Abstract

All-fiber optical parametric oscillator (OPO), offering advantages like robustness, compactness and low lost, has attracted intense interest in coherent anti-Stokes Raman scattering spectroscopy. In typical fiber-based OPO configurations, detrimental nonlinear effects due to intense pump field in fiber coupling devices would inevitably degrade the spectral purity and conversion efficiency, especially when the OPO operated at low repetition rates. Here we demonstrated a new OPO design by placing the main amplifier inside the cavity, where the amplified pump pulses were directly coupled into the nonlinear fiber. Consequently, lower threshold, higher output power and narrower spectrum were obtained. In particular, effective suppression of spectral noise was experimentally observed, resulting in threshold reductions of 37.5%, 17.2%, and 5.2% with a comparison to a conventional OPO operating at repetition rates of 1, 2 and 3 MHz, respectively. Furthermore, the generated synchronized two-color laser sources at a low repetition rate were then employed to detect CH vibrational bands in an ethanol sample. This spectral tailored cavity design is expected to greatly promote the spread of compact all-fiber laser source to nonlinear biomedical imaging.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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2018 (3)

2017 (3)

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-Free Molecular Imaging of Biological Cells and Tissues by Linear and Nonlinear Raman Spectroscopic Approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

T. Gottschall, T. Meyer, C. Jauregui, F. Just, T. Eidam, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “All-fiber optical parametric oscillator for bio-medical imaging applications,” Proc. SPIE 10083, 100831E (2017).

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In Vivo and in Situ Spectroscopic Imaging by a Handheld Stimulated Raman Scattering Microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

2016 (5)

2015 (4)

2014 (4)

R. Xie, J. Su, E. C. Rentchler, Z. Zhang, C. K. Johnson, H. Shi, and R. Hui, “Multi-modal label-free imaging based on a femtosecond fiber laser,” Biomed. Opt. Express 5(7), 2390–2396 (2014).
[Crossref] [PubMed]

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

T. Gottschall, T. Meyer, M. Baumgartl, B. Dietzek, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based optical parametric oscillator for high resolution coherent anti-Stokes Raman scattering (CARS) microscopy,” Opt. Express 22(18), 21921–21928 (2014).
[Crossref] [PubMed]

2013 (2)

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

E. S. Lamb, S. Lefrancois, M. Ji, W. J. Wadsworth, X. S. Xie, and F. W. Wise, “Fiber optical parametric oscillator for coherent anti-Stokes Raman scattering microscopy,” Opt. Lett. 38(20), 4154–4157 (2013).
[Crossref] [PubMed]

2012 (2)

2011 (5)

2006 (1)

1999 (1)

A. Zumbusch, G. R. Holtom, and X. S. Xie, “Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering,” Phys. Rev. Lett. 82(20), 4142–4145 (1999).
[Crossref]

Allen, J.

Andrés, M. V.

Apkarian, V. A.

Baldacchini, T.

Bardet, S. M.

Baumgartl, M.

Bégin, S.

Bentley, R. T.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In Vivo and in Situ Spectroscopic Imaging by a Handheld Stimulated Raman Scattering Microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Bernhardt, B.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Black, P. N.

Bocklitz, T.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-Free Molecular Imaging of Biological Cells and Tissues by Linear and Nonlinear Raman Spectroscopic Approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

Brinkmann, M.

Burgoyne, B.

Camp, C. H.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Capitaine, E.

Chemnitz, M.

Chen, K.

Chen, S.

Y. H. Zhai, C. Goulart, J. E. Sharping, H. Wei, S. Chen, W. Tong, M. N. Slipchenko, D. Zhang, and J. X. Cheng, “Multimodal coherent anti-Stokes Raman spectroscopic imaging with a fiber optical parametric oscillator,” Appl. Phys. Lett. 98(19), 191106 (2011).
[Crossref] [PubMed]

Chen, X.

Cheng, J.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In Vivo and in Situ Spectroscopic Imaging by a Handheld Stimulated Raman Scattering Microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Cheng, J. X.

C. S. Liao and J. X. Cheng, “In Situ and In Vivo Molecular Analysis by Coherent Raman Scattering Microscopy,” Annu. Rev. Anal. Chem. (Palo Alto, Calif.) 9(1), 69–93 (2016).
[Crossref] [PubMed]

Y. Zhang, C. S. Liao, W. Hong, K. C. Huang, H. Yang, G. Jin, and J. X. Cheng, “Coherent anti-Stokes Raman scattering imaging under ambient light,” Opt. Lett. 41(16), 3880–3883 (2016).
[Crossref] [PubMed]

Y. H. Zhai, C. Goulart, J. E. Sharping, H. Wei, S. Chen, W. Tong, M. N. Slipchenko, D. Zhang, and J. X. Cheng, “Multimodal coherent anti-Stokes Raman spectroscopic imaging with a fiber optical parametric oscillator,” Appl. Phys. Lett. 98(19), 191106 (2011).
[Crossref] [PubMed]

Y. Fu, H. Wang, R. Shi, and J. X. Cheng, “Characterization of photodamage in coherent anti-Stokes Raman scattering microscopy,” Opt. Express 14(9), 3942–3951 (2006).
[Crossref] [PubMed]

Cialla-May, D.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-Free Molecular Imaging of Biological Cells and Tissues by Linear and Nonlinear Raman Spectroscopic Approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

Cicerone, M. T.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Côté, D.

Couderc, V.

Crampton, K. T.

Dietzek, B.

Díez, A.

Dobner, S.

Duponchel, L.

Eakins, G.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In Vivo and in Situ Spectroscopic Imaging by a Handheld Stimulated Raman Scattering Microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Eidam, T.

T. Gottschall, T. Meyer, C. Jauregui, F. Just, T. Eidam, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “All-fiber optical parametric oscillator for bio-medical imaging applications,” Proc. SPIE 10083, 100831E (2017).

Fallnich, C.

Freudiger, C. W.

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

Fu, Y.

Gao, L.

Gottschall, T.

T. Gottschall, T. Meyer, C. Jauregui, F. Just, T. Eidam, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “All-fiber optical parametric oscillator for bio-medical imaging applications,” Proc. SPIE 10083, 100831E (2017).

T. Gottschall, T. Meyer, M. Baumgartl, B. Dietzek, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based optical parametric oscillator for high resolution coherent anti-Stokes Raman scattering (CARS) microscopy,” Opt. Express 22(18), 21921–21928 (2014).
[Crossref] [PubMed]

Goulart, C.

Y. H. Zhai, C. Goulart, J. E. Sharping, H. Wei, S. Chen, W. Tong, M. N. Slipchenko, D. Zhang, and J. X. Cheng, “Multimodal coherent anti-Stokes Raman spectroscopic imaging with a fiber optical parametric oscillator,” Appl. Phys. Lett. 98(19), 191106 (2011).
[Crossref] [PubMed]

Guelachvili, G.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Guo, Z.

K. Yang, J. Jiang, Z. Guo, Q. Hao, and H. Zeng, “Tunable Femtosecond Laser From 965 to 1025 nm in Fiber Optical Parametric Oscillator,” IEEE Photonics Technol. Lett. 30(7), 607–610 (2018).
[Crossref]

Hänsch, T. W.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Hao, Q.

K. Yang, J. Jiang, Z. Guo, Q. Hao, and H. Zeng, “Tunable Femtosecond Laser From 965 to 1025 nm in Fiber Optical Parametric Oscillator,” IEEE Photonics Technol. Lett. 30(7), 607–610 (2018).
[Crossref]

K. Yang, P. Ye, S. Zheng, J. Jiang, K. Huang, Q. Hao, and H. Zeng, “Polarization switch of four-wave mixing in a lawtunable fiber optical parametric oscillator,” Opt. Express 26(3), 2995–3003 (2018).
[Crossref] [PubMed]

Hartshorn, C. M.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

He, X. N.

Heddleston, J. M.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Hellwig, T.

Hight Walker, A. R.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Holtom, G. R.

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

A. Zumbusch, G. R. Holtom, and X. S. Xie, “Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering,” Phys. Rev. Lett. 82(20), 4142–4145 (1999).
[Crossref]

Holzner, S.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Hong, W.

Huang, C. Y.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In Vivo and in Situ Spectroscopic Imaging by a Handheld Stimulated Raman Scattering Microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Huang, H.

Huang, K.

Huang, K. C.

Huang, X.

Hui, R.

Ideguchi, T.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Janfrüchte, S.

Jauregui, C.

T. Gottschall, T. Meyer, C. Jauregui, F. Just, T. Eidam, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “All-fiber optical parametric oscillator for bio-medical imaging applications,” Proc. SPIE 10083, 100831E (2017).

M. Baumgartl, M. Chemnitz, C. Jauregui, T. Meyer, B. Dietzek, J. Popp, J. Limpert, and A. Tünnermann, “All-fiber laser source for CARS microscopy based on fiber optical parametric frequency conversion,” Opt. Express 20(4), 4484–4493 (2012).
[Crossref] [PubMed]

Ji, M.

Jiang, J.

K. Yang, J. Jiang, Z. Guo, Q. Hao, and H. Zeng, “Tunable Femtosecond Laser From 965 to 1025 nm in Fiber Optical Parametric Oscillator,” IEEE Photonics Technol. Lett. 30(7), 607–610 (2018).
[Crossref]

K. Yang, P. Ye, S. Zheng, J. Jiang, K. Huang, Q. Hao, and H. Zeng, “Polarization switch of four-wave mixing in a lawtunable fiber optical parametric oscillator,” Opt. Express 26(3), 2995–3003 (2018).
[Crossref] [PubMed]

Jiang, L.

Jin, G.

Johnson, C. K.

Just, F.

T. Gottschall, T. Meyer, C. Jauregui, F. Just, T. Eidam, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “All-fiber optical parametric oscillator for bio-medical imaging applications,” Proc. SPIE 10083, 100831E (2017).

Kano, H.

Kieu, K. Q.

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

Krafft, C.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-Free Molecular Imaging of Biological Cells and Tissues by Linear and Nonlinear Raman Spectroscopic Approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

Lamb, E. S.

Lathia, J. D.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Lee, Y. J.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Lefrancois, S.

Leproux, P.

Lévêque, P.

Li, F.

Li, Y.

Liang, R.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In Vivo and in Situ Spectroscopic Imaging by a Handheld Stimulated Raman Scattering Microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Liao, C.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In Vivo and in Situ Spectroscopic Imaging by a Handheld Stimulated Raman Scattering Microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Liao, C. S.

C. S. Liao and J. X. Cheng, “In Situ and In Vivo Molecular Analysis by Coherent Raman Scattering Microscopy,” Annu. Rev. Anal. Chem. (Palo Alto, Calif.) 9(1), 69–93 (2016).
[Crossref] [PubMed]

Y. Zhang, C. S. Liao, W. Hong, K. C. Huang, H. Yang, G. Jin, and J. X. Cheng, “Coherent anti-Stokes Raman scattering imaging under ambient light,” Opt. Lett. 41(16), 3880–3883 (2016).
[Crossref] [PubMed]

Limpert, J.

Lin, P.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In Vivo and in Situ Spectroscopic Imaging by a Handheld Stimulated Raman Scattering Microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Louot, C.

Lu, Y. F.

Luo, P.

Matthäus, C.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-Free Molecular Imaging of Biological Cells and Tissues by Linear and Nonlinear Raman Spectroscopic Approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

McCormick, D. T.

Mercier, V.

Meyer, T.

Mikami, H.

Moussa, N. O.

Palapattu, G. S.

Peyghambarian, N.

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

Picqué, N.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Popp, J.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-Free Molecular Imaging of Biological Cells and Tissues by Linear and Nonlinear Raman Spectroscopic Approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

T. Gottschall, T. Meyer, C. Jauregui, F. Just, T. Eidam, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “All-fiber optical parametric oscillator for bio-medical imaging applications,” Proc. SPIE 10083, 100831E (2017).

T. Gottschall, T. Meyer, M. Baumgartl, B. Dietzek, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based optical parametric oscillator for high resolution coherent anti-Stokes Raman scattering (CARS) microscopy,” Opt. Express 22(18), 21921–21928 (2014).
[Crossref] [PubMed]

M. Baumgartl, M. Chemnitz, C. Jauregui, T. Meyer, B. Dietzek, J. Popp, J. Limpert, and A. Tünnermann, “All-fiber laser source for CARS microscopy based on fiber optical parametric frequency conversion,” Opt. Express 20(4), 4484–4493 (2012).
[Crossref] [PubMed]

Rentchler, E. C.

Rich, J. N.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Schie, I. W.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-Free Molecular Imaging of Biological Cells and Tissues by Linear and Nonlinear Raman Spectroscopic Approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

Schmitt, M.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-Free Molecular Imaging of Biological Cells and Tissues by Linear and Nonlinear Raman Spectroscopic Approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

T. Gottschall, T. Meyer, C. Jauregui, F. Just, T. Eidam, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “All-fiber optical parametric oscillator for bio-medical imaging applications,” Proc. SPIE 10083, 100831E (2017).

Sharping, J. E.

Y. H. Zhai, C. Goulart, J. E. Sharping, H. Wei, S. Chen, W. Tong, M. N. Slipchenko, D. Zhang, and J. X. Cheng, “Multimodal coherent anti-Stokes Raman spectroscopic imaging with a fiber optical parametric oscillator,” Appl. Phys. Lett. 98(19), 191106 (2011).
[Crossref] [PubMed]

Shen, S. S.

Shi, H.

Shi, R.

Shiozawa, M.

Shirai, M.

Silvestre, E.

Slipchenko, M. N.

Y. H. Zhai, C. Goulart, J. E. Sharping, H. Wei, S. Chen, W. Tong, M. N. Slipchenko, D. Zhang, and J. X. Cheng, “Multimodal coherent anti-Stokes Raman spectroscopic imaging with a fiber optical parametric oscillator,” Appl. Phys. Lett. 98(19), 191106 (2011).
[Crossref] [PubMed]

Su, J.

Thrall, M. J.

Tong, W.

Y. H. Zhai, C. Goulart, J. E. Sharping, H. Wei, S. Chen, W. Tong, M. N. Slipchenko, D. Zhang, and J. X. Cheng, “Multimodal coherent anti-Stokes Raman spectroscopic imaging with a fiber optical parametric oscillator,” Appl. Phys. Lett. 98(19), 191106 (2011).
[Crossref] [PubMed]

Tünnermann, A.

Vallée, R.

Velázquez-Ibarra, L.

Villeneuve, A.

Wadsworth, W. J.

Wang, H.

Wang, K.

Wang, P.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In Vivo and in Situ Spectroscopic Imaging by a Handheld Stimulated Raman Scattering Microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Wang, Z.

Watanabe, K.

Wei, H.

K. Chen, T. Wu, H. Wei, T. Zhou, and Y. Li, “Quantitative chemical imaging with background-free multiplex coherent anti-Stokes Raman scattering by dual-soliton Stokes pulses,” Biomed. Opt. Express 7(10), 3927–3939 (2016).
[Crossref] [PubMed]

Y. H. Zhai, C. Goulart, J. E. Sharping, H. Wei, S. Chen, W. Tong, M. N. Slipchenko, D. Zhang, and J. X. Cheng, “Multimodal coherent anti-Stokes Raman spectroscopic imaging with a fiber optical parametric oscillator,” Appl. Phys. Lett. 98(19), 191106 (2011).
[Crossref] [PubMed]

Wise, F. W.

Wong, K.

Wong, K. K.

Wong, S. T.

Wong, S. T. C.

Wu, T.

Xie, R.

Xie, X. S.

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

E. S. Lamb, S. Lefrancois, M. Ji, W. J. Wadsworth, X. S. Xie, and F. W. Wise, “Fiber optical parametric oscillator for coherent anti-Stokes Raman scattering microscopy,” Opt. Lett. 38(20), 4154–4157 (2013).
[Crossref] [PubMed]

A. Zumbusch, G. R. Holtom, and X. S. Xie, “Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering,” Phys. Rev. Lett. 82(20), 4142–4145 (1999).
[Crossref]

Xu, C.

Xu, X.

Yang, H.

Yang, K.

K. Yang, P. Ye, S. Zheng, J. Jiang, K. Huang, Q. Hao, and H. Zeng, “Polarization switch of four-wave mixing in a lawtunable fiber optical parametric oscillator,” Opt. Express 26(3), 2995–3003 (2018).
[Crossref] [PubMed]

K. Yang, J. Jiang, Z. Guo, Q. Hao, and H. Zeng, “Tunable Femtosecond Laser From 965 to 1025 nm in Fiber Optical Parametric Oscillator,” IEEE Photonics Technol. Lett. 30(7), 607–610 (2018).
[Crossref]

Yang, W.

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

Yang, Y.

Ye, P.

Zadoyan, R.

Zeng, H.

K. Yang, J. Jiang, Z. Guo, Q. Hao, and H. Zeng, “Tunable Femtosecond Laser From 965 to 1025 nm in Fiber Optical Parametric Oscillator,” IEEE Photonics Technol. Lett. 30(7), 607–610 (2018).
[Crossref]

K. Yang, P. Ye, S. Zheng, J. Jiang, K. Huang, Q. Hao, and H. Zeng, “Polarization switch of four-wave mixing in a lawtunable fiber optical parametric oscillator,” Opt. Express 26(3), 2995–3003 (2018).
[Crossref] [PubMed]

Zeytunyan, A.

Zhai, Y. H.

Y. H. Zhai, C. Goulart, J. E. Sharping, H. Wei, S. Chen, W. Tong, M. N. Slipchenko, D. Zhang, and J. X. Cheng, “Multimodal coherent anti-Stokes Raman spectroscopic imaging with a fiber optical parametric oscillator,” Appl. Phys. Lett. 98(19), 191106 (2011).
[Crossref] [PubMed]

Zhang, D.

Y. H. Zhai, C. Goulart, J. E. Sharping, H. Wei, S. Chen, W. Tong, M. N. Slipchenko, D. Zhang, and J. X. Cheng, “Multimodal coherent anti-Stokes Raman spectroscopic imaging with a fiber optical parametric oscillator,” Appl. Phys. Lett. 98(19), 191106 (2011).
[Crossref] [PubMed]

Zhang, Y.

Zhang, Z.

Zheng, S.

Zhou, H.

Zhou, T.

Zumbusch, A.

A. Zumbusch, G. R. Holtom, and X. S. Xie, “Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering,” Phys. Rev. Lett. 82(20), 4142–4145 (1999).
[Crossref]

ACS Photonics (1)

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In Vivo and in Situ Spectroscopic Imaging by a Handheld Stimulated Raman Scattering Microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Angew. Chem. Int. Ed. Engl. (1)

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-Free Molecular Imaging of Biological Cells and Tissues by Linear and Nonlinear Raman Spectroscopic Approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

Annu. Rev. Anal. Chem. (Palo Alto, Calif.) (1)

C. S. Liao and J. X. Cheng, “In Situ and In Vivo Molecular Analysis by Coherent Raman Scattering Microscopy,” Annu. Rev. Anal. Chem. (Palo Alto, Calif.) 9(1), 69–93 (2016).
[Crossref] [PubMed]

Appl. Phys. Lett. (1)

Y. H. Zhai, C. Goulart, J. E. Sharping, H. Wei, S. Chen, W. Tong, M. N. Slipchenko, D. Zhang, and J. X. Cheng, “Multimodal coherent anti-Stokes Raman spectroscopic imaging with a fiber optical parametric oscillator,” Appl. Phys. Lett. 98(19), 191106 (2011).
[Crossref] [PubMed]

Biomed. Opt. Express (9)

R. Xie, J. Su, E. C. Rentchler, Z. Zhang, C. K. Johnson, H. Shi, and R. Hui, “Multi-modal label-free imaging based on a femtosecond fiber laser,” Biomed. Opt. Express 5(7), 2390–2396 (2014).
[Crossref] [PubMed]

E. Capitaine, N. O. Moussa, C. Louot, S. M. Bardet, H. Kano, L. Duponchel, P. Lévêque, V. Couderc, and P. Leproux, “Fast epi-detected broadband multiplex CARS and SHG imaging of mouse skull cells,” Biomed. Opt. Express 9(1), 245–253 (2018).
[Crossref] [PubMed]

E. S. Lamb and F. W. Wise, “Multimodal fiber source for nonlinear microscopy based on a dissipative soliton laser,” Biomed. Opt. Express 6(9), 3248–3255 (2015).
[Crossref] [PubMed]

S. Bégin, B. Burgoyne, V. Mercier, A. Villeneuve, R. Vallée, and D. Côté, “Coherent anti-Stokes Raman scattering hyperspectral tissue imaging with a wavelength-swept system,” Biomed. Opt. Express 2(5), 1296–1306 (2011).
[Crossref] [PubMed]

X. Chen, X. Xu, D. T. McCormick, K. Wong, and S. T. C. Wong, “Multimodal nonlinear endo-microscopy probe design for high resolution, label-free intraoperative imaging,” Biomed. Opt. Express 6(7), 2283–2293 (2015).
[Crossref] [PubMed]

K. Chen, T. Wu, H. Wei, T. Zhou, and Y. Li, “Quantitative chemical imaging with background-free multiplex coherent anti-Stokes Raman scattering by dual-soliton Stokes pulses,” Biomed. Opt. Express 7(10), 3927–3939 (2016).
[Crossref] [PubMed]

Y. Yang, F. Li, L. Gao, Z. Wang, M. J. Thrall, S. S. Shen, K. K. Wong, and S. T. Wong, “Differential diagnosis of breast cancer using quantitative, label-free and molecular vibrational imaging,” Biomed. Opt. Express 2(8), 2160–2174 (2011).
[Crossref] [PubMed]

L. Gao, H. Zhou, M. J. Thrall, F. Li, Y. Yang, Z. Wang, P. Luo, K. K. Wong, G. S. Palapattu, and S. T. Wong, “Label-free high-resolution imaging of prostate glands and cavernous nerves using coherent anti-Stokes Raman scattering microscopy,” Biomed. Opt. Express 2(4), 915–926 (2011).
[Crossref] [PubMed]

X. N. He, J. Allen, P. N. Black, T. Baldacchini, X. Huang, H. Huang, L. Jiang, and Y. F. Lu, “Coherent anti-Stokes Raman scattering and spontaneous Raman spectroscopy and microscopy of microalgae with nitrogen depletion,” Biomed. Opt. Express 3(11), 2896–2906 (2012).
[Crossref] [PubMed]

IEEE Photonics Technol. Lett. (1)

K. Yang, J. Jiang, Z. Guo, Q. Hao, and H. Zeng, “Tunable Femtosecond Laser From 965 to 1025 nm in Fiber Optical Parametric Oscillator,” IEEE Photonics Technol. Lett. 30(7), 607–610 (2018).
[Crossref]

Nat. Photonics (2)

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

Nature (1)

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Opt. Express (6)

Opt. Lett. (5)

Phys. Rev. Lett. (1)

A. Zumbusch, G. R. Holtom, and X. S. Xie, “Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering,” Phys. Rev. Lett. 82(20), 4142–4145 (1999).
[Crossref]

Proc. SPIE (1)

T. Gottschall, T. Meyer, C. Jauregui, F. Just, T. Eidam, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “All-fiber optical parametric oscillator for bio-medical imaging applications,” Proc. SPIE 10083, 100831E (2017).

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Figures (6)

Fig. 1
Fig. 1 (a)-(d) Simulated (black line) and measured (red line) spectra of output pulses after the different lengths of transmission fiber; (e)-(h) Simulated (black line) and measured (red line) spectra of output pulses after the parametric conversion process.
Fig. 2
Fig. 2 Experimental setup of fiber OPO (left). LD: laser diode; ISO: isolator; PBS: polarization beam splitter; HWP: half-wave plate; PC: polarization controller; IOC: integrated output coupler. The photos of the all-fiber integrated OPO assembled in a compact aluminum box including optics and electronics (right).
Fig. 3
Fig. 3 Spectra of 1-MHz fiber OPO in AIC (a) and AOC (b) configurations. Signal power and spectral bandwidth evolution of 1-MHz fiber OPO in AIC (c) and AOC (d) configurations.
Fig. 4
Fig. 4 Spectra of 2-MHz fiber OPO in AIC (a) and AOC (b) configurations; Signal power and spectral bandwidth evolution of 2-MHz fiber OPO in AIC (c) and AOC (d) configurations.
Fig. 5
Fig. 5 Spectra of 3-MHz fiber OPO in AIC (a) and AOC (b) configurations; Signal power and spectral bandwidth evolution of 3-MHz fiber OPO in AIC (c) and AOC (d) configurations.
Fig. 6
Fig. 6 (a) Schematic of CARS spectroscopy setup; Spectra of pump (b) and Stokes (c) pulses for AOC and AIC schemes; Measured CARS signals at 646 nm (d) and spectra (e) of ethanol sample for AOC and AIC schemes.

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