Minimally invasive assessment of the effect of mannitol and hypertonic saline therapy on traumatic brain edema using measurements of reduced scattering coefficient (μs′)

Jieru Xie; Zhiyu Qian; Tianming Yang; Weitao Li; Guangxia Hu

doi:10.1364/AO.49.005407

Applied Optics
Vol. 49,
Issue 28,
pp. 5407-5414
(2010)
•https://doi.org/10.1364/AO.49.005407

Minimally invasive assessment of the effect of mannitol and hypertonic saline therapy on traumatic brain edema using measurements of reduced scattering coefficient ( $μ_{s}^{'}$ )

Jieru Xie, Zhiyu Qian, Tianming Yang, Weitao Li, and Guangxia Hu

Not Accessible

Your library or personal account may give you access

Get PDF
Email
Share
Get Citation
Copy Citation Text
Jieru Xie, Zhiyu Qian, Tianming Yang, Weitao Li, and Guangxia Hu, "Minimally invasive assessment of the effect of mannitol and hypertonic saline therapy on traumatic brain edema using measurements of reduced scattering coefficient (μs′)," Appl. Opt. 49, 5407-5414 (2010)

Export Citation
- BibTex
- Endnote (RIS)
- HTML
- Plain Text
Citation alert
Save article

Related Topics
Table of Contents Category
- Medical Optics and Biotechnology
Optics & Photonics Topics
?

The topics in this list come from the Optics and Photonics Topics applied to this article.

About this Article
History
- Original Manuscript: December 11, 2009
- Revised Manuscript: May 9, 2010
- Manuscript Accepted: August 6, 2010
- Published: September 28, 2010
Virtual Issues
Virtual Journal for Biomedical Optics Vol. 5, Iss. 14

Abstract

Minimally invasive functional near infrared spectroscopy (fNIRs) technology was utilized to assess the effects of mannitol and hypertonic saline (HS) in treating traumatic brain edema (TBE). Rats with TBE models were given mannitol or HS in different dosages for different groups. The reduced scattering coefficient ( $μ_{s}^{'}$ ) of the local cortex of rats was simultaneously monitored and recorded in vivo and real time by the minimally invasive fNIRs system. Brain water content (BWC) was measured by the wet and dry weight method at 1, 6, 24, 72, and $120 h$ after injury and treatment. Effects of treating TBE with different dehydration agents were then assessed by recording $μ_{s}^{'}$ and BWC before and after administration of dehydration. In this study, the dynamic changes of brain edema and the effects of dehydration therapy were continuously monitored. Results implied that $μ_{s}^{'}$ of the local cortex in rats is a good indicator for assessing effects of treatment of TBE. By recording changes in the value of $μ_{s}^{'}$ , the following conclusions were obtained: HS is more effective than mannitol in reducing cerebral edema. The effect of dehydration of HS is only related to osmotic gradient and has no correlation with concentration.

Full Article | PDF Article

More Like This

Non-invasive diffuse optical monitoring of cerebral physiology in an adult swine-model of impact traumatic brain injury

Rodrigo M. Forti, Lucas J. Hobson, Emilie J. Benson, Tiffany S. Ko, Nicolina R. Ranieri, Gerard Laurent, M. Katie Weeks, Nicholas J. Widmann, Sarah Morton, Anthony M. Davis, Takayuki Sueishi, Yuxi Lin, Karli S. Wulwick, Nicholas Fagan, Samuel S. Shin, Shih-Han Kao, Daniel J. Licht, Brian R. White, Todd J. Kilbaugh, Arjun G. Yodh, and Wesley B. Baker
Biomed. Opt. Express 14(6) 2432-2448 (2023)

NIR light propagation in a digital head model for traumatic brain injury (TBI)

Robert Francis, Bilal Khan, George Alexandrakis, James Florence, and Duncan MacFarlane
Biomed. Opt. Express 6(9) 3256-3267 (2015)

Noninvasive monitoring of estrogen effects against ischemic stroke in rats by near-infrared spectroscopy

Mengna Xia, Shaohua Yang, James W. Simpkins, and Hanli Liu
Appl. Opt. 46(34) 8315-8321 (2007)

Previous Article Next Article

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (7)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Tables (3)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Equations (2)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Groups	Subgroups
Time	$1 h$	$6 h$	$24 h$	$72 h$	$120 h$
Group 1 ( $n = 20$ )	Control, not injured
Group 2 ( $n = 20$ )	Traumatic model without treatment
Group 3 ( $n = 20$ )	Traumatic model with $2 g / kg$ mannitol treatment
Group 4 ( $n = 20$ )	Traumatic model with 23.4% HS treatment
Group 5 ( $n = 20$ )	Traumatic model with 7.5% HS treatment

		Brain Water Content (%)
	Times	$1 h$	$6 h$	$24 h$	$72 h$	$120 h$
Group 1	Ipsilateral side	$77.51 \pm 0.37$	$77.49 \pm 0.41$	$77.56 \pm 0.47$	$77.39 \pm 0.53$	$77.46 \pm 0.40$
Group 1	Contralateral side	$77.60 \pm 0.32$	$77.62 \pm 0.39$	$77.43 \pm 0.36$	$77.47 \pm 0.41$	$77.52 \pm 0.36$
Group 2	Traumatic side	$78.08 \pm 0.53$	$79.25 \pm 0.56$ ^b ^d	$82.10 \pm 0.59$ ^b ^e	$82.43 \pm 0.81$ ^b ^e	$79.42 \pm 0.51$ ^b ^e
Group 2	Contralateral side	$77.71 \pm 0.49$	$78.10 \pm 0.58$	$78.42 \pm 0.43$ ^b	$79.20 \pm 0.66$ ^b	$77.92 \pm 0.57$
Group 3	Traumatic side	$77.16 \pm 0.44$	$78.61 \pm 0.53$ ^b	$80.12 \pm 0.61$ ^b ^c	$80.26 \pm 0.79$ ^b ^c	$81.06 \pm 0.83$ ^b ^c
Group 3	Contralateral side	$76.47 \pm 0.31$ ^b ^c	$77.68 \pm 0.39$	$76.92 \pm 0.47$ ^c	$77.59 \pm 0.56$ ^c	$76.68 \pm 0.53$ ^c
Group 4	Traumatic side	$76.84 \pm 0.38$ ^c	$78.60 \pm 0.49$ ^b	$79.63 \pm 0.52$ ^b ^c	$78.46 \pm 0.65$ ^b ^c	$79.52 \pm 0.62$ ^b
Group 4	Contralateral side	$76.33 \pm 0.29$ ^b ^c	$77.60 \pm 0.37$	$77.12 \pm 0.43$ ^c	$77.47 \pm 0.56$ ^c	$76.71 \pm 0.62$ ^c
Group 5	Traumatic side	$76.92 \pm 0.40$ ^c	$78.85 \pm 0.41$ ^b	$79.99 \pm 0.63$ ^b ^c	$78.83 \pm 0.60$ ^b ^c ^f	$79.60 \pm 0.66$ ^b ^f
Group 5	Contralateral side	$76.42 \pm 0.31$ ^b ^c	$77.58 \pm 0.42$	$77.30 \pm 0.40$ ^c	$77.56 \pm 0.58$ ^c	$76.63 \pm 0.60$ ^c

Group	Onset Time (min)	Time Required to Achieve the Relative Steady Phase (min)	Maximum Reduction Percent of $μ_{s}^{'}$ (%)
Group 3	20	60	2.73
Group 4	12	30	3.23
Group 5	14	36	2.82

Groups	Subgroups
Time	$1 h$	$6 h$	$24 h$	$72 h$	$120 h$
Group 1 ( $n = 20$ )	Control, not injured
Group 2 ( $n = 20$ )	Traumatic model without treatment
Group 3 ( $n = 20$ )	Traumatic model with $2 g / kg$ mannitol treatment
Group 4 ( $n = 20$ )	Traumatic model with 23.4% HS treatment
Group 5 ( $n = 20$ )	Traumatic model with 7.5% HS treatment

		Brain Water Content (%)
	Times	$1 h$	$6 h$	$24 h$	$72 h$	$120 h$
Group 1	Ipsilateral side	$77.51 \pm 0.37$	$77.49 \pm 0.41$	$77.56 \pm 0.47$	$77.39 \pm 0.53$	$77.46 \pm 0.40$
Group 1	Contralateral side	$77.60 \pm 0.32$	$77.62 \pm 0.39$	$77.43 \pm 0.36$	$77.47 \pm 0.41$	$77.52 \pm 0.36$
Group 2	Traumatic side	$78.08 \pm 0.53$	$79.25 \pm 0.56$ ^b ^d	$82.10 \pm 0.59$ ^b ^e	$82.43 \pm 0.81$ ^b ^e	$79.42 \pm 0.51$ ^b ^e
Group 2	Contralateral side	$77.71 \pm 0.49$	$78.10 \pm 0.58$	$78.42 \pm 0.43$ ^b	$79.20 \pm 0.66$ ^b	$77.92 \pm 0.57$
Group 3	Traumatic side	$77.16 \pm 0.44$	$78.61 \pm 0.53$ ^b	$80.12 \pm 0.61$ ^b ^c	$80.26 \pm 0.79$ ^b ^c	$81.06 \pm 0.83$ ^b ^c
Group 3	Contralateral side	$76.47 \pm 0.31$ ^b ^c	$77.68 \pm 0.39$	$76.92 \pm 0.47$ ^c	$77.59 \pm 0.56$ ^c	$76.68 \pm 0.53$ ^c
Group 4	Traumatic side	$76.84 \pm 0.38$ ^c	$78.60 \pm 0.49$ ^b	$79.63 \pm 0.52$ ^b ^c	$78.46 \pm 0.65$ ^b ^c	$79.52 \pm 0.62$ ^b
Group 4	Contralateral side	$76.33 \pm 0.29$ ^b ^c	$77.60 \pm 0.37$	$77.12 \pm 0.43$ ^c	$77.47 \pm 0.56$ ^c	$76.71 \pm 0.62$ ^c
Group 5	Traumatic side	$76.92 \pm 0.40$ ^c	$78.85 \pm 0.41$ ^b	$79.99 \pm 0.63$ ^b ^c	$78.83 \pm 0.60$ ^b ^c ^f	$79.60 \pm 0.66$ ^b ^f
Group 5	Contralateral side	$76.42 \pm 0.31$ ^b ^c	$77.58 \pm 0.42$	$77.30 \pm 0.40$ ^c	$77.56 \pm 0.58$ ^c	$76.63 \pm 0.60$ ^c

Abstract

Cited By

Figures (7)

Tables (3)

Equations (2)

Applied Optics