Abstract

The clinical significance of ABO blood typing extends beyond transfusion medicine and is demonstrated to be associated with susceptibility to various diseases, even including cancer. In this study, a home-made laser tweezers Raman spectroscopy (LTRS) system was applied to detect red blood cells (RBCs) with the aim to develop a label-free, simple and objective blood typing method for the first time. High-quality Raman spectra of RBCs in the fingerprint region of 420-1700 cm−1 can be obtained, meanwhile exciting blood typing results can be achieved, especially with an accuracy of 100% for identifying Type AB from other blood types with the use of multivariate statistical analysis based on principal component analysis (PCA) combined with linear discriminant analysis (LDA). This primary work demonstrates that the label-free RBCs LTRS analysis in conjunction with PCA-LDA diagnostic algorithms has great potential as a biosensor for ABO blood typing.

© 2016 Optical Society of America

Full Article  |  PDF Article
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References

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    [Crossref] [PubMed]
  5. R. Smith, K. L. Wright, and L. Ashton, “Raman spectroscopy: an evolving technique for live cell studies,” Analyst (Lond.) 141(12), 3590–3600 (2016).
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    [Crossref]
  7. Z. Tao, G. Wang, X. Xu, Y. Yuan, X. Wang, and Y. Li, “Monitoring and rapid quantification of total carotenoids in Rhodotorula glutinis cells using laser tweezers Raman spectroscopy,” FEMS Microbiol. Lett. 314(1), 42–48 (2011).
    [Crossref] [PubMed]
  8. J. W. Chan, “Recent advances in laser tweezers Raman spectroscopy (LTRS) for label-free analysis of single cells,” J. Biophotonics 6(1), 36–48 (2013).
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    [Crossref] [PubMed]
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  18. J. W. Chan, D. K. Lieu, T. Huser, and R. A. Li, “Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopy,” Anal. Chem. 81(4), 1324–1331 (2009).
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    [Crossref] [PubMed]
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    [Crossref]
  24. C. Xie, Y. Li, W. Tang, and R. J. Newton, “Study of dynamical process of heat denaturation in optically trapped single microorganisms by near-infrared Raman spectroscopy,” J. Appl. Phys. 94(9), 6138–6142 (2003).
    [Crossref]
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    [PubMed]
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    [Crossref]
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    [Crossref] [PubMed]
  28. S. Duraipandian, W. Zheng, J. Ng, J. J. Low, A. Ilancheran, and Z. Huang, “In vivo diagnosis of cervical precancer using Raman spectroscopy and genetic algorithm techniques,” Analyst (Lond.) 136(20), 4328–4336 (2011).
    [Crossref] [PubMed]
  29. Q. Tu and C. Chang, “Diagnostic applications of Raman spectroscopy,” Nanomedicine (Lond.) 8(5), 545–558 (2012).
    [PubMed]
  30. S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  32. D. Lin, G. Chen, S. Feng, J. Pan, J. Lin, Z. Huang, and R. Chen, “Development of a rapid macro-Raman spectroscopy system for nasopharyngeal cancer detection based on surface-enhanced Raman spectroscopy,” Appl. Phys. Lett. 106(1), 013701 (2015).
    [Crossref]

2016 (2)

R. Smith, K. L. Wright, and L. Ashton, “Raman spectroscopy: an evolving technique for live cell studies,” Analyst (Lond.) 141(12), 3590–3600 (2016).
[Crossref] [PubMed]

S. Ahlawat, A. Chowdhury, A. Uppal, N. Kumar, and P. K. Gupta, “Use of Raman optical tweezers for cell cycle analysis,” Analyst (Lond.) 141(4), 1339–1346 (2016).
[Crossref] [PubMed]

2015 (2)

M. Franchini and C. Bonfanti, “Evolutionary aspects of ABO blood group in humans,” Clin. Chim. Acta 444, 66–71 (2015).
[Crossref] [PubMed]

D. Lin, G. Chen, S. Feng, J. Pan, J. Lin, Z. Huang, and R. Chen, “Development of a rapid macro-Raman spectroscopy system for nasopharyngeal cancer detection based on surface-enhanced Raman spectroscopy,” Appl. Phys. Lett. 106(1), 013701 (2015).
[Crossref]

2014 (3)

D. Lin, J. Pan, H. Huang, G. Chen, S. Qiu, H. Shi, W. Chen, Y. Yu, S. Feng, and R. Chen, “Label-free blood plasma test based on surface-enhanced Raman scattering for tumor stages detection in nasopharyngeal cancer,” Sci. Rep. 4, 4751 (2014).
[PubMed]

N. Takada, C. Mori, M. Iida, R. Takai, T. Takayama, Y. Watanabe, K. Nakamura, and K. Takamizawa, “Development of an indirect competitive ELISA for the detection of ABO blood group antigens,” Leg. Med. (Tokyo) 16(3), 139–145 (2014).
[Crossref] [PubMed]

H. Huang, D. Lin, W. Chen, Y. Yu, J. Xu, Z. Liang, X. Lin, Z. Dong, and H. Shi, “Nondestructive discrimination between normal and hematological malignancy cell lines using near-infrared Raman spectroscopy and multivariate analysis,” Laser Phys. Lett. 11(8), 085601 (2014).
[Crossref]

2013 (5)

M. Franchini and G. M. Liumbruno, “ABO blood group: old dogma, new perspectives,” Clin. Chem. Lab. Med. 51(8), 1545–1553 (2013).
[PubMed]

S. Ahlawat, N. Kumar, R. Dasgupta, R. S. Verma, A. Uppal, and P. K. Gupta, “Raman spectroscopic investigations on optical trap induced deoxygenation of red blood cells,” Appl. Phys. Lett. 103(18), 183704 (2013).
[Crossref]

S. Raj, M. Wojdyla, and D. Petrov, “Studying single red blood cells under a tunable external force by combining passive microrheology with Raman spectroscopy,” Cell Biochem. Biophys. 65(3), 347–361 (2013).
[Crossref] [PubMed]

R. Liu, Z. Mao, D. L. Matthews, C.-S. Li, J. W. Chan, and N. Satake, “Novel single-cell functional analysis of red blood cells using laser tweezers Raman spectroscopy: Application for sickle cell disease,” Exp. Hematol. 41(7), 656–661 (2013).
[Crossref] [PubMed]

J. W. Chan, “Recent advances in laser tweezers Raman spectroscopy (LTRS) for label-free analysis of single cells,” J. Biophotonics 6(1), 36–48 (2013).
[Crossref] [PubMed]

2012 (3)

Q. Tu and C. Chang, “Diagnostic applications of Raman spectroscopy,” Nanomedicine (Lond.) 8(5), 545–558 (2012).
[PubMed]

S. Raj, M. Marro, M. Wojdyla, and D. Petrov, “Mechanochemistry of single red blood cells monitored using Raman tweezers,” Biomed. Opt. Express 3(4), 753–763 (2012).
[Crossref] [PubMed]

J. Shao, H. Yao, L. Meng, Y. Li, M. Lin, X. Ii, J. Liu, and J. Liang, “Raman spectroscopy of circulating single red blood cells in microvessels in vivo,” Vib. Spectrosc. 63, 367–370 (2012).
[Crossref]

2011 (5)

S. Fore, J. Chan, D. Taylor, and T. Huser, “Raman spectroscopy of individual monocytes reveals that single-beam optical trapping of mononuclear cells occurs by their nucleus,” J. Opt. 13(4), 044021 (2011).
[Crossref] [PubMed]

R. Dasgupta, R. S. Verma, S. Ahlawat, A. Uppal, and P. K. Gupta, “Studies on erythrocytes in malaria infected blood sample with Raman optical tweezers,” J. Biomed. Opt. 16(7), 077009 (2011).
[Crossref] [PubMed]

Z. Tao, G. Wang, X. Xu, Y. Yuan, X. Wang, and Y. Li, “Monitoring and rapid quantification of total carotenoids in Rhodotorula glutinis cells using laser tweezers Raman spectroscopy,” FEMS Microbiol. Lett. 314(1), 42–48 (2011).
[Crossref] [PubMed]

S. Duraipandian, W. Zheng, J. Ng, J. J. Low, A. Ilancheran, and Z. Huang, “In vivo diagnosis of cervical precancer using Raman spectroscopy and genetic algorithm techniques,” Analyst (Lond.) 136(20), 4328–4336 (2011).
[Crossref] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, and H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[Crossref] [PubMed]

2010 (2)

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref] [PubMed]

A. Bankapur, E. Zachariah, S. Chidangil, M. Valiathan, and D. Mathur, “Raman tweezers spectroscopy of live, single red and white blood cells,” PLoS One 5(4), e10427 (2010).
[Crossref] [PubMed]

2009 (3)

J. R. Storry and M. L. Olsson, “The ABO blood group system revisited: a review and update,” Immunohematology 25(2), 48–59 (2009).
[PubMed]

J. W. Chan, D. K. Lieu, T. Huser, and R. A. Li, “Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopy,” Anal. Chem. 81(4), 1324–1331 (2009).
[Crossref] [PubMed]

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near‐infrared Raman spectroscopy for gastric precancer diagnosis,” J. Raman Spectrosc. 40(8), 908–914 (2009).
[Crossref]

2008 (1)

2007 (1)

B. R. Wood, P. Caspers, G. J. Puppels, S. Pandiancherri, and D. McNaughton, “Resonance Raman spectroscopy of red blood cells using near-infrared laser excitation,” Anal. Bioanal. Chem. 387(5), 1691–1703 (2007).
[Crossref] [PubMed]

2006 (2)

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, and T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[Crossref] [PubMed]

K. Chen, Y. Qin, F. Zheng, M. Sun, and D. Shi, “Diagnosis of colorectal cancer using Raman spectroscopy of laser-trapped single living epithelial cells,” Opt. Lett. 31(13), 2015–2017 (2006).
[Crossref] [PubMed]

2005 (1)

J. Deng, Q. Wei, M. Zhang, Y. Wang, and Y.-Q. Li, “Study of the effect of alcohol on single human red blood cells using near‐infrared laser tweezers Raman spectroscopy,” J. Raman Spectrosc. 36(3), 257–261 (2005).
[Crossref]

2003 (2)

C. Xie, Y. Li, W. Tang, and R. J. Newton, “Study of dynamical process of heat denaturation in optically trapped single microorganisms by near-infrared Raman spectroscopy,” J. Appl. Phys. 94(9), 6138–6142 (2003).
[Crossref]

Z. Huang, A. McWilliams, H. Lui, D. I. McLean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 107(6), 1047–1052 (2003).
[Crossref] [PubMed]

Ahlawat, S.

S. Ahlawat, A. Chowdhury, A. Uppal, N. Kumar, and P. K. Gupta, “Use of Raman optical tweezers for cell cycle analysis,” Analyst (Lond.) 141(4), 1339–1346 (2016).
[Crossref] [PubMed]

S. Ahlawat, N. Kumar, R. Dasgupta, R. S. Verma, A. Uppal, and P. K. Gupta, “Raman spectroscopic investigations on optical trap induced deoxygenation of red blood cells,” Appl. Phys. Lett. 103(18), 183704 (2013).
[Crossref]

R. Dasgupta, R. S. Verma, S. Ahlawat, A. Uppal, and P. K. Gupta, “Studies on erythrocytes in malaria infected blood sample with Raman optical tweezers,” J. Biomed. Opt. 16(7), 077009 (2011).
[Crossref] [PubMed]

Ashton, L.

R. Smith, K. L. Wright, and L. Ashton, “Raman spectroscopy: an evolving technique for live cell studies,” Analyst (Lond.) 141(12), 3590–3600 (2016).
[Crossref] [PubMed]

Bankapur, A.

A. Bankapur, E. Zachariah, S. Chidangil, M. Valiathan, and D. Mathur, “Raman tweezers spectroscopy of live, single red and white blood cells,” PLoS One 5(4), e10427 (2010).
[Crossref] [PubMed]

Bonfanti, C.

M. Franchini and C. Bonfanti, “Evolutionary aspects of ABO blood group in humans,” Clin. Chim. Acta 444, 66–71 (2015).
[Crossref] [PubMed]

Caspers, P.

B. R. Wood, P. Caspers, G. J. Puppels, S. Pandiancherri, and D. McNaughton, “Resonance Raman spectroscopy of red blood cells using near-infrared laser excitation,” Anal. Bioanal. Chem. 387(5), 1691–1703 (2007).
[Crossref] [PubMed]

Chan, J.

S. Fore, J. Chan, D. Taylor, and T. Huser, “Raman spectroscopy of individual monocytes reveals that single-beam optical trapping of mononuclear cells occurs by their nucleus,” J. Opt. 13(4), 044021 (2011).
[Crossref] [PubMed]

Chan, J. W.

R. Liu, Z. Mao, D. L. Matthews, C.-S. Li, J. W. Chan, and N. Satake, “Novel single-cell functional analysis of red blood cells using laser tweezers Raman spectroscopy: Application for sickle cell disease,” Exp. Hematol. 41(7), 656–661 (2013).
[Crossref] [PubMed]

J. W. Chan, “Recent advances in laser tweezers Raman spectroscopy (LTRS) for label-free analysis of single cells,” J. Biophotonics 6(1), 36–48 (2013).
[Crossref] [PubMed]

J. W. Chan, D. K. Lieu, T. Huser, and R. A. Li, “Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopy,” Anal. Chem. 81(4), 1324–1331 (2009).
[Crossref] [PubMed]

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, and T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[Crossref] [PubMed]

Chang, C.

Q. Tu and C. Chang, “Diagnostic applications of Raman spectroscopy,” Nanomedicine (Lond.) 8(5), 545–558 (2012).
[PubMed]

Chen, G.

D. Lin, G. Chen, S. Feng, J. Pan, J. Lin, Z. Huang, and R. Chen, “Development of a rapid macro-Raman spectroscopy system for nasopharyngeal cancer detection based on surface-enhanced Raman spectroscopy,” Appl. Phys. Lett. 106(1), 013701 (2015).
[Crossref]

D. Lin, J. Pan, H. Huang, G. Chen, S. Qiu, H. Shi, W. Chen, Y. Yu, S. Feng, and R. Chen, “Label-free blood plasma test based on surface-enhanced Raman scattering for tumor stages detection in nasopharyngeal cancer,” Sci. Rep. 4, 4751 (2014).
[PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref] [PubMed]

Chen, J.

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, and H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[Crossref] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref] [PubMed]

Chen, K.

Chen, R.

D. Lin, G. Chen, S. Feng, J. Pan, J. Lin, Z. Huang, and R. Chen, “Development of a rapid macro-Raman spectroscopy system for nasopharyngeal cancer detection based on surface-enhanced Raman spectroscopy,” Appl. Phys. Lett. 106(1), 013701 (2015).
[Crossref]

D. Lin, J. Pan, H. Huang, G. Chen, S. Qiu, H. Shi, W. Chen, Y. Yu, S. Feng, and R. Chen, “Label-free blood plasma test based on surface-enhanced Raman scattering for tumor stages detection in nasopharyngeal cancer,” Sci. Rep. 4, 4751 (2014).
[PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, and H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[Crossref] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref] [PubMed]

Chen, W.

H. Huang, D. Lin, W. Chen, Y. Yu, J. Xu, Z. Liang, X. Lin, Z. Dong, and H. Shi, “Nondestructive discrimination between normal and hematological malignancy cell lines using near-infrared Raman spectroscopy and multivariate analysis,” Laser Phys. Lett. 11(8), 085601 (2014).
[Crossref]

D. Lin, J. Pan, H. Huang, G. Chen, S. Qiu, H. Shi, W. Chen, Y. Yu, S. Feng, and R. Chen, “Label-free blood plasma test based on surface-enhanced Raman scattering for tumor stages detection in nasopharyngeal cancer,” Sci. Rep. 4, 4751 (2014).
[PubMed]

Cheng, M.

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref] [PubMed]

Chidangil, S.

A. Bankapur, E. Zachariah, S. Chidangil, M. Valiathan, and D. Mathur, “Raman tweezers spectroscopy of live, single red and white blood cells,” PLoS One 5(4), e10427 (2010).
[Crossref] [PubMed]

Chowdhury, A.

S. Ahlawat, A. Chowdhury, A. Uppal, N. Kumar, and P. K. Gupta, “Use of Raman optical tweezers for cell cycle analysis,” Analyst (Lond.) 141(4), 1339–1346 (2016).
[Crossref] [PubMed]

Ciancia, R.

Dasgupta, R.

S. Ahlawat, N. Kumar, R. Dasgupta, R. S. Verma, A. Uppal, and P. K. Gupta, “Raman spectroscopic investigations on optical trap induced deoxygenation of red blood cells,” Appl. Phys. Lett. 103(18), 183704 (2013).
[Crossref]

R. Dasgupta, R. S. Verma, S. Ahlawat, A. Uppal, and P. K. Gupta, “Studies on erythrocytes in malaria infected blood sample with Raman optical tweezers,” J. Biomed. Opt. 16(7), 077009 (2011).
[Crossref] [PubMed]

De Luca, A. C.

Deng, J.

J. Deng, Q. Wei, M. Zhang, Y. Wang, and Y.-Q. Li, “Study of the effect of alcohol on single human red blood cells using near‐infrared laser tweezers Raman spectroscopy,” J. Raman Spectrosc. 36(3), 257–261 (2005).
[Crossref]

Dong, Z.

H. Huang, D. Lin, W. Chen, Y. Yu, J. Xu, Z. Liang, X. Lin, Z. Dong, and H. Shi, “Nondestructive discrimination between normal and hematological malignancy cell lines using near-infrared Raman spectroscopy and multivariate analysis,” Laser Phys. Lett. 11(8), 085601 (2014).
[Crossref]

Duraipandian, S.

S. Duraipandian, W. Zheng, J. Ng, J. J. Low, A. Ilancheran, and Z. Huang, “In vivo diagnosis of cervical precancer using Raman spectroscopy and genetic algorithm techniques,” Analyst (Lond.) 136(20), 4328–4336 (2011).
[Crossref] [PubMed]

Feng, S.

D. Lin, G. Chen, S. Feng, J. Pan, J. Lin, Z. Huang, and R. Chen, “Development of a rapid macro-Raman spectroscopy system for nasopharyngeal cancer detection based on surface-enhanced Raman spectroscopy,” Appl. Phys. Lett. 106(1), 013701 (2015).
[Crossref]

D. Lin, J. Pan, H. Huang, G. Chen, S. Qiu, H. Shi, W. Chen, Y. Yu, S. Feng, and R. Chen, “Label-free blood plasma test based on surface-enhanced Raman scattering for tumor stages detection in nasopharyngeal cancer,” Sci. Rep. 4, 4751 (2014).
[PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, and H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[Crossref] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref] [PubMed]

Fore, S.

S. Fore, J. Chan, D. Taylor, and T. Huser, “Raman spectroscopy of individual monocytes reveals that single-beam optical trapping of mononuclear cells occurs by their nucleus,” J. Opt. 13(4), 044021 (2011).
[Crossref] [PubMed]

Franchini, M.

M. Franchini and C. Bonfanti, “Evolutionary aspects of ABO blood group in humans,” Clin. Chim. Acta 444, 66–71 (2015).
[Crossref] [PubMed]

M. Franchini and G. M. Liumbruno, “ABO blood group: old dogma, new perspectives,” Clin. Chem. Lab. Med. 51(8), 1545–1553 (2013).
[PubMed]

Gupta, P. K.

S. Ahlawat, A. Chowdhury, A. Uppal, N. Kumar, and P. K. Gupta, “Use of Raman optical tweezers for cell cycle analysis,” Analyst (Lond.) 141(4), 1339–1346 (2016).
[Crossref] [PubMed]

S. Ahlawat, N. Kumar, R. Dasgupta, R. S. Verma, A. Uppal, and P. K. Gupta, “Raman spectroscopic investigations on optical trap induced deoxygenation of red blood cells,” Appl. Phys. Lett. 103(18), 183704 (2013).
[Crossref]

R. Dasgupta, R. S. Verma, S. Ahlawat, A. Uppal, and P. K. Gupta, “Studies on erythrocytes in malaria infected blood sample with Raman optical tweezers,” J. Biomed. Opt. 16(7), 077009 (2011).
[Crossref] [PubMed]

Ho, K. Y.

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near‐infrared Raman spectroscopy for gastric precancer diagnosis,” J. Raman Spectrosc. 40(8), 908–914 (2009).
[Crossref]

Huang, H.

D. Lin, J. Pan, H. Huang, G. Chen, S. Qiu, H. Shi, W. Chen, Y. Yu, S. Feng, and R. Chen, “Label-free blood plasma test based on surface-enhanced Raman scattering for tumor stages detection in nasopharyngeal cancer,” Sci. Rep. 4, 4751 (2014).
[PubMed]

H. Huang, D. Lin, W. Chen, Y. Yu, J. Xu, Z. Liang, X. Lin, Z. Dong, and H. Shi, “Nondestructive discrimination between normal and hematological malignancy cell lines using near-infrared Raman spectroscopy and multivariate analysis,” Laser Phys. Lett. 11(8), 085601 (2014).
[Crossref]

Huang, Z.

D. Lin, G. Chen, S. Feng, J. Pan, J. Lin, Z. Huang, and R. Chen, “Development of a rapid macro-Raman spectroscopy system for nasopharyngeal cancer detection based on surface-enhanced Raman spectroscopy,” Appl. Phys. Lett. 106(1), 013701 (2015).
[Crossref]

S. Duraipandian, W. Zheng, J. Ng, J. J. Low, A. Ilancheran, and Z. Huang, “In vivo diagnosis of cervical precancer using Raman spectroscopy and genetic algorithm techniques,” Analyst (Lond.) 136(20), 4328–4336 (2011).
[Crossref] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref] [PubMed]

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near‐infrared Raman spectroscopy for gastric precancer diagnosis,” J. Raman Spectrosc. 40(8), 908–914 (2009).
[Crossref]

Z. Huang, A. McWilliams, H. Lui, D. I. McLean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 107(6), 1047–1052 (2003).
[Crossref] [PubMed]

Huser, T.

S. Fore, J. Chan, D. Taylor, and T. Huser, “Raman spectroscopy of individual monocytes reveals that single-beam optical trapping of mononuclear cells occurs by their nucleus,” J. Opt. 13(4), 044021 (2011).
[Crossref] [PubMed]

J. W. Chan, D. K. Lieu, T. Huser, and R. A. Li, “Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopy,” Anal. Chem. 81(4), 1324–1331 (2009).
[Crossref] [PubMed]

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, and T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[Crossref] [PubMed]

Ihara, K.

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, and T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[Crossref] [PubMed]

Ii, X.

J. Shao, H. Yao, L. Meng, Y. Li, M. Lin, X. Ii, J. Liu, and J. Liang, “Raman spectroscopy of circulating single red blood cells in microvessels in vivo,” Vib. Spectrosc. 63, 367–370 (2012).
[Crossref]

Iida, M.

N. Takada, C. Mori, M. Iida, R. Takai, T. Takayama, Y. Watanabe, K. Nakamura, and K. Takamizawa, “Development of an indirect competitive ELISA for the detection of ABO blood group antigens,” Leg. Med. (Tokyo) 16(3), 139–145 (2014).
[Crossref] [PubMed]

Ilancheran, A.

S. Duraipandian, W. Zheng, J. Ng, J. J. Low, A. Ilancheran, and Z. Huang, “In vivo diagnosis of cervical precancer using Raman spectroscopy and genetic algorithm techniques,” Analyst (Lond.) 136(20), 4328–4336 (2011).
[Crossref] [PubMed]

Kumar, N.

S. Ahlawat, A. Chowdhury, A. Uppal, N. Kumar, and P. K. Gupta, “Use of Raman optical tweezers for cell cycle analysis,” Analyst (Lond.) 141(4), 1339–1346 (2016).
[Crossref] [PubMed]

S. Ahlawat, N. Kumar, R. Dasgupta, R. S. Verma, A. Uppal, and P. K. Gupta, “Raman spectroscopic investigations on optical trap induced deoxygenation of red blood cells,” Appl. Phys. Lett. 103(18), 183704 (2013).
[Crossref]

Lam, S.

Z. Huang, A. McWilliams, H. Lui, D. I. McLean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 107(6), 1047–1052 (2003).
[Crossref] [PubMed]

Lane, S. M.

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, and T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[Crossref] [PubMed]

Li, C.-S.

R. Liu, Z. Mao, D. L. Matthews, C.-S. Li, J. W. Chan, and N. Satake, “Novel single-cell functional analysis of red blood cells using laser tweezers Raman spectroscopy: Application for sickle cell disease,” Exp. Hematol. 41(7), 656–661 (2013).
[Crossref] [PubMed]

Li, R. A.

J. W. Chan, D. K. Lieu, T. Huser, and R. A. Li, “Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopy,” Anal. Chem. 81(4), 1324–1331 (2009).
[Crossref] [PubMed]

Li, Y.

J. Shao, H. Yao, L. Meng, Y. Li, M. Lin, X. Ii, J. Liu, and J. Liang, “Raman spectroscopy of circulating single red blood cells in microvessels in vivo,” Vib. Spectrosc. 63, 367–370 (2012).
[Crossref]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, and H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[Crossref] [PubMed]

Z. Tao, G. Wang, X. Xu, Y. Yuan, X. Wang, and Y. Li, “Monitoring and rapid quantification of total carotenoids in Rhodotorula glutinis cells using laser tweezers Raman spectroscopy,” FEMS Microbiol. Lett. 314(1), 42–48 (2011).
[Crossref] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref] [PubMed]

C. Xie, Y. Li, W. Tang, and R. J. Newton, “Study of dynamical process of heat denaturation in optically trapped single microorganisms by near-infrared Raman spectroscopy,” J. Appl. Phys. 94(9), 6138–6142 (2003).
[Crossref]

Li, Y.-Q.

J. Deng, Q. Wei, M. Zhang, Y. Wang, and Y.-Q. Li, “Study of the effect of alcohol on single human red blood cells using near‐infrared laser tweezers Raman spectroscopy,” J. Raman Spectrosc. 36(3), 257–261 (2005).
[Crossref]

Liang, J.

J. Shao, H. Yao, L. Meng, Y. Li, M. Lin, X. Ii, J. Liu, and J. Liang, “Raman spectroscopy of circulating single red blood cells in microvessels in vivo,” Vib. Spectrosc. 63, 367–370 (2012).
[Crossref]

Liang, Z.

H. Huang, D. Lin, W. Chen, Y. Yu, J. Xu, Z. Liang, X. Lin, Z. Dong, and H. Shi, “Nondestructive discrimination between normal and hematological malignancy cell lines using near-infrared Raman spectroscopy and multivariate analysis,” Laser Phys. Lett. 11(8), 085601 (2014).
[Crossref]

Lieu, D. K.

J. W. Chan, D. K. Lieu, T. Huser, and R. A. Li, “Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopy,” Anal. Chem. 81(4), 1324–1331 (2009).
[Crossref] [PubMed]

Lin, D.

D. Lin, G. Chen, S. Feng, J. Pan, J. Lin, Z. Huang, and R. Chen, “Development of a rapid macro-Raman spectroscopy system for nasopharyngeal cancer detection based on surface-enhanced Raman spectroscopy,” Appl. Phys. Lett. 106(1), 013701 (2015).
[Crossref]

H. Huang, D. Lin, W. Chen, Y. Yu, J. Xu, Z. Liang, X. Lin, Z. Dong, and H. Shi, “Nondestructive discrimination between normal and hematological malignancy cell lines using near-infrared Raman spectroscopy and multivariate analysis,” Laser Phys. Lett. 11(8), 085601 (2014).
[Crossref]

D. Lin, J. Pan, H. Huang, G. Chen, S. Qiu, H. Shi, W. Chen, Y. Yu, S. Feng, and R. Chen, “Label-free blood plasma test based on surface-enhanced Raman scattering for tumor stages detection in nasopharyngeal cancer,” Sci. Rep. 4, 4751 (2014).
[PubMed]

Lin, J.

D. Lin, G. Chen, S. Feng, J. Pan, J. Lin, Z. Huang, and R. Chen, “Development of a rapid macro-Raman spectroscopy system for nasopharyngeal cancer detection based on surface-enhanced Raman spectroscopy,” Appl. Phys. Lett. 106(1), 013701 (2015).
[Crossref]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, and H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[Crossref] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref] [PubMed]

Lin, M.

J. Shao, H. Yao, L. Meng, Y. Li, M. Lin, X. Ii, J. Liu, and J. Liang, “Raman spectroscopy of circulating single red blood cells in microvessels in vivo,” Vib. Spectrosc. 63, 367–370 (2012).
[Crossref]

Lin, X.

H. Huang, D. Lin, W. Chen, Y. Yu, J. Xu, Z. Liang, X. Lin, Z. Dong, and H. Shi, “Nondestructive discrimination between normal and hematological malignancy cell lines using near-infrared Raman spectroscopy and multivariate analysis,” Laser Phys. Lett. 11(8), 085601 (2014).
[Crossref]

Liu, J.

J. Shao, H. Yao, L. Meng, Y. Li, M. Lin, X. Ii, J. Liu, and J. Liang, “Raman spectroscopy of circulating single red blood cells in microvessels in vivo,” Vib. Spectrosc. 63, 367–370 (2012).
[Crossref]

Liu, R.

R. Liu, Z. Mao, D. L. Matthews, C.-S. Li, J. W. Chan, and N. Satake, “Novel single-cell functional analysis of red blood cells using laser tweezers Raman spectroscopy: Application for sickle cell disease,” Exp. Hematol. 41(7), 656–661 (2013).
[Crossref] [PubMed]

Liumbruno, G. M.

M. Franchini and G. M. Liumbruno, “ABO blood group: old dogma, new perspectives,” Clin. Chem. Lab. Med. 51(8), 1545–1553 (2013).
[PubMed]

Low, J. J.

S. Duraipandian, W. Zheng, J. Ng, J. J. Low, A. Ilancheran, and Z. Huang, “In vivo diagnosis of cervical precancer using Raman spectroscopy and genetic algorithm techniques,” Analyst (Lond.) 136(20), 4328–4336 (2011).
[Crossref] [PubMed]

Lui, H.

Z. Huang, A. McWilliams, H. Lui, D. I. McLean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 107(6), 1047–1052 (2003).
[Crossref] [PubMed]

Mao, Z.

R. Liu, Z. Mao, D. L. Matthews, C.-S. Li, J. W. Chan, and N. Satake, “Novel single-cell functional analysis of red blood cells using laser tweezers Raman spectroscopy: Application for sickle cell disease,” Exp. Hematol. 41(7), 656–661 (2013).
[Crossref] [PubMed]

Marro, M.

Martinelli, V.

Mathur, D.

A. Bankapur, E. Zachariah, S. Chidangil, M. Valiathan, and D. Mathur, “Raman tweezers spectroscopy of live, single red and white blood cells,” PLoS One 5(4), e10427 (2010).
[Crossref] [PubMed]

Matthews, D. L.

R. Liu, Z. Mao, D. L. Matthews, C.-S. Li, J. W. Chan, and N. Satake, “Novel single-cell functional analysis of red blood cells using laser tweezers Raman spectroscopy: Application for sickle cell disease,” Exp. Hematol. 41(7), 656–661 (2013).
[Crossref] [PubMed]

McLean, D. I.

Z. Huang, A. McWilliams, H. Lui, D. I. McLean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 107(6), 1047–1052 (2003).
[Crossref] [PubMed]

McNaughton, D.

B. R. Wood, P. Caspers, G. J. Puppels, S. Pandiancherri, and D. McNaughton, “Resonance Raman spectroscopy of red blood cells using near-infrared laser excitation,” Anal. Bioanal. Chem. 387(5), 1691–1703 (2007).
[Crossref] [PubMed]

McWilliams, A.

Z. Huang, A. McWilliams, H. Lui, D. I. McLean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 107(6), 1047–1052 (2003).
[Crossref] [PubMed]

Meng, L.

J. Shao, H. Yao, L. Meng, Y. Li, M. Lin, X. Ii, J. Liu, and J. Liang, “Raman spectroscopy of circulating single red blood cells in microvessels in vivo,” Vib. Spectrosc. 63, 367–370 (2012).
[Crossref]

Mori, C.

N. Takada, C. Mori, M. Iida, R. Takai, T. Takayama, Y. Watanabe, K. Nakamura, and K. Takamizawa, “Development of an indirect competitive ELISA for the detection of ABO blood group antigens,” Leg. Med. (Tokyo) 16(3), 139–145 (2014).
[Crossref] [PubMed]

Nakamura, K.

N. Takada, C. Mori, M. Iida, R. Takai, T. Takayama, Y. Watanabe, K. Nakamura, and K. Takamizawa, “Development of an indirect competitive ELISA for the detection of ABO blood group antigens,” Leg. Med. (Tokyo) 16(3), 139–145 (2014).
[Crossref] [PubMed]

Newton, R. J.

C. Xie, Y. Li, W. Tang, and R. J. Newton, “Study of dynamical process of heat denaturation in optically trapped single microorganisms by near-infrared Raman spectroscopy,” J. Appl. Phys. 94(9), 6138–6142 (2003).
[Crossref]

Ng, J.

S. Duraipandian, W. Zheng, J. Ng, J. J. Low, A. Ilancheran, and Z. Huang, “In vivo diagnosis of cervical precancer using Raman spectroscopy and genetic algorithm techniques,” Analyst (Lond.) 136(20), 4328–4336 (2011).
[Crossref] [PubMed]

Olsson, M. L.

J. R. Storry and M. L. Olsson, “The ABO blood group system revisited: a review and update,” Immunohematology 25(2), 48–59 (2009).
[PubMed]

Pan, J.

D. Lin, G. Chen, S. Feng, J. Pan, J. Lin, Z. Huang, and R. Chen, “Development of a rapid macro-Raman spectroscopy system for nasopharyngeal cancer detection based on surface-enhanced Raman spectroscopy,” Appl. Phys. Lett. 106(1), 013701 (2015).
[Crossref]

D. Lin, J. Pan, H. Huang, G. Chen, S. Qiu, H. Shi, W. Chen, Y. Yu, S. Feng, and R. Chen, “Label-free blood plasma test based on surface-enhanced Raman scattering for tumor stages detection in nasopharyngeal cancer,” Sci. Rep. 4, 4751 (2014).
[PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, and H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[Crossref] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref] [PubMed]

Pandiancherri, S.

B. R. Wood, P. Caspers, G. J. Puppels, S. Pandiancherri, and D. McNaughton, “Resonance Raman spectroscopy of red blood cells using near-infrared laser excitation,” Anal. Bioanal. Chem. 387(5), 1691–1703 (2007).
[Crossref] [PubMed]

Pesce, G.

Petrov, D.

S. Raj, M. Wojdyla, and D. Petrov, “Studying single red blood cells under a tunable external force by combining passive microrheology with Raman spectroscopy,” Cell Biochem. Biophys. 65(3), 347–361 (2013).
[Crossref] [PubMed]

S. Raj, M. Marro, M. Wojdyla, and D. Petrov, “Mechanochemistry of single red blood cells monitored using Raman tweezers,” Biomed. Opt. Express 3(4), 753–763 (2012).
[Crossref] [PubMed]

Puppels, G. J.

B. R. Wood, P. Caspers, G. J. Puppels, S. Pandiancherri, and D. McNaughton, “Resonance Raman spectroscopy of red blood cells using near-infrared laser excitation,” Anal. Bioanal. Chem. 387(5), 1691–1703 (2007).
[Crossref] [PubMed]

Qin, Y.

Qiu, S.

D. Lin, J. Pan, H. Huang, G. Chen, S. Qiu, H. Shi, W. Chen, Y. Yu, S. Feng, and R. Chen, “Label-free blood plasma test based on surface-enhanced Raman scattering for tumor stages detection in nasopharyngeal cancer,” Sci. Rep. 4, 4751 (2014).
[PubMed]

Raj, S.

S. Raj, M. Wojdyla, and D. Petrov, “Studying single red blood cells under a tunable external force by combining passive microrheology with Raman spectroscopy,” Cell Biochem. Biophys. 65(3), 347–361 (2013).
[Crossref] [PubMed]

S. Raj, M. Marro, M. Wojdyla, and D. Petrov, “Mechanochemistry of single red blood cells monitored using Raman tweezers,” Biomed. Opt. Express 3(4), 753–763 (2012).
[Crossref] [PubMed]

Rotoli, B.

Rusciano, G.

Sasso, A.

Satake, N.

R. Liu, Z. Mao, D. L. Matthews, C.-S. Li, J. W. Chan, and N. Satake, “Novel single-cell functional analysis of red blood cells using laser tweezers Raman spectroscopy: Application for sickle cell disease,” Exp. Hematol. 41(7), 656–661 (2013).
[Crossref] [PubMed]

Selvaggi, L.

Shao, J.

J. Shao, H. Yao, L. Meng, Y. Li, M. Lin, X. Ii, J. Liu, and J. Liang, “Raman spectroscopy of circulating single red blood cells in microvessels in vivo,” Vib. Spectrosc. 63, 367–370 (2012).
[Crossref]

Shi, D.

Shi, H.

D. Lin, J. Pan, H. Huang, G. Chen, S. Qiu, H. Shi, W. Chen, Y. Yu, S. Feng, and R. Chen, “Label-free blood plasma test based on surface-enhanced Raman scattering for tumor stages detection in nasopharyngeal cancer,” Sci. Rep. 4, 4751 (2014).
[PubMed]

H. Huang, D. Lin, W. Chen, Y. Yu, J. Xu, Z. Liang, X. Lin, Z. Dong, and H. Shi, “Nondestructive discrimination between normal and hematological malignancy cell lines using near-infrared Raman spectroscopy and multivariate analysis,” Laser Phys. Lett. 11(8), 085601 (2014).
[Crossref]

Smith, R.

R. Smith, K. L. Wright, and L. Ashton, “Raman spectroscopy: an evolving technique for live cell studies,” Analyst (Lond.) 141(12), 3590–3600 (2016).
[Crossref] [PubMed]

Storry, J. R.

J. R. Storry and M. L. Olsson, “The ABO blood group system revisited: a review and update,” Immunohematology 25(2), 48–59 (2009).
[PubMed]

Sun, M.

Takada, N.

N. Takada, C. Mori, M. Iida, R. Takai, T. Takayama, Y. Watanabe, K. Nakamura, and K. Takamizawa, “Development of an indirect competitive ELISA for the detection of ABO blood group antigens,” Leg. Med. (Tokyo) 16(3), 139–145 (2014).
[Crossref] [PubMed]

Takai, R.

N. Takada, C. Mori, M. Iida, R. Takai, T. Takayama, Y. Watanabe, K. Nakamura, and K. Takamizawa, “Development of an indirect competitive ELISA for the detection of ABO blood group antigens,” Leg. Med. (Tokyo) 16(3), 139–145 (2014).
[Crossref] [PubMed]

Takamizawa, K.

N. Takada, C. Mori, M. Iida, R. Takai, T. Takayama, Y. Watanabe, K. Nakamura, and K. Takamizawa, “Development of an indirect competitive ELISA for the detection of ABO blood group antigens,” Leg. Med. (Tokyo) 16(3), 139–145 (2014).
[Crossref] [PubMed]

Takayama, T.

N. Takada, C. Mori, M. Iida, R. Takai, T. Takayama, Y. Watanabe, K. Nakamura, and K. Takamizawa, “Development of an indirect competitive ELISA for the detection of ABO blood group antigens,” Leg. Med. (Tokyo) 16(3), 139–145 (2014).
[Crossref] [PubMed]

Tang, W.

C. Xie, Y. Li, W. Tang, and R. J. Newton, “Study of dynamical process of heat denaturation in optically trapped single microorganisms by near-infrared Raman spectroscopy,” J. Appl. Phys. 94(9), 6138–6142 (2003).
[Crossref]

Tao, Z.

Z. Tao, G. Wang, X. Xu, Y. Yuan, X. Wang, and Y. Li, “Monitoring and rapid quantification of total carotenoids in Rhodotorula glutinis cells using laser tweezers Raman spectroscopy,” FEMS Microbiol. Lett. 314(1), 42–48 (2011).
[Crossref] [PubMed]

Taylor, D.

S. Fore, J. Chan, D. Taylor, and T. Huser, “Raman spectroscopy of individual monocytes reveals that single-beam optical trapping of mononuclear cells occurs by their nucleus,” J. Opt. 13(4), 044021 (2011).
[Crossref] [PubMed]

Taylor, D. S.

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, and T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[Crossref] [PubMed]

Teh, M.

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near‐infrared Raman spectroscopy for gastric precancer diagnosis,” J. Raman Spectrosc. 40(8), 908–914 (2009).
[Crossref]

Teh, S. K.

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near‐infrared Raman spectroscopy for gastric precancer diagnosis,” J. Raman Spectrosc. 40(8), 908–914 (2009).
[Crossref]

Tu, Q.

Q. Tu and C. Chang, “Diagnostic applications of Raman spectroscopy,” Nanomedicine (Lond.) 8(5), 545–558 (2012).
[PubMed]

Uppal, A.

S. Ahlawat, A. Chowdhury, A. Uppal, N. Kumar, and P. K. Gupta, “Use of Raman optical tweezers for cell cycle analysis,” Analyst (Lond.) 141(4), 1339–1346 (2016).
[Crossref] [PubMed]

S. Ahlawat, N. Kumar, R. Dasgupta, R. S. Verma, A. Uppal, and P. K. Gupta, “Raman spectroscopic investigations on optical trap induced deoxygenation of red blood cells,” Appl. Phys. Lett. 103(18), 183704 (2013).
[Crossref]

R. Dasgupta, R. S. Verma, S. Ahlawat, A. Uppal, and P. K. Gupta, “Studies on erythrocytes in malaria infected blood sample with Raman optical tweezers,” J. Biomed. Opt. 16(7), 077009 (2011).
[Crossref] [PubMed]

Valiathan, M.

A. Bankapur, E. Zachariah, S. Chidangil, M. Valiathan, and D. Mathur, “Raman tweezers spectroscopy of live, single red and white blood cells,” PLoS One 5(4), e10427 (2010).
[Crossref] [PubMed]

Verma, R. S.

S. Ahlawat, N. Kumar, R. Dasgupta, R. S. Verma, A. Uppal, and P. K. Gupta, “Raman spectroscopic investigations on optical trap induced deoxygenation of red blood cells,” Appl. Phys. Lett. 103(18), 183704 (2013).
[Crossref]

R. Dasgupta, R. S. Verma, S. Ahlawat, A. Uppal, and P. K. Gupta, “Studies on erythrocytes in malaria infected blood sample with Raman optical tweezers,” J. Biomed. Opt. 16(7), 077009 (2011).
[Crossref] [PubMed]

Wang, G.

Z. Tao, G. Wang, X. Xu, Y. Yuan, X. Wang, and Y. Li, “Monitoring and rapid quantification of total carotenoids in Rhodotorula glutinis cells using laser tweezers Raman spectroscopy,” FEMS Microbiol. Lett. 314(1), 42–48 (2011).
[Crossref] [PubMed]

Wang, X.

Z. Tao, G. Wang, X. Xu, Y. Yuan, X. Wang, and Y. Li, “Monitoring and rapid quantification of total carotenoids in Rhodotorula glutinis cells using laser tweezers Raman spectroscopy,” FEMS Microbiol. Lett. 314(1), 42–48 (2011).
[Crossref] [PubMed]

Wang, Y.

J. Deng, Q. Wei, M. Zhang, Y. Wang, and Y.-Q. Li, “Study of the effect of alcohol on single human red blood cells using near‐infrared laser tweezers Raman spectroscopy,” J. Raman Spectrosc. 36(3), 257–261 (2005).
[Crossref]

Watanabe, Y.

N. Takada, C. Mori, M. Iida, R. Takai, T. Takayama, Y. Watanabe, K. Nakamura, and K. Takamizawa, “Development of an indirect competitive ELISA for the detection of ABO blood group antigens,” Leg. Med. (Tokyo) 16(3), 139–145 (2014).
[Crossref] [PubMed]

Wei, Q.

J. Deng, Q. Wei, M. Zhang, Y. Wang, and Y.-Q. Li, “Study of the effect of alcohol on single human red blood cells using near‐infrared laser tweezers Raman spectroscopy,” J. Raman Spectrosc. 36(3), 257–261 (2005).
[Crossref]

Wojdyla, M.

S. Raj, M. Wojdyla, and D. Petrov, “Studying single red blood cells under a tunable external force by combining passive microrheology with Raman spectroscopy,” Cell Biochem. Biophys. 65(3), 347–361 (2013).
[Crossref] [PubMed]

S. Raj, M. Marro, M. Wojdyla, and D. Petrov, “Mechanochemistry of single red blood cells monitored using Raman tweezers,” Biomed. Opt. Express 3(4), 753–763 (2012).
[Crossref] [PubMed]

Wood, B. R.

B. R. Wood, P. Caspers, G. J. Puppels, S. Pandiancherri, and D. McNaughton, “Resonance Raman spectroscopy of red blood cells using near-infrared laser excitation,” Anal. Bioanal. Chem. 387(5), 1691–1703 (2007).
[Crossref] [PubMed]

Wright, K. L.

R. Smith, K. L. Wright, and L. Ashton, “Raman spectroscopy: an evolving technique for live cell studies,” Analyst (Lond.) 141(12), 3590–3600 (2016).
[Crossref] [PubMed]

Wu, Y.

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, and H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[Crossref] [PubMed]

Xie, C.

C. Xie, Y. Li, W. Tang, and R. J. Newton, “Study of dynamical process of heat denaturation in optically trapped single microorganisms by near-infrared Raman spectroscopy,” J. Appl. Phys. 94(9), 6138–6142 (2003).
[Crossref]

Xu, J.

H. Huang, D. Lin, W. Chen, Y. Yu, J. Xu, Z. Liang, X. Lin, Z. Dong, and H. Shi, “Nondestructive discrimination between normal and hematological malignancy cell lines using near-infrared Raman spectroscopy and multivariate analysis,” Laser Phys. Lett. 11(8), 085601 (2014).
[Crossref]

Xu, X.

Z. Tao, G. Wang, X. Xu, Y. Yuan, X. Wang, and Y. Li, “Monitoring and rapid quantification of total carotenoids in Rhodotorula glutinis cells using laser tweezers Raman spectroscopy,” FEMS Microbiol. Lett. 314(1), 42–48 (2011).
[Crossref] [PubMed]

Yao, H.

J. Shao, H. Yao, L. Meng, Y. Li, M. Lin, X. Ii, J. Liu, and J. Liang, “Raman spectroscopy of circulating single red blood cells in microvessels in vivo,” Vib. Spectrosc. 63, 367–370 (2012).
[Crossref]

Yeoh, K. G.

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near‐infrared Raman spectroscopy for gastric precancer diagnosis,” J. Raman Spectrosc. 40(8), 908–914 (2009).
[Crossref]

Yu, Y.

D. Lin, J. Pan, H. Huang, G. Chen, S. Qiu, H. Shi, W. Chen, Y. Yu, S. Feng, and R. Chen, “Label-free blood plasma test based on surface-enhanced Raman scattering for tumor stages detection in nasopharyngeal cancer,” Sci. Rep. 4, 4751 (2014).
[PubMed]

H. Huang, D. Lin, W. Chen, Y. Yu, J. Xu, Z. Liang, X. Lin, Z. Dong, and H. Shi, “Nondestructive discrimination between normal and hematological malignancy cell lines using near-infrared Raman spectroscopy and multivariate analysis,” Laser Phys. Lett. 11(8), 085601 (2014).
[Crossref]

Yuan, Y.

Z. Tao, G. Wang, X. Xu, Y. Yuan, X. Wang, and Y. Li, “Monitoring and rapid quantification of total carotenoids in Rhodotorula glutinis cells using laser tweezers Raman spectroscopy,” FEMS Microbiol. Lett. 314(1), 42–48 (2011).
[Crossref] [PubMed]

Zachariah, E.

A. Bankapur, E. Zachariah, S. Chidangil, M. Valiathan, and D. Mathur, “Raman tweezers spectroscopy of live, single red and white blood cells,” PLoS One 5(4), e10427 (2010).
[Crossref] [PubMed]

Zeng, H.

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, and H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[Crossref] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref] [PubMed]

Z. Huang, A. McWilliams, H. Lui, D. I. McLean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 107(6), 1047–1052 (2003).
[Crossref] [PubMed]

Zhang, M.

J. Deng, Q. Wei, M. Zhang, Y. Wang, and Y.-Q. Li, “Study of the effect of alcohol on single human red blood cells using near‐infrared laser tweezers Raman spectroscopy,” J. Raman Spectrosc. 36(3), 257–261 (2005).
[Crossref]

Zheng, F.

Zheng, W.

S. Duraipandian, W. Zheng, J. Ng, J. J. Low, A. Ilancheran, and Z. Huang, “In vivo diagnosis of cervical precancer using Raman spectroscopy and genetic algorithm techniques,” Analyst (Lond.) 136(20), 4328–4336 (2011).
[Crossref] [PubMed]

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near‐infrared Raman spectroscopy for gastric precancer diagnosis,” J. Raman Spectrosc. 40(8), 908–914 (2009).
[Crossref]

Zwerdling, T.

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, and T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[Crossref] [PubMed]

Anal. Bioanal. Chem. (1)

B. R. Wood, P. Caspers, G. J. Puppels, S. Pandiancherri, and D. McNaughton, “Resonance Raman spectroscopy of red blood cells using near-infrared laser excitation,” Anal. Bioanal. Chem. 387(5), 1691–1703 (2007).
[Crossref] [PubMed]

Anal. Chem. (1)

J. W. Chan, D. K. Lieu, T. Huser, and R. A. Li, “Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopy,” Anal. Chem. 81(4), 1324–1331 (2009).
[Crossref] [PubMed]

Analyst (Lond.) (3)

S. Duraipandian, W. Zheng, J. Ng, J. J. Low, A. Ilancheran, and Z. Huang, “In vivo diagnosis of cervical precancer using Raman spectroscopy and genetic algorithm techniques,” Analyst (Lond.) 136(20), 4328–4336 (2011).
[Crossref] [PubMed]

R. Smith, K. L. Wright, and L. Ashton, “Raman spectroscopy: an evolving technique for live cell studies,” Analyst (Lond.) 141(12), 3590–3600 (2016).
[Crossref] [PubMed]

S. Ahlawat, A. Chowdhury, A. Uppal, N. Kumar, and P. K. Gupta, “Use of Raman optical tweezers for cell cycle analysis,” Analyst (Lond.) 141(4), 1339–1346 (2016).
[Crossref] [PubMed]

Appl. Phys. Lett. (2)

D. Lin, G. Chen, S. Feng, J. Pan, J. Lin, Z. Huang, and R. Chen, “Development of a rapid macro-Raman spectroscopy system for nasopharyngeal cancer detection based on surface-enhanced Raman spectroscopy,” Appl. Phys. Lett. 106(1), 013701 (2015).
[Crossref]

S. Ahlawat, N. Kumar, R. Dasgupta, R. S. Verma, A. Uppal, and P. K. Gupta, “Raman spectroscopic investigations on optical trap induced deoxygenation of red blood cells,” Appl. Phys. Lett. 103(18), 183704 (2013).
[Crossref]

Biomed. Opt. Express (1)

Biophys. J. (1)

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, and T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[Crossref] [PubMed]

Biosens. Bioelectron. (2)

S. Feng, R. Chen, J. Lin, J. Pan, G. Chen, Y. Li, M. Cheng, Z. Huang, J. Chen, and H. Zeng, “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron. 25(11), 2414–2419 (2010).
[Crossref] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, and H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[Crossref] [PubMed]

Cell Biochem. Biophys. (1)

S. Raj, M. Wojdyla, and D. Petrov, “Studying single red blood cells under a tunable external force by combining passive microrheology with Raman spectroscopy,” Cell Biochem. Biophys. 65(3), 347–361 (2013).
[Crossref] [PubMed]

Clin. Chem. Lab. Med. (1)

M. Franchini and G. M. Liumbruno, “ABO blood group: old dogma, new perspectives,” Clin. Chem. Lab. Med. 51(8), 1545–1553 (2013).
[PubMed]

Clin. Chim. Acta (1)

M. Franchini and C. Bonfanti, “Evolutionary aspects of ABO blood group in humans,” Clin. Chim. Acta 444, 66–71 (2015).
[Crossref] [PubMed]

Exp. Hematol. (1)

R. Liu, Z. Mao, D. L. Matthews, C.-S. Li, J. W. Chan, and N. Satake, “Novel single-cell functional analysis of red blood cells using laser tweezers Raman spectroscopy: Application for sickle cell disease,” Exp. Hematol. 41(7), 656–661 (2013).
[Crossref] [PubMed]

FEMS Microbiol. Lett. (1)

Z. Tao, G. Wang, X. Xu, Y. Yuan, X. Wang, and Y. Li, “Monitoring and rapid quantification of total carotenoids in Rhodotorula glutinis cells using laser tweezers Raman spectroscopy,” FEMS Microbiol. Lett. 314(1), 42–48 (2011).
[Crossref] [PubMed]

Immunohematology (1)

J. R. Storry and M. L. Olsson, “The ABO blood group system revisited: a review and update,” Immunohematology 25(2), 48–59 (2009).
[PubMed]

Int. J. Cancer (1)

Z. Huang, A. McWilliams, H. Lui, D. I. McLean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 107(6), 1047–1052 (2003).
[Crossref] [PubMed]

J. Appl. Phys. (1)

C. Xie, Y. Li, W. Tang, and R. J. Newton, “Study of dynamical process of heat denaturation in optically trapped single microorganisms by near-infrared Raman spectroscopy,” J. Appl. Phys. 94(9), 6138–6142 (2003).
[Crossref]

J. Biomed. Opt. (1)

R. Dasgupta, R. S. Verma, S. Ahlawat, A. Uppal, and P. K. Gupta, “Studies on erythrocytes in malaria infected blood sample with Raman optical tweezers,” J. Biomed. Opt. 16(7), 077009 (2011).
[Crossref] [PubMed]

J. Biophotonics (1)

J. W. Chan, “Recent advances in laser tweezers Raman spectroscopy (LTRS) for label-free analysis of single cells,” J. Biophotonics 6(1), 36–48 (2013).
[Crossref] [PubMed]

J. Opt. (1)

S. Fore, J. Chan, D. Taylor, and T. Huser, “Raman spectroscopy of individual monocytes reveals that single-beam optical trapping of mononuclear cells occurs by their nucleus,” J. Opt. 13(4), 044021 (2011).
[Crossref] [PubMed]

J. Raman Spectrosc. (2)

J. Deng, Q. Wei, M. Zhang, Y. Wang, and Y.-Q. Li, “Study of the effect of alcohol on single human red blood cells using near‐infrared laser tweezers Raman spectroscopy,” J. Raman Spectrosc. 36(3), 257–261 (2005).
[Crossref]

S. K. Teh, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, and Z. Huang, “Near‐infrared Raman spectroscopy for gastric precancer diagnosis,” J. Raman Spectrosc. 40(8), 908–914 (2009).
[Crossref]

Laser Phys. Lett. (1)

H. Huang, D. Lin, W. Chen, Y. Yu, J. Xu, Z. Liang, X. Lin, Z. Dong, and H. Shi, “Nondestructive discrimination between normal and hematological malignancy cell lines using near-infrared Raman spectroscopy and multivariate analysis,” Laser Phys. Lett. 11(8), 085601 (2014).
[Crossref]

Leg. Med. (Tokyo) (1)

N. Takada, C. Mori, M. Iida, R. Takai, T. Takayama, Y. Watanabe, K. Nakamura, and K. Takamizawa, “Development of an indirect competitive ELISA for the detection of ABO blood group antigens,” Leg. Med. (Tokyo) 16(3), 139–145 (2014).
[Crossref] [PubMed]

Nanomedicine (Lond.) (1)

Q. Tu and C. Chang, “Diagnostic applications of Raman spectroscopy,” Nanomedicine (Lond.) 8(5), 545–558 (2012).
[PubMed]

Opt. Express (1)

Opt. Lett. (1)

PLoS One (1)

A. Bankapur, E. Zachariah, S. Chidangil, M. Valiathan, and D. Mathur, “Raman tweezers spectroscopy of live, single red and white blood cells,” PLoS One 5(4), e10427 (2010).
[Crossref] [PubMed]

Sci. Rep. (1)

D. Lin, J. Pan, H. Huang, G. Chen, S. Qiu, H. Shi, W. Chen, Y. Yu, S. Feng, and R. Chen, “Label-free blood plasma test based on surface-enhanced Raman scattering for tumor stages detection in nasopharyngeal cancer,” Sci. Rep. 4, 4751 (2014).
[PubMed]

Vib. Spectrosc. (1)

J. Shao, H. Yao, L. Meng, Y. Li, M. Lin, X. Ii, J. Liu, and J. Liang, “Raman spectroscopy of circulating single red blood cells in microvessels in vivo,” Vib. Spectrosc. 63, 367–370 (2012).
[Crossref]

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Figures (4)

Fig. 1
Fig. 1 Schematic of the home-made laser tweezers Raman spectroscopy (LTRS) system. A 785 nm diode laser beam was delivered to an inverted microscope for both trapping RBCs and generating the Raman signals from cells. Backwards Raman scattering light was recorded by a back-illuminated, deep-depletion near-infrared intensified CCD. In this schematic, M: mirror; L: lens; PH: pinhole; BF: band pass filter; DM: dichroic mirror; MO: microscope objective; NF: notch filter.
Fig. 2
Fig. 2 Pair-comparison of normalized mean Raman spectra from Type A, Type B, Type AB and Type O RBCs samples. The shaded areas represent the standard deviations of the means. Also shown at the bottom is the difference spectrum.
Fig. 3
Fig. 3 Scatter plots of the posterior probabilities belonging to the ABO blood groups using the PCA-LDA together with leave-one-out and cross-validation method. Box represents the range of 25%-75%; Whisker represents the range of minimum to maximum. The diagnostic thresholds (dotted lines) are 0.484, 0.5, 0.395, 0.5, 0.442 and 0.061 for each combination.
Fig. 4
Fig. 4 Receiver operating characteristic (ROC) curves of classification results for ABO blood typing. AUC: the integration areas under the ROC curves.

Tables (2)

Tables Icon

Table 1 The Raman peak positions and tentative assignment of major vibrational bands observed in RBCs.

Tables Icon

Table 2 Classification results of the four blood types using RBCs LTRS combined with PCA-LDA algorithm.

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