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Image enhancement for fluorescence microscopy based on deep learning with prior knowledge of aberration

Lejia Hu, Shuwen Hu, Wei Gong, and Ke Si

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Abstract

In this Letter, we propose a deep learning method with prior knowledge of potential aberration to enhance the fluorescence microscopy without additional hardware. The proposed method could effectively reduce noise and improve the peak signal-to-noise ratio of the acquired images at high speed. The enhancement performance and generalization of this method is demonstrated on three commercial fluorescence microscopes. This work provides a computational alternative to overcome the degradation induced by the biological specimen, and it has the potential to be further applied in biological applications.

© 2021 Optical Society of America

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Data Availability

Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

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