Abstract

We demonstrate polyethylene-glycol-coated single-walled carbon nanotubes (CNTs) as contrast agents for both photothermal optical coherence tomography (OCT) and magnetic-resonance imaging (MRI). Photothermal OCT was accomplished with a spectral domain OCT system with an amplitude-modulated 750 nm pump beam using 10 mW of power, and $T_2$ MRI was achieved with a 4.7 T animal system. Photothermal OCT and $T_2$ MRI achieved sensitivities of nanomolar concentrations to CNTs dispersed in amine-terminated polyethylene glycol, thus establishing the potential for dual-modality molecular imaging with CNTs.

©2012 Optical Society of America

In vivo photothermal optical coherence tomography of gold nanorod contrast agents

J. M. Tucker-Schwartz, T. A. Meyer, C. A. Patil, C. L. Duvall, and M. C. Skala
Biomed. Opt. Express 3(11) 2881-2895 (2012)

Optical detection of indocyanine green encapsulated biocompatible poly (lactic-co-glycolic) acid nanoparticles with photothermal optical coherence tomography

Hrebesh M. Subhash, Hui Xie, Jeffrey W. Smith, and Owen J. T. McCarty
Opt. Lett. 37(5) 981-983 (2012)

Photothermal optical lock-in optical coherence tomography for in vivo imaging

Jason M. Tucker-Schwartz, Maryse Lapierre-Landry, Chetan A. Patil, and Melissa C. Skala
Biomed. Opt. Express 6(6) 2268-2282 (2015)

Optical coherence tomography with plasmon resonant nanorods of gold

Timothy S. Troutman, Jennifer K. Barton, and Marek Romanowski
Opt. Lett. 32(11) 1438-1440 (2007)

Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells

Chao Zhou, Tsung-Han Tsai, Desmond C. Adler, Hsiang-Chieh Lee, David W. Cohen, Amy Mondelblatt, Yihong Wang, James L. Connolly, and James G. Fujimoto
Opt. Lett. 35(5) 700-702 (2010)