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Study on the Influence of Optical Clearing on Polarization Imaging Contrast

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Abstract

During optical clearing process, different microstructural features may show different polarization change. We simulated the tissue clearing process focusing on two type tissue anisotropy: the interstitial birefringence and the fibrous scatterers. Based on our previous research, in our simulations, we set up a sphere-cylinder birefringence model (SCBM) to mimic the anisotropic tissues, and employ the multiple clearing mechanisms mainly by refractive index matching, and supplemented by the alignment of the fibrous structures and the birefringence of the interstitial medium. It can be seen that the change regularity of depolarization and phase retardance along with the clearing is connected with the tissue modeling parameters, implying in what case the polarization contrast can be improved by clearing should be discussed. By comparing experiments and simulations, we examine how the polarization contrast changes with the clearing and what characters can be suitable for the polarization imaging applied in tissue clearing.

© 2017 Optical Society of America

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