Mid-infrared Lasers for Medical Applications: introduction to the feature issue

Fatima Toor, Stuart Jackson, Xiaoming Shang, Shamsul Arafin, and Haining Yang

Biomed. Opt. Express 9(12), 6255-6257 (2018)  View: HTML | PDF

Characterizing stratum corneum structure, barrier function, and chemical content of human skin with coherent Raman scattering imaging

Sam Osseiran, Jomer Dela Cruz, Sinyoung Jeong, Hequn Wang, Christina Fthenakis, and Conor L. Evans

Biomed. Opt. Express 9(12), 6425-6443 (2018)  View: HTML | PDF

Multi-wavelength, en-face photoacoustic microscopy and optical coherence tomography imaging for early and selective detection of laser induced retinal vein occlusion

Van Phuc Nguyen, Yanxiu Li, Wei Zhang, Xueding Wang, and Yannis M. Paulus

Biomed. Opt. Express 9(12), 5915-5938 (2018)  View: HTML | PDF  [Suppl. Mat. (3)]

Within-subject assessment of foveal avascular zone enlargement in different stages of diabetic retinopathy using en face OCT reflectance and OCT angiography

Giselle Lynch, Jorge S. Andrade Romo, Rachel Linderman, Brian D. Krawitz, Shelley Mo, Amir Zakik, Joseph Carroll, Richard B. Rosen, and Toco Y. P. Chui

Biomed. Opt. Express 9(12), 5982-5996 (2018)  View: HTML | PDF

Attenuation correction assisted automatic segmentation for assessing choroidal thickness and vasculature with swept-source OCT

Hao Zhou, Zhongdi Chu, Qinqin Zhang, Yining Dai, Giovanni Gregori, Philip J. Rosenfeld, and Ruikang K. Wang

Biomed. Opt. Express 9(12), 6067-6080 (2018)  View: HTML | PDF

Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging

Jia-Pu Syu, Waradee Buddhakosai, Shih-Jen Chen, Chang-Chih Ke, Shih-Hwa Chiou, and Wen-Chuan Kuo

Biomed. Opt. Express 9(12), 6132-6144 (2018)  View: HTML | PDF  [Suppl. Mat. (2)]

Clinical feasibility of optical coherence micro-elastography for imaging tumor margins in breast-conserving surgery

Wes M. Allen, Ken Y. Foo, Renate Zilkens, Kelsey M. Kennedy, Qi Fang, Lixin Chin, Benjamin F. Dessauvagie, Bruce Latham, Christobel M. Saunders, and Brendan F. Kennedy

Biomed. Opt. Express 9(12), 6331-6349 (2018)  View: HTML | PDF  [Suppl. Mat. (5)]

Maximum value projection produces better en face OCT angiograms than mean value projection

Tristan T. Hormel, Jie Wang, Steven T. Bailey, Thomas S. Hwang, David Huang, and Yali Jia

Biomed. Opt. Express 9(12), 6412-6424 (2018)  View: HTML | PDF

Introduction to the Biophotonics Congress 2018 feature issue

Daniel Razansky, Spencer L. Smith, Michael Giacomelli, Christine P. Hendon, and Ronald Sroka

Biomed. Opt. Express 9(12), 6398-6399 (2018)  View: HTML | PDF

Live-cell imaging of human spermatozoa using structured illumination microscopy

Ida S. Opstad, Daria A. Popova, Ganesh Acharya, Purusotam Basnet, and Balpreet S. Ahluwalia

Biomed. Opt. Express 9(12), 5939-5945 (2018)  View: HTML | PDF

Full-scale Raman imaging for dental caries detection

Emmanuel Yakubu, Bolan Li, Yuanyuan Duan, and Shan Yang

Biomed. Opt. Express 9(12), 6009-6016 (2018)  View: HTML | PDF

Hyperspectral wide-field time domain single-pixel diffuse optical tomography platform

Qi Pian, Ruoyang Yao, and Xavier Intes

Biomed. Opt. Express 9(12), 6258-6272 (2018)  View: HTML | PDF

Dual-display laparoscopic laser speckle contrast imaging for real-time surgical assistance

Corey Zheng, Lung Wai Lau, and Jaepyeong Cha

Biomed. Opt. Express 9(12), 5962-5981 (2018)  View: HTML | PDF  [Suppl. Mat. (4)]

Sensitive light-sheet microscopy in multiwell plates using an AFM cantilever

Aleks Ponjavic, Yu Ye, Ernest Laue, Steven F. Lee, and David Klenerman

Biomed. Opt. Express 9(12), 5863-5880 (2018)  View: HTML | PDF  [Suppl. Mat. (2)]

Improving resolution of second harmonic generation microscopy via scanning structured illumination

Chia-Hua Yeh, Cheng-Zn Tan, Ching-hsiao Arthur Cheng, Jui-Ting Hung, and Szu-Yu Chen

Biomed. Opt. Express 9(12), 6081-6090 (2018)  View: HTML | PDF

Broadband hyperspectral stimulated Raman scattering microscopy with a parabolic fiber amplifier source

Benjamin Figueroa, Walter Fu, Tai Nguyen, Kseniya Shin, Bryce Manifold, Frank Wise, and Dan Fu

Biomed. Opt. Express 9(12), 6116-6131 (2018)  View: HTML | PDF

All-optical imaging and manipulation of whole-brain neuronal activities in behaving larval zebrafish

Zhen-Fei Jiao, Chun-Feng Shang, Yu-Fan Wang, Zhe Yang, Chen Yang, Fu-Ning Li, Jin-Ze Xie, Jing-Wei Pan, Ling Fu, and Jiu-Lin Du

Biomed. Opt. Express 9(12), 6154-6169 (2018)  View: HTML | PDF

Wavelength agile multi-photon microscopy with a fiber amplified diode laser

Matthias Eibl, Daniel Weng, Hubertus Hakert, Jan Philip Kolb, Tom Pfeiffer, Jennifer E. Hundt, Robert Huber, and Sebastian Karpf

Biomed. Opt. Express 9(12), 6273-6282 (2018)  View: HTML | PDF

Polarization-resolved second harmonic microscopy of skeletal muscle in sepsis

Matthieu Dubreuil, Florine Tissier, Lucas Le Roy, Jean-Pierre Pennec, Sylvain Rivet, Marie-Agnès Giroux-Metges, and Yann Le Grand

Biomed. Opt. Express 9(12), 6350-6358 (2018)  View: HTML | PDF

High-speed extended-volume blood flow measurement using engineered point-spread function

Yongzhuang Zhou, Vytautas Zickus, Paul Zammit, Jonathan M. Taylor, and Andrew R. Harvey

Biomed. Opt. Express 9(12), 6444-6454 (2018)  View: HTML | PDF  [Suppl. Mat. (4)]

Computational multifocal microscopy

Kuan He, Zihao Wang, Xiang Huang, Xiaolei Wang, Seunghwan Yoo, Pablo Ruiz, Itay Gdor, Alan Selewa, Nicola J. Ferrier, Norbert Scherer, Mark Hereld, Aggelos K. Katsaggelos, and Oliver Cossairt

Biomed. Opt. Express 9(12), 6477-6496 (2018)  View: HTML | PDF  [Suppl. Mat. (2)]

In vivo label-free confocal imaging of the deep mouse brain with long-wavelength illumination

Fei Xia, Chunyan Wu, David Sinefeld, Bo Li, Yifan Qin, and Chris Xu

Biomed. Opt. Express 9(12), 6545-6555 (2018)  View: HTML | PDF  [Suppl. Mat. (1)]

Ultrafast polarization bio-imaging based on coherent detection and time-stretch techniques

Lu Song, Yuanhua Feng, Xiaojie Guo, Yuecheng Shen, Daixuan Wu, Zhenhua Wu, Congran Zhou, Linyan Zhu, Shecheng Gao, Weiping Liu, Xuming Zhang, and Zhaohui Li

Biomed. Opt. Express 9(12), 6556-6568 (2018)  View: HTML | PDF

Enhanced Cerenkov luminescence tomography analysis based on Y₂O₃:Eu³⁺ rare earth oxide nanoparticles

Yongheng Gao, Xiaowei Ma, Fei Kang, Weidong Yang, Yi Liu, Zhengjie Wang, Wenhui Ma, Zhe Wang, Guoquan Li, Xu Cao, and Jing Wang

Biomed. Opt. Express 9(12), 6091-6102 (2018)  View: HTML | PDF

Assessment of microvasculature flow state with a high speed all-optic dual-modal system of optical coherence tomography and photoacoustic imaging

Zhenhe Ma, Shuzhuo Luo, Menghan Yu, Jian Liu, Yuqian Zhao, Yao Yu, Jiangtao Lv, Xiaofang Zhang, and Yi Wang

Biomed. Opt. Express 9(12), 6103-6115 (2018)  View: HTML | PDF

Retinal optical coherence tomography image enhancement via deep learning

Kerry J. Halupka, Bhavna J. Antony, Matthew H. Lee, Katie A. Lucy, Ravneet S. Rai, Hiroshi Ishikawa, Gadi Wollstein, Joel S. Schuman, and Rahil Garnavi

Biomed. Opt. Express 9(12), 6205-6221 (2018)  View: HTML | PDF

Cluster-based filtering framework for speckle reduction in OCT images

M. Hossein Eybposh, Zahra Turani, Darius Mehregan, and Mohammadreza Nasiriavanaki

Biomed. Opt. Express 9(12), 6359-6373 (2018)  View: HTML | PDF

Smart laser osteotomy: integrating a pulsed 1064nm fiber laser into the sample arm of a fiber optic 1310nm OCT system for ablation monitoring

Jamil Jivraj, Chaoliang Chen, Yize Huang, Joel Ramjist, Yi Lu, Barry Vuong, Xijia Gu, and Victor X. D. Yang

Biomed. Opt. Express 9(12), 6374-6387 (2018)  View: HTML | PDF

Assessing the biomechanical properties of the porcine crystalline lens as a function of intraocular pressure with optical coherence elastography

Chen Wu, Salavat R. Aglyamov, Zhaolong Han, Manmohan Singh, Chih-Hao Liu, and Kirill V. Larin

Biomed. Opt. Express 9(12), 6455-6466 (2018)  View: HTML | PDF

Active contour method for ILM segmentation in ONH volume scans in retinal OCT

Kay Gawlik, Frank Hausser, Friedemann Paul, Alexander U. Brandt, and Ella Maria Kadas

Biomed. Opt. Express 9(12), 6497-6518 (2018)  View: HTML | PDF

Complementary use of polarization-sensitive and standard OCT metrics for enhanced intraoperative differentiation of breast cancer

Jianfeng Wang, Yang Xu, Kelly J. Mesa, Fredrick A. South, Eric J. Chaney, Darold R. Spillman, Ronit Barkalifa, Marina Marjanovic, P. Scott Carney, Anna M. Higham, Z. George Liu, and Stephen A. Boppart

Biomed. Opt. Express 9(12), 6519-6528 (2018)  View: HTML | PDF

Buffer-averaging super-continuum source based spectral domain optical coherence tomography for high speed imaging

Chaoliang Chen, Weisong Shi, Robnier Reyes, and Victor X. D. Yang

Biomed. Opt. Express 9(12), 6529-6544 (2018)  View: HTML | PDF

250 kHz, 1.5 µm resolution SD-OCT for in-vivo cellular imaging of the human cornea

Bingyao Tan, Zohreh Hosseinaee, Le Han, Olivera Kralj, Luigina Sorbara, and Kostadinka Bizheva

Biomed. Opt. Express 9(12), 6569-6583 (2018)  View: HTML | PDF

Multidimensional thermal mapping during radiofrequency ablation treatments with minimally invasive fiber optic sensors

Giovanna Palumbo, Elena De Vita, Emiliano Schena, Carlo Massaroni, Paolo Verze, Nicola Carlomagno, Vincenzo Tammaro, Roberto La Rocca, Juliet Ippolito, Daniele Tosi, Paola Saccomandi, Michele Arturo Caponero, Agostino Iadicicco, and Stefania Campopiano

Biomed. Opt. Express 9(12), 5891-5902 (2018)  View: HTML | PDF

On the spectral signature of melanoma: a non-parametric classification framework for cancer detection in hyperspectral imaging of melanocytic lesions

Arturo Pardo, José A. Gutiérrez-Gutiérrez, I. Lihacova, José M. López-Higuera, and Olga M. Conde

Biomed. Opt. Express 9(12), 6283-6301 (2018)  View: HTML | PDF

Cardiac pulsatility mapping and vessel type identification using laser speckle contrast imaging

Dmitry D. Postnov, Sefik Evren Erdener, Kivilcim Kilic, and David A. Boas

Biomed. Opt. Express 9(12), 6388-6397 (2018)  View: HTML | PDF

Multipoint fluorescence correlation spectroscopy using spatial light modulator

Johtaro Yamamoto, Shintaro Mikuni, and Masataka Kinjo

Biomed. Opt. Express 9(12), 5881-5890 (2018)  View: HTML | PDF  [Suppl. Mat. (4)]

THz in vivo measurements: the effects of pressure on skin reflectivity

Jiarui Wang, Rayko I. Stantchev, Qiushuo Sun, Tor-Wo Chiu, Anil T. Ahuja, and Emma Pickwell MacPherson

Biomed. Opt. Express 9(12), 6467-6476 (2018)  View: HTML | PDF

Scattering-independent glucose absorption measurement using a spectrally resolved reflectance setup with specialized variable source-detector separations

Jin Liu, Caigang Zhu, Jingying Jiang, and Kexin Xu

Biomed. Opt. Express 9(12), 5903-5914 (2018)  View: HTML | PDF

Quantitative real-time pulse oximetry with ultrafast frequency-domain diffuse optics and deep neural network processing

Yanyu Zhao, Mattew B. Applegate, Raeef Istfan, Ashvin Pande, and Darren Roblyer

Biomed. Opt. Express 9(12), 5997-6008 (2018)  View: HTML | PDF  [Suppl. Mat. (1)]

Label-free detection of nasopharyngeal and liver cancer using surface-enhanced Raman spectroscopy and partial lease squares combined with support vector machine

Yun Yu, Yating Lin, Chaoxian Xu, Kecan Lin, Qing Ye, Xiaoyan Wang, Shusen Xie, Rong Chen, and Juqiang Lin

Biomed. Opt. Express 9(12), 6053-6066 (2018)  View: HTML | PDF

Approaches to denoise the diffuse optical signals for tissue blood flow measurement

Peng Zhang, Zhiguo Gui, GuoDong Guo, and Yu Shang

Biomed. Opt. Express 9(12), 6170-6185 (2018)  View: HTML | PDF

In vivo near-infrared autofluorescence imaging of retinal pigment epithelial cells with 757 nm excitation

Kate Grieve, Elena Gofas-Salas, R. Daniel Ferguson, José Alain Sahel, Michel Paques, and Ethan A. Rossi

Biomed. Opt. Express 9(12), 5946-5961 (2018)  View: HTML | PDF

Long eye relief fundus camera and fixation target with partial correction of ocular longitudinal chromatic aberration

Samuel Steven, Yusufu N. Sulai, Soon K. Cheong, Julie Bentley, and Alfredo Dubra

Biomed. Opt. Express 9(12), 6017-6037 (2018)  View: HTML | PDF

Open-source, machine and deep learning-based automated algorithm for gestational age estimation through smartphone lens imaging

Arjun D. Desai, Chunlei Peng, Leyuan Fang, Dibyendu Mukherjee, Andrew Yeung, Stephanie J. Jaffe, Jennifer B. Griffin, and Sina Farsiu

Biomed. Opt. Express 9(12), 6038-6052 (2018)  View: HTML | PDF

Reconstructing a 3D heart surface with stereo-endoscope by learning eigen-shapes

Bo Yang, Chao Liu, Wenfeng Zheng, Shan Liu, and Keli Huang

Biomed. Opt. Express 9(12), 6222-6236 (2018)  View: HTML | PDF  [Suppl. Mat. (4)]

Time-resolved quantitative inter-eye comparison of cardiac cycle-induced blood volume changes in the human retina

Ralf-Peter Tornow, Jan Odstrcilik, and Radim Kolar

Biomed. Opt. Express 9(12), 6237-6254 (2018)  View: HTML | PDF  [Suppl. Mat. (3)]

Experimental validations of a tunable-lens-based visual demonstrator of multifocal corrections

Vyas Akondi, Lucie Sawides, Yassine Marrakchi, Enrique Gambra, Susana Marcos, and Carlos Dorronsoro

Biomed. Opt. Express 9(12), 6302-6317 (2018)  View: HTML | PDF

Differential detection of retinal directionality

Salihah Qaysi, Denise Valente, and Brian Vohnsen

Biomed. Opt. Express 9(12), 6318-6330 (2018)  View: HTML | PDF  [Suppl. Mat. (2)]