Abstract

Nonlinear photothermal microscopy, in which the intensity of the pump heating beam is modulated at f and the photothermal signal is extracted from the probe beam with a lock-in amplifier referred to 2f, is applied to the imaging of mouse melanoma without any staining. The pump and probe pulses, with central wavelengths of 488 and 632 nm, and a pulse duration of 100ps, are filtered from a compact commercial supercontinuum fiber laser source. An auto-balanced detector is applied to accumulate the signal and remove the laser noise of the probe. The spatial resolution of the nonlinear photothermal imaging is enhanced by 18% in both theoretical calculations and experiments, compared with a linear photothermal mechanism, and the resolution enhancement is theoretically 42% compared with conventional optical microscopy. This imaging technique shows possibilities for the clinical evaluation of melanoma with a high contrast and spatial resolution.

© 2015 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Biological imaging with nonlinear photothermal microscopy using a compact supercontinuum fiber laser source

Jinping He, Jun Miyazaki, Nan Wang, Hiromichi Tsurui, and Takayoshi Kobayashi
Opt. Express 23(8) 9762-9771 (2015)

Enhanced resolution in a multimode fiber imaging system

Gregoire. P. J. Laporte, Nicolino Stasio, Christophe Moser, and Demetri Psaltis
Opt. Express 23(21) 27484-27493 (2015)

Sensitivity enhancement of photothermal microscopy with radially segmented balanced detection

Jun Miyazaki, Hiromichi Tsurui, Koshi Kawasumi, and Takayoshi Kobayashi
Opt. Lett. 40(4) 479-482 (2015)

References

  • View by:
  • |
  • |
  • |

  1. T. E. Matthews, I. R. Piletic, M. A. Selim, M. J. Simpson, and W. S. Warren, Sci. Transl. Med. 71, 71ra15 (2011).
  2. H. Kittler, H. Pehamberger, K. Wolff, and M. Binder, Lancet Oncol. 62, 751 (2010).
  3. R. Marchesini, A. Bono, and M. Carrara, J. Biomed. Opt. 14, 014027 (2009).
    [Crossref]
  4. G. Zonios, A. Dimou, M. Carrara, and R. Marchesini, Photochem. Photobiol. 86, 236 (2010).
    [Crossref]
  5. E. I. Galanzha, E. V. Shashkov, P. M. Spring, J. Y. Suen, and V. P. Zharov, Cancer Res. 69, 7926 (2009).
    [Crossref]
  6. M. Mehrmohammadi, S. J. Yoon, D. Yeager, and S. Y. Emelianov, Curr. Mol. Imaging 2, 89 (2013).
    [Crossref]
  7. V. P. Zharov, Nat. Photonics 5, 110 (2011).
    [Crossref]
  8. D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, J. Biophotonics 6, 523 (2013).
    [Crossref]
  9. D. Lasne, G. A. Blab, F. D. Giorgi, F. Ichas, B. Lounis, and L. Cognet, Opt. Express 15, 14184 (2007).
    [Crossref]
  10. L. J. Inglehart, A. Broniaotowski, D. Fournier, A. C. Boccara, and F. Lepoutre, Appl. Phys. Lett. 56, 1749 (1990).
    [Crossref]
  11. A. H. Sahraoui, C. Kolinsky, S. Delenclos, A. Daoudi, and J. M. Buisine, J. Appl. Phys. 82, 6209 (1997).
    [Crossref]
  12. M. Tokeshi, M. Uchida, A. Hibara, T. Sawada, and T. Kitamori, Anal. Chem. 73, 2112 (2001).
    [Crossref]
  13. S. Berciaud, L. Cognet, G. A. Blab, and B. Lounis, Phys. Rev. Lett. 93, 257402 (2004).
    [Crossref]
  14. D. Lasne, G. A. Blab, S. Berciaud, M. Heine, L. Groc, D. Choquet, L. Cognet, and B. Lounis, Biophys. J. 91, 4598 (2006).
    [Crossref]
  15. Y. N. Rajakarunanayake and H. K. Wickramasinghe, Appl. Phys. Lett. 48, 218 (1986).
    [Crossref]
  16. G. C. Wetsel and J. B. Spicer, Can. J. Phys. 64, 1269 (1986).
    [Crossref]
  17. A. Salnick, J. Opsal, A. Rosencwaig, and A. Mandelis, Solid State Commun. 114, 133 (2000).
    [Crossref]
  18. V. Gusev, A. Mandelis, and R. Bleiss, Mat. Sci. Eng. B 26, 111 (1994).
    [Crossref]
  19. G. Kalogiannakis, D. V. Hemelrijck, and C. Glorieux, NDT & E Int. 39, 236 (2006).
    [Crossref]
  20. V. Gusev, A. Mandelis, and R. Bleiss, Appl. Phys. A 57, 229 (1993).
    [Crossref]
  21. O. Dka, A. Mikls, and A. Lrincz, Appl. Phys. A 48, 415 (1989).
    [Crossref]
  22. V. Gusev, A. Mandelis, and R. Bleiss, Int. J. Thermophys. 14, 321 (1993).
    [Crossref]
  23. A. Mandelis, A. Salnick, J. Opsal, and A. Rosencwaig, J. Appl. Phys. 85, 1811 (1999).
    [Crossref]
  24. J. Zhao, J. Shen, and C. Hu, Opt. Lett. 27, 1755 (2002).
    [Crossref]
  25. H. S. Carslaw and J. C. Jaeger, Conduction of Heat in Solids2nd ed. (Oxford University, 1959).
  26. A. Gaiduk, P. V. Ruijgrok, M. Yorulmaz, and M. Orrit, Chem. Sci. 1, 343 (2010).
    [Crossref]
  27. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, Opt. Lett. 28, 2067 (2003).
    [Crossref]
  28. K. Fujita, M. Kobayashi, S. Kawano, M. Yamanaka, and S. Kawata, Phys. Rev. Lett. 99, 228105 (2007).
    [Crossref]
  29. S. Kawano, N. I. Smith, M. Yamanaka, S. Kawata, and K. Fujita, Appl. Phys. Express 4, 042401 (2011).
    [Crossref]

2013 (2)

M. Mehrmohammadi, S. J. Yoon, D. Yeager, and S. Y. Emelianov, Curr. Mol. Imaging 2, 89 (2013).
[Crossref]

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, J. Biophotonics 6, 523 (2013).
[Crossref]

2011 (3)

V. P. Zharov, Nat. Photonics 5, 110 (2011).
[Crossref]

T. E. Matthews, I. R. Piletic, M. A. Selim, M. J. Simpson, and W. S. Warren, Sci. Transl. Med. 71, 71ra15 (2011).

S. Kawano, N. I. Smith, M. Yamanaka, S. Kawata, and K. Fujita, Appl. Phys. Express 4, 042401 (2011).
[Crossref]

2010 (3)

A. Gaiduk, P. V. Ruijgrok, M. Yorulmaz, and M. Orrit, Chem. Sci. 1, 343 (2010).
[Crossref]

H. Kittler, H. Pehamberger, K. Wolff, and M. Binder, Lancet Oncol. 62, 751 (2010).

G. Zonios, A. Dimou, M. Carrara, and R. Marchesini, Photochem. Photobiol. 86, 236 (2010).
[Crossref]

2009 (2)

E. I. Galanzha, E. V. Shashkov, P. M. Spring, J. Y. Suen, and V. P. Zharov, Cancer Res. 69, 7926 (2009).
[Crossref]

R. Marchesini, A. Bono, and M. Carrara, J. Biomed. Opt. 14, 014027 (2009).
[Crossref]

2007 (2)

K. Fujita, M. Kobayashi, S. Kawano, M. Yamanaka, and S. Kawata, Phys. Rev. Lett. 99, 228105 (2007).
[Crossref]

D. Lasne, G. A. Blab, F. D. Giorgi, F. Ichas, B. Lounis, and L. Cognet, Opt. Express 15, 14184 (2007).
[Crossref]

2006 (2)

D. Lasne, G. A. Blab, S. Berciaud, M. Heine, L. Groc, D. Choquet, L. Cognet, and B. Lounis, Biophys. J. 91, 4598 (2006).
[Crossref]

G. Kalogiannakis, D. V. Hemelrijck, and C. Glorieux, NDT & E Int. 39, 236 (2006).
[Crossref]

2004 (1)

S. Berciaud, L. Cognet, G. A. Blab, and B. Lounis, Phys. Rev. Lett. 93, 257402 (2004).
[Crossref]

2003 (1)

2002 (1)

2001 (1)

M. Tokeshi, M. Uchida, A. Hibara, T. Sawada, and T. Kitamori, Anal. Chem. 73, 2112 (2001).
[Crossref]

2000 (1)

A. Salnick, J. Opsal, A. Rosencwaig, and A. Mandelis, Solid State Commun. 114, 133 (2000).
[Crossref]

1999 (1)

A. Mandelis, A. Salnick, J. Opsal, and A. Rosencwaig, J. Appl. Phys. 85, 1811 (1999).
[Crossref]

1997 (1)

A. H. Sahraoui, C. Kolinsky, S. Delenclos, A. Daoudi, and J. M. Buisine, J. Appl. Phys. 82, 6209 (1997).
[Crossref]

1994 (1)

V. Gusev, A. Mandelis, and R. Bleiss, Mat. Sci. Eng. B 26, 111 (1994).
[Crossref]

1993 (2)

V. Gusev, A. Mandelis, and R. Bleiss, Appl. Phys. A 57, 229 (1993).
[Crossref]

V. Gusev, A. Mandelis, and R. Bleiss, Int. J. Thermophys. 14, 321 (1993).
[Crossref]

1990 (1)

L. J. Inglehart, A. Broniaotowski, D. Fournier, A. C. Boccara, and F. Lepoutre, Appl. Phys. Lett. 56, 1749 (1990).
[Crossref]

1989 (1)

O. Dka, A. Mikls, and A. Lrincz, Appl. Phys. A 48, 415 (1989).
[Crossref]

1986 (2)

Y. N. Rajakarunanayake and H. K. Wickramasinghe, Appl. Phys. Lett. 48, 218 (1986).
[Crossref]

G. C. Wetsel and J. B. Spicer, Can. J. Phys. 64, 1269 (1986).
[Crossref]

Berciaud, S.

D. Lasne, G. A. Blab, S. Berciaud, M. Heine, L. Groc, D. Choquet, L. Cognet, and B. Lounis, Biophys. J. 91, 4598 (2006).
[Crossref]

S. Berciaud, L. Cognet, G. A. Blab, and B. Lounis, Phys. Rev. Lett. 93, 257402 (2004).
[Crossref]

Binder, M.

H. Kittler, H. Pehamberger, K. Wolff, and M. Binder, Lancet Oncol. 62, 751 (2010).

Blab, G. A.

D. Lasne, G. A. Blab, F. D. Giorgi, F. Ichas, B. Lounis, and L. Cognet, Opt. Express 15, 14184 (2007).
[Crossref]

D. Lasne, G. A. Blab, S. Berciaud, M. Heine, L. Groc, D. Choquet, L. Cognet, and B. Lounis, Biophys. J. 91, 4598 (2006).
[Crossref]

S. Berciaud, L. Cognet, G. A. Blab, and B. Lounis, Phys. Rev. Lett. 93, 257402 (2004).
[Crossref]

Bleiss, R.

V. Gusev, A. Mandelis, and R. Bleiss, Mat. Sci. Eng. B 26, 111 (1994).
[Crossref]

V. Gusev, A. Mandelis, and R. Bleiss, Appl. Phys. A 57, 229 (1993).
[Crossref]

V. Gusev, A. Mandelis, and R. Bleiss, Int. J. Thermophys. 14, 321 (1993).
[Crossref]

Boccara, A. C.

L. J. Inglehart, A. Broniaotowski, D. Fournier, A. C. Boccara, and F. Lepoutre, Appl. Phys. Lett. 56, 1749 (1990).
[Crossref]

Bono, A.

R. Marchesini, A. Bono, and M. Carrara, J. Biomed. Opt. 14, 014027 (2009).
[Crossref]

Bouma, B. E.

Broniaotowski, A.

L. J. Inglehart, A. Broniaotowski, D. Fournier, A. C. Boccara, and F. Lepoutre, Appl. Phys. Lett. 56, 1749 (1990).
[Crossref]

Buisine, J. M.

A. H. Sahraoui, C. Kolinsky, S. Delenclos, A. Daoudi, and J. M. Buisine, J. Appl. Phys. 82, 6209 (1997).
[Crossref]

Carrara, M.

G. Zonios, A. Dimou, M. Carrara, and R. Marchesini, Photochem. Photobiol. 86, 236 (2010).
[Crossref]

R. Marchesini, A. Bono, and M. Carrara, J. Biomed. Opt. 14, 014027 (2009).
[Crossref]

Carslaw, H. S.

H. S. Carslaw and J. C. Jaeger, Conduction of Heat in Solids2nd ed. (Oxford University, 1959).

Cense, B.

Choquet, D.

D. Lasne, G. A. Blab, S. Berciaud, M. Heine, L. Groc, D. Choquet, L. Cognet, and B. Lounis, Biophys. J. 91, 4598 (2006).
[Crossref]

Cognet, L.

D. Lasne, G. A. Blab, F. D. Giorgi, F. Ichas, B. Lounis, and L. Cognet, Opt. Express 15, 14184 (2007).
[Crossref]

D. Lasne, G. A. Blab, S. Berciaud, M. Heine, L. Groc, D. Choquet, L. Cognet, and B. Lounis, Biophys. J. 91, 4598 (2006).
[Crossref]

S. Berciaud, L. Cognet, G. A. Blab, and B. Lounis, Phys. Rev. Lett. 93, 257402 (2004).
[Crossref]

Daoudi, A.

A. H. Sahraoui, C. Kolinsky, S. Delenclos, A. Daoudi, and J. M. Buisine, J. Appl. Phys. 82, 6209 (1997).
[Crossref]

de Boer, J. F.

Delenclos, S.

A. H. Sahraoui, C. Kolinsky, S. Delenclos, A. Daoudi, and J. M. Buisine, J. Appl. Phys. 82, 6209 (1997).
[Crossref]

Dimou, A.

G. Zonios, A. Dimou, M. Carrara, and R. Marchesini, Photochem. Photobiol. 86, 236 (2010).
[Crossref]

Dka, O.

O. Dka, A. Mikls, and A. Lrincz, Appl. Phys. A 48, 415 (1989).
[Crossref]

Emelianov, S. Y.

M. Mehrmohammadi, S. J. Yoon, D. Yeager, and S. Y. Emelianov, Curr. Mol. Imaging 2, 89 (2013).
[Crossref]

Fournier, D.

L. J. Inglehart, A. Broniaotowski, D. Fournier, A. C. Boccara, and F. Lepoutre, Appl. Phys. Lett. 56, 1749 (1990).
[Crossref]

Fujita, K.

S. Kawano, N. I. Smith, M. Yamanaka, S. Kawata, and K. Fujita, Appl. Phys. Express 4, 042401 (2011).
[Crossref]

K. Fujita, M. Kobayashi, S. Kawano, M. Yamanaka, and S. Kawata, Phys. Rev. Lett. 99, 228105 (2007).
[Crossref]

Gaiduk, A.

A. Gaiduk, P. V. Ruijgrok, M. Yorulmaz, and M. Orrit, Chem. Sci. 1, 343 (2010).
[Crossref]

Galanzha, E. I.

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, J. Biophotonics 6, 523 (2013).
[Crossref]

E. I. Galanzha, E. V. Shashkov, P. M. Spring, J. Y. Suen, and V. P. Zharov, Cancer Res. 69, 7926 (2009).
[Crossref]

Giorgi, F. D.

Glorieux, C.

G. Kalogiannakis, D. V. Hemelrijck, and C. Glorieux, NDT & E Int. 39, 236 (2006).
[Crossref]

Groc, L.

D. Lasne, G. A. Blab, S. Berciaud, M. Heine, L. Groc, D. Choquet, L. Cognet, and B. Lounis, Biophys. J. 91, 4598 (2006).
[Crossref]

Gusev, V.

V. Gusev, A. Mandelis, and R. Bleiss, Mat. Sci. Eng. B 26, 111 (1994).
[Crossref]

V. Gusev, A. Mandelis, and R. Bleiss, Appl. Phys. A 57, 229 (1993).
[Crossref]

V. Gusev, A. Mandelis, and R. Bleiss, Int. J. Thermophys. 14, 321 (1993).
[Crossref]

Heine, M.

D. Lasne, G. A. Blab, S. Berciaud, M. Heine, L. Groc, D. Choquet, L. Cognet, and B. Lounis, Biophys. J. 91, 4598 (2006).
[Crossref]

Hemelrijck, D. V.

G. Kalogiannakis, D. V. Hemelrijck, and C. Glorieux, NDT & E Int. 39, 236 (2006).
[Crossref]

Hibara, A.

M. Tokeshi, M. Uchida, A. Hibara, T. Sawada, and T. Kitamori, Anal. Chem. 73, 2112 (2001).
[Crossref]

Hu, C.

Ichas, F.

Inglehart, L. J.

L. J. Inglehart, A. Broniaotowski, D. Fournier, A. C. Boccara, and F. Lepoutre, Appl. Phys. Lett. 56, 1749 (1990).
[Crossref]

Jaeger, J. C.

H. S. Carslaw and J. C. Jaeger, Conduction of Heat in Solids2nd ed. (Oxford University, 1959).

Juratli, M. A.

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, J. Biophotonics 6, 523 (2013).
[Crossref]

Kalogiannakis, G.

G. Kalogiannakis, D. V. Hemelrijck, and C. Glorieux, NDT & E Int. 39, 236 (2006).
[Crossref]

Kawano, S.

S. Kawano, N. I. Smith, M. Yamanaka, S. Kawata, and K. Fujita, Appl. Phys. Express 4, 042401 (2011).
[Crossref]

K. Fujita, M. Kobayashi, S. Kawano, M. Yamanaka, and S. Kawata, Phys. Rev. Lett. 99, 228105 (2007).
[Crossref]

Kawata, S.

S. Kawano, N. I. Smith, M. Yamanaka, S. Kawata, and K. Fujita, Appl. Phys. Express 4, 042401 (2011).
[Crossref]

K. Fujita, M. Kobayashi, S. Kawano, M. Yamanaka, and S. Kawata, Phys. Rev. Lett. 99, 228105 (2007).
[Crossref]

Kitamori, T.

M. Tokeshi, M. Uchida, A. Hibara, T. Sawada, and T. Kitamori, Anal. Chem. 73, 2112 (2001).
[Crossref]

Kittler, H.

H. Kittler, H. Pehamberger, K. Wolff, and M. Binder, Lancet Oncol. 62, 751 (2010).

Kobayashi, M.

K. Fujita, M. Kobayashi, S. Kawano, M. Yamanaka, and S. Kawata, Phys. Rev. Lett. 99, 228105 (2007).
[Crossref]

Kolinsky, C.

A. H. Sahraoui, C. Kolinsky, S. Delenclos, A. Daoudi, and J. M. Buisine, J. Appl. Phys. 82, 6209 (1997).
[Crossref]

Lasne, D.

D. Lasne, G. A. Blab, F. D. Giorgi, F. Ichas, B. Lounis, and L. Cognet, Opt. Express 15, 14184 (2007).
[Crossref]

D. Lasne, G. A. Blab, S. Berciaud, M. Heine, L. Groc, D. Choquet, L. Cognet, and B. Lounis, Biophys. J. 91, 4598 (2006).
[Crossref]

Lepoutre, F.

L. J. Inglehart, A. Broniaotowski, D. Fournier, A. C. Boccara, and F. Lepoutre, Appl. Phys. Lett. 56, 1749 (1990).
[Crossref]

Lounis, B.

D. Lasne, G. A. Blab, F. D. Giorgi, F. Ichas, B. Lounis, and L. Cognet, Opt. Express 15, 14184 (2007).
[Crossref]

D. Lasne, G. A. Blab, S. Berciaud, M. Heine, L. Groc, D. Choquet, L. Cognet, and B. Lounis, Biophys. J. 91, 4598 (2006).
[Crossref]

S. Berciaud, L. Cognet, G. A. Blab, and B. Lounis, Phys. Rev. Lett. 93, 257402 (2004).
[Crossref]

Lrincz, A.

O. Dka, A. Mikls, and A. Lrincz, Appl. Phys. A 48, 415 (1989).
[Crossref]

Mandelis, A.

A. Salnick, J. Opsal, A. Rosencwaig, and A. Mandelis, Solid State Commun. 114, 133 (2000).
[Crossref]

A. Mandelis, A. Salnick, J. Opsal, and A. Rosencwaig, J. Appl. Phys. 85, 1811 (1999).
[Crossref]

V. Gusev, A. Mandelis, and R. Bleiss, Mat. Sci. Eng. B 26, 111 (1994).
[Crossref]

V. Gusev, A. Mandelis, and R. Bleiss, Int. J. Thermophys. 14, 321 (1993).
[Crossref]

V. Gusev, A. Mandelis, and R. Bleiss, Appl. Phys. A 57, 229 (1993).
[Crossref]

Marchesini, R.

G. Zonios, A. Dimou, M. Carrara, and R. Marchesini, Photochem. Photobiol. 86, 236 (2010).
[Crossref]

R. Marchesini, A. Bono, and M. Carrara, J. Biomed. Opt. 14, 014027 (2009).
[Crossref]

Matthews, T. E.

T. E. Matthews, I. R. Piletic, M. A. Selim, M. J. Simpson, and W. S. Warren, Sci. Transl. Med. 71, 71ra15 (2011).

Mehrmohammadi, M.

M. Mehrmohammadi, S. J. Yoon, D. Yeager, and S. Y. Emelianov, Curr. Mol. Imaging 2, 89 (2013).
[Crossref]

Mikls, A.

O. Dka, A. Mikls, and A. Lrincz, Appl. Phys. A 48, 415 (1989).
[Crossref]

Moore, C. L.

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, J. Biophotonics 6, 523 (2013).
[Crossref]

Nedosekin, D. A.

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, J. Biophotonics 6, 523 (2013).
[Crossref]

Opsal, J.

A. Salnick, J. Opsal, A. Rosencwaig, and A. Mandelis, Solid State Commun. 114, 133 (2000).
[Crossref]

A. Mandelis, A. Salnick, J. Opsal, and A. Rosencwaig, J. Appl. Phys. 85, 1811 (1999).
[Crossref]

Orrit, M.

A. Gaiduk, P. V. Ruijgrok, M. Yorulmaz, and M. Orrit, Chem. Sci. 1, 343 (2010).
[Crossref]

Park, B. H.

Pehamberger, H.

H. Kittler, H. Pehamberger, K. Wolff, and M. Binder, Lancet Oncol. 62, 751 (2010).

Pierce, M. C.

Piletic, I. R.

T. E. Matthews, I. R. Piletic, M. A. Selim, M. J. Simpson, and W. S. Warren, Sci. Transl. Med. 71, 71ra15 (2011).

Rajakarunanayake, Y. N.

Y. N. Rajakarunanayake and H. K. Wickramasinghe, Appl. Phys. Lett. 48, 218 (1986).
[Crossref]

Rosencwaig, A.

A. Salnick, J. Opsal, A. Rosencwaig, and A. Mandelis, Solid State Commun. 114, 133 (2000).
[Crossref]

A. Mandelis, A. Salnick, J. Opsal, and A. Rosencwaig, J. Appl. Phys. 85, 1811 (1999).
[Crossref]

Ruijgrok, P. V.

A. Gaiduk, P. V. Ruijgrok, M. Yorulmaz, and M. Orrit, Chem. Sci. 1, 343 (2010).
[Crossref]

Rusch, N. J.

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, J. Biophotonics 6, 523 (2013).
[Crossref]

Sahraoui, A. H.

A. H. Sahraoui, C. Kolinsky, S. Delenclos, A. Daoudi, and J. M. Buisine, J. Appl. Phys. 82, 6209 (1997).
[Crossref]

Salnick, A.

A. Salnick, J. Opsal, A. Rosencwaig, and A. Mandelis, Solid State Commun. 114, 133 (2000).
[Crossref]

A. Mandelis, A. Salnick, J. Opsal, and A. Rosencwaig, J. Appl. Phys. 85, 1811 (1999).
[Crossref]

Sarimollaoglu, M.

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, J. Biophotonics 6, 523 (2013).
[Crossref]

Sawada, T.

M. Tokeshi, M. Uchida, A. Hibara, T. Sawada, and T. Kitamori, Anal. Chem. 73, 2112 (2001).
[Crossref]

Selim, M. A.

T. E. Matthews, I. R. Piletic, M. A. Selim, M. J. Simpson, and W. S. Warren, Sci. Transl. Med. 71, 71ra15 (2011).

Shashkov, E. V.

E. I. Galanzha, E. V. Shashkov, P. M. Spring, J. Y. Suen, and V. P. Zharov, Cancer Res. 69, 7926 (2009).
[Crossref]

Shen, J.

Simpson, M. J.

T. E. Matthews, I. R. Piletic, M. A. Selim, M. J. Simpson, and W. S. Warren, Sci. Transl. Med. 71, 71ra15 (2011).

Smeltzer, M. S.

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, J. Biophotonics 6, 523 (2013).
[Crossref]

Smith, N. I.

S. Kawano, N. I. Smith, M. Yamanaka, S. Kawata, and K. Fujita, Appl. Phys. Express 4, 042401 (2011).
[Crossref]

Spicer, J. B.

G. C. Wetsel and J. B. Spicer, Can. J. Phys. 64, 1269 (1986).
[Crossref]

Spring, P. M.

E. I. Galanzha, E. V. Shashkov, P. M. Spring, J. Y. Suen, and V. P. Zharov, Cancer Res. 69, 7926 (2009).
[Crossref]

Suen, J. Y.

E. I. Galanzha, E. V. Shashkov, P. M. Spring, J. Y. Suen, and V. P. Zharov, Cancer Res. 69, 7926 (2009).
[Crossref]

Tearney, G. J.

Tokeshi, M.

M. Tokeshi, M. Uchida, A. Hibara, T. Sawada, and T. Kitamori, Anal. Chem. 73, 2112 (2001).
[Crossref]

Uchida, M.

M. Tokeshi, M. Uchida, A. Hibara, T. Sawada, and T. Kitamori, Anal. Chem. 73, 2112 (2001).
[Crossref]

Warren, W. S.

T. E. Matthews, I. R. Piletic, M. A. Selim, M. J. Simpson, and W. S. Warren, Sci. Transl. Med. 71, 71ra15 (2011).

Wetsel, G. C.

G. C. Wetsel and J. B. Spicer, Can. J. Phys. 64, 1269 (1986).
[Crossref]

Wickramasinghe, H. K.

Y. N. Rajakarunanayake and H. K. Wickramasinghe, Appl. Phys. Lett. 48, 218 (1986).
[Crossref]

Wolff, K.

H. Kittler, H. Pehamberger, K. Wolff, and M. Binder, Lancet Oncol. 62, 751 (2010).

Yamanaka, M.

S. Kawano, N. I. Smith, M. Yamanaka, S. Kawata, and K. Fujita, Appl. Phys. Express 4, 042401 (2011).
[Crossref]

K. Fujita, M. Kobayashi, S. Kawano, M. Yamanaka, and S. Kawata, Phys. Rev. Lett. 99, 228105 (2007).
[Crossref]

Yeager, D.

M. Mehrmohammadi, S. J. Yoon, D. Yeager, and S. Y. Emelianov, Curr. Mol. Imaging 2, 89 (2013).
[Crossref]

Yoon, S. J.

M. Mehrmohammadi, S. J. Yoon, D. Yeager, and S. Y. Emelianov, Curr. Mol. Imaging 2, 89 (2013).
[Crossref]

Yorulmaz, M.

A. Gaiduk, P. V. Ruijgrok, M. Yorulmaz, and M. Orrit, Chem. Sci. 1, 343 (2010).
[Crossref]

Zhao, J.

Zharov, V. P.

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, J. Biophotonics 6, 523 (2013).
[Crossref]

V. P. Zharov, Nat. Photonics 5, 110 (2011).
[Crossref]

E. I. Galanzha, E. V. Shashkov, P. M. Spring, J. Y. Suen, and V. P. Zharov, Cancer Res. 69, 7926 (2009).
[Crossref]

Zonios, G.

G. Zonios, A. Dimou, M. Carrara, and R. Marchesini, Photochem. Photobiol. 86, 236 (2010).
[Crossref]

Anal. Chem. (1)

M. Tokeshi, M. Uchida, A. Hibara, T. Sawada, and T. Kitamori, Anal. Chem. 73, 2112 (2001).
[Crossref]

Appl. Phys. A (2)

V. Gusev, A. Mandelis, and R. Bleiss, Appl. Phys. A 57, 229 (1993).
[Crossref]

O. Dka, A. Mikls, and A. Lrincz, Appl. Phys. A 48, 415 (1989).
[Crossref]

Appl. Phys. Express (1)

S. Kawano, N. I. Smith, M. Yamanaka, S. Kawata, and K. Fujita, Appl. Phys. Express 4, 042401 (2011).
[Crossref]

Appl. Phys. Lett. (2)

L. J. Inglehart, A. Broniaotowski, D. Fournier, A. C. Boccara, and F. Lepoutre, Appl. Phys. Lett. 56, 1749 (1990).
[Crossref]

Y. N. Rajakarunanayake and H. K. Wickramasinghe, Appl. Phys. Lett. 48, 218 (1986).
[Crossref]

Biophys. J. (1)

D. Lasne, G. A. Blab, S. Berciaud, M. Heine, L. Groc, D. Choquet, L. Cognet, and B. Lounis, Biophys. J. 91, 4598 (2006).
[Crossref]

Can. J. Phys. (1)

G. C. Wetsel and J. B. Spicer, Can. J. Phys. 64, 1269 (1986).
[Crossref]

Cancer Res. (1)

E. I. Galanzha, E. V. Shashkov, P. M. Spring, J. Y. Suen, and V. P. Zharov, Cancer Res. 69, 7926 (2009).
[Crossref]

Chem. Sci. (1)

A. Gaiduk, P. V. Ruijgrok, M. Yorulmaz, and M. Orrit, Chem. Sci. 1, 343 (2010).
[Crossref]

Curr. Mol. Imaging (1)

M. Mehrmohammadi, S. J. Yoon, D. Yeager, and S. Y. Emelianov, Curr. Mol. Imaging 2, 89 (2013).
[Crossref]

Int. J. Thermophys. (1)

V. Gusev, A. Mandelis, and R. Bleiss, Int. J. Thermophys. 14, 321 (1993).
[Crossref]

J. Appl. Phys. (2)

A. Mandelis, A. Salnick, J. Opsal, and A. Rosencwaig, J. Appl. Phys. 85, 1811 (1999).
[Crossref]

A. H. Sahraoui, C. Kolinsky, S. Delenclos, A. Daoudi, and J. M. Buisine, J. Appl. Phys. 82, 6209 (1997).
[Crossref]

J. Biomed. Opt. (1)

R. Marchesini, A. Bono, and M. Carrara, J. Biomed. Opt. 14, 014027 (2009).
[Crossref]

J. Biophotonics (1)

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, J. Biophotonics 6, 523 (2013).
[Crossref]

Lancet Oncol. (1)

H. Kittler, H. Pehamberger, K. Wolff, and M. Binder, Lancet Oncol. 62, 751 (2010).

Mat. Sci. Eng. B (1)

V. Gusev, A. Mandelis, and R. Bleiss, Mat. Sci. Eng. B 26, 111 (1994).
[Crossref]

Nat. Photonics (1)

V. P. Zharov, Nat. Photonics 5, 110 (2011).
[Crossref]

NDT & E Int. (1)

G. Kalogiannakis, D. V. Hemelrijck, and C. Glorieux, NDT & E Int. 39, 236 (2006).
[Crossref]

Opt. Express (1)

Opt. Lett. (2)

Photochem. Photobiol. (1)

G. Zonios, A. Dimou, M. Carrara, and R. Marchesini, Photochem. Photobiol. 86, 236 (2010).
[Crossref]

Phys. Rev. Lett. (2)

S. Berciaud, L. Cognet, G. A. Blab, and B. Lounis, Phys. Rev. Lett. 93, 257402 (2004).
[Crossref]

K. Fujita, M. Kobayashi, S. Kawano, M. Yamanaka, and S. Kawata, Phys. Rev. Lett. 99, 228105 (2007).
[Crossref]

Sci. Transl. Med. (1)

T. E. Matthews, I. R. Piletic, M. A. Selim, M. J. Simpson, and W. S. Warren, Sci. Transl. Med. 71, 71ra15 (2011).

Solid State Commun. (1)

A. Salnick, J. Opsal, A. Rosencwaig, and A. Mandelis, Solid State Commun. 114, 133 (2000).
[Crossref]

Other (1)

H. S. Carslaw and J. C. Jaeger, Conduction of Heat in Solids2nd ed. (Oxford University, 1959).

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (3)

Fig. 1.
Fig. 1. (a) Schematic diagram of the experimental setup. EOM, electro-optic modulator; DM, short-wavelength transmitting dichroic mirror with a switching wavelength of 560 nm; BS, beamsplitter; MMF, multi-mode fiber; Filter, bandpass filter with a central wavelength of 632 nm and a bandwidth of 10 nm; BD, auto-balanced detector with a bandwidth of 125 kHz; LIA1,2, lock-in amplifiers. (b) Temporal intensity modulation behavior of the pump and probe pulse trains before and after interacting with the sample. The intensity of the pump pulse is modulated at f with the EOM and the output probe pulse is modulated at both f and f with a modulation depth of ΔIf and ΔI2f, respectively, because of the generation of the second-harmonic of the thermal wave. The LPT and NLPT signals are demodulated from the output probe beam with two LIAs referring to f and 2f, respectively.
Fig. 2.
Fig. 2. (a) Dependence of the LPT and NLPT signals on the modulation frequency of the EOM. Responses of the LPT and NLPT signals to (b) the probe power and (c) the pump power. The pump power is 1 mW in (b) and the probe power is set to 0.5 mW in (c). In (d), the x and y axes are the logarithm to the base 10 of pump power and NLPT signal, respectively. The slopes of the red, green, and blue parts of the fitting curve are 1.00, 1.52, and 1.75, respectively.
Fig. 3.
Fig. 3. (a) LPT and (b) NLPT imaging of mouse melanoma with the range of 10μm×10μm and whole pixels of 300×300. The powers of the pump and probe pulses are 0.62 and 0.45 mW, respectively. The line profiles in (c) indicated by the red line in (a) and (b) show that the spatial resolution for the LPT and NLPT imaging are 212 and 174 nm, respectively. The NLPT signal is about 100 times smaller than the LPT signal.

Equations (8)

Equations on this page are rendered with MathJax. Learn more.

CTt·(kT)=Q(r,t),
C(T)C(T0)+[CT|T0]T1C0(1+δ1T1),
k(T)k(T0)+[kT|T0]T1k0(1+δ2T1),
(21D0t)T1=1k0Q(r,t)12(δ22δ1D0t)T12,
Tf(z,t)=Af(z)cos(ft+ϕf),
T2f(z,t)=A2f(z)cos(2ft+ϕ2f),
Δn=TfnT1+T2fnT1=ΔnL+ΔnNL,
SIpump2·Iprobe.

Metrics