Abstract

An integrated endoscopy system for simultaneous imaging and spectroscopy was developed to facilitate more accurate and convenient detection of early lung cancers. A specially designed three-CCD camera in combination with a dedicated light source permits capture of both white-light color images and tissue autofluorescence images without the need to switch between two different cameras. A mirror with an optical fiber at its center, placed at an interim imaging plane inside the camera unit, facilitates simultaneous imaging and spectroscopy measurements in either white-light reflectance mode or fluorescence mode. The system has been successfully tested in a clinic, demonstrating a practical approach to improve both diagnostic sensitivity and specificity at the same time.

© 2004 Optical Society of America

Full Article  |  PDF Article
More Like This
Quantitative spectroscopic imaging for noninvasive early cancer detection

Chung-Chieh Yu, Condon Lau, Geoff O’Donoghue, Jelena Mirkovic, Sasha McGee, Luis Galindo, Alphi Elackattu, Elizabeth Stier, Gregory Grillone, Kamran Badizadegan, Ramachandra R. Dasari, and Michael S. Feld
Opt. Express 16(20) 16227-16239 (2008)

Fluorescence polarization imaging for delineating nonmelanoma skin cancers

A. N. Yaroslavsky, V. Neel, and R. R. Anderson
Opt. Lett. 29(17) 2010-2012 (2004)

Integrated Raman spectroscopy and trimodal wide-field imaging techniques for real-time in vivo tissue Raman measurements at endoscopy

Zhiwei Huang, Seng Khoon Teh, Wei Zheng, Jianhua Mo, Kan Lin, Xiaozhuo Shao, Khek Yu Ho, Ming Teh, and Khay Guan Yeoh
Opt. Lett. 34(6) 758-760 (2009)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (4)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Metrics