The editors introduce the Biomedical Optics Express feature issue “Optical Molecular Probes, Imaging, and Drug Delivery,” which is associated with a Topical Meeting of the same name held at the 2013 Optical Society of America (OSA) Optics in the Life Sciences Congress in Waikoloa Beach, Hawaii, April 14-18, 2013. The international meeting focused on the convergence of optical physics, photonics technology, nanoscience, and photochemistry with drug discovery and clinical medicine. Papers in this feature issue are representative of meeting topics, including advances in microscopy, nanotechnology, and optics in cancer research.
© 2014 Optical Society of America
The 2013 Optical Society of America (OSA) Optics in the Life Sciences Congress included the second biennial offering of a Topical Meeting on “Optical Molecular Probes, Imaging, and Drug Delivery.” At the meeting, more than 50 papers were presented over four days in 14 scientific sessions, providing an excellent opportunity for researchers and engineers from academia and industry to communicate the most recent advances in this rapidly evolving field.
Topics presented at the OMP meeting included optical visualization and detection of biomolecular processes and pathways in living cells and tissues, novel reporters and contrast agents for fluorescence and bioluminescence imaging, advanced optical molecular imaging instrumentation for assays and pre-clinical models of disease, novel tools for image data analysis and reconstruction, optical monitoring of delivery, localization, and action of drugs and contrast agents, quantitative validation methods for optical molecular imaging, multi-modal molecular imaging techniques, and clinical translation of optical molecular imaging, spectroscopy, and image guided therapy.
The contents of this Biomedical Optics Express feature issue  exemplify several of the topics presented at the OMP meeting, with an emphasis on clinical translation. Novel instrumentation for optical molecular imaging is described for Second Harmonic Generation (SHG) microscopy coupled with polarization analysis , enabling rapid and accurate data collection using cost-effective components. For Raman-based instrumentation, a miniaturized lens assembly is presented that maintains high quality microscopy images while decreasing the size of coherent Raman scattering imaging probes . Different optical interferometric approaches to detect the presence and concentration of plasmonic nanoparticle contrast agents are described and compared quantitatively in . The feasibility of using immunolabeled gold nanorods (GNRs) to classify normal and malignant brain tissues is evaluated for application to tumor margin delineation during surgical procedures . Endoscopic NIR fluorescence imaging methods employing clinical-grade endoscopes and an NIR fluorophore-labeled monoclonal antibody are validated pre-clinically in . A study is reported using spectrally and temporally resolved endogenous fluorescence from biopsied tissue specimens to discriminate normal from diseased human tissues .
References and links
1. Biomedical Optics Express Feature Issue on Optical Molecular Probes, Imaging, and Drug Delivery, http://www.opticsinfobase.org/boe/virtual_issue.cfm?vid=218
2. C.-H. Lien, K. Tilbury, S.-J. Chen, and P. J. Campagnola, “Precise, motion-free polarization control in Second Harmonic Generation microscopy using a liquid crystal modulator in the infinity space,” Biomed. Opt. Express 4(10), 1991–2002 (2013). [CrossRef] [PubMed]
5. K. Seekell, S. Lewis, C. Wilson, S. Li, G. Grant, and A. Wax, “Feasibility study of brain tumor delineation using immunolabeled gold nanorods,” Biomed. Opt. Express 4(11), 2284–2295 (2013). [CrossRef] [PubMed]
6. P. B. Garcia-Allende, J. Glatz, M. Koch, J. J. Tjalma, E. Hartmans, A. G. T. Terwisscha van Scheltinga, P. Symvoulidis, G. M. van Dam, W. B. Nagengast, and V. Ntziachristos, “Towards clinically translatable NIR fluorescence molecular guidance for colonoscopy,” Biomed. Opt. Express 5(1), 78–92 (2014). [CrossRef] [PubMed]
7. S. Coda, A. J. Thompson, G. T. Kennedy, K. L. Roche, L. Ayaru, D. S. Bansi, G. W. Stamp, A. V. Thillainayagam, P. M. W. French, and C. Dunsby, “Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe,” Biomed. Opt. Express 5(2), 515–538 (2014). [CrossRef]