Abstract
Our previous study showed that switching the inhaled gas from hypoxic gas to hyperoxic gas for 10
minutes increased tumor oxygenation and that the magnitude of oxyhemoglobin increase responded earlier
than tumor volume change after chemotherapy. During 10 minutes of inhaled-oxygen modulation,
oxyhemoglobin concentration first shows a rapid increase and then a slow but gradual increase, which has
been fitted with a double-exponential equation in this study. Two amplitude values, amplitudes 1 and 2,
respectively represent the magnitudes of rapid and slow increase of oxyhemoglobin. The trends of changes
in amplitudes 1 and 2 were different, depending on tumor volume when chemotherapy started. However, both
amplitudes 1 and 2 changed earlier than tumor volume, regardless of when chemotherapy was initiated.
These results imply that by observing amplitude 1 changes post chemotherapy, we can reduce the time of a
respiratory challenge from 10 minutes to less than 2 minutes, to see the chemotherapy response. We
believe that by reducing the time of the respiratory challenge, we have taken a step forward to
translating our previous study into clinical application.
© 2018 Optical Society of Korea
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