Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

X-ray-induced shortwave infrared luminescence computed tomography

Not Accessible

Your library or personal account may give you access

Abstract

X-ray luminescence computed tomography (XLCT) based on x-ray-excitable nanophosphors has been proposed as a new modality for molecular imaging. The technique has two main advantages compared to other modalities. First, autofluorescence, which is problematic for fluorescence imaging, can be substantially reduced. Second, deep-tissue in vivo imaging with high optical contrast and spatial resolution becomes achievable. Here, we extend the novel XLCT modality from the visible or infrared region to a shortwave infrared wavelength by developing an x-ray-induced shortwave infrared luminescence computed tomography (SWIR-XLCT). For this application, rare-earth nanophosphors (RENPs) were synthesized as core/shell structures consisting of a Ho-doped NaYbF4 core surrounded by a NaYF4 shell that emit light efficiently in the shortwave infrared spectral region under x-ray excitation. Through numerical simulations and phantom experiments, we showed the feasibility of SWIR-XLCT and demonstrated its potential for x-ray luminescence imaging with high spatial resolution and deep depth.

© 2019 Optical Society of America

Full Article  |  PDF Article
More Like This
Background luminescence in x-ray luminescence computed tomography (XLCT) imaging

Michael C. Lun and Changqing Li
Appl. Opt. 58(4) 1084-1092 (2019)

Contrast agents for x-ray luminescence computed tomography

Michael C. Lun, Meenakshi Ranasinghe, Mohammad Arifuzzaman, Yile Fang, Yiping Guo, Jeffrey N. Anker, and Changqing Li
Appl. Opt. 60(23) 6769-6775 (2021)

Sensitivity study of x-ray luminescence computed tomography

Michael C. Lun, Wei Zhang, and Changqing Li
Appl. Opt. 56(11) 3010-3019 (2017)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (6)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Equations (7)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved