Abstract
One of the major challenges in population screening is identifying the patients at risk of cancer. For instance, in colorectal cancer, while the entire population of age 50 should be subject to screening, the lifetime risk of CRC is only ~5%. Indeed, average risk colonoscopy can detect significant polyps <10% of the time. Screening for low prevalence lesions leads to increase costs, unnecessary morbidity and most particularly false positives. Thus, risk stratification to identify patients most likely to benefit from tests such as colonoscopy is critical.
© 2016 Optical Society of America
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