Abstract

We have constructed a near-real-time combined imager suitable for simultaneous ultrasound and near-infrared diffusive light imaging and coregistration. The imager consists of a combined hand-held probe and the associated electronics for data acquisition. A two-dimensional ultrasound array is deployed at the center of the combined probe, and 12 dual-wavelength laser source fibers (780 and 830 nm) and 8 optical detector fibers are deployed at the periphery. We have experimentally evaluated the effects of missing optical sources in the middle of the combined probe on the accuracy of the reconstructed optical absorption coefficient and assessed the improvements of a reconstructed absorption coefficient with the guidance of the coregistered ultrasound. The results have shown that, when the central ultrasound array area is in the neighborhood of 2 cm × 2 cm, which corresponds to the size of most commercial ultrasound transducers, the optical imaging is not affected. The results have also shown that the iterative inversion algorithm converges quickly with the guidance of a priori three-dimensional target distribution, and only one iteration is needed to reconstruct an accurate optical absorption coefficient.

© 2001 Optical Society of America

Imager that combines near-infrared diffusive light and ultrasound

Q. Zhu, T. Durduran, V. Ntziachristos, M. Holboke, and A. G. Yodh
Opt. Lett. 24(15) 1050-1052 (1999)

Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound

Quing Zhu, NanGuang Chen, and Scott H. Kurtzman
Opt. Lett. 28(5) 337-339 (2003)

Design of near-infrared imaging probe with the assistance of ultrasound localization

Quing Zhu, Nan Guang Chen, Daqing Piao, Puyun Guo, and XiaoHui Ding
Appl. Opt. 40(19) 3288-3303 (2001)

Estimation of chest-wall-induced diffused wave distortion with the assistance of ultrasound

Chen Xu and Quing Zhu
Appl. Opt. 44(20) 4255-4264 (2005)

Simultaneous reconstruction of absorption and scattering maps with ultrasound localization: feasibility study using transmission geometry

Minming Huang, Tuqiang Xie, Nan Guang Chen, and Quing Zhu
Appl. Opt. 42(19) 4102-4114 (2003)