Abstract

Spatial frequency domain imaging (SFDI) is a widefield imaging technique that allows for the quantitative extraction of tissue optical properties. SFDI is currently being explored for small animal tumor imaging, but severe imaging artifacts occur for highly curved surfaces (e.g. the tumor edge). We propose a modified Lambertian angle correction, adapted from the Minnaert correction method for satellite imagery, to account for tissue surface angles up to 75°. The method was tested in a hemisphere phantom study as well as a small animal tumor model. The proposed method reduced µa and µs` extraction errors by an average of 64% and 16% respectively compared to performing no angle correction, and provided more physiologically agreeable optical property and chromophore values on tumors.

© 2016 Optical Society of America

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References

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2015 (2)

2014 (3)

A. Ponticorvo, D. M. Burmeister, B. Yang, B. Choi, R. J. Christy, and A. J. Durkin, “Quantitative assessment of graded burn wounds in a porcine model using spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI),” Biomed. Opt. Express 5(10), 3467–3481 (2014).
[Crossref] [PubMed]

A. Mazhar, S. Saggese, A. C. Pollins, N. L. Cardwell, L. Nanney, and D. J. Cuccia, “Noncontact imaging of burn depth and extent in a porcine model using spatial frequency domain imaging,” J. Biomed. Opt. 19(8), 086019 (2014).
[Crossref] [PubMed]

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

2013 (2)

K. P. Nadeau, P. Khoury, A. Mazhar, D. Cuccia, and J. Durkin, “Component and system evaluation for the development of a handheld point-of-care spatial frequency domain imaging (SFDI) device,” Proc. SPIE 8573, 857304 (2013).
[Crossref]

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L.-H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

2012 (3)

A. Mazhar, S. Sharif, S. Saggese, B. Choi, D. J. Cuccia, and A. J. Durkin, “Implementation of an LED based Clinical Spatial Frequency Domain Imaging System,” Proc. SPIE 8254, 82540A (2012).
[Crossref]

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

S. A. Sharif, E. Taydas, A. Mazhar, R. Rahimian, K. M. Kelly, B. Choi, and A. J. Durkin, “Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review,” Br. J. Dermatol. 167(6), 1215–1223 (2012).
[Crossref] [PubMed]

2011 (4)

S. Gioux, A. Mazhar, B. T. Lee, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, N. Durr, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Preclinical and clinical validation of a novel oxygenation imaging system,” Spectroscopy (Springf.) 7896, 78961R (2011).

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

M. Martinelli, A. Gardner, D. Cuccia, C. Hayakawa, J. Spanier, and V. Venugopalan, “Analysis of single Monte Carlo methods for prediction of reflectance from turbid media,” Opt. Express 19(20), 19627–19642 (2011).
[Crossref] [PubMed]

2009 (3)

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

S. D. Konecky, A. Mazhar, D. Cuccia, A. J. Durkin, J. C. Schotland, and B. J. Tromberg, “Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light,” Opt. Express 17(17), 14780–14790 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

2005 (1)

1996 (1)

S. Ekstrand, “Landsat TM-Based Forest Damage Assessment: Correction for Topographic Effects,” Photogramm. Eng. Remote Sensing 62(2), 151–161 (1996).

1941 (1)

M. Minnaert, “The reciprocity principle in lunar photometry,” Astrophys. J. 93, 403 (1941).
[Crossref]

Ashitate, Y.

S. Gioux, A. Mazhar, B. T. Lee, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, N. Durr, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Preclinical and clinical validation of a novel oxygenation imaging system,” Spectroscopy (Springf.) 7896, 78961R (2011).

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Ayers, F. R.

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Bernal, N.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L.-H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Bevilacqua, F.

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, and B. J. Tromberg, “Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain,” Opt. Lett. 30(11), 1354–1356 (2005).
[Crossref] [PubMed]

Burmeister, D. M.

Cardwell, N. L.

A. Mazhar, S. Saggese, A. C. Pollins, N. L. Cardwell, L. Nanney, and D. J. Cuccia, “Noncontact imaging of burn depth and extent in a porcine model using spatial frequency domain imaging,” J. Biomed. Opt. 19(8), 086019 (2014).
[Crossref] [PubMed]

Choi, B.

A. Ponticorvo, D. M. Burmeister, B. Yang, B. Choi, R. J. Christy, and A. J. Durkin, “Quantitative assessment of graded burn wounds in a porcine model using spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI),” Biomed. Opt. Express 5(10), 3467–3481 (2014).
[Crossref] [PubMed]

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L.-H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

S. A. Sharif, E. Taydas, A. Mazhar, R. Rahimian, K. M. Kelly, B. Choi, and A. J. Durkin, “Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review,” Br. J. Dermatol. 167(6), 1215–1223 (2012).
[Crossref] [PubMed]

A. Mazhar, S. Sharif, S. Saggese, B. Choi, D. J. Cuccia, and A. J. Durkin, “Implementation of an LED based Clinical Spatial Frequency Domain Imaging System,” Proc. SPIE 8254, 82540A (2012).
[Crossref]

Christy, R. J.

Crouzet, C.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L.-H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Cuccia, D.

Cuccia, D. J.

A. Mazhar, S. Saggese, A. C. Pollins, N. L. Cardwell, L. Nanney, and D. J. Cuccia, “Noncontact imaging of burn depth and extent in a porcine model using spatial frequency domain imaging,” J. Biomed. Opt. 19(8), 086019 (2014).
[Crossref] [PubMed]

A. Mazhar, S. Sharif, S. Saggese, B. Choi, D. J. Cuccia, and A. J. Durkin, “Implementation of an LED based Clinical Spatial Frequency Domain Imaging System,” Proc. SPIE 8254, 82540A (2012).
[Crossref]

S. Gioux, A. Mazhar, B. T. Lee, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, N. Durr, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Preclinical and clinical validation of a novel oxygenation imaging system,” Spectroscopy (Springf.) 7896, 78961R (2011).

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, and B. J. Tromberg, “Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain,” Opt. Lett. 30(11), 1354–1356 (2005).
[Crossref] [PubMed]

Diep, P.

Durkin, A. J.

A. Ponticorvo, D. M. Burmeister, B. Yang, B. Choi, R. J. Christy, and A. J. Durkin, “Quantitative assessment of graded burn wounds in a porcine model using spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI),” Biomed. Opt. Express 5(10), 3467–3481 (2014).
[Crossref] [PubMed]

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L.-H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

S. A. Sharif, E. Taydas, A. Mazhar, R. Rahimian, K. M. Kelly, B. Choi, and A. J. Durkin, “Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review,” Br. J. Dermatol. 167(6), 1215–1223 (2012).
[Crossref] [PubMed]

A. Mazhar, S. Sharif, S. Saggese, B. Choi, D. J. Cuccia, and A. J. Durkin, “Implementation of an LED based Clinical Spatial Frequency Domain Imaging System,” Proc. SPIE 8254, 82540A (2012).
[Crossref]

S. Gioux, A. Mazhar, B. T. Lee, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, N. Durr, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Preclinical and clinical validation of a novel oxygenation imaging system,” Spectroscopy (Springf.) 7896, 78961R (2011).

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

S. D. Konecky, A. Mazhar, D. Cuccia, A. J. Durkin, J. C. Schotland, and B. J. Tromberg, “Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light,” Opt. Express 17(17), 14780–14790 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, and B. J. Tromberg, “Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain,” Opt. Lett. 30(11), 1354–1356 (2005).
[Crossref] [PubMed]

Durkin, J.

K. P. Nadeau, P. Khoury, A. Mazhar, D. Cuccia, and J. Durkin, “Component and system evaluation for the development of a handheld point-of-care spatial frequency domain imaging (SFDI) device,” Proc. SPIE 8573, 857304 (2013).
[Crossref]

Durr, N.

S. Gioux, A. Mazhar, B. T. Lee, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, N. Durr, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Preclinical and clinical validation of a novel oxygenation imaging system,” Spectroscopy (Springf.) 7896, 78961R (2011).

Durr, N. J.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Ekstrand, S.

S. Ekstrand, “Landsat TM-Based Forest Damage Assessment: Correction for Topographic Effects,” Photogramm. Eng. Remote Sensing 62(2), 151–161 (1996).

Erramilli, S.

Frangioni, J. V.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, N. Durr, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Preclinical and clinical validation of a novel oxygenation imaging system,” Spectroscopy (Springf.) 7896, 78961R (2011).

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

Gardner, A.

Gioux, S.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, N. Durr, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Preclinical and clinical validation of a novel oxygenation imaging system,” Spectroscopy (Springf.) 7896, 78961R (2011).

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

Hayakawa, C.

Huihui, J.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Istfan, R.

Kelly, E.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Kelly, K. M.

S. A. Sharif, E. Taydas, A. Mazhar, R. Rahimian, K. M. Kelly, B. Choi, and A. J. Durkin, “Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review,” Br. J. Dermatol. 167(6), 1215–1223 (2012).
[Crossref] [PubMed]

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

Keymel, K.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Khoury, P.

K. P. Nadeau, P. Khoury, A. Mazhar, D. Cuccia, and J. Durkin, “Component and system evaluation for the development of a handheld point-of-care spatial frequency domain imaging (SFDI) device,” Proc. SPIE 8573, 857304 (2013).
[Crossref]

Kolste, K.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Konecky, S. D.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

S. D. Konecky, A. Mazhar, D. Cuccia, A. J. Durkin, J. C. Schotland, and B. J. Tromberg, “Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light,” Opt. Express 17(17), 14780–14790 (2009).
[Crossref] [PubMed]

Leblond, F.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Lee, B. T.

S. Gioux, A. Mazhar, B. T. Lee, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, N. Durr, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Preclinical and clinical validation of a novel oxygenation imaging system,” Spectroscopy (Springf.) 7896, 78961R (2011).

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Liaw, L.-H.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L.-H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Lin, S. J.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Lo, J.

Mai, T.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L.-H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Martinelli, M.

Mazhar, A.

A. Mazhar, S. Saggese, A. C. Pollins, N. L. Cardwell, L. Nanney, and D. J. Cuccia, “Noncontact imaging of burn depth and extent in a porcine model using spatial frequency domain imaging,” J. Biomed. Opt. 19(8), 086019 (2014).
[Crossref] [PubMed]

K. P. Nadeau, P. Khoury, A. Mazhar, D. Cuccia, and J. Durkin, “Component and system evaluation for the development of a handheld point-of-care spatial frequency domain imaging (SFDI) device,” Proc. SPIE 8573, 857304 (2013).
[Crossref]

A. Mazhar, S. Sharif, S. Saggese, B. Choi, D. J. Cuccia, and A. J. Durkin, “Implementation of an LED based Clinical Spatial Frequency Domain Imaging System,” Proc. SPIE 8254, 82540A (2012).
[Crossref]

S. A. Sharif, E. Taydas, A. Mazhar, R. Rahimian, K. M. Kelly, B. Choi, and A. J. Durkin, “Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review,” Br. J. Dermatol. 167(6), 1215–1223 (2012).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, N. Durr, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Preclinical and clinical validation of a novel oxygenation imaging system,” Spectroscopy (Springf.) 7896, 78961R (2011).

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

S. D. Konecky, A. Mazhar, D. Cuccia, A. J. Durkin, J. C. Schotland, and B. J. Tromberg, “Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light,” Opt. Express 17(17), 14780–14790 (2009).
[Crossref] [PubMed]

Minnaert, M.

M. Minnaert, “The reciprocity principle in lunar photometry,” Astrophys. J. 93, 403 (1941).
[Crossref]

Moffitt, L. A.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Morgan, J.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Muffoletto, D.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Nadeau, K. P.

K. P. Nadeau, P. Khoury, A. Mazhar, D. Cuccia, and J. Durkin, “Component and system evaluation for the development of a handheld point-of-care spatial frequency domain imaging (SFDI) device,” Proc. SPIE 8573, 857304 (2013).
[Crossref]

Nanney, L.

A. Mazhar, S. Saggese, A. C. Pollins, N. L. Cardwell, L. Nanney, and D. J. Cuccia, “Noncontact imaging of burn depth and extent in a porcine model using spatial frequency domain imaging,” J. Biomed. Opt. 19(8), 086019 (2014).
[Crossref] [PubMed]

Nguyen, J. Q.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L.-H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Oketokoun, R.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, N. Durr, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Preclinical and clinical validation of a novel oxygenation imaging system,” Spectroscopy (Springf.) 7896, 78961R (2011).

Owen, C. M.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Pannem, S.

Paquette, A.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Paulsen, K. D.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Pollins, A. C.

A. Mazhar, S. Saggese, A. C. Pollins, N. L. Cardwell, L. Nanney, and D. J. Cuccia, “Noncontact imaging of burn depth and extent in a porcine model using spatial frequency domain imaging,” J. Biomed. Opt. 19(8), 086019 (2014).
[Crossref] [PubMed]

Ponticorvo, A.

A. Ponticorvo, D. M. Burmeister, B. Yang, B. Choi, R. J. Christy, and A. J. Durkin, “Quantitative assessment of graded burn wounds in a porcine model using spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI),” Biomed. Opt. Express 5(10), 3467–3481 (2014).
[Crossref] [PubMed]

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L.-H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Rahimian, R.

S. A. Sharif, E. Taydas, A. Mazhar, R. Rahimian, K. M. Kelly, B. Choi, and A. J. Durkin, “Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review,” Br. J. Dermatol. 167(6), 1215–1223 (2012).
[Crossref] [PubMed]

Rice, T.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Riola, K.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L.-H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Roberts, D. W.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Roblyer, D.

Rohrbach, D. J.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Saager, R.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Saager, R. B.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

Saggese, S.

A. Mazhar, S. Saggese, A. C. Pollins, N. L. Cardwell, L. Nanney, and D. J. Cuccia, “Noncontact imaging of burn depth and extent in a porcine model using spatial frequency domain imaging,” J. Biomed. Opt. 19(8), 086019 (2014).
[Crossref] [PubMed]

A. Mazhar, S. Sharif, S. Saggese, B. Choi, D. J. Cuccia, and A. J. Durkin, “Implementation of an LED based Clinical Spatial Frequency Domain Imaging System,” Proc. SPIE 8254, 82540A (2012).
[Crossref]

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

Schotland, J. C.

Sharif, S.

A. Mazhar, S. Sharif, S. Saggese, B. Choi, D. J. Cuccia, and A. J. Durkin, “Implementation of an LED based Clinical Spatial Frequency Domain Imaging System,” Proc. SPIE 8254, 82540A (2012).
[Crossref]

Sharif, S. A.

S. A. Sharif, E. Taydas, A. Mazhar, R. Rahimian, K. M. Kelly, B. Choi, and A. J. Durkin, “Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review,” Br. J. Dermatol. 167(6), 1215–1223 (2012).
[Crossref] [PubMed]

Snyder, M.

Spanier, J.

Stockdale, A.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, N. Durr, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Preclinical and clinical validation of a novel oxygenation imaging system,” Spectroscopy (Springf.) 7896, 78961R (2011).

Stueber, G.

Sunar, U.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Sweer, J.

Tabassum, S.

Taydas, E.

S. A. Sharif, E. Taydas, A. Mazhar, R. Rahimian, K. M. Kelly, B. Choi, and A. J. Durkin, “Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review,” Br. J. Dermatol. 167(6), 1215–1223 (2012).
[Crossref] [PubMed]

Tobias, A. M.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Tromberg, B. J.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, N. Durr, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Preclinical and clinical validation of a novel oxygenation imaging system,” Spectroscopy (Springf.) 7896, 78961R (2011).

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

S. D. Konecky, A. Mazhar, D. Cuccia, A. J. Durkin, J. C. Schotland, and B. J. Tromberg, “Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light,” Opt. Express 17(17), 14780–14790 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, and B. J. Tromberg, “Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain,” Opt. Lett. 30(11), 1354–1356 (2005).
[Crossref] [PubMed]

Uchitel, D.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L.-H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Valdés, P. A.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Venugopalan, V.

Weinmann, M.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Wilson, B. C.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Wu, J.

Yang, B.

Zeitouni, N.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Zhao, Y.

Acad. Radiol. (1)

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Astrophys. J. (1)

M. Minnaert, “The reciprocity principle in lunar photometry,” Astrophys. J. 93, 403 (1941).
[Crossref]

Biomed. Opt. Express (2)

Br. J. Dermatol. (1)

S. A. Sharif, E. Taydas, A. Mazhar, R. Rahimian, K. M. Kelly, B. Choi, and A. J. Durkin, “Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review,” Br. J. Dermatol. 167(6), 1215–1223 (2012).
[Crossref] [PubMed]

J. Biomed. Opt. (8)

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
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S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
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A. Mazhar, S. Saggese, A. C. Pollins, N. L. Cardwell, L. Nanney, and D. J. Cuccia, “Noncontact imaging of burn depth and extent in a porcine model using spatial frequency domain imaging,” J. Biomed. Opt. 19(8), 086019 (2014).
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S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
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Y. Zhao and D. Roblyer, “Spatial mapping of fluorophore quantum yield in diffusive media,” J. Biomed. Opt. 20(8), 086013 (2015).
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K. P. Nadeau, P. Khoury, A. Mazhar, D. Cuccia, and J. Durkin, “Component and system evaluation for the development of a handheld point-of-care spatial frequency domain imaging (SFDI) device,” Proc. SPIE 8573, 857304 (2013).
[Crossref]

A. Mazhar, S. Sharif, S. Saggese, B. Choi, D. J. Cuccia, and A. J. Durkin, “Implementation of an LED based Clinical Spatial Frequency Domain Imaging System,” Proc. SPIE 8254, 82540A (2012).
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Spectroscopy (Springf.) (1)

S. Gioux, A. Mazhar, B. T. Lee, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, N. Durr, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Preclinical and clinical validation of a novel oxygenation imaging system,” Spectroscopy (Springf.) 7896, 78961R (2011).

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Figures (8)

Fig. 1
Fig. 1 Diagram of angle θ in SFDI imaging geometry.
Fig. 2
Fig. 2 White light image of the 2 cm diameter hemisphere phantoms. Optical properties are shown for 526 nm.
Fig. 3
Fig. 3 Angle-corrected Mac versus coefficient k.
Fig. 4
Fig. 4 Coefficient k versus spatial frequency.
Fig. 5
Fig. 5 Line profiles of absorption and reduced scattering through the center of a 2 cm diameter hemisphere using different angle correction methods.
Fig. 6
Fig. 6 Absorption and reduced scattering plots rendered with 3D heights, and histograms of the hemisphere region. Optical properties are shown for a 2 cm diameter hemisphere at 526 nm.
Fig. 7
Fig. 7 RMSE bar plots of 2 cm diameter hemisphere phantoms, measured at 659 nm.
Fig. 8
Fig. 8 Comparison of three methods on mouse tumor data and their distributions shown in histograms, measured at 659nm, 691 nm, 731 nm, and 851 nm. The plotted absorption data was measured at 659 nm. Optical properties are only shown for the tumor ROI. Zoomed-in figures are shown for the tumor optical absorption and total hemoglobin.

Tables (1)

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Table 1 Optical properties of the 2 cm diameter hemisphere phantoms. 1 cm and 3 cm hemispheres were fabricated from the same batch and had closely matching optical properties.

Equations (4)

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R d,tis ( f x )= M ac,tis ( f x ) M ac,ref ( f x ) R d,ref ( f x ).
M AC,corrected = M AC,uncorrected × 1 cos(θ) .
M AC,corrected = M AC,uncorrected × 1 cos (θ) k .
k= argmin k[0,1] i=1 n ( M ac ( f x ) i 1 cos ( θ i ) k M ac,ref ) 2

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