Abstract

An image analysis method to measure retinal nerve fiber layer (RNFL) striations from digitized fundus photographs was developed to improve detection and monitoring of progressive diffuse RNFL loss. Striations were measured by comparing the high spatial frequency variability across with the variability along the RNFL. This locally normalized measure of striations compensates for the wide density variations both within individuals and between individuals and RNFL photographs. Five repeated measurements were taken at each of three locations from each retinal image. Measurements from five patients with recorded visual field loss due to optic nerve diseases were compared with five normal subjects and five suspect eyes. Measurements clearly distinguished the three groups when taken at the temporal arcades. Measurements above and below the arcades were also consistent, but did not distinguish normals from suspects. The measure was correlated with graded estimates of RNFL integrity of two trained observers (ρ = −0.57, p <0.001 and ρ = −0.61, p < 0.001).

© 1989 Optical Society of America

Exploration of the retinal nerve fiber layer thickness by measurement of the linear dichroism

Olivier Karim Naoun, Valérie Louis Dorr, Paul Allé, Jean-Christophe Sablon, and Anne-Marie Benoit
Appl. Opt. 44(33) 7074-7082 (2005)

Imaging of the optic disc and retinal nerve fiber layer: the effects of age, optic disc area, refractive error, and gender

Christopher Bowd, Linda M. Zangwill, Eytan Z. Blumenthal, Cristiana Vasile, Andreas G. Boehm, Parag A. Gokhale, Kourosh Mohammadi, Payam Amini, Timothy M. Sankary, and Robert N. Weinreb
J. Opt. Soc. Am. A 19(1) 197-207 (2002)

Segregation of neuronal-vascular components in a retinal nerve fiber layer for thickness measurement using OCT and OCT angiography

Ai Ping Yow, Bingyao Tan, Jacqueline Chua, Rahat Husain, Leopold Schmetterer, and Damon Wong
Biomed. Opt. Express 12(6) 3228-3240 (2021)

Pulsatile retinal nerve fiber layer imaging with functional optical coherence tomography

Lin An, Bixuan Yan, Yansong Zhao, Ke He, Xiaocui Wu, Gongpu Lan, Yanping Huang, Jingjiang Xu, Chubin Ou, Xi Zeng, Shuna Wang, Xiaoli Wang, Jinfeng Long, Xunbin Wei, and Jia Qin
Opt. Continuum 1(2) 283-296 (2022)

Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT

Sylvia Desissaire, Andreas Pollreisz, Aleksandra Sedova, Dorottya Hajdu, Felix Datlinger, Stefan Steiner, Clemens Vass, Florian Schwarzhans, Georg Fischer, Michael Pircher, Ursula Schmidt-Erfurth, and Christoph K. Hitzenberger
Biomed. Opt. Express 11(10) 5488-5505 (2020)