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Local and Global Visual Function Deficits in Patients with Stargardt Disease

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Abstract

We examined the ability of patients with Stargardt disease to perform a global hyperacuity task. Stimuli were circular D4 contours and their deformations. A spatial 2 AFC paradigm was employed. In each trial, the patients indicated which of two stimuli was deformed. The patients showed a substantial elevation in the threshold for detecting circular D4 deformation while still retaining relatively good visual acuity. The results support the hypothesis that optimal performance for detecting circular D4 deformation involves some kind of global mechanism. The results also suggest the global hyperacuity is an effective test for quantifying early visual loss from macular degeneration.

© 2000 Optical Society of America

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