahamsson, J. Chen, B. Hajj, S. Stallinga, A. Y. Katsov, J. Wisniewski, G. Mizuguchi, P. Soule, F. Mueller, C. D. Darzacq, X. Darzacq, C. Wu, C. I. Bargmann, D. A. Agard, M. Dahan, and M. G. L. Gustafsson, “Fast multicolor 3D imaging using aberration-corrected multifocus microscopy,” Nat. Methods 10, 60–63 (2013).
[Crossref]

M. Broxton, L. Grosenick, S. Yang, N. Cohen, A. Andalman, K. Deisseroth, and M. Levoy, “Wave optics theory and 3-D deconvolution for the light field microscope,” Opt. Express 21, 25418–25422 (2013).
[Crossref]

2011 (2)

A. R. Lyon, C. Dunsby, D. Wilding, K. T. MacLeod, M. B. Sikkel, and S. Kumar, “Application of oblique plane microscopy to high speed live cell imaging,” Proc. SPIE 8086, 80860V (2011).
[Crossref]

S. Kumar, D. Wilding, M. B. Sikkel, A. R. Lyon, K. T. MacLeod, and C. Dunsby, “High-speed 2D and 3D fluorescence microscopy of cardiac myocytes,” Opt. Express 19, 13839–13847 (2011).
[Crossref]

2008 (3)

C. Dunsby, “Optically sectioned imaging by oblique plane microscopy,” Opt. Express 16, 20306–20316 (2008).
[Crossref]

P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. K. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322, 1065–1069 (2008).
[Crossref]

E. J. Botcherby, R. Juškaitis, M. J. Booth, and T. Wilson, “An optical technique for remote focusing in microscopy,” Opt. Commun. 281, 880–887 (2008).
[Crossref]

2006 (1)

M. Levoy, R. Ng, A. Adams, M. Footer, and M. Horowitz, “Light field microscopy,” ACM Trans. Graph. 25, 924–934 (2006).
[Crossref]

2004 (1)

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305, 1007–1009 (2004).
[Crossref]

1990 (1)

W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science 248, 73–76 (1990).
[Crossref]

1989 (1)

Abrahamsson, S.

Adams, A.

M. Levoy, R. Ng, A. Adams, M. Footer, and M. Horowitz, “Light field microscopy,” ACM Trans. Graph. 25, 924–934 (2006).
[Crossref]

Agard, D. A.

S. Abrahamsson, J. Chen, B. Hajj, S. Stallinga, A. Y. Katsov, J. Wisniewski, G. Mizuguchi, P. Soule, F. Mueller, C. D. Darzacq, X. Darzacq, C. Wu, C. I. Bargmann, D. A. Agard, M. Dahan, and M. G. L. Gustafsson, “Fast multicolor 3D imaging using aberration-corrected multifocus microscopy,” Nat. Methods 10, 60–63 (2013).
[Crossref]

Agostinho, A.

Ahrens, M. B.

M. B. Ahrens, M. B. Orger, D. N. Robson, J. M. Li, and P. J. Keller, “Whole-brain functional imaging at cellular resolution using light-sheet microscopy,” Nat. Methods 10, 413–420 (2013).
[Crossref]

Andalman, A.

Bai, L.

L. Cong, Z. Wang, Y. Chai, W. Hang, C. Shang, W. Yang, L. Bai, J. Du, K. Wang, and Q. Wen, “Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio),” eLife 6, e28158 (2017).
[Crossref]

Baltuska, A.

R. Prevedel, A. J. Verhoef, A. J. Pernía-Andrade, S. Weisenburger, B. S. Huang, T. Nöbauer, A. Fernández, J. E. Delcour, P. Golshani, A. Baltuska, and A. Vaziri, “Fast volumetric calcium imaging across multiple cortical layers using sculpted light,” Nat. Methods 13, 1021–1028 (2016).
[Crossref]

Bargmann, C. I.

B. Hajj, B. Mehl, C. Wu, C. Cho, C. I. Bargmann, J. A. Liddle, J. Wisniewski, J.-B. Fiche, J. Pulupa, L. Oudjedi, L. Chen, L. Yu, M. Davanco, M. Nollmann, M. Dahan, M. El Beheiry, M. Mir, R. Ilic, S. Abrahamsson, T. Lionnet, X. Darzacq, and X. Jin, “Multifocus microscopy with precise color multi-phase diffractive optics applied in functional neuronal imaging,” Biomed. Opt. Express 7, 855–869 (2016).
[Crossref]

S. Abrahamsson, J. Chen, B. Hajj, S. Stallinga, A. Y. Katsov, J. Wisniewski, G. Mizuguchi, P. Soule, F. Mueller, C. D. Darzacq, X. Darzacq, C. Wu, C. I. Bargmann, D. A. Agard, M. Dahan, and M. G. L. Gustafsson, “Fast multicolor 3D imaging using aberration-corrected multifocus microscopy,” Nat. Methods 10, 60–63 (2013).
[Crossref]

Bernhem, K.

Bierfeld, J.

R. Lu, W. Sun, Y. Liang, A. Kerlin, J. Bierfeld, J. D. Seelig, D. E. Wilson, B. Scholl, B. Mohar, M. Tanimoto, M. Koyama, D. Fitzpatrick, M. B. Orger, and N. Ji, “Video-rate volumetric functional imaging of the brain at synaptic resolution,” Nat. Neurosci. 20, 620–628 (2017).
[Crossref]

Blom, H.

Booth, M. J.

E. J. Botcherby, R. Juškaitis, M. J. Booth, and T. Wilson, “An optical technique for remote focusing in microscopy,” Opt. Commun. 281, 880–887 (2008).
[Crossref]

Botcherby, E. J.

E. J. Botcherby, R. Juškaitis, M. J. Booth, and T. Wilson, “An optical technique for remote focusing in microscopy,” Opt. Commun. 281, 880–887 (2008).
[Crossref]

Bouchard, M. B.

M. B. Bouchard, V. Voleti, C. S. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high-speed volumetric imaging of behaving organisms,” Nat. Photonics 9, 113–119 (2015).
[Crossref]

Boyden, E. S.

R. Prevedel, Y.-G. Yoon, M. Hoffmann, N. Pak, G. Wetzstein, S. Kato, T. Schrödel, R. Raskar, M. Zimmer, E. S. Boyden, and A. Vaziri, “Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy,” Nat. Methods 11, 727–730 (2014).
[Crossref]

Brismar, H.

Broxton, M.

Bruno, R. M.

M. B. Bouchard, V. Voleti, C. S. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high-speed volumetric imaging of behaving organisms,” Nat. Photonics 9, 113–119 (2015).
[Crossref]

Chai, Y.

L. Cong, Z. Wang, Y. Chai, W. Hang, C. Shang, W. Yang, L. Bai, J. Du, K. Wang, and Q. Wen, “Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio),” eLife 6, e28158 (2017).
[Crossref]

Chen, J.

S. Abrahamsson, J. Chen, B. Hajj, S. Stallinga, A. Y. Katsov, J. Wisniewski, G. Mizuguchi, P. Soule, F. Mueller, C. D. Darzacq, X. Darzacq, C. Wu, C. I. Bargmann, D. A. Agard, M. Dahan, and M. G. L. Gustafsson, “Fast multicolor 3D imaging using aberration-corrected multifocus microscopy,” Nat. Methods 10, 60–63 (2013).
[Crossref]

Chen, L.

Cho, C.

Cohen, N.

Cong, L.

L. Cong, Z. Wang, Y. Chai, W. Hang, C. Shang, W. Yang, L. Bai, J. Du, K. Wang, and Q. Wen, “Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio),” eLife 6, e28158 (2017).
[Crossref]

Dahan, M.

B. Hajj, B. Mehl, C. Wu, C. Cho, C. I. Bargmann, J. A. Liddle, J. Wisniewski, J.-B. Fiche, J. Pulupa, L. Oudjedi, L. Chen, L. Yu, M. Davanco, M. Nollmann, M. Dahan, M. El Beheiry, M. Mir, R. Ilic, S. Abrahamsson, T. Lionnet, X. Darzacq, and X. Jin, “Multifocus microscopy with precise color multi-phase diffractive optics applied in functional neuronal imaging,” Biomed. Opt. Express 7, 855–869 (2016).
[Crossref]

S. Abrahamsson, J. Chen, B. Hajj, S. Stallinga, A. Y. Katsov, J. Wisniewski, G. Mizuguchi, P. Soule, F. Mueller, C. D. Darzacq, X. Darzacq, C. Wu, C. I. Bargmann, D. A. Agard, M. Dahan, and M. G. L. Gustafsson, “Fast multicolor 3D imaging using aberration-corrected multifocus microscopy,” Nat. Methods 10, 60–63 (2013).
[Crossref]

Darzacq, C. D.

S. Abrahamsson, J. Chen, B. Hajj, S. Stallinga, A. Y. Katsov, J. Wisniewski, G. Mizuguchi, P. Soule, F. Mueller, C. D. Darzacq, X. Darzacq, C. Wu, C. I. Bargmann, D. A. Agard, M. Dahan, and M. G. L. Gustafsson, “Fast multicolor 3D imaging using aberration-corrected multifocus microscopy,” Nat. Methods 10, 60–63 (2013).
[Crossref]

Darzacq, X.

B. Hajj, B. Mehl, C. Wu, C. Cho, C. I. Bargmann, J. A. Liddle, J. Wisniewski, J.-B. Fiche, J. Pulupa, L. Oudjedi, L. Chen, L. Yu, M. Davanco, M. Nollmann, M. Dahan, M. El Beheiry, M. Mir, R. Ilic, S. Abrahamsson, T. Lionnet, X. Darzacq, and X. Jin, “Multifocus microscopy with precise color multi-phase diffractive optics applied in functional neuronal imaging,” Biomed. Opt. Express 7, 855–869 (2016).
[Crossref]

S. Abrahamsson, J. Chen, B. Hajj, S. Stallinga, A. Y. Katsov, J. Wisniewski, G. Mizuguchi, P. Soule, F. Mueller, C. D. Darzacq, X. Darzacq, C. Wu, C. I. Bargmann, D. A. Agard, M. Dahan, and M. G. L. Gustafsson, “Fast multicolor 3D imaging using aberration-corrected multifocus microscopy,” Nat. Methods 10, 60–63 (2013).
[Crossref]

Davanco, M.

Deisseroth, K.

Del Bene, F.

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305, 1007–1009 (2004).
[Crossref]

Delcour, J. E.

R. Prevedel, A. J. Verhoef, A. J. Pernía-Andrade, S. Weisenburger, B. S. Huang, T. Nöbauer, A. Fernández, J. E. Delcour, P. Golshani, A. Baltuska, and A. Vaziri, “Fast volumetric calcium imaging across multiple cortical layers using sculpted light,” Nat. Methods 13, 1021–1028 (2016).
[Crossref]

Denk, W.

W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science 248, 73–76 (1990).
[Crossref]

Drake, S. J.

S. J. Drake, “Systems and methods for forming an image of a specimen at an oblique viewing angle,” PCT PatentWO2003027644A1 (April3, 2003).

Du, J.

L. Cong, Z. Wang, Y. Chai, W. Hang, C. Shang, W. Yang, L. Bai, J. Du, K. Wang, and Q. Wen, “Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio),” eLife 6, e28158 (2017).
[Crossref]

Dunsby, C.

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Smith, I. T.

J. N. Stirman, I. T. Smith, M. W. Kudenov, and S. L. Smith, “Wide field-of-view, multi-region, two-photon imaging of neuronal activity in the mammalian brain,” Nat. Biotechnol. 34, 857–862 (2016).
[Crossref]

Smith, S. L.

J. N. Stirman, I. T. Smith, M. W. Kudenov, and S. L. Smith, “Wide field-of-view, multi-region, two-photon imaging of neuronal activity in the mammalian brain,” Nat. Biotechnol. 34, 857–862 (2016).
[Crossref]

Sofroniew, N. J.

N. J. Sofroniew, D. Flickinger, J. King, and K. Svoboda, “A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging,” eLife 5, 413 (2016).
[Crossref]

Soule, P.

S. Abrahamsson, J. Chen, B. Hajj, S. Stallinga, A. Y. Katsov, J. Wisniewski, G. Mizuguchi, P. Soule, F. Mueller, C. D. Darzacq, X. Darzacq, C. Wu, C. I. Bargmann, D. A. Agard, M. Dahan, and M. G. L. Gustafsson, “Fast multicolor 3D imaging using aberration-corrected multifocus microscopy,” Nat. Methods 10, 60–63 (2013).
[Crossref]

Stallinga, S.

S. Abrahamsson, J. Chen, B. Hajj, S. Stallinga, A. Y. Katsov, J. Wisniewski, G. Mizuguchi, P. Soule, F. Mueller, C. D. Darzacq, X. Darzacq, C. Wu, C. I. Bargmann, D. A. Agard, M. Dahan, and M. G. L. Gustafsson, “Fast multicolor 3D imaging using aberration-corrected multifocus microscopy,” Nat. Methods 10, 60–63 (2013).
[Crossref]

Stelzer, E. H.

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305, 1007–1009 (2004).
[Crossref]

Stelzer, E. H. K.

P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. K. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322, 1065–1069 (2008).
[Crossref]

Stirman, J. N.

J. N. Stirman, I. T. Smith, M. W. Kudenov, and S. L. Smith, “Wide field-of-view, multi-region, two-photon imaging of neuronal activity in the mammalian brain,” Nat. Biotechnol. 34, 857–862 (2016).
[Crossref]

Strickler, J. H.

W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science 248, 73–76 (1990).
[Crossref]

Sun, W.

R. Lu, W. Sun, Y. Liang, A. Kerlin, J. Bierfeld, J. D. Seelig, D. E. Wilson, B. Scholl, B. Mohar, M. Tanimoto, M. Koyama, D. Fitzpatrick, M. B. Orger, and N. Ji, “Video-rate volumetric functional imaging of the brain at synaptic resolution,” Nat. Neurosci. 20, 620–628 (2017).
[Crossref]

Svoboda, K.

N. J. Sofroniew, D. Flickinger, J. King, and K. Svoboda, “A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging,” eLife 5, 413 (2016).
[Crossref]

Swoger, J.

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305, 1007–1009 (2004).
[Crossref]

Tanimoto, M.

R. Lu, W. Sun, Y. Liang, A. Kerlin, J. Bierfeld, J. D. Seelig, D. E. Wilson, B. Scholl, B. Mohar, M. Tanimoto, M. Koyama, D. Fitzpatrick, M. B. Orger, and N. Ji, “Video-rate volumetric functional imaging of the brain at synaptic resolution,” Nat. Neurosci. 20, 620–628 (2017).
[Crossref]

Traub, F. M.

T. Nöbauer, O. Skocek, A. J. Pernía-Andrade, L. Weilguny, F. M. Traub, M. I. Molodtsov, and A. Vaziri, “Video rate volumetric Ca2+ imaging across cortex using seeded iterative demixing (SID) microscopy,” Nat. Methods 14, 811–818 (2017).
[Crossref]

Vaadia, R. D.

R. D. Vaadia, W. Li, V. Voleti, A. Singhania, E. M. C. Hillman, and W. B. Grueber, “Characterization of proprioceptive system dynamics in behaving Drosophila larvae using high-speed volumetric microscopy,” Curr. Biol. 29, 935–944 (2019).
[Crossref]

Vaziri, A.

T. Nöbauer, O. Skocek, A. J. Pernía-Andrade, L. Weilguny, F. M. Traub, M. I. Molodtsov, and A. Vaziri, “Video rate volumetric Ca2+ imaging across cortex using seeded iterative demixing (SID) microscopy,” Nat. Methods 14, 811–818 (2017).
[Crossref]

R. Prevedel, A. J. Verhoef, A. J. Pernía-Andrade, S. Weisenburger, B. S. Huang, T. Nöbauer, A. Fernández, J. E. Delcour, P. Golshani, A. Baltuska, and A. Vaziri, “Fast volumetric calcium imaging across multiple cortical layers using sculpted light,” Nat. Methods 13, 1021–1028 (2016).
[Crossref]

R. Prevedel, Y.-G. Yoon, M. Hoffmann, N. Pak, G. Wetzstein, S. Kato, T. Schrödel, R. Raskar, M. Zimmer, E. S. Boyden, and A. Vaziri, “Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy,” Nat. Methods 11, 727–730 (2014).
[Crossref]

Verhoef, A. J.

R. Prevedel, A. J. Verhoef, A. J. Pernía-Andrade, S. Weisenburger, B. S. Huang, T. Nöbauer, A. Fernández, J. E. Delcour, P. Golshani, A. Baltuska, and A. Vaziri, “Fast volumetric calcium imaging across multiple cortical layers using sculpted light,” Nat. Methods 13, 1021–1028 (2016).
[Crossref]

Voleti, V.

R. D. Vaadia, W. Li, V. Voleti, A. Singhania, E. M. C. Hillman, and W. B. Grueber, “Characterization of proprioceptive system dynamics in behaving Drosophila larvae using high-speed volumetric microscopy,” Curr. Biol. 29, 935–944 (2019).
[Crossref]

M. B. Bouchard, V. Voleti, C. S. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high-speed volumetric imaging of behaving organisms,” Nat. Photonics 9, 113–119 (2015).
[Crossref]

Wang, K.

L. Cong, Z. Wang, Y. Chai, W. Hang, C. Shang, W. Yang, L. Bai, J. Du, K. Wang, and Q. Wen, “Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio),” eLife 6, e28158 (2017).
[Crossref]

Wang, Z.

L. Cong, Z. Wang, Y. Chai, W. Hang, C. Shang, W. Yang, L. Bai, J. Du, K. Wang, and Q. Wen, “Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio),” eLife 6, e28158 (2017).
[Crossref]

Webb, W. W.

W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science 248, 73–76 (1990).
[Crossref]

Weilguny, L.

T. Nöbauer, O. Skocek, A. J. Pernía-Andrade, L. Weilguny, F. M. Traub, M. I. Molodtsov, and A. Vaziri, “Video rate volumetric Ca2+ imaging across cortex using seeded iterative demixing (SID) microscopy,” Nat. Methods 14, 811–818 (2017).
[Crossref]

Weisenburger, S.

R. Prevedel, A. J. Verhoef, A. J. Pernía-Andrade, S. Weisenburger, B. S. Huang, T. Nöbauer, A. Fernández, J. E. Delcour, P. Golshani, A. Baltuska, and A. Vaziri, “Fast volumetric calcium imaging across multiple cortical layers using sculpted light,” Nat. Methods 13, 1021–1028 (2016).
[Crossref]

Wen, Q.

L. Cong, Z. Wang, Y. Chai, W. Hang, C. Shang, W. Yang, L. Bai, J. Du, K. Wang, and Q. Wen, “Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio),” eLife 6, e28158 (2017).
[Crossref]

Wetzstein, G.

R. Prevedel, Y.-G. Yoon, M. Hoffmann, N. Pak, G. Wetzstein, S. Kato, T. Schrödel, R. Raskar, M. Zimmer, E. S. Boyden, and A. Vaziri, “Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy,” Nat. Methods 11, 727–730 (2014).
[Crossref]

Wilding, D.

S. Kumar, D. Wilding, M. B. Sikkel, A. R. Lyon, K. T. MacLeod, and C. Dunsby, “High-speed 2D and 3D fluorescence microscopy of cardiac myocytes,” Opt. Express 19, 13839–13847 (2011).
[Crossref]

A. R. Lyon, C. Dunsby, D. Wilding, K. T. MacLeod, M. B. Sikkel, and S. Kumar, “Application of oblique plane microscopy to high speed live cell imaging,” Proc. SPIE 8086, 80860V (2011).
[Crossref]

Wilson, D. E.

R. Lu, W. Sun, Y. Liang, A. Kerlin, J. Bierfeld, J. D. Seelig, D. E. Wilson, B. Scholl, B. Mohar, M. Tanimoto, M. Koyama, D. Fitzpatrick, M. B. Orger, and N. Ji, “Video-rate volumetric functional imaging of the brain at synaptic resolution,” Nat. Neurosci. 20, 620–628 (2017).
[Crossref]

Wilson, T.

E. J. Botcherby, R. Juškaitis, M. J. Booth, and T. Wilson, “An optical technique for remote focusing in microscopy,” Opt. Commun. 281, 880–887 (2008).
[Crossref]

Wisniewski, J.

B. Hajj, B. Mehl, C. Wu, C. Cho, C. I. Bargmann, J. A. Liddle, J. Wisniewski, J.-B. Fiche, J. Pulupa, L. Oudjedi, L. Chen, L. Yu, M. Davanco, M. Nollmann, M. Dahan, M. El Beheiry, M. Mir, R. Ilic, S. Abrahamsson, T. Lionnet, X. Darzacq, and X. Jin, “Multifocus microscopy with precise color multi-phase diffractive optics applied in functional neuronal imaging,” Biomed. Opt. Express 7, 855–869 (2016).
[Crossref]

S. Abrahamsson, J. Chen, B. Hajj, S. Stallinga, A. Y. Katsov, J. Wisniewski, G. Mizuguchi, P. Soule, F. Mueller, C. D. Darzacq, X. Darzacq, C. Wu, C. I. Bargmann, D. A. Agard, M. Dahan, and M. G. L. Gustafsson, “Fast multicolor 3D imaging using aberration-corrected multifocus microscopy,” Nat. Methods 10, 60–63 (2013).
[Crossref]

Wittbrodt, J.

P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. K. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322, 1065–1069 (2008).
[Crossref]

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305, 1007–1009 (2004).
[Crossref]

Wu, C.

B. Hajj, B. Mehl, C. Wu, C. Cho, C. I. Bargmann, J. A. Liddle, J. Wisniewski, J.-B. Fiche, J. Pulupa, L. Oudjedi, L. Chen, L. Yu, M. Davanco, M. Nollmann, M. Dahan, M. El Beheiry, M. Mir, R. Ilic, S. Abrahamsson, T. Lionnet, X. Darzacq, and X. Jin, “Multifocus microscopy with precise color multi-phase diffractive optics applied in functional neuronal imaging,” Biomed. Opt. Express 7, 855–869 (2016).
[Crossref]

S. Abrahamsson, J. Chen, B. Hajj, S. Stallinga, A. Y. Katsov, J. Wisniewski, G. Mizuguchi, P. Soule, F. Mueller, C. D. Darzacq, X. Darzacq, C. Wu, C. I. Bargmann, D. A. Agard, M. Dahan, and M. G. L. Gustafsson, “Fast multicolor 3D imaging using aberration-corrected multifocus microscopy,” Nat. Methods 10, 60–63 (2013).
[Crossref]

Xie, D.

Yang, S.

Yang, W.

L. Cong, Z. Wang, Y. Chai, W. Hang, C. Shang, W. Yang, L. Bai, J. Du, K. Wang, and Q. Wen, “Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio),” eLife 6, e28158 (2017).
[Crossref]

Yoon, Y.-G.

R. Prevedel, Y.-G. Yoon, M. Hoffmann, N. Pak, G. Wetzstein, S. Kato, T. Schrödel, R. Raskar, M. Zimmer, E. S. Boyden, and A. Vaziri, “Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy,” Nat. Methods 11, 727–730 (2014).
[Crossref]

Yu, L.

Zimmer, M.

R. Prevedel, Y.-G. Yoon, M. Hoffmann, N. Pak, G. Wetzstein, S. Kato, T. Schrödel, R. Raskar, M. Zimmer, E. S. Boyden, and A. Vaziri, “Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy,” Nat. Methods 11, 727–730 (2014).
[Crossref]

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M. Levoy, R. Ng, A. Adams, M. Footer, and M. Horowitz, “Light field microscopy,” ACM Trans. Graph. 25, 924–934 (2006).
[Crossref]

Appl. Opt. (1)

Biomed. Opt. Express (2)

Curr. Biol. (1)

R. D. Vaadia, W. Li, V. Voleti, A. Singhania, E. M. C. Hillman, and W. B. Grueber, “Characterization of proprioceptive system dynamics in behaving Drosophila larvae using high-speed volumetric microscopy,” Curr. Biol. 29, 935–944 (2019).
[Crossref]

eLife (2)

L. Cong, Z. Wang, Y. Chai, W. Hang, C. Shang, W. Yang, L. Bai, J. Du, K. Wang, and Q. Wen, “Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio),” eLife 6, e28158 (2017).
[Crossref]

N. J. Sofroniew, D. Flickinger, J. King, and K. Svoboda, “A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging,” eLife 5, 413 (2016).
[Crossref]

J. Biophoton. (2)

Y. Shin, D. Kim, and H.-S. Kwon, “Oblique scanning 2-photon light-sheet fluorescence microscopy for rapid volumetric imaging,” J. Biophoton. 11, e201700270 (2018).
[Crossref]

M. B. Sikkel, S. Kumar, V. Maioli, C. Rowlands, F. Gordon, S. E. Harding, A. R. Lyon, K. T. MacLeod, and C. Dunsby, “High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes,” J. Biophoton. 9, 311–323 (2016).
[Crossref]

Nat. Biotechnol. (1)

J. N. Stirman, I. T. Smith, M. W. Kudenov, and S. L. Smith, “Wide field-of-view, multi-region, two-photon imaging of neuronal activity in the mammalian brain,” Nat. Biotechnol. 34, 857–862 (2016).
[Crossref]

Nat. Methods (5)

R. Prevedel, A. J. Verhoef, A. J. Pernía-Andrade, S. Weisenburger, B. S. Huang, T. Nöbauer, A. Fernández, J. E. Delcour, P. Golshani, A. Baltuska, and A. Vaziri, “Fast volumetric calcium imaging across multiple cortical layers using sculpted light,” Nat. Methods 13, 1021–1028 (2016).
[Crossref]

R. Prevedel, Y.-G. Yoon, M. Hoffmann, N. Pak, G. Wetzstein, S. Kato, T. Schrödel, R. Raskar, M. Zimmer, E. S. Boyden, and A. Vaziri, “Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy,” Nat. Methods 11, 727–730 (2014).
[Crossref]

T. Nöbauer, O. Skocek, A. J. Pernía-Andrade, L. Weilguny, F. M. Traub, M. I. Molodtsov, and A. Vaziri, “Video rate volumetric Ca2+ imaging across cortex using seeded iterative demixing (SID) microscopy,” Nat. Methods 14, 811–818 (2017).
[Crossref]

S. Abrahamsson, J. Chen, B. Hajj, S. Stallinga, A. Y. Katsov, J. Wisniewski, G. Mizuguchi, P. Soule, F. Mueller, C. D. Darzacq, X. Darzacq, C. Wu, C. I. Bargmann, D. A. Agard, M. Dahan, and M. G. L. Gustafsson, “Fast multicolor 3D imaging using aberration-corrected multifocus microscopy,” Nat. Methods 10, 60–63 (2013).
[Crossref]

M. B. Ahrens, M. B. Orger, D. N. Robson, J. M. Li, and P. J. Keller, “Whole-brain functional imaging at cellular resolution using light-sheet microscopy,” Nat. Methods 10, 413–420 (2013).
[Crossref]

Nat. Neurosci. (1)

R. Lu, W. Sun, Y. Liang, A. Kerlin, J. Bierfeld, J. D. Seelig, D. E. Wilson, B. Scholl, B. Mohar, M. Tanimoto, M. Koyama, D. Fitzpatrick, M. B. Orger, and N. Ji, “Video-rate volumetric functional imaging of the brain at synaptic resolution,” Nat. Neurosci. 20, 620–628 (2017).
[Crossref]

Nat. Photonics (1)

M. B. Bouchard, V. Voleti, C. S. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high-speed volumetric imaging of behaving organisms,” Nat. Photonics 9, 113–119 (2015).
[Crossref]

Opt. Commun. (1)

E. J. Botcherby, R. Juškaitis, M. J. Booth, and T. Wilson, “An optical technique for remote focusing in microscopy,” Opt. Commun. 281, 880–887 (2008).
[Crossref]

Opt. Express (5)

Opt. Lett. (1)

Proc. SPIE (1)

A. R. Lyon, C. Dunsby, D. Wilding, K. T. MacLeod, M. B. Sikkel, and S. Kumar, “Application of oblique plane microscopy to high speed live cell imaging,” Proc. SPIE 8086, 80860V (2011).
[Crossref]

Science (3)

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305, 1007–1009 (2004).
[Crossref]

W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science 248, 73–76 (1990).
[Crossref]

P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. K. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322, 1065–1069 (2008).
[Crossref]

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S. J. Drake, “Systems and methods for forming an image of a specimen at an oblique viewing angle,” PCT PatentWO2003027644A1 (April3, 2003).

J. Mertz, Introduction to Optical Microscopy (Roberts Publishers, 2010).

Supplementary Material (3)

NameDescription
» Supplement 1       Supplemental Document
» Visualization 1       Maximum intensity projection of backprojected fluorescence traces of the regions of interest in Fig. 3(d) of juvenile Zebrafish (elavl3:H2B-GCaMP6s, 33 days post fertilization) imaged at 0.8 Hz, replay: 25x.
» Visualization 2       Maximum intensity projection of fluorescent timeseries of larval Zebrafish (elavl3:H2B-GCaMP6s, 4 days post fertilization) at different locations in the field of view, imaged at 1.75Hz, replay: 11x.

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Figures (3)

Fig. 1.
Fig. 1. Principle of operation. (a) Recording geometry of oblique plane microscopy: a swept Gaussian laser beam (dark blue) excites an oblique plane within the specimen (dashed box); the optical section is the result of the angle between the detection point spread function (PSF, green ellipsoid) and the excitation PSF (Gaussian beam). The emitted fluorescence light within the acceptance angle (green cone) is captured by the objective. Volumetric imaging is achieved by scanning the excitation light to parallel planes (light blue). The white circles represent sample points on the sheared volumetric grid and successive camera images. (b) Oblique reimaging for two different numerical apertures: an intermediate image plane (circles) is created and reimaged by two identical objectives. A part of the light cone emerging from the first objective (green) is not collected (red) because it does not propagate within the acceptance angle of the second objective. As the numerical aperture (NA) decreases, the light is completely lost. (c) Diffractive oblique reimaging: the inserted diffraction grating diffracts parts of the light into a direction almost perpendicular to the grating and allows reimaging at low NA. The angle of the grating matches the angles of the imaging planes in (b). (d) Setup: the laser focus at the galvanometric scanning mirror (SMX) is imaged onto a decentered spot at the backfocal aperture of the imaging objective OBJ1 by the 4f system consisting of the two tube lenses TL1 and TL2. This leads to an oblique incidence at the sample. Scanning the mirror SMX excites fluorescence in an oblique plane. The emitted fluorescence from the oblique plane is imaged onto a blazed diffraction grating (GR) at the intermediate image plane (IIM) with unit magnification by means of two identical imaging systems (OBJ1 TL1, OBJ2 TL2). The surface of the diffraction grating (GR) is imaged by a third imaging system (OBJ3, TL3) place perpendicular to the grating surface. The third imaging system collects the diffracted fluorescence at the IIM and images it onto the camera. A volume is imaged by scanning and descanning the imaging plane in the sample by scanning the galvanometric scanning mirror SMY.
Fig. 2.
Fig. 2. Quantification of system resolution. (a) Beads in full FOV, maximum intensity projection of bead volume after shear transformation (ST), scale bar 1000 μm. (b) Example beads, maximum intensity projections of five 1 μm sized beads along x, y, and z after ST; the location in the total FOV is indicated by the arrows in (a), scale bar 20 μm. (c) Resolution across the FOV; each plot shows the dependency of the resolution (mean ± SD) along x, y, and z on bead position along x, y, and z (top to bottom).
Fig. 3.
Fig. 3. Measurement of neuronal activity over a large field of view (FOV). (a) Larval zebrafish at different locations across the accessible FOV: montage of a restrained 4dpf Huc:GCaMP6s nuclear zebrafish larva sequentially imaged at nine different locations within the accessible FOV [maximum intensity projection (MIP)]; see Supplement 1, Visualization 1. (b) Slice of the larval zebrafish brain at 100 μm depth and location v. (c) MIP of a 33 dpf Huc:GCaMP6s in the accessible microscope FOV, which was recorded in the time lapse experiments. The dashed red box represents the imaged region. (d) MIP of the brain with overlayed contours of the regions of interest along all three dimensions of the volume; see Supplement 1, Visualization 2. (e) Extracted temporal dF/F traces of the regions of interest shown in (d); scale bar in (a), (b), (c), (d) 250 μm.

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