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1 April 2021, Volume 12, Issue 4, pp. 1774-2549  
50 articles

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Measuring glucose concentration in a solution based on the indices of polarimetric purity

Dekui Li, Chenxiang Xu, Man Zhang, Xinyang Wang, Kai Guo, Yongxuan Sun, Jun Gao, and Zhongyi Guo

Biomed. Opt. Express 12(4), 2447-2459 (2021)  View: HTML | PDF

Auto-detection of cervical collagen and elastin in Mueller matrix polarimetry microscopic images using K-NN and semantic segmentation classification

Camilo Roa, V. N. Du Le, Mala Mahendroo, Ilyas Saytashev, and Jessica C. Ramella-Roman

Biomed. Opt. Express 12(4), 2236-2249 (2021)  View: HTML | PDF

Photoacoustic dual-scan mammoscope: results from 38 patients

Nikhila Nyayapathi, Huijuan Zhang, Emily Zheng, Srinidhi Nagarajan, Ermelinda Bonaccio, Kazuaki Takabe, Xinhao C. Fan, and Jun Xia

Biomed. Opt. Express 12(4), 2054-2063 (2021)  View: HTML | PDF

Photoacoustic-guided surgery from head to toe [Invited]

Alycen Wiacek and Muyinatu A. Lediju Bell

Biomed. Opt. Express 12(4), 2079-2117 (2021)  View: HTML | PDF

Photoacoustic tomography reconstruction using lag-based delay multiply and sum with a coherence factor improves in vivo ovarian cancer diagnosis

Guang Yang, Eghbal Amidi, and Quing Zhu

Biomed. Opt. Express 12(4), 2250-2263 (2021)  View: HTML | PDF

Development of a multi-functional preclinical device for the treatment of glioblastoma

Khaled Metwally, Chiara Bastiancich, Florian Correard, Anthony Novell, Samantha Fernandez, Benjamin Guillet, Benoit Larrat, Serge Mensah, Marie-Anne Estève, and Anabela Da Silva

Biomed. Opt. Express 12(4), 2264-2279 (2021)  View: HTML | PDF

Photoacoustic imaging of the spatial distribution of oxygen saturation in an ischemia-reperfusion model in humans

Aboma Merdasa, Josefine Bunke, Magdalena Naumovska, John Albinsson, Tobias Erlöv, Magnus Cinthio, Nina Reistad, Rafi Sheikh, and Malin Malmsjö

Biomed. Opt. Express 12(4), 2484-2495 (2021)  View: HTML | PDF

Editors' Pick

Smartphone-based optical spectroscopic platforms for biomedical applications: a review [Invited]

Iftak Hussain and Audrey K. Bowden

Biomed. Opt. Express 12(4), 1974-1998 (2021)  View: HTML | PDF

Editors' Pick

In-vivo mechanical characterization of coronary atherosclerotic plaques in living swine using intravascular laser speckle imaging

Zeinab Hajjarian, Jimmy D. Toussaint, J. Luis Guerrero, and Seemantini K. Nadkarni

Biomed. Opt. Express 12(4), 2064-2078 (2021)  View: HTML | PDF

Real-time brain-wide multi-planar microscopy for simultaneous cortex and hippocampus imaging at the cellular resolution in mice

Chaowei Zhuang, Jiangbei Cao, Rujin Zhang, Guihua Xiao, Jing Hu, Hao Xie, and Qionghai Dai

Biomed. Opt. Express 12(4), 1858-1868 (2021)  View: HTML | PDF

Limited-angle tomographic phase microscopy utilizing confocal scanning fluorescence microscopy

Rongli Guo, Itay Barnea, and Natan T. Shaked

Biomed. Opt. Express 12(4), 1869-1881 (2021)  View: HTML | PDF  [Suppl. Mat. (8)]

Displacement and strain mapping for osteocytes under fluid shear stress using digital holographic microscopy and digital image correlation

Runyu Cao, Wen Xiao, Feng Pan, Ran Tian, Xintong Wu, and Lianwen Sun

Biomed. Opt. Express 12(4), 1922-1933 (2021)  View: HTML | PDF  [Suppl. Mat. (3)]

Investigating tunneling nanotubes in ovarian cancer based on two-photon excitation FLIM-FRET

Shiqi Wang, Yanping Li, Yihua Zhao, Fangrui Lin, Junle Qu, and Liwei Liu

Biomed. Opt. Express 12(4), 1962-1973 (2021)  View: HTML | PDF  [Suppl. Mat. (3)]

Dual-view light-sheet imaging through a tilted glass interface using a deformable mirror

Nikita Vladimirov, Friedrich Preusser, Jan Wisniewski, Ziv Yaniv, Ravi Anand Desai, Andrew Woehler, and Stephan Preibisch

Biomed. Opt. Express 12(4), 2186-2203 (2021)  View: HTML | PDF  [Suppl. Mat. (2)]

Computational tissue staining of non-linear multimodal imaging using supervised and unsupervised deep learning

Pranita Pradhan, Tobias Meyer, Michael Vieth, Andreas Stallmach, Maximilian Waldner, Michael Schmitt, Juergen Popp, and Thomas Bocklitz

Biomed. Opt. Express 12(4), 2280-2298 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Open-top axially swept light-sheet microscopy

Bumju Kim, Myeongsu Na, Soohyun Park, Kitae Kim, Jung-Hoon Park, Euiheon Chung, Sunghoe Chang, and Ki Hean Kim

Biomed. Opt. Express 12(4), 2328-2338 (2021)  View: HTML | PDF

Single-scan HiLo with line-illumination strategy for optical section imaging of thick tissues

Wei Qiao, Rui Jin, Tianpeng Luo, Yafeng Li, Guoqing Fan, Qingming Luo, and Jing Yuan

Biomed. Opt. Express 12(4), 2373-2383 (2021)  View: HTML | PDF

Synchronously pumped Raman laser for simultaneous degenerate and nondegenerate two-photon microscopy

Michael L. Buttolph, Menansili A. Mejooli, Pavel Sidorenko, Chi-Yong Eom, Chris B. Schaffer, and Frank W. Wise

Biomed. Opt. Express 12(4), 2496-2507 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Anti-HER2 PLGA-PEG polymer nanoparticle containing gold nanorods and paclitaxel for laser-activated breast cancer detection and therapy

Yanjie Wang, Maurice Pasternak, Krishnan Sathiyamoorthy, and Michael C. Kolios

Biomed. Opt. Express 12(4), 2171-2185 (2021)  View: HTML | PDF  [Suppl. Mat. (3)]

Understanding the sources of errors in ex vivo Hsp90 molecular imaging for rapid-on-site breast cancer diagnosis

Roujia Wang, Daniel A. Alvarez, Brian T. Crouch, Aditi Pilani, Christopher Lam, Caigang Zhu, Philip Hughes, David Katz, Timothy Haystead, and Nirmala Ramanujam

Biomed. Opt. Express 12(4), 2299-2311 (2021)  View: HTML | PDF

Multi-spectral intravascular photoacoustic/ultrasound/optical coherence tomography tri-modality system with a fully-integrated 0.9-mm full field-of-view catheter for plaque vulnerability imaging

Ji Leng, Jinke Zhang, Chenguang Li, Chengyou Shu, Boquan Wang, Riqiang Lin, Yanmei Liang, Keqiang Wang, Li Shen, Kwok-ho Lam, Zhihua Xie, Xiaojing Gong, Junbo Ge, and Liang Song

Biomed. Opt. Express 12(4), 1934-1946 (2021)  View: HTML | PDF

Digital holographic microscopy evaluation of dynamic cell response to electroporation

Violeta L. Calin, Mona Mihailescu, Nicolae Tarba, Ana Maria Sandu, Eugen Scarlat, Mihaela G. Moisescu, and Tudor Savopol

Biomed. Opt. Express 12(4), 2519-2530 (2021)  View: HTML | PDF  [Suppl. Mat. (5)]

Waveguide-based absorption measurement system for visible wavelength applications

P. Neutens, R. Jansen, G. Woronoff, M. Rutowska, N. Hosseini, F. Buja, A. Humbert, F. Colle, T. Stakenborg, and W. Van Roy

Biomed. Opt. Express 12(4), 2041-2053 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice

Conrad W. Merkle, Marco Augustin, Danielle J. Harper, Johanna Gesperger, Antonia Lichtenegger, Pablo Eugui, Gerhard Garhöfer, Martin Glösmann, and Bernhard Baumann

Biomed. Opt. Express 12(4), 1774-1791 (2021)  View: HTML | PDF  [Suppl. Mat. (2)]

Fast OCT image enhancement method based on the sigmoid-energy conservation equation

Shiliang Lou, Xiaodong Chen, Jing Liu, Yu Shi, Hui Qu, Yi Wang, and Huaiyu Cai

Biomed. Opt. Express 12(4), 1792-1803 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Quantitative analysis of vascular changes during photoimmunotherapy using speckle variance optical coherence tomography (SV-OCT)

Shulian Wu, Ryuhei Okada, Yi Liu, Yuhong Fang, Feng Yan, Chen Wang, Hui Li, Hisataka Kobayashi, Yu Chen, and Qinggong Tang

Biomed. Opt. Express 12(4), 1804-1820 (2021)  View: HTML | PDF

Static compression optical coherence elastography to measure the mechanical properties of soft contact lenses

Zachery Quince, David Alonso-Caneiro, Scott A. Read, and Michael J. Collins

Biomed. Opt. Express 12(4), 1821-1833 (2021)  View: HTML | PDF

Method for parametric imaging of attenuation by intravascular optical coherence tomography

Sun Zheng, Yang Fei, and Sun Jian

Biomed. Opt. Express 12(4), 1882-1904 (2021)  View: HTML | PDF

Real-time noise reduction based on ground truth free deep learning for optical coherence tomography

Yong Huang, Nan Zhang, and Qun Hao

Biomed. Opt. Express 12(4), 2027-2040 (2021)  View: HTML | PDF  [Suppl. Mat. (3)]

Long-range optical coherence tomography with extended depth-of-focus: a visual feedback system for smart laser osteotomy

Arsham Hamidi, Yakub A. Bayhaqi, Ferda Canbaz, Alexander A. Navarini, Philippe C. Cattin, and Azhar Zam

Biomed. Opt. Express 12(4), 2118-2133 (2021)  View: HTML | PDF

In vivo quantitative analysis of anterior chamber white blood cell mixture composition using spectroscopic optical coherence tomography

Ruobing Qian, Ryan P. McNabb, Kevin C. Zhou, Hazem M. Mousa, Daniel R. Saban, Victor L. Perez, Anthony N. Kuo, and Joseph A. Izatt

Biomed. Opt. Express 12(4), 2134-2148 (2021)  View: HTML | PDF

Model-based optical coherence tomography angiography enables motion-insensitive vascular imaging

Wei Wei, Andrea Cogliati, and Cristina Canavesi

Biomed. Opt. Express 12(4), 2149-2170 (2021)  View: HTML | PDF

Multi-scale GCN-assisted two-stage network for joint segmentation of retinal layers and discs in peripapillary OCT images

Jiaxuan Li, Peiyao Jin, Jianfeng Zhu, Haidong Zou, Xun Xu, Min Tang, Minwen Zhou, Yu Gan, Jiangnan He, Yuye Ling, and Yikai Su

Biomed. Opt. Express 12(4), 2204-2220 (2021)  View: HTML | PDF

Weakly supervised serous retinal detachment segmentation in SD-OCT images by two-stage learning

Ruiwen Xing, Sijie Niu, Xizhan Gao, Tingting Liu, Wen Fan, and Yuehui Chen

Biomed. Opt. Express 12(4), 2312-2327 (2021)  View: HTML | PDF

Quantitative spectroscopic comparison of the optical properties of mouse cochlea microstructures using optical coherence tomography at 1.06 µm and 1.3 µm wavelengths

Ting-Yen Tsai, Ting-Hao Chen, Hsin-Chien Chen, Chuan-Bor Chueh, Yin-Peng Huang, Yi-Ping Hung, Meng-Tsan Tsai, Bernhard Baumann, Chih-Hung Wang, and Hsiang-Chieh Lee

Biomed. Opt. Express 12(4), 2339-2352 (2021)  View: HTML | PDF

Multi-MHz MEMS-VCSEL swept-source optical coherence tomography for endoscopic structural and angiographic imaging with miniaturized brushless motor probes

Jason Zhang, Tan Nguyen, Benjamin Potsaid, Vijaysekhar Jayaraman, Christopher Burgner, Siyu Chen, Jinxi Li, Kaicheng Liang, Alex Cable, Giovanni Traverso, Hiroshi Mashimo, and James G. Fujimoto

Biomed. Opt. Express 12(4), 2384-2403 (2021)  View: HTML | PDF

Deep-learning-aided forward optical coherence tomography endoscope for percutaneous nephrostomy guidance

Chen Wang, Paul Calle, Nu Bao Tran Ton, Zuyuan Zhang, Feng Yan, Anthony M. Donaldson, Nathan A. Bradley, Zhongxin Yu, Kar-ming Fung, Chongle Pan, and Qinggong Tang

Biomed. Opt. Express 12(4), 2404-2418 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Phase-stabilized complex-decorrelation angiography

Xiang Wei, Tristan T. Hormel, and Yali Jia

Biomed. Opt. Express 12(4), 2419-2431 (2021)  View: HTML | PDF

Graph-based rotational nonuniformity correction for localized compliance measurement in the human nasopharynx

Yusi Miao, Joseph J. Jing, and Zhongping Chen

Biomed. Opt. Express 12(4), 2508-2518 (2021)  View: HTML | PDF  [Suppl. Mat. (2)]

3-D compressed sensing optical coherence tomography using predictive coding

James P. McLean and Christine P. Hendon

Biomed. Opt. Express 12(4), 2531-2549 (2021)  View: HTML | PDF

Noninvasive and real-time monitoring of Au nanoparticle promoted cancer metastasis using in vivo flow cytometry

Wen Pang, Shihui Ding, Liyun Lin, Chen Wang, Man Lei, Jiale Xu, Xintong Wang, Junle Qu, Xunbin Wei, and Bobo Gu

Biomed. Opt. Express 12(4), 1846-1857 (2021)  View: HTML | PDF

Primary study of identification of parathyroid gland based on laser-induced breakdown spectroscopy

Qianqian Wang, Wenting Xiangli, Xiaohong Chen, Jinghong Zhang, Geer Teng, Xutai Cui, Bushra Sana Idrees, and Kai Wei

Biomed. Opt. Express 12(4), 1999-2014 (2021)  View: HTML | PDF

Combined autofluorescence and diffuse reflectance for brain tumour surgical guidance: initial ex vivo study results

Huihui Lu, Konstantin Grygoryev, Niamh Bermingham, Michael Jansen, Michael O’Sullivan, Gerard Nunan, Kevin Buckley, Kevin Manley, Ray Burke, and Stefan Andersson-Engels

Biomed. Opt. Express 12(4), 2432-2446 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Strip-based digital image registration for distortion minimization and robust eye motion measurement from scanned ophthalmic imaging systems

Min Zhang, Elena Gofas-Salas, Bianca T. Leonard, Yuhua Rui, Valerie C. Snyder, Hope M. Reecher, Pedro Mecê, and Ethan A. Rossi

Biomed. Opt. Express 12(4), 2353-2372 (2021)  View: HTML | PDF  [Suppl. Mat. (5)]

Axial accuracy and signal enhancement in acoustic-resolution photoacoustic microscopy by laser jitter effect correction and pulse energy compensation

Amir Asadollahi, Hamid Latifi, Manojit Pramanik, Hamed Qazvini, Ali Rezaei, Hamed Nikbakht, and Abolfazl Abedi

Biomed. Opt. Express 12(4), 1834-1845 (2021)  View: HTML | PDF

Terahertz pulses induce segment renewal via cell proliferation and differentiation overriding the endogenous regeneration program of the earthworm Eisenia andrei

Mahmoud H. Abufadda, Anita Erdélyi, Edit Pollák, Priyo S. Nugraha, János Hebling, József A. Fülöp, and László Molnár

Biomed. Opt. Express 12(4), 1947-1961 (2021)  View: HTML | PDF

Accuracy of homogeneous models for photon diffusion in estimating neonatal cerebral hemodynamics by TD-NIRS

Caterina Amendola, Lorenzo Spinelli, Davide Contini, Agnese De Carli, Cesare Martinelli, Monica Fumagalli, and Alessandro Torricelli

Biomed. Opt. Express 12(4), 1905-1921 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Clinical integration of fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma

Radu Boitor, Coen de Wolf, Frank Weesie, Dustin W. Shipp, Sandeep Varma, David Veitch, Aaron Wernham, Alexey Koloydenko, Gerwin Puppels, Tamar Nijsten, Hywel C. Williams, Peter Caspers, and Ioan Notingher

Biomed. Opt. Express 12(4), 2015-2026 (2021)  View: HTML | PDF  [Suppl. Mat. (1)]

Combination of pathological and spectroscopic characterization to promote diagnosis of retinal pigment epithelium-Bruch’s membrane complex in a diabetic rat model

Yang Chen, Ting Xie, Minlu Ye, Qiaoling Lai, Yuting Wang, Yunchao Xu, Wenyi Chen, Weidong Zheng, Shangyuan Feng, and Yan Huang

Biomed. Opt. Express 12(4), 2221-2235 (2021)  View: HTML | PDF

Iterative reconstruction algorithm based on discriminant adaptive-weighted TV regularization for fibrous biological tissues using in-line X-ray phase-contrast imaging

Mengting Zheng, Yuqing Zhao, Shuo Han, Dongjiang Ji, Yimin Li, Wenjuan Lv, Xiaohong Xin, Xinyan Zhao, and Chunhong Hu

Biomed. Opt. Express 12(4), 2460-2483 (2021)  View: HTML | PDF

article thumbnail

Vascular leakage in the mouse retina imaged with contrast-enhanced OCT before (left) and after (right) tracer injection. See Merkle et al. Optical Materials Express 12, 1774-1791 (2021).

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