Abstract

The goal of this work is to demonstrate that a CCD-based system can be used as a unified device which allows visible, β, X and γ rays imaging. A system composed of a CCD coupled with lens mounted on a black light-tight box and a high resolution intensifying screen for the radiations conversion were used. In order to investigate the detection of different type of radiations in vitro and in vivo experiments were performed. The comparison of the results obtained with our prototype and those obtained with dedicated commercial devices showed a good agreement.

© 2015 Optical Society of America

Full Article  |  PDF Article
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2015 (2)

A. E. Spinelli and F. Boschi, “Novel biomedical applications of Cerenkov radiation and radioluminescence imaging,” Phys. Med. 31(2), 120–129 (2015).
[Crossref] [PubMed]

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

2014 (1)

M. Pagliazzi, F. Boschi, and A. E. Spinelli, “Imaging of luminescence induced by beta and gamma emitters in conventional non-scintillating materials,” RSC Adv. 4(26), 13687–13692 (2014).
[Crossref]

2013 (3)

L. Uccelli, A. Boschi, M. Pasquali, A. Duatti, G. Di Domenico, G. Pupillo, J. Esposito, M. Giganti, A. Taibi, and M. Gambaccini, “Influence of the generator in-growth time on the final radiochemical purity and stability of 99mTc radiopharmaceuticals,” Sci. Technol. Nucl. Install. 2013, 379283 (2013).
[Crossref]

F. Boschi, M. Pagliazzi, B. Rossi, M. P. Cecchini, G. Gorgoni, M. Salgarello, and A. E. Spinelli, “Small-animal radionuclide luminescence imaging of thyroid and salivary glands with 99mTc-pertechnetate,” J. Biomed. Opt. 18(7), 076005 (2013).
[Crossref] [PubMed]

A. E. Spinelli, M. Ferdeghini, C. Cavedon, E. Zivelonghi, R. Calandrino, A. Fenzi, A. Sbarbati, and F. Boschi, “First human Cerenkography,” J. Biomed. Opt. 18(2), 020502 (2013).
[Crossref] [PubMed]

2012 (6)

S. R. Kothapalli, H. Liu, J. C. Liao, Z. Cheng, and S. S. Gambhir, “Endoscopic imaging of Cerenkov luminescence,” Biomed. Opt. Express 3(6), 1215–1225 (2012).
[Crossref] [PubMed]

H. Liu, C. M. Carpenter, H. Jiang, G. Pratx, C. Sun, M. P. Buchin, S. S. Gambhir, L. Xing, and Z. Cheng, “Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study,” J. Nucl. Med. 53(10), 1579–1584 (2012).
[Crossref] [PubMed]

F. Boschi and A. E. Spinelli, “Quantum dots excitation using pure beta minus radioisotopes emitting Cerenkov radiation,” RSC Adv. 2(29), 11049–11052 (2012).
[Crossref]

A. E. Spinelli, M. Marengo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of radioisotopes: a novel multimodal approach to molecular imaging,” Q. J. Nucl. Med. Mol. Imaging 56(3), 280–290 (2012).
[PubMed]

D. Lj. Thorek, R. Robertson, W. A. Bacchus, J. Hahn, J. Rothberg, B. J. Beattie, and J. Grimm, “Cerenkov imaging - a new modality for molecular imaging,” Am. J. Nucl. Med. Mol. Imaging 2(2), 163–173 (2012).
[PubMed]

T. Métayé, T. Rosenberg, J. Guilhot, M. H. Bouin-Pineau, and R. Perdrisot, “The Presence of Sodium Nitrate in Generator Eluate Decreases the Radiochemical Purity of Tc99m-Sestamibi,” J. Nucl. Med. Technol. 40(3), 187–193 (2012).
[Crossref] [PubMed]

2011 (6)

F. Boschi, S. L. Meo, P. L. Rossi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “Optical imaging of alpha emitters: simulations, phantom, and in vivo results,” J. Biomed. Opt. 16(12), 126011 (2011).
[Crossref] [PubMed]

A. E. Spinelli, S. Lo Meo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of Tc-99m-based tracers: in vitro and in vivo results,” J. Biomed. Opt. 16(11), 116023 (2011).
[Crossref] [PubMed]

D. M. Close, T. Xu, G. S. Sayler, and S. Ripp, “In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals,” Sensors (Basel) 11(1), 180–206 (2011).
[Crossref] [PubMed]

A. E. Spinelli, F. Boschi, D. D’Ambrosio, L. Calderan, M. Marengo, A. Fenzi, M. Menegazzi, A. Sbarbati, A. Del Vecchio, and R. Calandrino, “Cherenkov radiation imaging of beta emitters: in vitro and in vivo results,” Nucl. Instrum. Meth. A 648(1), S310–S312 (2011).
[Crossref]

G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Li, and S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Philos. Trans. A. Math Phys. Eng. Sci. 369(1955), 4605–4619 (2011).
[Crossref] [PubMed]

F. Boschi, L. Calderan, D. D’Ambrosio, M. Marengo, A. Fenzi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “In vivo (18)F-FDG tumour uptake measurements in small animals using Cerenkov radiation,” Eur. J. Nucl. Med. Mol. Imaging 38(1), 120–127 (2011).
[Crossref] [PubMed]

2010 (5)

R. S. Dothager, R. J. Goiffon, E. Jackson, S. Harpstrite, and D. Piwnica-Worms, “Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems,” PLoS ONE 5(10), e13300 (2010).
[Crossref] [PubMed]

A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, A. Sbarbati, and F. Boschi, “Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers,” Phys. Med. Biol. 55(2), 483–495 (2010).
[Crossref] [PubMed]

A. Ruggiero, J. P. Holland, J. S. Lewis, and J. Grimm, “Cerenkov luminescence imaging of medical isotopes,” J. Nucl. Med. 51(7), 1123–1130 (2010).
[Crossref] [PubMed]

H. Liu, G. Ren, Z. Miao, X. Zhang, X. Tang, P. Han, S. S. Gambhir, and Z. Cheng, “Molecular optical imaging with radioactive probes,” PLoS ONE 5(3), e9470 (2010).
[Crossref] [PubMed]

Y. Inoue, S. Kiryu, M. Watanabe, A. Tojo, and K. Ohtomo, “Timing of imaging after D-luciferin injection affects the longitudinal assessment of tumor growth using in vivo bioluminescence imaging,” Int. J. Biomed. Imaging 2010(8), 471408 (2010).
[PubMed]

2009 (4)

F. Boschi, A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, and A. Sbarbati, “Combined optical and single photon emission imaging: preliminary results,” Phys. Med. Biol. 54(23), L57–L62 (2009).
[Crossref] [PubMed]

R. Robertson, M. S. Germanos, C. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, “Optical imaging of Cerenkov light generation from positron-emitting radiotracers,” Phys. Med. Biol. 54(16), N355–N365 (2009).
[Crossref] [PubMed]

L. Lança and A. Silva, “Digital radiography detectors - A technical overview: Part 1,” Radiography 15(1), 58–62 (2009).
[Crossref]

C. M. Schaefer-Prokop, D. W. De Boo, M. Uffmann, and M. Prokop, “DR and CR: Recent advances in technology,” Eur. J. Radiol. 72(2), 194–201 (2009).
[Crossref] [PubMed]

2007 (1)

M. Körner, C. H. Weber, S. Wirth, K. J. Pfeifer, M. F. Reiser, and M. Treitl, “Advances in digital radiography: physical principles and system overview,” Radiographics 27(3), 675–686 (2007).
[Crossref] [PubMed]

2003 (1)

M. S. Robbins and B. J. Hadwen, “The noise performance of electron multiplying charge-coupled devices,” IEEE Trans. Electron Dev. 50(5), 1227–1232 (2003).
[Crossref]

2002 (1)

J. A. Rowlands, “The physics of computed radiography,” Phys. Med. Biol. 47(23), R123–R166 (2002).
[Crossref] [PubMed]

1998 (1)

E. Samei, M. J. Flynn, and D. A. Reimann, “A method for measuring the presampled MTF of digital radiographic systems using an edge test device,” Med. Phys. 25(1), 102–113 (1998).
[Crossref] [PubMed]

1992 (1)

H. Fujita, D. Y. Tsai, T. Itoh, K. Doi, J. Morishita, K. Ueda, and A. Ohtsuka, “A simple method for determining the modulation transfer function in digital radiography,” IEEE Trans. Med. Imaging 11(1), 34–39 (1992).
[Crossref] [PubMed]

Bacchus, W. A.

D. Lj. Thorek, R. Robertson, W. A. Bacchus, J. Hahn, J. Rothberg, B. J. Beattie, and J. Grimm, “Cerenkov imaging - a new modality for molecular imaging,” Am. J. Nucl. Med. Mol. Imaging 2(2), 163–173 (2012).
[PubMed]

Beattie, B. J.

D. Lj. Thorek, R. Robertson, W. A. Bacchus, J. Hahn, J. Rothberg, B. J. Beattie, and J. Grimm, “Cerenkov imaging - a new modality for molecular imaging,” Am. J. Nucl. Med. Mol. Imaging 2(2), 163–173 (2012).
[PubMed]

Boschi, A.

L. Uccelli, A. Boschi, M. Pasquali, A. Duatti, G. Di Domenico, G. Pupillo, J. Esposito, M. Giganti, A. Taibi, and M. Gambaccini, “Influence of the generator in-growth time on the final radiochemical purity and stability of 99mTc radiopharmaceuticals,” Sci. Technol. Nucl. Install. 2013, 379283 (2013).
[Crossref]

Boschi, F.

A. E. Spinelli and F. Boschi, “Novel biomedical applications of Cerenkov radiation and radioluminescence imaging,” Phys. Med. 31(2), 120–129 (2015).
[Crossref] [PubMed]

M. Pagliazzi, F. Boschi, and A. E. Spinelli, “Imaging of luminescence induced by beta and gamma emitters in conventional non-scintillating materials,” RSC Adv. 4(26), 13687–13692 (2014).
[Crossref]

F. Boschi, M. Pagliazzi, B. Rossi, M. P. Cecchini, G. Gorgoni, M. Salgarello, and A. E. Spinelli, “Small-animal radionuclide luminescence imaging of thyroid and salivary glands with 99mTc-pertechnetate,” J. Biomed. Opt. 18(7), 076005 (2013).
[Crossref] [PubMed]

A. E. Spinelli, M. Ferdeghini, C. Cavedon, E. Zivelonghi, R. Calandrino, A. Fenzi, A. Sbarbati, and F. Boschi, “First human Cerenkography,” J. Biomed. Opt. 18(2), 020502 (2013).
[Crossref] [PubMed]

F. Boschi and A. E. Spinelli, “Quantum dots excitation using pure beta minus radioisotopes emitting Cerenkov radiation,” RSC Adv. 2(29), 11049–11052 (2012).
[Crossref]

A. E. Spinelli, M. Marengo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of radioisotopes: a novel multimodal approach to molecular imaging,” Q. J. Nucl. Med. Mol. Imaging 56(3), 280–290 (2012).
[PubMed]

A. E. Spinelli, F. Boschi, D. D’Ambrosio, L. Calderan, M. Marengo, A. Fenzi, M. Menegazzi, A. Sbarbati, A. Del Vecchio, and R. Calandrino, “Cherenkov radiation imaging of beta emitters: in vitro and in vivo results,” Nucl. Instrum. Meth. A 648(1), S310–S312 (2011).
[Crossref]

F. Boschi, L. Calderan, D. D’Ambrosio, M. Marengo, A. Fenzi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “In vivo (18)F-FDG tumour uptake measurements in small animals using Cerenkov radiation,” Eur. J. Nucl. Med. Mol. Imaging 38(1), 120–127 (2011).
[Crossref] [PubMed]

A. E. Spinelli, S. Lo Meo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of Tc-99m-based tracers: in vitro and in vivo results,” J. Biomed. Opt. 16(11), 116023 (2011).
[Crossref] [PubMed]

F. Boschi, S. L. Meo, P. L. Rossi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “Optical imaging of alpha emitters: simulations, phantom, and in vivo results,” J. Biomed. Opt. 16(12), 126011 (2011).
[Crossref] [PubMed]

A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, A. Sbarbati, and F. Boschi, “Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers,” Phys. Med. Biol. 55(2), 483–495 (2010).
[Crossref] [PubMed]

F. Boschi, A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, and A. Sbarbati, “Combined optical and single photon emission imaging: preliminary results,” Phys. Med. Biol. 54(23), L57–L62 (2009).
[Crossref] [PubMed]

Boucher, D. L.

G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Li, and S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Philos. Trans. A. Math Phys. Eng. Sci. 369(1955), 4605–4619 (2011).
[Crossref] [PubMed]

Bouin-Pineau, M. H.

T. Métayé, T. Rosenberg, J. Guilhot, M. H. Bouin-Pineau, and R. Perdrisot, “The Presence of Sodium Nitrate in Generator Eluate Decreases the Radiochemical Purity of Tc99m-Sestamibi,” J. Nucl. Med. Technol. 40(3), 187–193 (2012).
[Crossref] [PubMed]

Buchin, M. P.

H. Liu, C. M. Carpenter, H. Jiang, G. Pratx, C. Sun, M. P. Buchin, S. S. Gambhir, L. Xing, and Z. Cheng, “Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study,” J. Nucl. Med. 53(10), 1579–1584 (2012).
[Crossref] [PubMed]

Calandrino, R.

A. E. Spinelli, M. Ferdeghini, C. Cavedon, E. Zivelonghi, R. Calandrino, A. Fenzi, A. Sbarbati, and F. Boschi, “First human Cerenkography,” J. Biomed. Opt. 18(2), 020502 (2013).
[Crossref] [PubMed]

A. E. Spinelli, M. Marengo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of radioisotopes: a novel multimodal approach to molecular imaging,” Q. J. Nucl. Med. Mol. Imaging 56(3), 280–290 (2012).
[PubMed]

A. E. Spinelli, F. Boschi, D. D’Ambrosio, L. Calderan, M. Marengo, A. Fenzi, M. Menegazzi, A. Sbarbati, A. Del Vecchio, and R. Calandrino, “Cherenkov radiation imaging of beta emitters: in vitro and in vivo results,” Nucl. Instrum. Meth. A 648(1), S310–S312 (2011).
[Crossref]

F. Boschi, L. Calderan, D. D’Ambrosio, M. Marengo, A. Fenzi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “In vivo (18)F-FDG tumour uptake measurements in small animals using Cerenkov radiation,” Eur. J. Nucl. Med. Mol. Imaging 38(1), 120–127 (2011).
[Crossref] [PubMed]

F. Boschi, S. L. Meo, P. L. Rossi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “Optical imaging of alpha emitters: simulations, phantom, and in vivo results,” J. Biomed. Opt. 16(12), 126011 (2011).
[Crossref] [PubMed]

A. E. Spinelli, S. Lo Meo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of Tc-99m-based tracers: in vitro and in vivo results,” J. Biomed. Opt. 16(11), 116023 (2011).
[Crossref] [PubMed]

Calderan, L.

A. E. Spinelli, F. Boschi, D. D’Ambrosio, L. Calderan, M. Marengo, A. Fenzi, M. Menegazzi, A. Sbarbati, A. Del Vecchio, and R. Calandrino, “Cherenkov radiation imaging of beta emitters: in vitro and in vivo results,” Nucl. Instrum. Meth. A 648(1), S310–S312 (2011).
[Crossref]

F. Boschi, L. Calderan, D. D’Ambrosio, M. Marengo, A. Fenzi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “In vivo (18)F-FDG tumour uptake measurements in small animals using Cerenkov radiation,” Eur. J. Nucl. Med. Mol. Imaging 38(1), 120–127 (2011).
[Crossref] [PubMed]

A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, A. Sbarbati, and F. Boschi, “Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers,” Phys. Med. Biol. 55(2), 483–495 (2010).
[Crossref] [PubMed]

F. Boschi, A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, and A. Sbarbati, “Combined optical and single photon emission imaging: preliminary results,” Phys. Med. Biol. 54(23), L57–L62 (2009).
[Crossref] [PubMed]

Cao, X.

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

Carpenter, C. M.

H. Liu, C. M. Carpenter, H. Jiang, G. Pratx, C. Sun, M. P. Buchin, S. S. Gambhir, L. Xing, and Z. Cheng, “Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study,” J. Nucl. Med. 53(10), 1579–1584 (2012).
[Crossref] [PubMed]

Cavedon, C.

A. E. Spinelli, M. Ferdeghini, C. Cavedon, E. Zivelonghi, R. Calandrino, A. Fenzi, A. Sbarbati, and F. Boschi, “First human Cerenkography,” J. Biomed. Opt. 18(2), 020502 (2013).
[Crossref] [PubMed]

Cecchini, M. P.

F. Boschi, M. Pagliazzi, B. Rossi, M. P. Cecchini, G. Gorgoni, M. Salgarello, and A. E. Spinelli, “Small-animal radionuclide luminescence imaging of thyroid and salivary glands with 99mTc-pertechnetate,” J. Biomed. Opt. 18(7), 076005 (2013).
[Crossref] [PubMed]

Chen, X.

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

Cheng, Z.

S. R. Kothapalli, H. Liu, J. C. Liao, Z. Cheng, and S. S. Gambhir, “Endoscopic imaging of Cerenkov luminescence,” Biomed. Opt. Express 3(6), 1215–1225 (2012).
[Crossref] [PubMed]

H. Liu, C. M. Carpenter, H. Jiang, G. Pratx, C. Sun, M. P. Buchin, S. S. Gambhir, L. Xing, and Z. Cheng, “Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study,” J. Nucl. Med. 53(10), 1579–1584 (2012).
[Crossref] [PubMed]

H. Liu, G. Ren, Z. Miao, X. Zhang, X. Tang, P. Han, S. S. Gambhir, and Z. Cheng, “Molecular optical imaging with radioactive probes,” PLoS ONE 5(3), e9470 (2010).
[Crossref] [PubMed]

Cherry, S. R.

G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Li, and S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Philos. Trans. A. Math Phys. Eng. Sci. 369(1955), 4605–4619 (2011).
[Crossref] [PubMed]

R. Robertson, M. S. Germanos, C. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, “Optical imaging of Cerenkov light generation from positron-emitting radiotracers,” Phys. Med. Biol. 54(16), N355–N365 (2009).
[Crossref] [PubMed]

Close, D. M.

D. M. Close, T. Xu, G. S. Sayler, and S. Ripp, “In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals,” Sensors (Basel) 11(1), 180–206 (2011).
[Crossref] [PubMed]

D’Ambrosio, D.

F. Boschi, L. Calderan, D. D’Ambrosio, M. Marengo, A. Fenzi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “In vivo (18)F-FDG tumour uptake measurements in small animals using Cerenkov radiation,” Eur. J. Nucl. Med. Mol. Imaging 38(1), 120–127 (2011).
[Crossref] [PubMed]

A. E. Spinelli, F. Boschi, D. D’Ambrosio, L. Calderan, M. Marengo, A. Fenzi, M. Menegazzi, A. Sbarbati, A. Del Vecchio, and R. Calandrino, “Cherenkov radiation imaging of beta emitters: in vitro and in vivo results,” Nucl. Instrum. Meth. A 648(1), S310–S312 (2011).
[Crossref]

A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, A. Sbarbati, and F. Boschi, “Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers,” Phys. Med. Biol. 55(2), 483–495 (2010).
[Crossref] [PubMed]

F. Boschi, A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, and A. Sbarbati, “Combined optical and single photon emission imaging: preliminary results,” Phys. Med. Biol. 54(23), L57–L62 (2009).
[Crossref] [PubMed]

De Boo, D. W.

C. M. Schaefer-Prokop, D. W. De Boo, M. Uffmann, and M. Prokop, “DR and CR: Recent advances in technology,” Eur. J. Radiol. 72(2), 194–201 (2009).
[Crossref] [PubMed]

Del Vecchio, A.

A. E. Spinelli, F. Boschi, D. D’Ambrosio, L. Calderan, M. Marengo, A. Fenzi, M. Menegazzi, A. Sbarbati, A. Del Vecchio, and R. Calandrino, “Cherenkov radiation imaging of beta emitters: in vitro and in vivo results,” Nucl. Instrum. Meth. A 648(1), S310–S312 (2011).
[Crossref]

Di Domenico, G.

L. Uccelli, A. Boschi, M. Pasquali, A. Duatti, G. Di Domenico, G. Pupillo, J. Esposito, M. Giganti, A. Taibi, and M. Gambaccini, “Influence of the generator in-growth time on the final radiochemical purity and stability of 99mTc radiopharmaceuticals,” Sci. Technol. Nucl. Install. 2013, 379283 (2013).
[Crossref]

Doi, K.

H. Fujita, D. Y. Tsai, T. Itoh, K. Doi, J. Morishita, K. Ueda, and A. Ohtsuka, “A simple method for determining the modulation transfer function in digital radiography,” IEEE Trans. Med. Imaging 11(1), 34–39 (1992).
[Crossref] [PubMed]

Dothager, R. S.

R. S. Dothager, R. J. Goiffon, E. Jackson, S. Harpstrite, and D. Piwnica-Worms, “Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems,” PLoS ONE 5(10), e13300 (2010).
[Crossref] [PubMed]

Duatti, A.

L. Uccelli, A. Boschi, M. Pasquali, A. Duatti, G. Di Domenico, G. Pupillo, J. Esposito, M. Giganti, A. Taibi, and M. Gambaccini, “Influence of the generator in-growth time on the final radiochemical purity and stability of 99mTc radiopharmaceuticals,” Sci. Technol. Nucl. Install. 2013, 379283 (2013).
[Crossref]

Esposito, J.

L. Uccelli, A. Boschi, M. Pasquali, A. Duatti, G. Di Domenico, G. Pupillo, J. Esposito, M. Giganti, A. Taibi, and M. Gambaccini, “Influence of the generator in-growth time on the final radiochemical purity and stability of 99mTc radiopharmaceuticals,” Sci. Technol. Nucl. Install. 2013, 379283 (2013).
[Crossref]

Fenzi, A.

A. E. Spinelli, M. Ferdeghini, C. Cavedon, E. Zivelonghi, R. Calandrino, A. Fenzi, A. Sbarbati, and F. Boschi, “First human Cerenkography,” J. Biomed. Opt. 18(2), 020502 (2013).
[Crossref] [PubMed]

F. Boschi, L. Calderan, D. D’Ambrosio, M. Marengo, A. Fenzi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “In vivo (18)F-FDG tumour uptake measurements in small animals using Cerenkov radiation,” Eur. J. Nucl. Med. Mol. Imaging 38(1), 120–127 (2011).
[Crossref] [PubMed]

A. E. Spinelli, F. Boschi, D. D’Ambrosio, L. Calderan, M. Marengo, A. Fenzi, M. Menegazzi, A. Sbarbati, A. Del Vecchio, and R. Calandrino, “Cherenkov radiation imaging of beta emitters: in vitro and in vivo results,” Nucl. Instrum. Meth. A 648(1), S310–S312 (2011).
[Crossref]

Ferdeghini, M.

A. E. Spinelli, M. Ferdeghini, C. Cavedon, E. Zivelonghi, R. Calandrino, A. Fenzi, A. Sbarbati, and F. Boschi, “First human Cerenkography,” J. Biomed. Opt. 18(2), 020502 (2013).
[Crossref] [PubMed]

Flynn, M. J.

E. Samei, M. J. Flynn, and D. A. Reimann, “A method for measuring the presampled MTF of digital radiographic systems using an edge test device,” Med. Phys. 25(1), 102–113 (1998).
[Crossref] [PubMed]

Fujita, H.

H. Fujita, D. Y. Tsai, T. Itoh, K. Doi, J. Morishita, K. Ueda, and A. Ohtsuka, “A simple method for determining the modulation transfer function in digital radiography,” IEEE Trans. Med. Imaging 11(1), 34–39 (1992).
[Crossref] [PubMed]

Gambaccini, M.

L. Uccelli, A. Boschi, M. Pasquali, A. Duatti, G. Di Domenico, G. Pupillo, J. Esposito, M. Giganti, A. Taibi, and M. Gambaccini, “Influence of the generator in-growth time on the final radiochemical purity and stability of 99mTc radiopharmaceuticals,” Sci. Technol. Nucl. Install. 2013, 379283 (2013).
[Crossref]

Gambhir, S. S.

H. Liu, C. M. Carpenter, H. Jiang, G. Pratx, C. Sun, M. P. Buchin, S. S. Gambhir, L. Xing, and Z. Cheng, “Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study,” J. Nucl. Med. 53(10), 1579–1584 (2012).
[Crossref] [PubMed]

S. R. Kothapalli, H. Liu, J. C. Liao, Z. Cheng, and S. S. Gambhir, “Endoscopic imaging of Cerenkov luminescence,” Biomed. Opt. Express 3(6), 1215–1225 (2012).
[Crossref] [PubMed]

H. Liu, G. Ren, Z. Miao, X. Zhang, X. Tang, P. Han, S. S. Gambhir, and Z. Cheng, “Molecular optical imaging with radioactive probes,” PLoS ONE 5(3), e9470 (2010).
[Crossref] [PubMed]

Germanos, M. S.

R. Robertson, M. S. Germanos, C. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, “Optical imaging of Cerenkov light generation from positron-emitting radiotracers,” Phys. Med. Biol. 54(16), N355–N365 (2009).
[Crossref] [PubMed]

Giganti, M.

L. Uccelli, A. Boschi, M. Pasquali, A. Duatti, G. Di Domenico, G. Pupillo, J. Esposito, M. Giganti, A. Taibi, and M. Gambaccini, “Influence of the generator in-growth time on the final radiochemical purity and stability of 99mTc radiopharmaceuticals,” Sci. Technol. Nucl. Install. 2013, 379283 (2013).
[Crossref]

Gill, R. K.

G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Li, and S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Philos. Trans. A. Math Phys. Eng. Sci. 369(1955), 4605–4619 (2011).
[Crossref] [PubMed]

Goiffon, R. J.

R. S. Dothager, R. J. Goiffon, E. Jackson, S. Harpstrite, and D. Piwnica-Worms, “Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems,” PLoS ONE 5(10), e13300 (2010).
[Crossref] [PubMed]

Gorgoni, G.

F. Boschi, M. Pagliazzi, B. Rossi, M. P. Cecchini, G. Gorgoni, M. Salgarello, and A. E. Spinelli, “Small-animal radionuclide luminescence imaging of thyroid and salivary glands with 99mTc-pertechnetate,” J. Biomed. Opt. 18(7), 076005 (2013).
[Crossref] [PubMed]

Grimm, J.

D. Lj. Thorek, R. Robertson, W. A. Bacchus, J. Hahn, J. Rothberg, B. J. Beattie, and J. Grimm, “Cerenkov imaging - a new modality for molecular imaging,” Am. J. Nucl. Med. Mol. Imaging 2(2), 163–173 (2012).
[PubMed]

A. Ruggiero, J. P. Holland, J. S. Lewis, and J. Grimm, “Cerenkov luminescence imaging of medical isotopes,” J. Nucl. Med. 51(7), 1123–1130 (2010).
[Crossref] [PubMed]

Guilhot, J.

T. Métayé, T. Rosenberg, J. Guilhot, M. H. Bouin-Pineau, and R. Perdrisot, “The Presence of Sodium Nitrate in Generator Eluate Decreases the Radiochemical Purity of Tc99m-Sestamibi,” J. Nucl. Med. Technol. 40(3), 187–193 (2012).
[Crossref] [PubMed]

Hadwen, B. J.

M. S. Robbins and B. J. Hadwen, “The noise performance of electron multiplying charge-coupled devices,” IEEE Trans. Electron Dev. 50(5), 1227–1232 (2003).
[Crossref]

Hahn, J.

D. Lj. Thorek, R. Robertson, W. A. Bacchus, J. Hahn, J. Rothberg, B. J. Beattie, and J. Grimm, “Cerenkov imaging - a new modality for molecular imaging,” Am. J. Nucl. Med. Mol. Imaging 2(2), 163–173 (2012).
[PubMed]

Han, P.

H. Liu, G. Ren, Z. Miao, X. Zhang, X. Tang, P. Han, S. S. Gambhir, and Z. Cheng, “Molecular optical imaging with radioactive probes,” PLoS ONE 5(3), e9470 (2010).
[Crossref] [PubMed]

Harpstrite, S.

R. S. Dothager, R. J. Goiffon, E. Jackson, S. Harpstrite, and D. Piwnica-Worms, “Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems,” PLoS ONE 5(10), e13300 (2010).
[Crossref] [PubMed]

Holland, J. P.

A. Ruggiero, J. P. Holland, J. S. Lewis, and J. Grimm, “Cerenkov luminescence imaging of medical isotopes,” J. Nucl. Med. 51(7), 1123–1130 (2010).
[Crossref] [PubMed]

Hu, H.

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

Inoue, Y.

Y. Inoue, S. Kiryu, M. Watanabe, A. Tojo, and K. Ohtomo, “Timing of imaging after D-luciferin injection affects the longitudinal assessment of tumor growth using in vivo bioluminescence imaging,” Int. J. Biomed. Imaging 2010(8), 471408 (2010).
[PubMed]

Itoh, T.

H. Fujita, D. Y. Tsai, T. Itoh, K. Doi, J. Morishita, K. Ueda, and A. Ohtsuka, “A simple method for determining the modulation transfer function in digital radiography,” IEEE Trans. Med. Imaging 11(1), 34–39 (1992).
[Crossref] [PubMed]

Jackson, E.

R. S. Dothager, R. J. Goiffon, E. Jackson, S. Harpstrite, and D. Piwnica-Worms, “Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems,” PLoS ONE 5(10), e13300 (2010).
[Crossref] [PubMed]

Jiang, H.

H. Liu, C. M. Carpenter, H. Jiang, G. Pratx, C. Sun, M. P. Buchin, S. S. Gambhir, L. Xing, and Z. Cheng, “Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study,” J. Nucl. Med. 53(10), 1579–1584 (2012).
[Crossref] [PubMed]

Kang, F.

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

Kiryu, S.

Y. Inoue, S. Kiryu, M. Watanabe, A. Tojo, and K. Ohtomo, “Timing of imaging after D-luciferin injection affects the longitudinal assessment of tumor growth using in vivo bioluminescence imaging,” Int. J. Biomed. Imaging 2010(8), 471408 (2010).
[PubMed]

Körner, M.

M. Körner, C. H. Weber, S. Wirth, K. J. Pfeifer, M. F. Reiser, and M. Treitl, “Advances in digital radiography: physical principles and system overview,” Radiographics 27(3), 675–686 (2007).
[Crossref] [PubMed]

Kothapalli, S. R.

Lança, L.

L. Lança and A. Silva, “Digital radiography detectors - A technical overview: Part 1,” Radiography 15(1), 58–62 (2009).
[Crossref]

Lewis, J. S.

A. Ruggiero, J. P. Holland, J. S. Lewis, and J. Grimm, “Cerenkov luminescence imaging of medical isotopes,” J. Nucl. Med. 51(7), 1123–1130 (2010).
[Crossref] [PubMed]

Li, C.

G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Li, and S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Philos. Trans. A. Math Phys. Eng. Sci. 369(1955), 4605–4619 (2011).
[Crossref] [PubMed]

R. Robertson, M. S. Germanos, C. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, “Optical imaging of Cerenkov light generation from positron-emitting radiotracers,” Phys. Med. Biol. 54(16), N355–N365 (2009).
[Crossref] [PubMed]

Li, S.

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

Liang, J.

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

Liao, J. C.

Lin, Y.

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

Liu, H.

S. R. Kothapalli, H. Liu, J. C. Liao, Z. Cheng, and S. S. Gambhir, “Endoscopic imaging of Cerenkov luminescence,” Biomed. Opt. Express 3(6), 1215–1225 (2012).
[Crossref] [PubMed]

H. Liu, C. M. Carpenter, H. Jiang, G. Pratx, C. Sun, M. P. Buchin, S. S. Gambhir, L. Xing, and Z. Cheng, “Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study,” J. Nucl. Med. 53(10), 1579–1584 (2012).
[Crossref] [PubMed]

H. Liu, G. Ren, Z. Miao, X. Zhang, X. Tang, P. Han, S. S. Gambhir, and Z. Cheng, “Molecular optical imaging with radioactive probes,” PLoS ONE 5(3), e9470 (2010).
[Crossref] [PubMed]

Liu, M.

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

Lo Meo, S.

A. E. Spinelli, S. Lo Meo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of Tc-99m-based tracers: in vitro and in vivo results,” J. Biomed. Opt. 16(11), 116023 (2011).
[Crossref] [PubMed]

Marengo, M.

A. E. Spinelli, M. Marengo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of radioisotopes: a novel multimodal approach to molecular imaging,” Q. J. Nucl. Med. Mol. Imaging 56(3), 280–290 (2012).
[PubMed]

F. Boschi, L. Calderan, D. D’Ambrosio, M. Marengo, A. Fenzi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “In vivo (18)F-FDG tumour uptake measurements in small animals using Cerenkov radiation,” Eur. J. Nucl. Med. Mol. Imaging 38(1), 120–127 (2011).
[Crossref] [PubMed]

A. E. Spinelli, F. Boschi, D. D’Ambrosio, L. Calderan, M. Marengo, A. Fenzi, M. Menegazzi, A. Sbarbati, A. Del Vecchio, and R. Calandrino, “Cherenkov radiation imaging of beta emitters: in vitro and in vivo results,” Nucl. Instrum. Meth. A 648(1), S310–S312 (2011).
[Crossref]

A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, A. Sbarbati, and F. Boschi, “Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers,” Phys. Med. Biol. 55(2), 483–495 (2010).
[Crossref] [PubMed]

F. Boschi, A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, and A. Sbarbati, “Combined optical and single photon emission imaging: preliminary results,” Phys. Med. Biol. 54(23), L57–L62 (2009).
[Crossref] [PubMed]

Menegazzi, M.

A. E. Spinelli, F. Boschi, D. D’Ambrosio, L. Calderan, M. Marengo, A. Fenzi, M. Menegazzi, A. Sbarbati, A. Del Vecchio, and R. Calandrino, “Cherenkov radiation imaging of beta emitters: in vitro and in vivo results,” Nucl. Instrum. Meth. A 648(1), S310–S312 (2011).
[Crossref]

Meo, S. L.

F. Boschi, S. L. Meo, P. L. Rossi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “Optical imaging of alpha emitters: simulations, phantom, and in vivo results,” J. Biomed. Opt. 16(12), 126011 (2011).
[Crossref] [PubMed]

Métayé, T.

T. Métayé, T. Rosenberg, J. Guilhot, M. H. Bouin-Pineau, and R. Perdrisot, “The Presence of Sodium Nitrate in Generator Eluate Decreases the Radiochemical Purity of Tc99m-Sestamibi,” J. Nucl. Med. Technol. 40(3), 187–193 (2012).
[Crossref] [PubMed]

Miao, Z.

H. Liu, G. Ren, Z. Miao, X. Zhang, X. Tang, P. Han, S. S. Gambhir, and Z. Cheng, “Molecular optical imaging with radioactive probes,” PLoS ONE 5(3), e9470 (2010).
[Crossref] [PubMed]

Mitchell, G. S.

G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Li, and S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Philos. Trans. A. Math Phys. Eng. Sci. 369(1955), 4605–4619 (2011).
[Crossref] [PubMed]

R. Robertson, M. S. Germanos, C. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, “Optical imaging of Cerenkov light generation from positron-emitting radiotracers,” Phys. Med. Biol. 54(16), N355–N365 (2009).
[Crossref] [PubMed]

Morishita, J.

H. Fujita, D. Y. Tsai, T. Itoh, K. Doi, J. Morishita, K. Ueda, and A. Ohtsuka, “A simple method for determining the modulation transfer function in digital radiography,” IEEE Trans. Med. Imaging 11(1), 34–39 (1992).
[Crossref] [PubMed]

Nie, Y.

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

Ohtomo, K.

Y. Inoue, S. Kiryu, M. Watanabe, A. Tojo, and K. Ohtomo, “Timing of imaging after D-luciferin injection affects the longitudinal assessment of tumor growth using in vivo bioluminescence imaging,” Int. J. Biomed. Imaging 2010(8), 471408 (2010).
[PubMed]

Ohtsuka, A.

H. Fujita, D. Y. Tsai, T. Itoh, K. Doi, J. Morishita, K. Ueda, and A. Ohtsuka, “A simple method for determining the modulation transfer function in digital radiography,” IEEE Trans. Med. Imaging 11(1), 34–39 (1992).
[Crossref] [PubMed]

Pagliazzi, M.

M. Pagliazzi, F. Boschi, and A. E. Spinelli, “Imaging of luminescence induced by beta and gamma emitters in conventional non-scintillating materials,” RSC Adv. 4(26), 13687–13692 (2014).
[Crossref]

F. Boschi, M. Pagliazzi, B. Rossi, M. P. Cecchini, G. Gorgoni, M. Salgarello, and A. E. Spinelli, “Small-animal radionuclide luminescence imaging of thyroid and salivary glands with 99mTc-pertechnetate,” J. Biomed. Opt. 18(7), 076005 (2013).
[Crossref] [PubMed]

Pasquali, M.

L. Uccelli, A. Boschi, M. Pasquali, A. Duatti, G. Di Domenico, G. Pupillo, J. Esposito, M. Giganti, A. Taibi, and M. Gambaccini, “Influence of the generator in-growth time on the final radiochemical purity and stability of 99mTc radiopharmaceuticals,” Sci. Technol. Nucl. Install. 2013, 379283 (2013).
[Crossref]

Perdrisot, R.

T. Métayé, T. Rosenberg, J. Guilhot, M. H. Bouin-Pineau, and R. Perdrisot, “The Presence of Sodium Nitrate in Generator Eluate Decreases the Radiochemical Purity of Tc99m-Sestamibi,” J. Nucl. Med. Technol. 40(3), 187–193 (2012).
[Crossref] [PubMed]

Pfeifer, K. J.

M. Körner, C. H. Weber, S. Wirth, K. J. Pfeifer, M. F. Reiser, and M. Treitl, “Advances in digital radiography: physical principles and system overview,” Radiographics 27(3), 675–686 (2007).
[Crossref] [PubMed]

Piwnica-Worms, D.

R. S. Dothager, R. J. Goiffon, E. Jackson, S. Harpstrite, and D. Piwnica-Worms, “Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems,” PLoS ONE 5(10), e13300 (2010).
[Crossref] [PubMed]

Pratx, G.

H. Liu, C. M. Carpenter, H. Jiang, G. Pratx, C. Sun, M. P. Buchin, S. S. Gambhir, L. Xing, and Z. Cheng, “Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study,” J. Nucl. Med. 53(10), 1579–1584 (2012).
[Crossref] [PubMed]

Prokop, M.

C. M. Schaefer-Prokop, D. W. De Boo, M. Uffmann, and M. Prokop, “DR and CR: Recent advances in technology,” Eur. J. Radiol. 72(2), 194–201 (2009).
[Crossref] [PubMed]

Pupillo, G.

L. Uccelli, A. Boschi, M. Pasquali, A. Duatti, G. Di Domenico, G. Pupillo, J. Esposito, M. Giganti, A. Taibi, and M. Gambaccini, “Influence of the generator in-growth time on the final radiochemical purity and stability of 99mTc radiopharmaceuticals,” Sci. Technol. Nucl. Install. 2013, 379283 (2013).
[Crossref]

Reimann, D. A.

E. Samei, M. J. Flynn, and D. A. Reimann, “A method for measuring the presampled MTF of digital radiographic systems using an edge test device,” Med. Phys. 25(1), 102–113 (1998).
[Crossref] [PubMed]

Reiser, M. F.

M. Körner, C. H. Weber, S. Wirth, K. J. Pfeifer, M. F. Reiser, and M. Treitl, “Advances in digital radiography: physical principles and system overview,” Radiographics 27(3), 675–686 (2007).
[Crossref] [PubMed]

Ren, G.

H. Liu, G. Ren, Z. Miao, X. Zhang, X. Tang, P. Han, S. S. Gambhir, and Z. Cheng, “Molecular optical imaging with radioactive probes,” PLoS ONE 5(3), e9470 (2010).
[Crossref] [PubMed]

Ripp, S.

D. M. Close, T. Xu, G. S. Sayler, and S. Ripp, “In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals,” Sensors (Basel) 11(1), 180–206 (2011).
[Crossref] [PubMed]

Robbins, M. S.

M. S. Robbins and B. J. Hadwen, “The noise performance of electron multiplying charge-coupled devices,” IEEE Trans. Electron Dev. 50(5), 1227–1232 (2003).
[Crossref]

Robertson, R.

D. Lj. Thorek, R. Robertson, W. A. Bacchus, J. Hahn, J. Rothberg, B. J. Beattie, and J. Grimm, “Cerenkov imaging - a new modality for molecular imaging,” Am. J. Nucl. Med. Mol. Imaging 2(2), 163–173 (2012).
[PubMed]

R. Robertson, M. S. Germanos, C. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, “Optical imaging of Cerenkov light generation from positron-emitting radiotracers,” Phys. Med. Biol. 54(16), N355–N365 (2009).
[Crossref] [PubMed]

Rosenberg, T.

T. Métayé, T. Rosenberg, J. Guilhot, M. H. Bouin-Pineau, and R. Perdrisot, “The Presence of Sodium Nitrate in Generator Eluate Decreases the Radiochemical Purity of Tc99m-Sestamibi,” J. Nucl. Med. Technol. 40(3), 187–193 (2012).
[Crossref] [PubMed]

Rossi, B.

F. Boschi, M. Pagliazzi, B. Rossi, M. P. Cecchini, G. Gorgoni, M. Salgarello, and A. E. Spinelli, “Small-animal radionuclide luminescence imaging of thyroid and salivary glands with 99mTc-pertechnetate,” J. Biomed. Opt. 18(7), 076005 (2013).
[Crossref] [PubMed]

Rossi, P. L.

F. Boschi, S. L. Meo, P. L. Rossi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “Optical imaging of alpha emitters: simulations, phantom, and in vivo results,” J. Biomed. Opt. 16(12), 126011 (2011).
[Crossref] [PubMed]

Rothberg, J.

D. Lj. Thorek, R. Robertson, W. A. Bacchus, J. Hahn, J. Rothberg, B. J. Beattie, and J. Grimm, “Cerenkov imaging - a new modality for molecular imaging,” Am. J. Nucl. Med. Mol. Imaging 2(2), 163–173 (2012).
[PubMed]

Rowlands, J. A.

J. A. Rowlands, “The physics of computed radiography,” Phys. Med. Biol. 47(23), R123–R166 (2002).
[Crossref] [PubMed]

Ruggiero, A.

A. Ruggiero, J. P. Holland, J. S. Lewis, and J. Grimm, “Cerenkov luminescence imaging of medical isotopes,” J. Nucl. Med. 51(7), 1123–1130 (2010).
[Crossref] [PubMed]

Salgarello, M.

F. Boschi, M. Pagliazzi, B. Rossi, M. P. Cecchini, G. Gorgoni, M. Salgarello, and A. E. Spinelli, “Small-animal radionuclide luminescence imaging of thyroid and salivary glands with 99mTc-pertechnetate,” J. Biomed. Opt. 18(7), 076005 (2013).
[Crossref] [PubMed]

Samei, E.

E. Samei, M. J. Flynn, and D. A. Reimann, “A method for measuring the presampled MTF of digital radiographic systems using an edge test device,” Med. Phys. 25(1), 102–113 (1998).
[Crossref] [PubMed]

Sayler, G. S.

D. M. Close, T. Xu, G. S. Sayler, and S. Ripp, “In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals,” Sensors (Basel) 11(1), 180–206 (2011).
[Crossref] [PubMed]

Sbarbati, A.

A. E. Spinelli, M. Ferdeghini, C. Cavedon, E. Zivelonghi, R. Calandrino, A. Fenzi, A. Sbarbati, and F. Boschi, “First human Cerenkography,” J. Biomed. Opt. 18(2), 020502 (2013).
[Crossref] [PubMed]

A. E. Spinelli, M. Marengo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of radioisotopes: a novel multimodal approach to molecular imaging,” Q. J. Nucl. Med. Mol. Imaging 56(3), 280–290 (2012).
[PubMed]

A. E. Spinelli, F. Boschi, D. D’Ambrosio, L. Calderan, M. Marengo, A. Fenzi, M. Menegazzi, A. Sbarbati, A. Del Vecchio, and R. Calandrino, “Cherenkov radiation imaging of beta emitters: in vitro and in vivo results,” Nucl. Instrum. Meth. A 648(1), S310–S312 (2011).
[Crossref]

F. Boschi, L. Calderan, D. D’Ambrosio, M. Marengo, A. Fenzi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “In vivo (18)F-FDG tumour uptake measurements in small animals using Cerenkov radiation,” Eur. J. Nucl. Med. Mol. Imaging 38(1), 120–127 (2011).
[Crossref] [PubMed]

A. E. Spinelli, S. Lo Meo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of Tc-99m-based tracers: in vitro and in vivo results,” J. Biomed. Opt. 16(11), 116023 (2011).
[Crossref] [PubMed]

F. Boschi, S. L. Meo, P. L. Rossi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “Optical imaging of alpha emitters: simulations, phantom, and in vivo results,” J. Biomed. Opt. 16(12), 126011 (2011).
[Crossref] [PubMed]

A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, A. Sbarbati, and F. Boschi, “Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers,” Phys. Med. Biol. 55(2), 483–495 (2010).
[Crossref] [PubMed]

F. Boschi, A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, and A. Sbarbati, “Combined optical and single photon emission imaging: preliminary results,” Phys. Med. Biol. 54(23), L57–L62 (2009).
[Crossref] [PubMed]

Schaefer-Prokop, C. M.

C. M. Schaefer-Prokop, D. W. De Boo, M. Uffmann, and M. Prokop, “DR and CR: Recent advances in technology,” Eur. J. Radiol. 72(2), 194–201 (2009).
[Crossref] [PubMed]

Silva, A.

L. Lança and A. Silva, “Digital radiography detectors - A technical overview: Part 1,” Radiography 15(1), 58–62 (2009).
[Crossref]

Silva, M. D.

R. Robertson, M. S. Germanos, C. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, “Optical imaging of Cerenkov light generation from positron-emitting radiotracers,” Phys. Med. Biol. 54(16), N355–N365 (2009).
[Crossref] [PubMed]

Spinelli, A. E.

A. E. Spinelli and F. Boschi, “Novel biomedical applications of Cerenkov radiation and radioluminescence imaging,” Phys. Med. 31(2), 120–129 (2015).
[Crossref] [PubMed]

M. Pagliazzi, F. Boschi, and A. E. Spinelli, “Imaging of luminescence induced by beta and gamma emitters in conventional non-scintillating materials,” RSC Adv. 4(26), 13687–13692 (2014).
[Crossref]

F. Boschi, M. Pagliazzi, B. Rossi, M. P. Cecchini, G. Gorgoni, M. Salgarello, and A. E. Spinelli, “Small-animal radionuclide luminescence imaging of thyroid and salivary glands with 99mTc-pertechnetate,” J. Biomed. Opt. 18(7), 076005 (2013).
[Crossref] [PubMed]

A. E. Spinelli, M. Ferdeghini, C. Cavedon, E. Zivelonghi, R. Calandrino, A. Fenzi, A. Sbarbati, and F. Boschi, “First human Cerenkography,” J. Biomed. Opt. 18(2), 020502 (2013).
[Crossref] [PubMed]

F. Boschi and A. E. Spinelli, “Quantum dots excitation using pure beta minus radioisotopes emitting Cerenkov radiation,” RSC Adv. 2(29), 11049–11052 (2012).
[Crossref]

A. E. Spinelli, M. Marengo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of radioisotopes: a novel multimodal approach to molecular imaging,” Q. J. Nucl. Med. Mol. Imaging 56(3), 280–290 (2012).
[PubMed]

A. E. Spinelli, F. Boschi, D. D’Ambrosio, L. Calderan, M. Marengo, A. Fenzi, M. Menegazzi, A. Sbarbati, A. Del Vecchio, and R. Calandrino, “Cherenkov radiation imaging of beta emitters: in vitro and in vivo results,” Nucl. Instrum. Meth. A 648(1), S310–S312 (2011).
[Crossref]

F. Boschi, L. Calderan, D. D’Ambrosio, M. Marengo, A. Fenzi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “In vivo (18)F-FDG tumour uptake measurements in small animals using Cerenkov radiation,” Eur. J. Nucl. Med. Mol. Imaging 38(1), 120–127 (2011).
[Crossref] [PubMed]

F. Boschi, S. L. Meo, P. L. Rossi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “Optical imaging of alpha emitters: simulations, phantom, and in vivo results,” J. Biomed. Opt. 16(12), 126011 (2011).
[Crossref] [PubMed]

A. E. Spinelli, S. Lo Meo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of Tc-99m-based tracers: in vitro and in vivo results,” J. Biomed. Opt. 16(11), 116023 (2011).
[Crossref] [PubMed]

A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, A. Sbarbati, and F. Boschi, “Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers,” Phys. Med. Biol. 55(2), 483–495 (2010).
[Crossref] [PubMed]

F. Boschi, A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, and A. Sbarbati, “Combined optical and single photon emission imaging: preliminary results,” Phys. Med. Biol. 54(23), L57–L62 (2009).
[Crossref] [PubMed]

Sun, C.

H. Liu, C. M. Carpenter, H. Jiang, G. Pratx, C. Sun, M. P. Buchin, S. S. Gambhir, L. Xing, and Z. Cheng, “Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study,” J. Nucl. Med. 53(10), 1579–1584 (2012).
[Crossref] [PubMed]

Taibi, A.

L. Uccelli, A. Boschi, M. Pasquali, A. Duatti, G. Di Domenico, G. Pupillo, J. Esposito, M. Giganti, A. Taibi, and M. Gambaccini, “Influence of the generator in-growth time on the final radiochemical purity and stability of 99mTc radiopharmaceuticals,” Sci. Technol. Nucl. Install. 2013, 379283 (2013).
[Crossref]

Tang, X.

H. Liu, G. Ren, Z. Miao, X. Zhang, X. Tang, P. Han, S. S. Gambhir, and Z. Cheng, “Molecular optical imaging with radioactive probes,” PLoS ONE 5(3), e9470 (2010).
[Crossref] [PubMed]

Thorek, D. Lj.

D. Lj. Thorek, R. Robertson, W. A. Bacchus, J. Hahn, J. Rothberg, B. J. Beattie, and J. Grimm, “Cerenkov imaging - a new modality for molecular imaging,” Am. J. Nucl. Med. Mol. Imaging 2(2), 163–173 (2012).
[PubMed]

Tojo, A.

Y. Inoue, S. Kiryu, M. Watanabe, A. Tojo, and K. Ohtomo, “Timing of imaging after D-luciferin injection affects the longitudinal assessment of tumor growth using in vivo bioluminescence imaging,” Int. J. Biomed. Imaging 2010(8), 471408 (2010).
[PubMed]

Treitl, M.

M. Körner, C. H. Weber, S. Wirth, K. J. Pfeifer, M. F. Reiser, and M. Treitl, “Advances in digital radiography: physical principles and system overview,” Radiographics 27(3), 675–686 (2007).
[Crossref] [PubMed]

Tsai, D. Y.

H. Fujita, D. Y. Tsai, T. Itoh, K. Doi, J. Morishita, K. Ueda, and A. Ohtsuka, “A simple method for determining the modulation transfer function in digital radiography,” IEEE Trans. Med. Imaging 11(1), 34–39 (1992).
[Crossref] [PubMed]

Uccelli, L.

L. Uccelli, A. Boschi, M. Pasquali, A. Duatti, G. Di Domenico, G. Pupillo, J. Esposito, M. Giganti, A. Taibi, and M. Gambaccini, “Influence of the generator in-growth time on the final radiochemical purity and stability of 99mTc radiopharmaceuticals,” Sci. Technol. Nucl. Install. 2013, 379283 (2013).
[Crossref]

Ueda, K.

H. Fujita, D. Y. Tsai, T. Itoh, K. Doi, J. Morishita, K. Ueda, and A. Ohtsuka, “A simple method for determining the modulation transfer function in digital radiography,” IEEE Trans. Med. Imaging 11(1), 34–39 (1992).
[Crossref] [PubMed]

Uffmann, M.

C. M. Schaefer-Prokop, D. W. De Boo, M. Uffmann, and M. Prokop, “DR and CR: Recent advances in technology,” Eur. J. Radiol. 72(2), 194–201 (2009).
[Crossref] [PubMed]

Wang, J.

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

Wang, M.

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

Watanabe, M.

Y. Inoue, S. Kiryu, M. Watanabe, A. Tojo, and K. Ohtomo, “Timing of imaging after D-luciferin injection affects the longitudinal assessment of tumor growth using in vivo bioluminescence imaging,” Int. J. Biomed. Imaging 2010(8), 471408 (2010).
[PubMed]

Weber, C. H.

M. Körner, C. H. Weber, S. Wirth, K. J. Pfeifer, M. F. Reiser, and M. Treitl, “Advances in digital radiography: physical principles and system overview,” Radiographics 27(3), 675–686 (2007).
[Crossref] [PubMed]

Wirth, S.

M. Körner, C. H. Weber, S. Wirth, K. J. Pfeifer, M. F. Reiser, and M. Treitl, “Advances in digital radiography: physical principles and system overview,” Radiographics 27(3), 675–686 (2007).
[Crossref] [PubMed]

Wu, K.

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

Xing, L.

H. Liu, C. M. Carpenter, H. Jiang, G. Pratx, C. Sun, M. P. Buchin, S. S. Gambhir, L. Xing, and Z. Cheng, “Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study,” J. Nucl. Med. 53(10), 1579–1584 (2012).
[Crossref] [PubMed]

Xu, T.

D. M. Close, T. Xu, G. S. Sayler, and S. Ripp, “In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals,” Sensors (Basel) 11(1), 180–206 (2011).
[Crossref] [PubMed]

Yao, L.

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

Zhang, X.

H. Liu, G. Ren, Z. Miao, X. Zhang, X. Tang, P. Han, S. S. Gambhir, and Z. Cheng, “Molecular optical imaging with radioactive probes,” PLoS ONE 5(3), e9470 (2010).
[Crossref] [PubMed]

Zivelonghi, E.

A. E. Spinelli, M. Ferdeghini, C. Cavedon, E. Zivelonghi, R. Calandrino, A. Fenzi, A. Sbarbati, and F. Boschi, “First human Cerenkography,” J. Biomed. Opt. 18(2), 020502 (2013).
[Crossref] [PubMed]

Am. J. Nucl. Med. Mol. Imaging (1)

D. Lj. Thorek, R. Robertson, W. A. Bacchus, J. Hahn, J. Rothberg, B. J. Beattie, and J. Grimm, “Cerenkov imaging - a new modality for molecular imaging,” Am. J. Nucl. Med. Mol. Imaging 2(2), 163–173 (2012).
[PubMed]

Biomed. Opt. Express (1)

Eur. J. Nucl. Med. Mol. Imaging (1)

F. Boschi, L. Calderan, D. D’Ambrosio, M. Marengo, A. Fenzi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “In vivo (18)F-FDG tumour uptake measurements in small animals using Cerenkov radiation,” Eur. J. Nucl. Med. Mol. Imaging 38(1), 120–127 (2011).
[Crossref] [PubMed]

Eur. J. Radiol. (1)

C. M. Schaefer-Prokop, D. W. De Boo, M. Uffmann, and M. Prokop, “DR and CR: Recent advances in technology,” Eur. J. Radiol. 72(2), 194–201 (2009).
[Crossref] [PubMed]

Eur. Radiol. (1)

H. Hu, X. Cao, F. Kang, M. Wang, Y. Lin, M. Liu, S. Li, L. Yao, J. Liang, J. Liang, Y. Nie, X. Chen, J. Wang, and K. Wu, “Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results,” Eur. Radiol. 2015, 3574 (2015).
[PubMed]

IEEE Trans. Electron Dev. (1)

M. S. Robbins and B. J. Hadwen, “The noise performance of electron multiplying charge-coupled devices,” IEEE Trans. Electron Dev. 50(5), 1227–1232 (2003).
[Crossref]

IEEE Trans. Med. Imaging (1)

H. Fujita, D. Y. Tsai, T. Itoh, K. Doi, J. Morishita, K. Ueda, and A. Ohtsuka, “A simple method for determining the modulation transfer function in digital radiography,” IEEE Trans. Med. Imaging 11(1), 34–39 (1992).
[Crossref] [PubMed]

Int. J. Biomed. Imaging (1)

Y. Inoue, S. Kiryu, M. Watanabe, A. Tojo, and K. Ohtomo, “Timing of imaging after D-luciferin injection affects the longitudinal assessment of tumor growth using in vivo bioluminescence imaging,” Int. J. Biomed. Imaging 2010(8), 471408 (2010).
[PubMed]

J. Biomed. Opt. (4)

F. Boschi, S. L. Meo, P. L. Rossi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, “Optical imaging of alpha emitters: simulations, phantom, and in vivo results,” J. Biomed. Opt. 16(12), 126011 (2011).
[Crossref] [PubMed]

A. E. Spinelli, S. Lo Meo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of Tc-99m-based tracers: in vitro and in vivo results,” J. Biomed. Opt. 16(11), 116023 (2011).
[Crossref] [PubMed]

F. Boschi, M. Pagliazzi, B. Rossi, M. P. Cecchini, G. Gorgoni, M. Salgarello, and A. E. Spinelli, “Small-animal radionuclide luminescence imaging of thyroid and salivary glands with 99mTc-pertechnetate,” J. Biomed. Opt. 18(7), 076005 (2013).
[Crossref] [PubMed]

A. E. Spinelli, M. Ferdeghini, C. Cavedon, E. Zivelonghi, R. Calandrino, A. Fenzi, A. Sbarbati, and F. Boschi, “First human Cerenkography,” J. Biomed. Opt. 18(2), 020502 (2013).
[Crossref] [PubMed]

J. Nucl. Med. (2)

H. Liu, C. M. Carpenter, H. Jiang, G. Pratx, C. Sun, M. P. Buchin, S. S. Gambhir, L. Xing, and Z. Cheng, “Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study,” J. Nucl. Med. 53(10), 1579–1584 (2012).
[Crossref] [PubMed]

A. Ruggiero, J. P. Holland, J. S. Lewis, and J. Grimm, “Cerenkov luminescence imaging of medical isotopes,” J. Nucl. Med. 51(7), 1123–1130 (2010).
[Crossref] [PubMed]

J. Nucl. Med. Technol. (1)

T. Métayé, T. Rosenberg, J. Guilhot, M. H. Bouin-Pineau, and R. Perdrisot, “The Presence of Sodium Nitrate in Generator Eluate Decreases the Radiochemical Purity of Tc99m-Sestamibi,” J. Nucl. Med. Technol. 40(3), 187–193 (2012).
[Crossref] [PubMed]

Med. Phys. (1)

E. Samei, M. J. Flynn, and D. A. Reimann, “A method for measuring the presampled MTF of digital radiographic systems using an edge test device,” Med. Phys. 25(1), 102–113 (1998).
[Crossref] [PubMed]

Nucl. Instrum. Meth. A (1)

A. E. Spinelli, F. Boschi, D. D’Ambrosio, L. Calderan, M. Marengo, A. Fenzi, M. Menegazzi, A. Sbarbati, A. Del Vecchio, and R. Calandrino, “Cherenkov radiation imaging of beta emitters: in vitro and in vivo results,” Nucl. Instrum. Meth. A 648(1), S310–S312 (2011).
[Crossref]

Philos. Trans. A. Math Phys. Eng. Sci. (1)

G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Li, and S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Philos. Trans. A. Math Phys. Eng. Sci. 369(1955), 4605–4619 (2011).
[Crossref] [PubMed]

Phys. Med. (1)

A. E. Spinelli and F. Boschi, “Novel biomedical applications of Cerenkov radiation and radioluminescence imaging,” Phys. Med. 31(2), 120–129 (2015).
[Crossref] [PubMed]

Phys. Med. Biol. (4)

R. Robertson, M. S. Germanos, C. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, “Optical imaging of Cerenkov light generation from positron-emitting radiotracers,” Phys. Med. Biol. 54(16), N355–N365 (2009).
[Crossref] [PubMed]

A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, A. Sbarbati, and F. Boschi, “Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers,” Phys. Med. Biol. 55(2), 483–495 (2010).
[Crossref] [PubMed]

J. A. Rowlands, “The physics of computed radiography,” Phys. Med. Biol. 47(23), R123–R166 (2002).
[Crossref] [PubMed]

F. Boschi, A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, and A. Sbarbati, “Combined optical and single photon emission imaging: preliminary results,” Phys. Med. Biol. 54(23), L57–L62 (2009).
[Crossref] [PubMed]

PLoS ONE (2)

H. Liu, G. Ren, Z. Miao, X. Zhang, X. Tang, P. Han, S. S. Gambhir, and Z. Cheng, “Molecular optical imaging with radioactive probes,” PLoS ONE 5(3), e9470 (2010).
[Crossref] [PubMed]

R. S. Dothager, R. J. Goiffon, E. Jackson, S. Harpstrite, and D. Piwnica-Worms, “Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems,” PLoS ONE 5(10), e13300 (2010).
[Crossref] [PubMed]

Q. J. Nucl. Med. Mol. Imaging (1)

A. E. Spinelli, M. Marengo, R. Calandrino, A. Sbarbati, and F. Boschi, “Optical imaging of radioisotopes: a novel multimodal approach to molecular imaging,” Q. J. Nucl. Med. Mol. Imaging 56(3), 280–290 (2012).
[PubMed]

Radiographics (1)

M. Körner, C. H. Weber, S. Wirth, K. J. Pfeifer, M. F. Reiser, and M. Treitl, “Advances in digital radiography: physical principles and system overview,” Radiographics 27(3), 675–686 (2007).
[Crossref] [PubMed]

Radiography (1)

L. Lança and A. Silva, “Digital radiography detectors - A technical overview: Part 1,” Radiography 15(1), 58–62 (2009).
[Crossref]

RSC Adv. (2)

F. Boschi and A. E. Spinelli, “Quantum dots excitation using pure beta minus radioisotopes emitting Cerenkov radiation,” RSC Adv. 2(29), 11049–11052 (2012).
[Crossref]

M. Pagliazzi, F. Boschi, and A. E. Spinelli, “Imaging of luminescence induced by beta and gamma emitters in conventional non-scintillating materials,” RSC Adv. 4(26), 13687–13692 (2014).
[Crossref]

Sci. Technol. Nucl. Install. (1)

L. Uccelli, A. Boschi, M. Pasquali, A. Duatti, G. Di Domenico, G. Pupillo, J. Esposito, M. Giganti, A. Taibi, and M. Gambaccini, “Influence of the generator in-growth time on the final radiochemical purity and stability of 99mTc radiopharmaceuticals,” Sci. Technol. Nucl. Install. 2013, 379283 (2013).
[Crossref]

Sensors (Basel) (1)

D. M. Close, T. Xu, G. S. Sayler, and S. Ripp, “In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals,” Sensors (Basel) 11(1), 180–206 (2011).
[Crossref] [PubMed]

Other (2)

European Directorate for the Quality of Medicines, European Pharmacopoeia, 5th ed., European Directorate for the Quality of Medicines (2004).

T. B. Saleh, “Radiopharmaceutical Quality Control,” in Basic Sciences of Nuclear Medicine, M. M. Khalil Ed., Springer-Verlag Berlin Heidelberg (2011).

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Figures (14)

Fig. 1
Fig. 1 Pictures of the imaging system: the CCD camera coupled with the lens is mounted on a black light-tight enclosure. An adjustable stage for the positioning of the sample is placed inside the enclosure.
Fig. 2
Fig. 2 Quantum efficiency of the EMCCD camera iXon Ultra as a function of the photons wavelength (adapted from Andor specification sheet). The QE is > 80% in the 450-750nm range.
Fig. 3
Fig. 3 Schematic representation of the experimental set-up for X rays images acquisition.
Fig. 4
Fig. 4 Fusion of the black and white photographic and of the corresponding emissive image of a 137Cs source obtained with our optical system (a) and with the IVIS SpectrumCT (b).
Fig. 5
Fig. 5 Normalized profile of the signal of the 137Cs source detected by our optical system (blue solid line) and by the IVIS SpectrumCT (red dashed line). The measured FWHM is 0.94 mm with both the acquisition systems.
Fig. 6
Fig. 6 The fusion of the black and white photographic image and of the corresponding emissive image of the strip where 7 kBq of 68Ga-DOTANOC was deposited obtained with our optical system (a). The normalized profile of the activity shown on b) is evaluated along the yellow line drawn on the fused image.
Fig. 7
Fig. 7 On the left the activity along the chromatographic where 7 kBq of 68Ga-DOTANOC was deposited read using the Cyclone system is shown. The activity profile, normalized and background subtracted, shown on the right is evaluated along the yellow line drawn on the emissive image.
Fig. 8
Fig. 8 The fusion of the black and white photographic and the emissive image of the strips where 5 kBq of 99mTc-HMDP was deposited obtained with our optical system (a). The normalized profile of the activity shown on b) is evaluated along the yellow line drawn on the fused image.
Fig. 9
Fig. 9 The activity along the chromatographic strips where 5 kBq of 99mTc-HMDP was deposited read using the Cyclone Plus Storage Phosphor (a). The normalized activity profile shown on (b) is evaluated along the yellow line drawn on the emissive image.
Fig. 10
Fig. 10 X rays image of lead grid phantom obtained with our optical system (a) and a zoom of the observable finest grid are shown (b). X ray image of the same phantom obtained with the CR-35X is also shown (c). The intensity profiles were evaluated along the yellow lines drawn on the image.
Fig. 11
Fig. 11 Normalized intensity profiles evaluated along the yellow lines drawn in Figs. 10(b) and 10(c) on the lead grid phantom X rays image obtained with the optical system (blue solid line) and with the CR-35X (red solid line).
Fig. 12
Fig. 12 X rays images of a few millimeters lead thick plate tilted of few degrees with respect to the axes of the detector pixel matrix used as an edge-test device obtained with the optical system (a) and with the CR-35X system (b). The MTFs of the systems are evaluated starting from the ESF measured in the drawn ROIs.
Fig. 13
Fig. 13 Normalized MTF of the optical system (blue solid line) and of the CR-35X (red dashed line) obtained with the slant edge technique.
Fig. 14
Fig. 14 In vivo BLI image acquired respectively with the optical system (a) and with the IVIS SpectrumCT used in bioluminescence mode (b). The emissive images were fused with the black and white photographic image of the mouse taken with the two systems.

Equations (3)

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σ eff = ( F 2 ( σ signal 2 + σ dark 2 )+ σ readout 2 M 2
β= v c 1 n .
RCP= R R+I ×100

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