Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Rapid functional optoacoustic micro-angiography in a burst mode

Not Accessible

Your library or personal account may give you access

Abstract

Optoacoustic microscopy (OAM) can image intrinsic optical absorption contrast at depths of several millimeters where state-of-the-art optical microscopy techniques fail due to intense light scattering in living tissues. Yet, wide adoption of OAM in biology and medicine is hindered by slow image acquisition speed, small field of view (FOV), and/or lack of spectral differentiation capacity of common system implementations. We report on a rapid acquisition functional optoacoustic micro-angiography approach that employs a burst-mode laser triggering scheme to simultaneously acquire multi-wavelength 3D images over an extended FOV covering ${50}\;{\rm mm} \times {50}\;{\rm mm}$ in a single mechanical overfly scan, attaining 28 µm and 14 µm resolution in lateral and axial dimensions, respectively. Owing to an ultrawideband low-noise design featuring a spherically focused polyvinylidene difluoride transducer, we demonstrate imaging of human skin and underlying vasculature at up to 3.8 mm depth when using per-pulse laser energies of only 25 µJ without employing signal averaging. Overall, the developed system greatly enhances performance and usability of OAM for dermatologic and micro-angiographic studies.

© 2020 Optical Society of America

Full Article  |  PDF Article
More Like This
In vivo optoacoustic monitoring of percutaneous laser ablation of tumors in a murine breast cancer model

Vijitha Periyasamy, Çağla Özsoy, Michael Reiss, Xosé Luís Deán-Ben, and Daniel Razansky
Opt. Lett. 45(7) 2006-2009 (2020)

Coregistered transcranial optoacoustic and magnetic resonance angiography of the human brain

Ruiqing Ni, Xosé Luís Deán-Ben, Valerie Treyer, Anton Gietl, Christoph Hock, Jan Klohs, Roger M. Nitsch, and Daniel Razansky
Opt. Lett. 48(3) 648-651 (2023)

Low-cost single-point optoacoustic sensor for spectroscopic measurement of local vascular oxygenation

Antonios Stylogiannis, Lucas Riobo, Ludwig Prade, Sarah Glasl, Sabine Klein, Giulia Lucidi, Martin Fuchs, Dieter Saur, and Vasilis Ntziachristos
Opt. Lett. 45(24) 6579-6582 (2020)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved