Abstract

A near-IR (NIR) tomography system with spectral-encoded sources was built to quantify the temporal contrast in human breast tissue using guidance from magnetic resonance imaging. The systems were integrated with a custom breast coil interface to provide simultaneous acquisition. The NIR signal was synchronized to simultaneous finger pulse oximeter plethysmogram, which offered a frequency reference. A $\mathrm{0.1}\mathrm{s}$ temporal delay of the absorption pulse within adipose tissue relative to fibroglandular tissue was found, in an initial human study, showing the potential for novel contrast imaging of fast flow signals in deep tissue.

© 2010 Optical Society of America

Measurement of pressure-displacement kinetics of hemoglobin in normal breast tissue with near-infrared spectral imaging

Shudong Jiang, Brian W. Pogue, Ashley M. Laughney, Christine A. Kogel, and Keith D. Paulsen
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Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size

Colin M. Carpenter, Brian W. Pogue, Shudong Jiang, Hamid Dehghani, Xin Wang, Keith D. Paulsen, Wendy A. Wells, Jorge Forero, Christine Kogel, John B. Weaver, Steven P. Poplack, and Peter A. Kaufman
Opt. Lett. 32(8) 933-935 (2007)

Characterizing accuracy of total hemoglobin recovery using contrast-detail analysis in 3D image-guided near infrared spectroscopy with the boundary element method

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Opt. Express 18(15) 15917-15935 (2010)

Video-rate near infrared tomography to image pulsatile absorption properties in thick tissue

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Opt. Express 17(14) 12043-12056 (2009)

Near-infrared tomography of breast cancer hemoglobin, water, lipid, and scattering using combined frequency domain and cw measurement

Jia Wang, Brian W. Pogue, Shudong Jiang, and Keith D. Paulsen
Opt. Lett. 35(1) 82-84 (2010)