Collagen content was estimated on 109 subjects (53 healthy and 56 with malignant breast lesions) performing time domain 7-wavelength (635-1060 nm) optical mammography. Subjects with higher age-matched collagen content (top 15%) show higher cancer occurrence. Collagen correlates with mammographic density (recognized risk factor for breast cancer). However, top 15% clustering based on percentage mammographic density identifies a different set of patients, potentially indicating collagen as an independent breast cancer risk factor. If confirmed on a wider population, these initial results could have huge impact on personalized diagnostics and health care systems.

© 2016 Optical Society of America

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