Abstract

A method to realize surface-enhanced Raman spectroscopy (SERS) at a titanium alloy substrate for glucose detection has been experimentally demonstrated. A silver-coated laser-induced periodic surface structure (LIPSS) was prepared via femtosecond laser micro-processing. The low detection limit of glucose is ${{10}^{- 7}}\;{\rm mol}/{\rm L}$ and, a good linear relationship between the glucose concentration and Raman intensity is found in the range between ${1} \times {{10}^{- 7}}$ and ${1} \times {{10}^{- 3}}\;{\rm mol}/{\rm L}$. Moreover, we investigate SERS detection for glucose sensing in human urine samples, while the results are in good agreement with clinical results. The Letter provides a facile method for producing a structure-controlled SERS substrate to realize glucose detection, which is promising for long-term in vivo diagnostics.

© 2021 Optical Society of America

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