Abstract

We present three-dimensional tomographic images of the absorption coefficient that is due to the presence of a fluorophore reconstructed from frequency domain fluence measurements of a tissue phantom containing a single, fluorescence contrast-enhanced inclusion. We show that such a reconstruction may be improved when the importance of measurement error correlations between relative phase shift and amplitude is assessed and when measurements are preprocessed to reduce the magnitude and the bias of system error.

© 2001 Optical Society of America

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