Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • Journal of the Optical Society of Korea
  • Vol. 10,
  • Issue 3,
  • pp. 130-142
  • (2006)

Highly Sensitive Biological Analysis Using Optical Microfluidic Sensor

Open Access Open Access

Abstract

Lab-on-a-chip technology is attracting great interest because the miniaturization of reaction systems offers practical advantages over classical bench-top chemical systems. Rapid mixing of the fluids flowing through a microchannel is very important for various applications of microfluidic systems. In addition, highly sensitive on-chip detection techniques are essential for the in situ monitoring of chemical reactions because the detection volume in a channel is extremely small. Recently, a confocal surface enhanced Raman spectroscopic (SERS) technique, for the highly sensitive biological analysis in a microfluidic sensor, has been developed in our research group. Here, a highly precise quantitative measurement can be obtained if continuous flow and homogeneous mixing condition between analytes and silver nano-colloids are maintained. Recently, we also reported a new analytical method of DNA hybridization involving a PDMS microfluidic sensor using fluorescence energy transfer (FRET). This method overcomes many of the drawbacks of microarray chips, such as long hybridization times and inconvenient immobilization procedures. In this paper, our recent applications of the confocal Raman/fluorescence microscopic technology to a highly sensitive lab-on-a-chip detection will be reviewed.

© 2006 Optical Society of Korea

PDF Article
More Like This
Hybrid nanophotonic–microfluidic sensor for highly sensitive liquid and gas analyses

Aleksei Kuzin, Vasiliy Chernyshev, Vadim Kovalyuk, Pavel An, Alexander Golikov, Roman Ozhegov, Dmitry Gorin, Nikolay Gippius, and Gregory Goltsman
Opt. Lett. 47(9) 2358-2361 (2022)

Sensitive real-time monitoring of refractive indices and components using a microstructure optical fiber microfluidic sensor

Boyao Li, Zicheng Sheng, Meng Wu, Xinyu Liu, Guiyao Zhou, Jiantao Liu, Zhiyun Hou, and Changming Xia
Opt. Lett. 43(20) 5070-5073 (2018)

Photothermal microfluidic-assisted self-cleaning effect for a highly reusable SERS sensor

Shaojing Liu, Huiqing Zhong, Zongbao Li, Yu Xu, Xiaowen Hu, Zhidong Zheng, Liu Liu, Pengxin Chen, Xiang Cai, Xiaofang Jiang, Aiping Luo, Jianlin Huang, and Xiaobo Xing
Opt. Lett. 46(19) 4714-4717 (2021)

Cited By

Optica participates in Crossref's Cited-By Linking service. Citing articles from Optica Publishing Group journals and other participating publishers are listed here.


Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved