Abstract

We implemented a completely label-free biophysical (morphometric and optical) property characterization of living monocytes in flow, using measurements obtained from two coherent imaging techniques: a pure light scattering approach to obtain an optical signature (OS) of cells, and a digital holography (DH) approach to achieve optical cell reconstructions in flow. A precise 3D cell alignment platform, taking advantage of viscoelastic fluid properties and microfluidic channel geometry, was used to investigate the OS of cells to achieve their refractive index, ratio of the nucleus over cytoplasm, and overall cell dimension. Further quantitative phase-contrast reconstructions by DH were employed to calculate surface area, dry mass, and biovolume of monocytes by using the OS outcomes as input parameters. The results show significantly different biophysical cell properties, confirming the possibility to differentiate monocytes from other cell classes in flow, thus avoiding chemical cell staining or labeling, which are nowadays used.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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  38. G. Romeo, G. D’Avino, F. Greco, P. A. Netti, and P. L. Maffettone, “Viscoelastic flow-focusing in microchannels: scaling properties of the particle radial distributions,” Lab Chip 13(14), 2802–2807 (2013).
    [Crossref] [PubMed]
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  41. K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, and Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  43. G. P. Downey, D. E. Doherty, B. Schwab, E. L. Elson, P. M. Henson, and G. S. Worthen, “Retention of leukocytes in capillaries: role of cell size and deformability,” J. Appl. Physiol. 69(5), 1767–1778 (1990).
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    [Crossref]

2017 (5)

Y. Wolf, A. Shemer, M. Polonsky, M. Gross, A. Mildner, S. Yona, E. David, K. W. Kim, T. Goldmann, I. Amit, M. Heikenwalder, S. Nedospasov, M. Prinz, N. Friedman, and S. Jung, “Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation,” J. Exp. Med. 214(4), 905–917 (2017).
[Crossref] [PubMed]

L. Kastl, M. Isbach, D. Dirksen, J. Schnekenburger, and B. Kemper, “Quantitative phase imaging for cell culture quality control,” Cytometry A 91(5), 470–481 (2017).
[Crossref] [PubMed]

F. Merola, P. Memmolo, L. Miccio, R. Savoia, M. Mugnano, A. Fontana, G. D’Ippolito, A. Sardo, A. Iolascon, A. Gambale, and P. Ferraro, “Tomographic flow cytometry by digital holography,” Light Sci. Appl. 6(4), e16241 (2017).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, P. Memmolo, F. Causa, A. Finizio, P. Ferraro, and P. A. Netti, “Label-free analysis of mononuclear human blood cells in microfluidic flow by coherent imaging tools,” J. Biophotonics 10(5), 683–689 (2017).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, M. Ripaldi, P. A. Netti, and F. Causa, “Single-cell screening of multiple biophysical properties in leukemia diagnosis from peripheral blood by pure light scattering,” Sci. Rep. 7(1), 12666 (2017).
[Crossref] [PubMed]

2016 (5)

D. A. Arber, A. Orazi, R. Hasserjian, J. Thiele, M. J. Borowitz, M. M. Le Beau, C. D. Bloomfield, M. Cazzola, and J. W. Vardiman, “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia,” Blood 127(20), 2391–2405 (2016).
[PubMed]

M. Masaeli, D. Gupta, S. O’Byrne, H. T. K. Tse, D. R. Gossett, P. Tseng, A. S. Utada, H. J. Jung, S. Young, A. T. Clark, and D. Di Carlo, “Multiparameter mechanical and morphometric screening of cells,” Sci. Rep. 6(1), 37863 (2016).
[Crossref] [PubMed]

Z. Liu, W. Guo, D. Zhang, Y. Pang, J. Shi, S. Wan, K. Cheng, J. Wang, and S. Cheng, “Circulating tumor cell detection in hepatocellular carcinoma based on karyoplasmic ratios using imaging flow cytometry,” Sci. Rep. 6(1), 39808 (2016).
[Crossref] [PubMed]

C. H. Wu, T. D. Wang, C. H. Hsieh, S. H. Huang, J. W. Lin, S. C. Hsu, H. T. Wu, Y. M. Wu, and T. M. Liu, “Imaging Cytometry of human leukocytes with third harmonic generation microscopy,” Sci. Rep. 6(1), 37210 (2016).
[Crossref] [PubMed]

T. Blasi, H. Hennig, H. D. Summers, F. J. Theis, J. Cerveira, J. O. Patterson, D. Davies, A. Filby, A. E. Carpenter, and P. Rees, “Label-free cell cycle analysis for high-throughput imaging flow cytometry,” Nat. Commun. 7, 10256 (2016).
[Crossref] [PubMed]

2015 (8)

A. Forcucci, M. E. Pawlowski, C. Majors, R. Richards-Kortum, and T. S. Tkaczyk, “All-plastic, miniature, digital fluorescence microscope for three part white blood cell differential measurements at the point of care,” Biomed. Opt. Express 6(11), 4433–4446 (2015).
[Crossref] [PubMed]

J. Yoon, K. Kim, H. Park, C. Choi, S. Jang, and Y. Park, “Label-free characterization of white blood cells by measuring 3D refractive index maps,” Biomed. Opt. Express 6(10), 3865–3875 (2015).
[Crossref] [PubMed]

R. Pliquett, C. Linhart, C. Ulrich, and M. Grindt, “Role of systemic inflammation and monocyte activation in acutely-decompensated cardiorenal syndrome patients,” FASEB J. 29(1), 808 (2015).

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

L. Miccio, P. Memmolo, F. Merola, P. A. Netti, and P. Ferraro, “Red blood cell as an adaptive optofluidic microlens,” Nat. Commun. 6(1), 6502 (2015).
[Crossref] [PubMed]

S. V. Kesavan, F. Momey, O. Cioni, B. David-Watine, N. Dubrulle, S. Shorte, E. Sulpice, D. Freida, B. Chalmond, J. M. Dinten, X. Gidrol, and C. Allier, “High-throughput monitoring of major cell functions by means of lensfree video microscopy,” Sci. Rep. 4(1), 5942 (2015).
[Crossref] [PubMed]

F. Merola, P. Memmolo, L. Miccio, V. Bianco, M. Paturzo, and P. Ferraro, “Diagnostic tools for lab-on-chip applications based on coherent imaging microscopy,” Proc. IEEE 103(2), 192–204 (2015).
[Crossref]

P. Memmolo, L. Miccio, M. Paturzo, G. D. Caprio, G. Coppola, P. A. Netti, and P. Ferraro, “Recent advances in holographic 3D particle tracking,” Adv. Opt. Photonics 7(4), 713 (2015).
[Crossref]

2014 (8)

X. Yu, J. Hong, C. Liu, and M. K. Kim, “Review of digital holographic microscopy for three-dimensional profiling and tracking,” Opt. Eng. 53(11), 112306 (2014).
[Crossref]

R. A. Kellogg, R. Gómez-Sjöberg, A. A. Leyrat, and S. Tay, “High-throughput microfluidic single-cell analysis pipeline for studies of signaling dynamics,” Nat. Protoc. 9(7), 1713–1726 (2014).
[Crossref] [PubMed]

P. Memmolo, L. Miccio, F. Merola, O. Gennari, P. A. Netti, and P. Ferraro, “3D morphometry of red blood cells by digital holography,” Cytometry A 85(12), 1030–1036 (2014).
[Crossref] [PubMed]

D. Dannhauser, G. Romeo, F. Causa, I. De Santo, and P. A. Netti, “Multiplex single particle analysis in microfluidics,” Analyst (Lond.) 139(20), 5239–5246 (2014).
[Crossref] [PubMed]

W. Osten, A. Faridian, P. Gao, K. Körner, D. Naik, G. Pedrini, A. K. Singh, M. Takeda, and M. Wilke, “Recent advances in digital holography [invited],” Appl. Opt. 53(27), G44–G63 (2014).
[Crossref] [PubMed]

P. Hu, H. Shen, G. Wang, P. Zhang, Q. Liu, and J. Du, “Prognostic significance of systemic inflammation-based lymphocyte- monocyte ratio in patients with lung cancer: based on a large cohort study,” PLoS One 9(9), e108062 (2014).
[Crossref] [PubMed]

G. Musumeci, “Past, present and future: overview on histology and histopathology,” Journal of Histology and Histopathology 1(1), 5 (2014).
[Crossref]

L. Ziegler-Heitbrock, “Monocyte subsets in man and other species,” Cell. Immunol. 289(1-2), 135–139 (2014).
[Crossref] [PubMed]

2013 (4)

S. M. Daly and M. J. Leahy, “‘Go with the flow ’: a review of methods and advancements in blood flow imaging,” J. Biophotonics 6(3), 217–255 (2013).
[Crossref] [PubMed]

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
[Crossref]

G. Romeo, G. D’Avino, F. Greco, P. A. Netti, and P. L. Maffettone, “Viscoelastic flow-focusing in microchannels: scaling properties of the particle radial distributions,” Lab Chip 13(14), 2802–2807 (2013).
[Crossref] [PubMed]

K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, and Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
[Crossref] [PubMed]

2012 (3)

K. Kim and Y. Park, “Fourier transform light scattering angular spectroscopy using digital inline holography,” Opt. Lett. 37(19), 4161–4163 (2012).
[Crossref] [PubMed]

S. A. Arpali, C. Arpali, A. F. Coskun, H. H. Chiang, and A. Ozcan, “High-throughput screening of large volumes of whole blood using structured illumination and fluorescent on-chip imaging,” Lab Chip 12(23), 4968–4971 (2012).
[Crossref] [PubMed]

D. Min, B. Brooks, J. Wong, R. Salomon, W. Bao, B. Harrisberg, S. M. Twigg, D. K. Yue, and S. V. McLennan, “Alterations in monocyte CD16 in association with diabetes complications,” Mediators Inflamm. 2012, 649083 (2012).
[Crossref] [PubMed]

2011 (1)

M. A. Yurkin and A. G. Hoekstra, “The discrete-dipole-approximation code ADDA: Capabilities and known limitations,” J. Quant. Spectrosc. Radiat. Transf. 112(13), 2234–2247 (2011).
[Crossref]

2010 (2)

M. K. Kim, “Principles and techniques of digital holographic microscopy,” SPIE Rev. 1(1), 018005 (2010)

S. Seo, S. O. Isikman, I. Sencan, O. Mudanyali, T. W. Su, W. Bishara, A. Erlinger, and A. Ozcan, “High-throughput lens-free blood analysis on a chip,” Anal. Chem. 82(11), 4621–4627 (2010).
[Crossref] [PubMed]

2008 (3)

N. Mohandas and P. G. Gallagher, “Red cell membrane: past, present, and future,” Blood 112(10), 3939–3948 (2008).
[Crossref] [PubMed]

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[Crossref] [PubMed]

D. W. Inglis, J. A. Davis, T. J. Zieziulewicz, D. A. Lawrence, R. H. Austin, and J. C. Sturm, “Determining blood cell size using microfluidic hydrodynamics,” J. Immunol. Methods 329(1-2), 151–156 (2008).
[Crossref] [PubMed]

2007 (1)

M. Zandecki, F. Genevieve, J. Gerard, and A. Godon, “Spurious counts and spurious results on haematology analysers: a review. Part I: platelets,” Int. J. Lab. Hematol. 29(1), 4–20 (2007).
[PubMed]

2006 (1)

V. A. Loiko, G. I. Ruban, O. A. Gritsai, A. D. Gruzdev, S. M. Kosmacheva, N. V. Goncharova, and A. A. Miskevich, “Morphometric model of lymphocyte as applied to scanning flow cytometry,” J. Quant. Spectrosc. Radiat. Transf. 102(1), 73–84 (2006).
[Crossref]

1999 (1)

A. N. Shvalov, I. V. Surovtsev, A. V. Chernyshev, J. T. Soini, and V. P. Maltsev, “Particle classification from light scattering with the scanning flow cytometer,” Cytometry 37(3), 215–220 (1999).
[Crossref] [PubMed]

1990 (1)

G. P. Downey, D. E. Doherty, B. Schwab, E. L. Elson, P. M. Henson, and G. S. Worthen, “Retention of leukocytes in capillaries: role of cell size and deformability,” J. Appl. Physiol. 69(5), 1767–1778 (1990).
[Crossref] [PubMed]

Allier, C.

S. V. Kesavan, F. Momey, O. Cioni, B. David-Watine, N. Dubrulle, S. Shorte, E. Sulpice, D. Freida, B. Chalmond, J. M. Dinten, X. Gidrol, and C. Allier, “High-throughput monitoring of major cell functions by means of lensfree video microscopy,” Sci. Rep. 4(1), 5942 (2015).
[Crossref] [PubMed]

Amit, I.

Y. Wolf, A. Shemer, M. Polonsky, M. Gross, A. Mildner, S. Yona, E. David, K. W. Kim, T. Goldmann, I. Amit, M. Heikenwalder, S. Nedospasov, M. Prinz, N. Friedman, and S. Jung, “Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation,” J. Exp. Med. 214(4), 905–917 (2017).
[Crossref] [PubMed]

Arber, D. A.

D. A. Arber, A. Orazi, R. Hasserjian, J. Thiele, M. J. Borowitz, M. M. Le Beau, C. D. Bloomfield, M. Cazzola, and J. W. Vardiman, “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia,” Blood 127(20), 2391–2405 (2016).
[PubMed]

Arpali, C.

S. A. Arpali, C. Arpali, A. F. Coskun, H. H. Chiang, and A. Ozcan, “High-throughput screening of large volumes of whole blood using structured illumination and fluorescent on-chip imaging,” Lab Chip 12(23), 4968–4971 (2012).
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Arpali, S. A.

S. A. Arpali, C. Arpali, A. F. Coskun, H. H. Chiang, and A. Ozcan, “High-throughput screening of large volumes of whole blood using structured illumination and fluorescent on-chip imaging,” Lab Chip 12(23), 4968–4971 (2012).
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D. W. Inglis, J. A. Davis, T. J. Zieziulewicz, D. A. Lawrence, R. H. Austin, and J. C. Sturm, “Determining blood cell size using microfluidic hydrodynamics,” J. Immunol. Methods 329(1-2), 151–156 (2008).
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D. Min, B. Brooks, J. Wong, R. Salomon, W. Bao, B. Harrisberg, S. M. Twigg, D. K. Yue, and S. V. McLennan, “Alterations in monocyte CD16 in association with diabetes complications,” Mediators Inflamm. 2012, 649083 (2012).
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Bianco, V.

F. Merola, P. Memmolo, L. Miccio, V. Bianco, M. Paturzo, and P. Ferraro, “Diagnostic tools for lab-on-chip applications based on coherent imaging microscopy,” Proc. IEEE 103(2), 192–204 (2015).
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Bishara, W.

S. Seo, S. O. Isikman, I. Sencan, O. Mudanyali, T. W. Su, W. Bishara, A. Erlinger, and A. Ozcan, “High-throughput lens-free blood analysis on a chip,” Anal. Chem. 82(11), 4621–4627 (2010).
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T. Blasi, H. Hennig, H. D. Summers, F. J. Theis, J. Cerveira, J. O. Patterson, D. Davies, A. Filby, A. E. Carpenter, and P. Rees, “Label-free cell cycle analysis for high-throughput imaging flow cytometry,” Nat. Commun. 7, 10256 (2016).
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D. A. Arber, A. Orazi, R. Hasserjian, J. Thiele, M. J. Borowitz, M. M. Le Beau, C. D. Bloomfield, M. Cazzola, and J. W. Vardiman, “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia,” Blood 127(20), 2391–2405 (2016).
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H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
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D. A. Arber, A. Orazi, R. Hasserjian, J. Thiele, M. J. Borowitz, M. M. Le Beau, C. D. Bloomfield, M. Cazzola, and J. W. Vardiman, “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia,” Blood 127(20), 2391–2405 (2016).
[PubMed]

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Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
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D. Min, B. Brooks, J. Wong, R. Salomon, W. Bao, B. Harrisberg, S. M. Twigg, D. K. Yue, and S. V. McLennan, “Alterations in monocyte CD16 in association with diabetes complications,” Mediators Inflamm. 2012, 649083 (2012).
[Crossref] [PubMed]

Caprio, G. D.

P. Memmolo, L. Miccio, M. Paturzo, G. D. Caprio, G. Coppola, P. A. Netti, and P. Ferraro, “Recent advances in holographic 3D particle tracking,” Adv. Opt. Photonics 7(4), 713 (2015).
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Carpenter, A. E.

T. Blasi, H. Hennig, H. D. Summers, F. J. Theis, J. Cerveira, J. O. Patterson, D. Davies, A. Filby, A. E. Carpenter, and P. Rees, “Label-free cell cycle analysis for high-throughput imaging flow cytometry,” Nat. Commun. 7, 10256 (2016).
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Causa, F.

D. Dannhauser, D. Rossi, M. Ripaldi, P. A. Netti, and F. Causa, “Single-cell screening of multiple biophysical properties in leukemia diagnosis from peripheral blood by pure light scattering,” Sci. Rep. 7(1), 12666 (2017).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, P. Memmolo, F. Causa, A. Finizio, P. Ferraro, and P. A. Netti, “Label-free analysis of mononuclear human blood cells in microfluidic flow by coherent imaging tools,” J. Biophotonics 10(5), 683–689 (2017).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

D. Dannhauser, G. Romeo, F. Causa, I. De Santo, and P. A. Netti, “Multiplex single particle analysis in microfluidics,” Analyst (Lond.) 139(20), 5239–5246 (2014).
[Crossref] [PubMed]

Cazzola, M.

D. A. Arber, A. Orazi, R. Hasserjian, J. Thiele, M. J. Borowitz, M. M. Le Beau, C. D. Bloomfield, M. Cazzola, and J. W. Vardiman, “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia,” Blood 127(20), 2391–2405 (2016).
[PubMed]

Cerveira, J.

T. Blasi, H. Hennig, H. D. Summers, F. J. Theis, J. Cerveira, J. O. Patterson, D. Davies, A. Filby, A. E. Carpenter, and P. Rees, “Label-free cell cycle analysis for high-throughput imaging flow cytometry,” Nat. Commun. 7, 10256 (2016).
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S. V. Kesavan, F. Momey, O. Cioni, B. David-Watine, N. Dubrulle, S. Shorte, E. Sulpice, D. Freida, B. Chalmond, J. M. Dinten, X. Gidrol, and C. Allier, “High-throughput monitoring of major cell functions by means of lensfree video microscopy,” Sci. Rep. 4(1), 5942 (2015).
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A. N. Shvalov, I. V. Surovtsev, A. V. Chernyshev, J. T. Soini, and V. P. Maltsev, “Particle classification from light scattering with the scanning flow cytometer,” Cytometry 37(3), 215–220 (1999).
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S. A. Arpali, C. Arpali, A. F. Coskun, H. H. Chiang, and A. Ozcan, “High-throughput screening of large volumes of whole blood using structured illumination and fluorescent on-chip imaging,” Lab Chip 12(23), 4968–4971 (2012).
[Crossref] [PubMed]

Choi, C.

Cioni, O.

S. V. Kesavan, F. Momey, O. Cioni, B. David-Watine, N. Dubrulle, S. Shorte, E. Sulpice, D. Freida, B. Chalmond, J. M. Dinten, X. Gidrol, and C. Allier, “High-throughput monitoring of major cell functions by means of lensfree video microscopy,” Sci. Rep. 4(1), 5942 (2015).
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M. Masaeli, D. Gupta, S. O’Byrne, H. T. K. Tse, D. R. Gossett, P. Tseng, A. S. Utada, H. J. Jung, S. Young, A. T. Clark, and D. Di Carlo, “Multiparameter mechanical and morphometric screening of cells,” Sci. Rep. 6(1), 37863 (2016).
[Crossref] [PubMed]

Coppola, G.

P. Memmolo, L. Miccio, M. Paturzo, G. D. Caprio, G. Coppola, P. A. Netti, and P. Ferraro, “Recent advances in holographic 3D particle tracking,” Adv. Opt. Photonics 7(4), 713 (2015).
[Crossref]

Coskun, A. F.

S. A. Arpali, C. Arpali, A. F. Coskun, H. H. Chiang, and A. Ozcan, “High-throughput screening of large volumes of whole blood using structured illumination and fluorescent on-chip imaging,” Lab Chip 12(23), 4968–4971 (2012).
[Crossref] [PubMed]

Cotte, Y.

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
[Crossref]

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G. Romeo, G. D’Avino, F. Greco, P. A. Netti, and P. L. Maffettone, “Viscoelastic flow-focusing in microchannels: scaling properties of the particle radial distributions,” Lab Chip 13(14), 2802–2807 (2013).
[Crossref] [PubMed]

D’Ippolito, G.

F. Merola, P. Memmolo, L. Miccio, R. Savoia, M. Mugnano, A. Fontana, G. D’Ippolito, A. Sardo, A. Iolascon, A. Gambale, and P. Ferraro, “Tomographic flow cytometry by digital holography,” Light Sci. Appl. 6(4), e16241 (2017).
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S. M. Daly and M. J. Leahy, “‘Go with the flow ’: a review of methods and advancements in blood flow imaging,” J. Biophotonics 6(3), 217–255 (2013).
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D. Dannhauser, D. Rossi, P. Memmolo, F. Causa, A. Finizio, P. Ferraro, and P. A. Netti, “Label-free analysis of mononuclear human blood cells in microfluidic flow by coherent imaging tools,” J. Biophotonics 10(5), 683–689 (2017).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, M. Ripaldi, P. A. Netti, and F. Causa, “Single-cell screening of multiple biophysical properties in leukemia diagnosis from peripheral blood by pure light scattering,” Sci. Rep. 7(1), 12666 (2017).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

D. Dannhauser, G. Romeo, F. Causa, I. De Santo, and P. A. Netti, “Multiplex single particle analysis in microfluidics,” Analyst (Lond.) 139(20), 5239–5246 (2014).
[Crossref] [PubMed]

David, E.

Y. Wolf, A. Shemer, M. Polonsky, M. Gross, A. Mildner, S. Yona, E. David, K. W. Kim, T. Goldmann, I. Amit, M. Heikenwalder, S. Nedospasov, M. Prinz, N. Friedman, and S. Jung, “Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation,” J. Exp. Med. 214(4), 905–917 (2017).
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S. V. Kesavan, F. Momey, O. Cioni, B. David-Watine, N. Dubrulle, S. Shorte, E. Sulpice, D. Freida, B. Chalmond, J. M. Dinten, X. Gidrol, and C. Allier, “High-throughput monitoring of major cell functions by means of lensfree video microscopy,” Sci. Rep. 4(1), 5942 (2015).
[Crossref] [PubMed]

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T. Blasi, H. Hennig, H. D. Summers, F. J. Theis, J. Cerveira, J. O. Patterson, D. Davies, A. Filby, A. E. Carpenter, and P. Rees, “Label-free cell cycle analysis for high-throughput imaging flow cytometry,” Nat. Commun. 7, 10256 (2016).
[Crossref] [PubMed]

Davis, J. A.

D. W. Inglis, J. A. Davis, T. J. Zieziulewicz, D. A. Lawrence, R. H. Austin, and J. C. Sturm, “Determining blood cell size using microfluidic hydrodynamics,” J. Immunol. Methods 329(1-2), 151–156 (2008).
[Crossref] [PubMed]

De Santo, I.

D. Dannhauser, G. Romeo, F. Causa, I. De Santo, and P. A. Netti, “Multiplex single particle analysis in microfluidics,” Analyst (Lond.) 139(20), 5239–5246 (2014).
[Crossref] [PubMed]

Depeursinge, C.

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
[Crossref]

Di Carlo, D.

M. Masaeli, D. Gupta, S. O’Byrne, H. T. K. Tse, D. R. Gossett, P. Tseng, A. S. Utada, H. J. Jung, S. Young, A. T. Clark, and D. Di Carlo, “Multiparameter mechanical and morphometric screening of cells,” Sci. Rep. 6(1), 37863 (2016).
[Crossref] [PubMed]

Ding, H.

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[Crossref] [PubMed]

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S. V. Kesavan, F. Momey, O. Cioni, B. David-Watine, N. Dubrulle, S. Shorte, E. Sulpice, D. Freida, B. Chalmond, J. M. Dinten, X. Gidrol, and C. Allier, “High-throughput monitoring of major cell functions by means of lensfree video microscopy,” Sci. Rep. 4(1), 5942 (2015).
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P. Hu, H. Shen, G. Wang, P. Zhang, Q. Liu, and J. Du, “Prognostic significance of systemic inflammation-based lymphocyte- monocyte ratio in patients with lung cancer: based on a large cohort study,” PLoS One 9(9), e108062 (2014).
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S. V. Kesavan, F. Momey, O. Cioni, B. David-Watine, N. Dubrulle, S. Shorte, E. Sulpice, D. Freida, B. Chalmond, J. M. Dinten, X. Gidrol, and C. Allier, “High-throughput monitoring of major cell functions by means of lensfree video microscopy,” Sci. Rep. 4(1), 5942 (2015).
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Eremin, Y.

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

Erlinger, A.

S. Seo, S. O. Isikman, I. Sencan, O. Mudanyali, T. W. Su, W. Bishara, A. Erlinger, and A. Ozcan, “High-throughput lens-free blood analysis on a chip,” Anal. Chem. 82(11), 4621–4627 (2010).
[Crossref] [PubMed]

Faridian, A.

Ferraro, P.

D. Dannhauser, D. Rossi, P. Memmolo, F. Causa, A. Finizio, P. Ferraro, and P. A. Netti, “Label-free analysis of mononuclear human blood cells in microfluidic flow by coherent imaging tools,” J. Biophotonics 10(5), 683–689 (2017).
[Crossref] [PubMed]

F. Merola, P. Memmolo, L. Miccio, R. Savoia, M. Mugnano, A. Fontana, G. D’Ippolito, A. Sardo, A. Iolascon, A. Gambale, and P. Ferraro, “Tomographic flow cytometry by digital holography,” Light Sci. Appl. 6(4), e16241 (2017).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

P. Memmolo, L. Miccio, M. Paturzo, G. D. Caprio, G. Coppola, P. A. Netti, and P. Ferraro, “Recent advances in holographic 3D particle tracking,” Adv. Opt. Photonics 7(4), 713 (2015).
[Crossref]

F. Merola, P. Memmolo, L. Miccio, V. Bianco, M. Paturzo, and P. Ferraro, “Diagnostic tools for lab-on-chip applications based on coherent imaging microscopy,” Proc. IEEE 103(2), 192–204 (2015).
[Crossref]

L. Miccio, P. Memmolo, F. Merola, P. A. Netti, and P. Ferraro, “Red blood cell as an adaptive optofluidic microlens,” Nat. Commun. 6(1), 6502 (2015).
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P. Memmolo, L. Miccio, F. Merola, O. Gennari, P. A. Netti, and P. Ferraro, “3D morphometry of red blood cells by digital holography,” Cytometry A 85(12), 1030–1036 (2014).
[Crossref] [PubMed]

Filby, A.

T. Blasi, H. Hennig, H. D. Summers, F. J. Theis, J. Cerveira, J. O. Patterson, D. Davies, A. Filby, A. E. Carpenter, and P. Rees, “Label-free cell cycle analysis for high-throughput imaging flow cytometry,” Nat. Commun. 7, 10256 (2016).
[Crossref] [PubMed]

Finizio, A.

D. Dannhauser, D. Rossi, P. Memmolo, F. Causa, A. Finizio, P. Ferraro, and P. A. Netti, “Label-free analysis of mononuclear human blood cells in microfluidic flow by coherent imaging tools,” J. Biophotonics 10(5), 683–689 (2017).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

Fontana, A.

F. Merola, P. Memmolo, L. Miccio, R. Savoia, M. Mugnano, A. Fontana, G. D’Ippolito, A. Sardo, A. Iolascon, A. Gambale, and P. Ferraro, “Tomographic flow cytometry by digital holography,” Light Sci. Appl. 6(4), e16241 (2017).
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Forcucci, A.

Freida, D.

S. V. Kesavan, F. Momey, O. Cioni, B. David-Watine, N. Dubrulle, S. Shorte, E. Sulpice, D. Freida, B. Chalmond, J. M. Dinten, X. Gidrol, and C. Allier, “High-throughput monitoring of major cell functions by means of lensfree video microscopy,” Sci. Rep. 4(1), 5942 (2015).
[Crossref] [PubMed]

Friedman, N.

Y. Wolf, A. Shemer, M. Polonsky, M. Gross, A. Mildner, S. Yona, E. David, K. W. Kim, T. Goldmann, I. Amit, M. Heikenwalder, S. Nedospasov, M. Prinz, N. Friedman, and S. Jung, “Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation,” J. Exp. Med. 214(4), 905–917 (2017).
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Gambale, A.

F. Merola, P. Memmolo, L. Miccio, R. Savoia, M. Mugnano, A. Fontana, G. D’Ippolito, A. Sardo, A. Iolascon, A. Gambale, and P. Ferraro, “Tomographic flow cytometry by digital holography,” Light Sci. Appl. 6(4), e16241 (2017).
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Gao, P.

Genevieve, F.

M. Zandecki, F. Genevieve, J. Gerard, and A. Godon, “Spurious counts and spurious results on haematology analysers: a review. Part I: platelets,” Int. J. Lab. Hematol. 29(1), 4–20 (2007).
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Gennari, O.

P. Memmolo, L. Miccio, F. Merola, O. Gennari, P. A. Netti, and P. Ferraro, “3D morphometry of red blood cells by digital holography,” Cytometry A 85(12), 1030–1036 (2014).
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Gerard, J.

M. Zandecki, F. Genevieve, J. Gerard, and A. Godon, “Spurious counts and spurious results on haematology analysers: a review. Part I: platelets,” Int. J. Lab. Hematol. 29(1), 4–20 (2007).
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Gidrol, X.

S. V. Kesavan, F. Momey, O. Cioni, B. David-Watine, N. Dubrulle, S. Shorte, E. Sulpice, D. Freida, B. Chalmond, J. M. Dinten, X. Gidrol, and C. Allier, “High-throughput monitoring of major cell functions by means of lensfree video microscopy,” Sci. Rep. 4(1), 5942 (2015).
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Godon, A.

M. Zandecki, F. Genevieve, J. Gerard, and A. Godon, “Spurious counts and spurious results on haematology analysers: a review. Part I: platelets,” Int. J. Lab. Hematol. 29(1), 4–20 (2007).
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Goldmann, T.

Y. Wolf, A. Shemer, M. Polonsky, M. Gross, A. Mildner, S. Yona, E. David, K. W. Kim, T. Goldmann, I. Amit, M. Heikenwalder, S. Nedospasov, M. Prinz, N. Friedman, and S. Jung, “Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation,” J. Exp. Med. 214(4), 905–917 (2017).
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Gómez-Sjöberg, R.

R. A. Kellogg, R. Gómez-Sjöberg, A. A. Leyrat, and S. Tay, “High-throughput microfluidic single-cell analysis pipeline for studies of signaling dynamics,” Nat. Protoc. 9(7), 1713–1726 (2014).
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Goncharova, N. V.

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Gossett, D. R.

M. Masaeli, D. Gupta, S. O’Byrne, H. T. K. Tse, D. R. Gossett, P. Tseng, A. S. Utada, H. J. Jung, S. Young, A. T. Clark, and D. Di Carlo, “Multiparameter mechanical and morphometric screening of cells,” Sci. Rep. 6(1), 37863 (2016).
[Crossref] [PubMed]

Greco, F.

G. Romeo, G. D’Avino, F. Greco, P. A. Netti, and P. L. Maffettone, “Viscoelastic flow-focusing in microchannels: scaling properties of the particle radial distributions,” Lab Chip 13(14), 2802–2807 (2013).
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R. Pliquett, C. Linhart, C. Ulrich, and M. Grindt, “Role of systemic inflammation and monocyte activation in acutely-decompensated cardiorenal syndrome patients,” FASEB J. 29(1), 808 (2015).

Gritsai, O. A.

V. A. Loiko, G. I. Ruban, O. A. Gritsai, A. D. Gruzdev, S. M. Kosmacheva, N. V. Goncharova, and A. A. Miskevich, “Morphometric model of lymphocyte as applied to scanning flow cytometry,” J. Quant. Spectrosc. Radiat. Transf. 102(1), 73–84 (2006).
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Gross, M.

Y. Wolf, A. Shemer, M. Polonsky, M. Gross, A. Mildner, S. Yona, E. David, K. W. Kim, T. Goldmann, I. Amit, M. Heikenwalder, S. Nedospasov, M. Prinz, N. Friedman, and S. Jung, “Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation,” J. Exp. Med. 214(4), 905–917 (2017).
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Gruzdev, A. D.

V. A. Loiko, G. I. Ruban, O. A. Gritsai, A. D. Gruzdev, S. M. Kosmacheva, N. V. Goncharova, and A. A. Miskevich, “Morphometric model of lymphocyte as applied to scanning flow cytometry,” J. Quant. Spectrosc. Radiat. Transf. 102(1), 73–84 (2006).
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Kim, K.

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D. Min, B. Brooks, J. Wong, R. Salomon, W. Bao, B. Harrisberg, S. M. Twigg, D. K. Yue, and S. V. McLennan, “Alterations in monocyte CD16 in association with diabetes complications,” Mediators Inflamm. 2012, 649083 (2012).
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P. Memmolo, L. Miccio, M. Paturzo, G. D. Caprio, G. Coppola, P. A. Netti, and P. Ferraro, “Recent advances in holographic 3D particle tracking,” Adv. Opt. Photonics 7(4), 713 (2015).
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F. Merola, P. Memmolo, L. Miccio, V. Bianco, M. Paturzo, and P. Ferraro, “Diagnostic tools for lab-on-chip applications based on coherent imaging microscopy,” Proc. IEEE 103(2), 192–204 (2015).
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L. Miccio, P. Memmolo, F. Merola, P. A. Netti, and P. Ferraro, “Red blood cell as an adaptive optofluidic microlens,” Nat. Commun. 6(1), 6502 (2015).
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P. Memmolo, L. Miccio, F. Merola, O. Gennari, P. A. Netti, and P. Ferraro, “3D morphometry of red blood cells by digital holography,” Cytometry A 85(12), 1030–1036 (2014).
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P. Memmolo, L. Miccio, M. Paturzo, G. D. Caprio, G. Coppola, P. A. Netti, and P. Ferraro, “Recent advances in holographic 3D particle tracking,” Adv. Opt. Photonics 7(4), 713 (2015).
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F. Merola, P. Memmolo, L. Miccio, V. Bianco, M. Paturzo, and P. Ferraro, “Diagnostic tools for lab-on-chip applications based on coherent imaging microscopy,” Proc. IEEE 103(2), 192–204 (2015).
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L. Miccio, P. Memmolo, F. Merola, P. A. Netti, and P. Ferraro, “Red blood cell as an adaptive optofluidic microlens,” Nat. Commun. 6(1), 6502 (2015).
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P. Memmolo, L. Miccio, F. Merola, O. Gennari, P. A. Netti, and P. Ferraro, “3D morphometry of red blood cells by digital holography,” Cytometry A 85(12), 1030–1036 (2014).
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Min, D.

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V. A. Loiko, G. I. Ruban, O. A. Gritsai, A. D. Gruzdev, S. M. Kosmacheva, N. V. Goncharova, and A. A. Miskevich, “Morphometric model of lymphocyte as applied to scanning flow cytometry,” J. Quant. Spectrosc. Radiat. Transf. 102(1), 73–84 (2006).
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S. Seo, S. O. Isikman, I. Sencan, O. Mudanyali, T. W. Su, W. Bishara, A. Erlinger, and A. Ozcan, “High-throughput lens-free blood analysis on a chip,” Anal. Chem. 82(11), 4621–4627 (2010).
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Mugnano, M.

F. Merola, P. Memmolo, L. Miccio, R. Savoia, M. Mugnano, A. Fontana, G. D’Ippolito, A. Sardo, A. Iolascon, A. Gambale, and P. Ferraro, “Tomographic flow cytometry by digital holography,” Light Sci. Appl. 6(4), e16241 (2017).
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Netti, P. A.

D. Dannhauser, D. Rossi, P. Memmolo, F. Causa, A. Finizio, P. Ferraro, and P. A. Netti, “Label-free analysis of mononuclear human blood cells in microfluidic flow by coherent imaging tools,” J. Biophotonics 10(5), 683–689 (2017).
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[Crossref] [PubMed]

L. Miccio, P. Memmolo, F. Merola, P. A. Netti, and P. Ferraro, “Red blood cell as an adaptive optofluidic microlens,” Nat. Commun. 6(1), 6502 (2015).
[Crossref] [PubMed]

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D. Dannhauser, G. Romeo, F. Causa, I. De Santo, and P. A. Netti, “Multiplex single particle analysis in microfluidics,” Analyst (Lond.) 139(20), 5239–5246 (2014).
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D. A. Arber, A. Orazi, R. Hasserjian, J. Thiele, M. J. Borowitz, M. M. Le Beau, C. D. Bloomfield, M. Cazzola, and J. W. Vardiman, “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia,” Blood 127(20), 2391–2405 (2016).
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Pang, Y.

Z. Liu, W. Guo, D. Zhang, Y. Pang, J. Shi, S. Wan, K. Cheng, J. Wang, and S. Cheng, “Circulating tumor cell detection in hepatocellular carcinoma based on karyoplasmic ratios using imaging flow cytometry,” Sci. Rep. 6(1), 39808 (2016).
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Park, Y.

Patterson, J. O.

T. Blasi, H. Hennig, H. D. Summers, F. J. Theis, J. Cerveira, J. O. Patterson, D. Davies, A. Filby, A. E. Carpenter, and P. Rees, “Label-free cell cycle analysis for high-throughput imaging flow cytometry,” Nat. Commun. 7, 10256 (2016).
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Paturzo, M.

F. Merola, P. Memmolo, L. Miccio, V. Bianco, M. Paturzo, and P. Ferraro, “Diagnostic tools for lab-on-chip applications based on coherent imaging microscopy,” Proc. IEEE 103(2), 192–204 (2015).
[Crossref]

P. Memmolo, L. Miccio, M. Paturzo, G. D. Caprio, G. Coppola, P. A. Netti, and P. Ferraro, “Recent advances in holographic 3D particle tracking,” Adv. Opt. Photonics 7(4), 713 (2015).
[Crossref]

Pavillon, N.

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
[Crossref]

Pawlowski, M. E.

Pedrini, G.

Pliquett, R.

R. Pliquett, C. Linhart, C. Ulrich, and M. Grindt, “Role of systemic inflammation and monocyte activation in acutely-decompensated cardiorenal syndrome patients,” FASEB J. 29(1), 808 (2015).

Polonsky, M.

Y. Wolf, A. Shemer, M. Polonsky, M. Gross, A. Mildner, S. Yona, E. David, K. W. Kim, T. Goldmann, I. Amit, M. Heikenwalder, S. Nedospasov, M. Prinz, N. Friedman, and S. Jung, “Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation,” J. Exp. Med. 214(4), 905–917 (2017).
[Crossref] [PubMed]

Popescu, G.

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[Crossref] [PubMed]

Prinz, M.

Y. Wolf, A. Shemer, M. Polonsky, M. Gross, A. Mildner, S. Yona, E. David, K. W. Kim, T. Goldmann, I. Amit, M. Heikenwalder, S. Nedospasov, M. Prinz, N. Friedman, and S. Jung, “Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation,” J. Exp. Med. 214(4), 905–917 (2017).
[Crossref] [PubMed]

Rees, P.

T. Blasi, H. Hennig, H. D. Summers, F. J. Theis, J. Cerveira, J. O. Patterson, D. Davies, A. Filby, A. E. Carpenter, and P. Rees, “Label-free cell cycle analysis for high-throughput imaging flow cytometry,” Nat. Commun. 7, 10256 (2016).
[Crossref] [PubMed]

Richards-Kortum, R.

Ripaldi, M.

D. Dannhauser, D. Rossi, M. Ripaldi, P. A. Netti, and F. Causa, “Single-cell screening of multiple biophysical properties in leukemia diagnosis from peripheral blood by pure light scattering,” Sci. Rep. 7(1), 12666 (2017).
[Crossref] [PubMed]

Romeo, G.

D. Dannhauser, G. Romeo, F. Causa, I. De Santo, and P. A. Netti, “Multiplex single particle analysis in microfluidics,” Analyst (Lond.) 139(20), 5239–5246 (2014).
[Crossref] [PubMed]

G. Romeo, G. D’Avino, F. Greco, P. A. Netti, and P. L. Maffettone, “Viscoelastic flow-focusing in microchannels: scaling properties of the particle radial distributions,” Lab Chip 13(14), 2802–2807 (2013).
[Crossref] [PubMed]

Rossi, D.

D. Dannhauser, D. Rossi, P. Memmolo, F. Causa, A. Finizio, P. Ferraro, and P. A. Netti, “Label-free analysis of mononuclear human blood cells in microfluidic flow by coherent imaging tools,” J. Biophotonics 10(5), 683–689 (2017).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, M. Ripaldi, P. A. Netti, and F. Causa, “Single-cell screening of multiple biophysical properties in leukemia diagnosis from peripheral blood by pure light scattering,” Sci. Rep. 7(1), 12666 (2017).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

Ruban, G. I.

V. A. Loiko, G. I. Ruban, O. A. Gritsai, A. D. Gruzdev, S. M. Kosmacheva, N. V. Goncharova, and A. A. Miskevich, “Morphometric model of lymphocyte as applied to scanning flow cytometry,” J. Quant. Spectrosc. Radiat. Transf. 102(1), 73–84 (2006).
[Crossref]

Salomon, R.

D. Min, B. Brooks, J. Wong, R. Salomon, W. Bao, B. Harrisberg, S. M. Twigg, D. K. Yue, and S. V. McLennan, “Alterations in monocyte CD16 in association with diabetes complications,” Mediators Inflamm. 2012, 649083 (2012).
[Crossref] [PubMed]

Sardo, A.

F. Merola, P. Memmolo, L. Miccio, R. Savoia, M. Mugnano, A. Fontana, G. D’Ippolito, A. Sardo, A. Iolascon, A. Gambale, and P. Ferraro, “Tomographic flow cytometry by digital holography,” Light Sci. Appl. 6(4), e16241 (2017).
[Crossref] [PubMed]

Savoia, R.

F. Merola, P. Memmolo, L. Miccio, R. Savoia, M. Mugnano, A. Fontana, G. D’Ippolito, A. Sardo, A. Iolascon, A. Gambale, and P. Ferraro, “Tomographic flow cytometry by digital holography,” Light Sci. Appl. 6(4), e16241 (2017).
[Crossref] [PubMed]

Schnekenburger, J.

L. Kastl, M. Isbach, D. Dirksen, J. Schnekenburger, and B. Kemper, “Quantitative phase imaging for cell culture quality control,” Cytometry A 91(5), 470–481 (2017).
[Crossref] [PubMed]

Schwab, B.

G. P. Downey, D. E. Doherty, B. Schwab, E. L. Elson, P. M. Henson, and G. S. Worthen, “Retention of leukocytes in capillaries: role of cell size and deformability,” J. Appl. Physiol. 69(5), 1767–1778 (1990).
[Crossref] [PubMed]

Sencan, I.

S. Seo, S. O. Isikman, I. Sencan, O. Mudanyali, T. W. Su, W. Bishara, A. Erlinger, and A. Ozcan, “High-throughput lens-free blood analysis on a chip,” Anal. Chem. 82(11), 4621–4627 (2010).
[Crossref] [PubMed]

Seo, S.

S. Seo, S. O. Isikman, I. Sencan, O. Mudanyali, T. W. Su, W. Bishara, A. Erlinger, and A. Ozcan, “High-throughput lens-free blood analysis on a chip,” Anal. Chem. 82(11), 4621–4627 (2010).
[Crossref] [PubMed]

Shemer, A.

Y. Wolf, A. Shemer, M. Polonsky, M. Gross, A. Mildner, S. Yona, E. David, K. W. Kim, T. Goldmann, I. Amit, M. Heikenwalder, S. Nedospasov, M. Prinz, N. Friedman, and S. Jung, “Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation,” J. Exp. Med. 214(4), 905–917 (2017).
[Crossref] [PubMed]

Shen, H.

P. Hu, H. Shen, G. Wang, P. Zhang, Q. Liu, and J. Du, “Prognostic significance of systemic inflammation-based lymphocyte- monocyte ratio in patients with lung cancer: based on a large cohort study,” PLoS One 9(9), e108062 (2014).
[Crossref] [PubMed]

Shi, J.

Z. Liu, W. Guo, D. Zhang, Y. Pang, J. Shi, S. Wan, K. Cheng, J. Wang, and S. Cheng, “Circulating tumor cell detection in hepatocellular carcinoma based on karyoplasmic ratios using imaging flow cytometry,” Sci. Rep. 6(1), 39808 (2016).
[Crossref] [PubMed]

Shorte, S.

S. V. Kesavan, F. Momey, O. Cioni, B. David-Watine, N. Dubrulle, S. Shorte, E. Sulpice, D. Freida, B. Chalmond, J. M. Dinten, X. Gidrol, and C. Allier, “High-throughput monitoring of major cell functions by means of lensfree video microscopy,” Sci. Rep. 4(1), 5942 (2015).
[Crossref] [PubMed]

Shvalov, A. N.

A. N. Shvalov, I. V. Surovtsev, A. V. Chernyshev, J. T. Soini, and V. P. Maltsev, “Particle classification from light scattering with the scanning flow cytometer,” Cytometry 37(3), 215–220 (1999).
[Crossref] [PubMed]

Singh, A. K.

Soini, J. T.

A. N. Shvalov, I. V. Surovtsev, A. V. Chernyshev, J. T. Soini, and V. P. Maltsev, “Particle classification from light scattering with the scanning flow cytometer,” Cytometry 37(3), 215–220 (1999).
[Crossref] [PubMed]

Sturm, J. C.

D. W. Inglis, J. A. Davis, T. J. Zieziulewicz, D. A. Lawrence, R. H. Austin, and J. C. Sturm, “Determining blood cell size using microfluidic hydrodynamics,” J. Immunol. Methods 329(1-2), 151–156 (2008).
[Crossref] [PubMed]

Su, T. W.

S. Seo, S. O. Isikman, I. Sencan, O. Mudanyali, T. W. Su, W. Bishara, A. Erlinger, and A. Ozcan, “High-throughput lens-free blood analysis on a chip,” Anal. Chem. 82(11), 4621–4627 (2010).
[Crossref] [PubMed]

Sulpice, E.

S. V. Kesavan, F. Momey, O. Cioni, B. David-Watine, N. Dubrulle, S. Shorte, E. Sulpice, D. Freida, B. Chalmond, J. M. Dinten, X. Gidrol, and C. Allier, “High-throughput monitoring of major cell functions by means of lensfree video microscopy,” Sci. Rep. 4(1), 5942 (2015).
[Crossref] [PubMed]

Summers, H. D.

T. Blasi, H. Hennig, H. D. Summers, F. J. Theis, J. Cerveira, J. O. Patterson, D. Davies, A. Filby, A. E. Carpenter, and P. Rees, “Label-free cell cycle analysis for high-throughput imaging flow cytometry,” Nat. Commun. 7, 10256 (2016).
[Crossref] [PubMed]

Surovtsev, I. V.

A. N. Shvalov, I. V. Surovtsev, A. V. Chernyshev, J. T. Soini, and V. P. Maltsev, “Particle classification from light scattering with the scanning flow cytometer,” Cytometry 37(3), 215–220 (1999).
[Crossref] [PubMed]

Takeda, M.

Tay, S.

R. A. Kellogg, R. Gómez-Sjöberg, A. A. Leyrat, and S. Tay, “High-throughput microfluidic single-cell analysis pipeline for studies of signaling dynamics,” Nat. Protoc. 9(7), 1713–1726 (2014).
[Crossref] [PubMed]

Theis, F. J.

T. Blasi, H. Hennig, H. D. Summers, F. J. Theis, J. Cerveira, J. O. Patterson, D. Davies, A. Filby, A. E. Carpenter, and P. Rees, “Label-free cell cycle analysis for high-throughput imaging flow cytometry,” Nat. Commun. 7, 10256 (2016).
[Crossref] [PubMed]

Thiele, J.

D. A. Arber, A. Orazi, R. Hasserjian, J. Thiele, M. J. Borowitz, M. M. Le Beau, C. D. Bloomfield, M. Cazzola, and J. W. Vardiman, “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia,” Blood 127(20), 2391–2405 (2016).
[PubMed]

Tkaczyk, T. S.

Toy, F.

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
[Crossref]

Tse, H. T. K.

M. Masaeli, D. Gupta, S. O’Byrne, H. T. K. Tse, D. R. Gossett, P. Tseng, A. S. Utada, H. J. Jung, S. Young, A. T. Clark, and D. Di Carlo, “Multiparameter mechanical and morphometric screening of cells,” Sci. Rep. 6(1), 37863 (2016).
[Crossref] [PubMed]

Tseng, P.

M. Masaeli, D. Gupta, S. O’Byrne, H. T. K. Tse, D. R. Gossett, P. Tseng, A. S. Utada, H. J. Jung, S. Young, A. T. Clark, and D. Di Carlo, “Multiparameter mechanical and morphometric screening of cells,” Sci. Rep. 6(1), 37863 (2016).
[Crossref] [PubMed]

Twigg, S. M.

D. Min, B. Brooks, J. Wong, R. Salomon, W. Bao, B. Harrisberg, S. M. Twigg, D. K. Yue, and S. V. McLennan, “Alterations in monocyte CD16 in association with diabetes complications,” Mediators Inflamm. 2012, 649083 (2012).
[Crossref] [PubMed]

Ulrich, C.

R. Pliquett, C. Linhart, C. Ulrich, and M. Grindt, “Role of systemic inflammation and monocyte activation in acutely-decompensated cardiorenal syndrome patients,” FASEB J. 29(1), 808 (2015).

Utada, A. S.

M. Masaeli, D. Gupta, S. O’Byrne, H. T. K. Tse, D. R. Gossett, P. Tseng, A. S. Utada, H. J. Jung, S. Young, A. T. Clark, and D. Di Carlo, “Multiparameter mechanical and morphometric screening of cells,” Sci. Rep. 6(1), 37863 (2016).
[Crossref] [PubMed]

Vardiman, J. W.

D. A. Arber, A. Orazi, R. Hasserjian, J. Thiele, M. J. Borowitz, M. M. Le Beau, C. D. Bloomfield, M. Cazzola, and J. W. Vardiman, “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia,” Blood 127(20), 2391–2405 (2016).
[PubMed]

Wan, S.

Z. Liu, W. Guo, D. Zhang, Y. Pang, J. Shi, S. Wan, K. Cheng, J. Wang, and S. Cheng, “Circulating tumor cell detection in hepatocellular carcinoma based on karyoplasmic ratios using imaging flow cytometry,” Sci. Rep. 6(1), 39808 (2016).
[Crossref] [PubMed]

Wang, G.

P. Hu, H. Shen, G. Wang, P. Zhang, Q. Liu, and J. Du, “Prognostic significance of systemic inflammation-based lymphocyte- monocyte ratio in patients with lung cancer: based on a large cohort study,” PLoS One 9(9), e108062 (2014).
[Crossref] [PubMed]

Wang, J.

Z. Liu, W. Guo, D. Zhang, Y. Pang, J. Shi, S. Wan, K. Cheng, J. Wang, and S. Cheng, “Circulating tumor cell detection in hepatocellular carcinoma based on karyoplasmic ratios using imaging flow cytometry,” Sci. Rep. 6(1), 39808 (2016).
[Crossref] [PubMed]

Wang, T. D.

C. H. Wu, T. D. Wang, C. H. Hsieh, S. H. Huang, J. W. Lin, S. C. Hsu, H. T. Wu, Y. M. Wu, and T. M. Liu, “Imaging Cytometry of human leukocytes with third harmonic generation microscopy,” Sci. Rep. 6(1), 37210 (2016).
[Crossref] [PubMed]

Wang, Z.

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[Crossref] [PubMed]

Wilke, M.

Wolf, Y.

Y. Wolf, A. Shemer, M. Polonsky, M. Gross, A. Mildner, S. Yona, E. David, K. W. Kim, T. Goldmann, I. Amit, M. Heikenwalder, S. Nedospasov, M. Prinz, N. Friedman, and S. Jung, “Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation,” J. Exp. Med. 214(4), 905–917 (2017).
[Crossref] [PubMed]

Wong, J.

D. Min, B. Brooks, J. Wong, R. Salomon, W. Bao, B. Harrisberg, S. M. Twigg, D. K. Yue, and S. V. McLennan, “Alterations in monocyte CD16 in association with diabetes complications,” Mediators Inflamm. 2012, 649083 (2012).
[Crossref] [PubMed]

Worthen, G. S.

G. P. Downey, D. E. Doherty, B. Schwab, E. L. Elson, P. M. Henson, and G. S. Worthen, “Retention of leukocytes in capillaries: role of cell size and deformability,” J. Appl. Physiol. 69(5), 1767–1778 (1990).
[Crossref] [PubMed]

Wriedt, T.

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

Wu, C. H.

C. H. Wu, T. D. Wang, C. H. Hsieh, S. H. Huang, J. W. Lin, S. C. Hsu, H. T. Wu, Y. M. Wu, and T. M. Liu, “Imaging Cytometry of human leukocytes with third harmonic generation microscopy,” Sci. Rep. 6(1), 37210 (2016).
[Crossref] [PubMed]

Wu, H. T.

C. H. Wu, T. D. Wang, C. H. Hsieh, S. H. Huang, J. W. Lin, S. C. Hsu, H. T. Wu, Y. M. Wu, and T. M. Liu, “Imaging Cytometry of human leukocytes with third harmonic generation microscopy,” Sci. Rep. 6(1), 37210 (2016).
[Crossref] [PubMed]

Wu, Y. M.

C. H. Wu, T. D. Wang, C. H. Hsieh, S. H. Huang, J. W. Lin, S. C. Hsu, H. T. Wu, Y. M. Wu, and T. M. Liu, “Imaging Cytometry of human leukocytes with third harmonic generation microscopy,” Sci. Rep. 6(1), 37210 (2016).
[Crossref] [PubMed]

Yona, S.

Y. Wolf, A. Shemer, M. Polonsky, M. Gross, A. Mildner, S. Yona, E. David, K. W. Kim, T. Goldmann, I. Amit, M. Heikenwalder, S. Nedospasov, M. Prinz, N. Friedman, and S. Jung, “Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation,” J. Exp. Med. 214(4), 905–917 (2017).
[Crossref] [PubMed]

Yoon, J.

Young, S.

M. Masaeli, D. Gupta, S. O’Byrne, H. T. K. Tse, D. R. Gossett, P. Tseng, A. S. Utada, H. J. Jung, S. Young, A. T. Clark, and D. Di Carlo, “Multiparameter mechanical and morphometric screening of cells,” Sci. Rep. 6(1), 37863 (2016).
[Crossref] [PubMed]

Yu, X.

X. Yu, J. Hong, C. Liu, and M. K. Kim, “Review of digital holographic microscopy for three-dimensional profiling and tracking,” Opt. Eng. 53(11), 112306 (2014).
[Crossref]

Yue, D. K.

D. Min, B. Brooks, J. Wong, R. Salomon, W. Bao, B. Harrisberg, S. M. Twigg, D. K. Yue, and S. V. McLennan, “Alterations in monocyte CD16 in association with diabetes complications,” Mediators Inflamm. 2012, 649083 (2012).
[Crossref] [PubMed]

Yurkin, M. A.

M. A. Yurkin and A. G. Hoekstra, “The discrete-dipole-approximation code ADDA: Capabilities and known limitations,” J. Quant. Spectrosc. Radiat. Transf. 112(13), 2234–2247 (2011).
[Crossref]

Zandecki, M.

M. Zandecki, F. Genevieve, J. Gerard, and A. Godon, “Spurious counts and spurious results on haematology analysers: a review. Part I: platelets,” Int. J. Lab. Hematol. 29(1), 4–20 (2007).
[PubMed]

Zhang, D.

Z. Liu, W. Guo, D. Zhang, Y. Pang, J. Shi, S. Wan, K. Cheng, J. Wang, and S. Cheng, “Circulating tumor cell detection in hepatocellular carcinoma based on karyoplasmic ratios using imaging flow cytometry,” Sci. Rep. 6(1), 39808 (2016).
[Crossref] [PubMed]

Zhang, P.

P. Hu, H. Shen, G. Wang, P. Zhang, Q. Liu, and J. Du, “Prognostic significance of systemic inflammation-based lymphocyte- monocyte ratio in patients with lung cancer: based on a large cohort study,” PLoS One 9(9), e108062 (2014).
[Crossref] [PubMed]

Ziegler-Heitbrock, L.

L. Ziegler-Heitbrock, “Monocyte subsets in man and other species,” Cell. Immunol. 289(1-2), 135–139 (2014).
[Crossref] [PubMed]

Zieziulewicz, T. J.

D. W. Inglis, J. A. Davis, T. J. Zieziulewicz, D. A. Lawrence, R. H. Austin, and J. C. Sturm, “Determining blood cell size using microfluidic hydrodynamics,” J. Immunol. Methods 329(1-2), 151–156 (2008).
[Crossref] [PubMed]

Adv. Opt. Photonics (1)

P. Memmolo, L. Miccio, M. Paturzo, G. D. Caprio, G. Coppola, P. A. Netti, and P. Ferraro, “Recent advances in holographic 3D particle tracking,” Adv. Opt. Photonics 7(4), 713 (2015).
[Crossref]

Anal. Chem. (1)

S. Seo, S. O. Isikman, I. Sencan, O. Mudanyali, T. W. Su, W. Bishara, A. Erlinger, and A. Ozcan, “High-throughput lens-free blood analysis on a chip,” Anal. Chem. 82(11), 4621–4627 (2010).
[Crossref] [PubMed]

Analyst (Lond.) (1)

D. Dannhauser, G. Romeo, F. Causa, I. De Santo, and P. A. Netti, “Multiplex single particle analysis in microfluidics,” Analyst (Lond.) 139(20), 5239–5246 (2014).
[Crossref] [PubMed]

Appl. Opt. (1)

Biomed. Opt. Express (2)

Blood (2)

N. Mohandas and P. G. Gallagher, “Red cell membrane: past, present, and future,” Blood 112(10), 3939–3948 (2008).
[Crossref] [PubMed]

D. A. Arber, A. Orazi, R. Hasserjian, J. Thiele, M. J. Borowitz, M. M. Le Beau, C. D. Bloomfield, M. Cazzola, and J. W. Vardiman, “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia,” Blood 127(20), 2391–2405 (2016).
[PubMed]

Cell. Immunol. (1)

L. Ziegler-Heitbrock, “Monocyte subsets in man and other species,” Cell. Immunol. 289(1-2), 135–139 (2014).
[Crossref] [PubMed]

Cytometry (1)

A. N. Shvalov, I. V. Surovtsev, A. V. Chernyshev, J. T. Soini, and V. P. Maltsev, “Particle classification from light scattering with the scanning flow cytometer,” Cytometry 37(3), 215–220 (1999).
[Crossref] [PubMed]

Cytometry A (2)

L. Kastl, M. Isbach, D. Dirksen, J. Schnekenburger, and B. Kemper, “Quantitative phase imaging for cell culture quality control,” Cytometry A 91(5), 470–481 (2017).
[Crossref] [PubMed]

P. Memmolo, L. Miccio, F. Merola, O. Gennari, P. A. Netti, and P. Ferraro, “3D morphometry of red blood cells by digital holography,” Cytometry A 85(12), 1030–1036 (2014).
[Crossref] [PubMed]

FASEB J. (1)

R. Pliquett, C. Linhart, C. Ulrich, and M. Grindt, “Role of systemic inflammation and monocyte activation in acutely-decompensated cardiorenal syndrome patients,” FASEB J. 29(1), 808 (2015).

Int. J. Lab. Hematol. (1)

M. Zandecki, F. Genevieve, J. Gerard, and A. Godon, “Spurious counts and spurious results on haematology analysers: a review. Part I: platelets,” Int. J. Lab. Hematol. 29(1), 4–20 (2007).
[PubMed]

J. Appl. Physiol. (1)

G. P. Downey, D. E. Doherty, B. Schwab, E. L. Elson, P. M. Henson, and G. S. Worthen, “Retention of leukocytes in capillaries: role of cell size and deformability,” J. Appl. Physiol. 69(5), 1767–1778 (1990).
[Crossref] [PubMed]

J. Biophotonics (2)

S. M. Daly and M. J. Leahy, “‘Go with the flow ’: a review of methods and advancements in blood flow imaging,” J. Biophotonics 6(3), 217–255 (2013).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, P. Memmolo, F. Causa, A. Finizio, P. Ferraro, and P. A. Netti, “Label-free analysis of mononuclear human blood cells in microfluidic flow by coherent imaging tools,” J. Biophotonics 10(5), 683–689 (2017).
[Crossref] [PubMed]

J. Exp. Med. (1)

Y. Wolf, A. Shemer, M. Polonsky, M. Gross, A. Mildner, S. Yona, E. David, K. W. Kim, T. Goldmann, I. Amit, M. Heikenwalder, S. Nedospasov, M. Prinz, N. Friedman, and S. Jung, “Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation,” J. Exp. Med. 214(4), 905–917 (2017).
[Crossref] [PubMed]

J. Immunol. Methods (1)

D. W. Inglis, J. A. Davis, T. J. Zieziulewicz, D. A. Lawrence, R. H. Austin, and J. C. Sturm, “Determining blood cell size using microfluidic hydrodynamics,” J. Immunol. Methods 329(1-2), 151–156 (2008).
[Crossref] [PubMed]

J. Quant. Spectrosc. Radiat. Transf. (2)

V. A. Loiko, G. I. Ruban, O. A. Gritsai, A. D. Gruzdev, S. M. Kosmacheva, N. V. Goncharova, and A. A. Miskevich, “Morphometric model of lymphocyte as applied to scanning flow cytometry,” J. Quant. Spectrosc. Radiat. Transf. 102(1), 73–84 (2006).
[Crossref]

M. A. Yurkin and A. G. Hoekstra, “The discrete-dipole-approximation code ADDA: Capabilities and known limitations,” J. Quant. Spectrosc. Radiat. Transf. 112(13), 2234–2247 (2011).
[Crossref]

Journal of Histology and Histopathology (1)

G. Musumeci, “Past, present and future: overview on histology and histopathology,” Journal of Histology and Histopathology 1(1), 5 (2014).
[Crossref]

Lab Chip (3)

S. A. Arpali, C. Arpali, A. F. Coskun, H. H. Chiang, and A. Ozcan, “High-throughput screening of large volumes of whole blood using structured illumination and fluorescent on-chip imaging,” Lab Chip 12(23), 4968–4971 (2012).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

G. Romeo, G. D’Avino, F. Greco, P. A. Netti, and P. L. Maffettone, “Viscoelastic flow-focusing in microchannels: scaling properties of the particle radial distributions,” Lab Chip 13(14), 2802–2807 (2013).
[Crossref] [PubMed]

Light Sci. Appl. (1)

F. Merola, P. Memmolo, L. Miccio, R. Savoia, M. Mugnano, A. Fontana, G. D’Ippolito, A. Sardo, A. Iolascon, A. Gambale, and P. Ferraro, “Tomographic flow cytometry by digital holography,” Light Sci. Appl. 6(4), e16241 (2017).
[Crossref] [PubMed]

Mediators Inflamm. (1)

D. Min, B. Brooks, J. Wong, R. Salomon, W. Bao, B. Harrisberg, S. M. Twigg, D. K. Yue, and S. V. McLennan, “Alterations in monocyte CD16 in association with diabetes complications,” Mediators Inflamm. 2012, 649083 (2012).
[Crossref] [PubMed]

Nat. Commun. (2)

L. Miccio, P. Memmolo, F. Merola, P. A. Netti, and P. Ferraro, “Red blood cell as an adaptive optofluidic microlens,” Nat. Commun. 6(1), 6502 (2015).
[Crossref] [PubMed]

T. Blasi, H. Hennig, H. D. Summers, F. J. Theis, J. Cerveira, J. O. Patterson, D. Davies, A. Filby, A. E. Carpenter, and P. Rees, “Label-free cell cycle analysis for high-throughput imaging flow cytometry,” Nat. Commun. 7, 10256 (2016).
[Crossref] [PubMed]

Nat. Photonics (1)

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
[Crossref]

Nat. Protoc. (1)

R. A. Kellogg, R. Gómez-Sjöberg, A. A. Leyrat, and S. Tay, “High-throughput microfluidic single-cell analysis pipeline for studies of signaling dynamics,” Nat. Protoc. 9(7), 1713–1726 (2014).
[Crossref] [PubMed]

Opt. Eng. (1)

X. Yu, J. Hong, C. Liu, and M. K. Kim, “Review of digital holographic microscopy for three-dimensional profiling and tracking,” Opt. Eng. 53(11), 112306 (2014).
[Crossref]

Opt. Express (1)

Opt. Lett. (1)

Phys. Rev. Lett. (1)

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[Crossref] [PubMed]

PLoS One (1)

P. Hu, H. Shen, G. Wang, P. Zhang, Q. Liu, and J. Du, “Prognostic significance of systemic inflammation-based lymphocyte- monocyte ratio in patients with lung cancer: based on a large cohort study,” PLoS One 9(9), e108062 (2014).
[Crossref] [PubMed]

Proc. IEEE (1)

F. Merola, P. Memmolo, L. Miccio, V. Bianco, M. Paturzo, and P. Ferraro, “Diagnostic tools for lab-on-chip applications based on coherent imaging microscopy,” Proc. IEEE 103(2), 192–204 (2015).
[Crossref]

Sci. Rep. (5)

S. V. Kesavan, F. Momey, O. Cioni, B. David-Watine, N. Dubrulle, S. Shorte, E. Sulpice, D. Freida, B. Chalmond, J. M. Dinten, X. Gidrol, and C. Allier, “High-throughput monitoring of major cell functions by means of lensfree video microscopy,” Sci. Rep. 4(1), 5942 (2015).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, M. Ripaldi, P. A. Netti, and F. Causa, “Single-cell screening of multiple biophysical properties in leukemia diagnosis from peripheral blood by pure light scattering,” Sci. Rep. 7(1), 12666 (2017).
[Crossref] [PubMed]

M. Masaeli, D. Gupta, S. O’Byrne, H. T. K. Tse, D. R. Gossett, P. Tseng, A. S. Utada, H. J. Jung, S. Young, A. T. Clark, and D. Di Carlo, “Multiparameter mechanical and morphometric screening of cells,” Sci. Rep. 6(1), 37863 (2016).
[Crossref] [PubMed]

Z. Liu, W. Guo, D. Zhang, Y. Pang, J. Shi, S. Wan, K. Cheng, J. Wang, and S. Cheng, “Circulating tumor cell detection in hepatocellular carcinoma based on karyoplasmic ratios using imaging flow cytometry,” Sci. Rep. 6(1), 39808 (2016).
[Crossref] [PubMed]

C. H. Wu, T. D. Wang, C. H. Hsieh, S. H. Huang, J. W. Lin, S. C. Hsu, H. T. Wu, Y. M. Wu, and T. M. Liu, “Imaging Cytometry of human leukocytes with third harmonic generation microscopy,” Sci. Rep. 6(1), 37210 (2016).
[Crossref] [PubMed]

SPIE Rev. (1)

M. K. Kim, “Principles and techniques of digital holographic microscopy,” SPIE Rev. 1(1), 018005 (2010)

Other (2)

D. Dannhauser, P. Memmolo, D. Rossi, F. Merola, L. Miccio, F. Causa, P. Ferraro, and P. A. Netti, “Cells characterization in microfluidic flows by small angle light scattering and 3D holographic technique,” Optical Methods for Inspection, Characterization, and Imaging of Biomaterials II, P. Ferraro, S. Grilli, M. Ritsch-Marte, and D. Stifter, eds, (SPIE, 2015).

G. Popescu, Quantitative Phase Imaging of Cells and Tissues (McGraw-Hill, 2011).

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Figures (5)

Fig. 1
Fig. 1 Monocyte isolation procedure and flow cytometer measurement. (a) The three-step isolation procedure of monocytes from whole blood is illustrated. At the first step a gradient separation with ‘Ficoll’ was performed. The obtained PBMC ring is taken and suspended in PBS. Magnetic Ab-beads are added in the second step. Afterwards in the third step a magnet retains the bound content to the falcon tube surface, while monocytes remain free in the suspension to analyze. (b) Flow cytometer control of isolated monocytes (red) and added lymphocytes (gray), where two distinct zones are noticed. Monocytes show significant bigger forward and side scattering intensity values compared to lymphocytes.
Fig. 2
Fig. 2 Monocyte observations. (a) Bright-field observation with 100× oil immersion objective of monocytes in 0.2g dL−1 PEO-PBS. Trypan blue investigations with a 20x objective in color before (b) and after (c) cell measurements. (d) 3D reconstruction of confocal fluorescent z-stack images (ImageJ: plugin/Stacks - Z-functions/360- 3D project... Macro). (e) Confocal image of one slide of the fluorescent z-stack. (Green color shows the ‘Wheat germ Agglutinin’, while red color indicates the ‘Sytox Green’)
Fig. 3
Fig. 3 (a) Viscoelastic alignment of monocytes in flow. The alignment takes place in a narrow round shaped capillary, before sedimentation forces can act in the aligned cells in wide squared shaped microfluidic channel. The entrance of the channel where scattering measurement have been performed is indicated by x0, while 15 mm (l) downstream a second measurement position x1 indicates the position, where DH observation have been performed. (b) Simulation model is illustrated; the indices n, c and l are used for nucleus, cytosol, and extracellular liquid, respectively. The nucleus is assumed to be in the center of the cell.
Fig. 4
Fig. 4 Schematic illustration of the OS- and DH-setup for monocyte investigations. (a) Illustration of the light scattering setup, where the incident light passes the microfluidic device from below, striking, one by one, monocytes aligned in the centerline of the measurement channel. The OS of each individual cell is collected and mapped on the camera sensor by two lenses in series, while the incident light is blocked by a beam stop. Moreover, the round shaped capillary for the cell alignment, the square shaped measurement channel as well as the ferrule which connect both microfluidic parts are indicated. The inset of LSP of a single monocyte is reported. (b) A sketch of the holographic setup is shown, where the incident light source is split into an object- and reference-beam by a beam-splitter. The object-beam strikes passing monocytes before both beams are simultaneously collected by the camera sensor. (c) Microfluidic device combined with the coherent imaging approach of OS (position x0) and DH (position x1) is shown.
Fig. 5
Fig. 5 (a) LSP of monocyte measurement and overlaid simulation curve is shown. (b) The corresponding OS image recorded by the camera sensor is illustrated. (c) Optical axis results of monocytes investigated in measurement position x1. An increased cell displacement from the initial optical axis position (z = 0) is observed for decreasing ∆P values and vice-versa. (d) Phase-contrast image of a typical monocyte investigated in flow is shown. The inset shows detected nucleus content.

Tables (1)

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Table 1 Biophysical monocyte properties from collaborative OS and DH imaging technique for ΔP of 2000 mbar and 0.2 g dL−1 PEO-PBS as well as literature values.

Equations (9)

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θ= γ ˙ ^ λ t + β 2 ( L/ r c ),
β= d c / 2 r c .
γ ˙ ^ = ( Δ Pr c )/ ( 4 η 0 L ) ,
Δφ( x,y )= 2π λ [ n( x,y ) n l ]t
V= λ 2π( n OS n l ) φ ^ S
S=K ρ 2
φ ^ = 1 K j=1 K Δ φ j
E= a min / a max
DM= 10λ 2λα φ ^ S

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